Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.greenbergcls.cls #KO_GAQ_versus_KO_NA.greenbergcls.cls #KO_GAQ_versus_KO_NA_repos |
| Phenotype | greenbergcls.cls#KO_GAQ_versus_KO_NA_repos |
| Upregulated in class | KO_NA |
| GeneSet | CROONQUIST_NRAS_SIGNALING_DN |
| Enrichment Score (ES) | -0.83377105 |
| Normalized Enrichment Score (NES) | -1.7176281 |
| Nominal p-value | 0.0 |
| FDR q-value | 5.7858054E-4 |
| FWER p-Value | 0.007 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | SBNO2 | strawberry notch homolog 2 [Source:HGNC Symbol;Acc:HGNC:29158] | 128 | 3.319 | 0.0241 | No |
| 2 | EIF5 | eukaryotic translation initiation factor 5 [Source:HGNC Symbol;Acc:HGNC:3299] | 1757 | 0.981 | -0.0117 | No |
| 3 | GNAI1 | G protein subunit alpha i1 [Source:HGNC Symbol;Acc:HGNC:4384] | 2069 | 0.867 | -0.0129 | No |
| 4 | SNRPA1 | small nuclear ribonucleoprotein polypeptide A' [Source:HGNC Symbol;Acc:HGNC:11152] | 2757 | 0.652 | -0.0260 | No |
| 5 | HMGA1 | high mobility group AT-hook 1 [Source:HGNC Symbol;Acc:HGNC:5010] | 3600 | 0.471 | -0.0449 | No |
| 6 | MYRF | myelin regulatory factor [Source:HGNC Symbol;Acc:HGNC:1181] | 5212 | 0.201 | -0.0867 | No |
| 7 | APOBEC3B | apolipoprotein B mRNA editing enzyme catalytic subunit 3B [Source:HGNC Symbol;Acc:HGNC:17352] | 12685 | 0.000 | -0.2886 | No |
| 8 | CENPA | centromere protein A [Source:HGNC Symbol;Acc:HGNC:1851] | 24136 | 0.000 | -0.5978 | No |
| 9 | ZWINT | ZW10 interacting kinetochore protein [Source:HGNC Symbol;Acc:HGNC:13195] | 26185 | 0.000 | -0.6532 | No |
| 10 | CDK1 | cyclin dependent kinase 1 [Source:HGNC Symbol;Acc:HGNC:1722] | 27890 | -0.049 | -0.6988 | No |
| 11 | PTTG1 | PTTG1 regulator of sister chromatid separation, securin [Source:HGNC Symbol;Acc:HGNC:9690] | 29208 | -0.205 | -0.7326 | No |
| 12 | PLOD2 | procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 [Source:HGNC Symbol;Acc:HGNC:9082] | 30118 | -0.320 | -0.7545 | No |
| 13 | CSE1L | chromosome segregation 1 like [Source:HGNC Symbol;Acc:HGNC:2431] | 31222 | -0.473 | -0.7804 | No |
| 14 | CKS1B | CDC28 protein kinase regulatory subunit 1B [Source:HGNC Symbol;Acc:HGNC:19083] | 32738 | -0.765 | -0.8150 | No |
| 15 | AURKA | aurora kinase A [Source:HGNC Symbol;Acc:HGNC:11393] | 33435 | -0.948 | -0.8259 | Yes |
| 16 | HMGB2 | high mobility group box 2 [Source:HGNC Symbol;Acc:HGNC:5000] | 33703 | -1.035 | -0.8245 | Yes |
| 17 | TPX2 | TPX2 microtubule nucleation factor [Source:HGNC Symbol;Acc:HGNC:1249] | 33875 | -1.087 | -0.8201 | Yes |
| 18 | TRIP13 | thyroid hormone receptor interactor 13 [Source:HGNC Symbol;Acc:HGNC:12307] | 33881 | -1.088 | -0.8112 | Yes |
| 19 | CCNB1 | cyclin B1 [Source:HGNC Symbol;Acc:HGNC:1579] | 33967 | -1.118 | -0.8042 | Yes |
| 20 | RFC3 | replication factor C subunit 3 [Source:HGNC Symbol;Acc:HGNC:9971] | 33988 | -1.124 | -0.7954 | Yes |
| 21 | TRAIP | TRAF interacting protein [Source:HGNC Symbol;Acc:HGNC:30764] | 34273 | -1.223 | -0.7929 | Yes |
| 22 | PCNA | proliferating cell nuclear antigen [Source:HGNC Symbol;Acc:HGNC:8729] | 34299 | -1.231 | -0.7833 | Yes |
| 23 | BRD8 | bromodomain containing 8 [Source:HGNC Symbol;Acc:HGNC:19874] | 34418 | -1.275 | -0.7759 | Yes |
| 24 | PLK4 | polo like kinase 4 [Source:HGNC Symbol;Acc:HGNC:11397] | 34419 | -1.276 | -0.7653 | Yes |
| 25 | MCM3 | minichromosome maintenance complex component 3 [Source:HGNC Symbol;Acc:HGNC:6945] | 34678 | -1.382 | -0.7608 | Yes |
| 26 | CHEK1 | checkpoint kinase 1 [Source:HGNC Symbol;Acc:HGNC:1925] | 34680 | -1.382 | -0.7494 | Yes |
| 27 | SMC4 | structural maintenance of chromosomes 4 [Source:HGNC Symbol;Acc:HGNC:14013] | 34692 | -1.386 | -0.7382 | Yes |
| 28 | MCM4 | minichromosome maintenance complex component 4 [Source:HGNC Symbol;Acc:HGNC:6947] | 34760 | -1.422 | -0.7282 | Yes |
| 29 | POLD3 | DNA polymerase delta 3, accessory subunit [Source:HGNC Symbol;Acc:HGNC:20932] | 34825 | -1.445 | -0.7179 | Yes |
| 30 | CDC20 | cell division cycle 20 [Source:HGNC Symbol;Acc:HGNC:1723] | 34948 | -1.490 | -0.7088 | Yes |
| 31 | OIP5 | Opa interacting protein 5 [Source:HGNC Symbol;Acc:HGNC:20300] | 35070 | -1.546 | -0.6992 | Yes |
| 32 | PLK1 | polo like kinase 1 [Source:HGNC Symbol;Acc:HGNC:9077] | 35100 | -1.565 | -0.6870 | Yes |
| 33 | KIF2C | kinesin family member 2C [Source:HGNC Symbol;Acc:HGNC:6393] | 35135 | -1.581 | -0.6748 | Yes |
| 34 | SPAG5 | sperm associated antigen 5 [Source:HGNC Symbol;Acc:HGNC:13452] | 35378 | -1.712 | -0.6671 | Yes |
| 35 | CDC25C | cell division cycle 25C [Source:HGNC Symbol;Acc:HGNC:1727] | 35383 | -1.713 | -0.6530 | Yes |
| 36 | DUT | deoxyuridine triphosphatase [Source:HGNC Symbol;Acc:HGNC:3078] | 35438 | -1.743 | -0.6400 | Yes |
| 37 | NASP | nuclear autoantigenic sperm protein [Source:HGNC Symbol;Acc:HGNC:7644] | 35440 | -1.743 | -0.6255 | Yes |
| 38 | UBE2C | ubiquitin conjugating enzyme E2 C [Source:HGNC Symbol;Acc:HGNC:15937] | 35447 | -1.747 | -0.6111 | Yes |
| 39 | SPC25 | SPC25 component of NDC80 kinetochore complex [Source:HGNC Symbol;Acc:HGNC:24031] | 35481 | -1.764 | -0.5974 | Yes |
| 40 | CDKN3 | cyclin dependent kinase inhibitor 3 [Source:HGNC Symbol;Acc:HGNC:1791] | 35583 | -1.827 | -0.5849 | Yes |
| 41 | SMC2 | structural maintenance of chromosomes 2 [Source:HGNC Symbol;Acc:HGNC:14011] | 35602 | -1.838 | -0.5701 | Yes |
| 42 | PCLAF | PCNA clamp associated factor [Source:HGNC Symbol;Acc:HGNC:28961] | 35608 | -1.839 | -0.5550 | Yes |
| 43 | CDC6 | cell division cycle 6 [Source:HGNC Symbol;Acc:HGNC:1744] | 35691 | -1.899 | -0.5414 | Yes |
| 44 | BUB1B | BUB1 mitotic checkpoint serine/threonine kinase B [Source:HGNC Symbol;Acc:HGNC:1149] | 35704 | -1.908 | -0.5259 | Yes |
| 45 | KIF11 | kinesin family member 11 [Source:HGNC Symbol;Acc:HGNC:6388] | 35949 | -2.088 | -0.5151 | Yes |
| 46 | TOP2A | DNA topoisomerase II alpha [Source:HGNC Symbol;Acc:HGNC:11989] | 35971 | -2.105 | -0.4982 | Yes |
| 47 | RAD51C | RAD51 paralog C [Source:HGNC Symbol;Acc:HGNC:9820] | 36002 | -2.139 | -0.4813 | Yes |
| 48 | CHAF1A | chromatin assembly factor 1 subunit A [Source:HGNC Symbol;Acc:HGNC:1910] | 36039 | -2.167 | -0.4642 | Yes |
| 49 | STIL | STIL centriolar assembly protein [Source:HGNC Symbol;Acc:HGNC:10879] | 36049 | -2.173 | -0.4464 | Yes |
| 50 | MCM2 | minichromosome maintenance complex component 2 [Source:HGNC Symbol;Acc:HGNC:6944] | 36147 | -2.266 | -0.4302 | Yes |
| 51 | GALE | UDP-galactose-4-epimerase [Source:HGNC Symbol;Acc:HGNC:4116] | 36157 | -2.280 | -0.4115 | Yes |
| 52 | KIF22 | kinesin family member 22 [Source:HGNC Symbol;Acc:HGNC:6391] | 36195 | -2.312 | -0.3933 | Yes |
| 53 | NCAPH | non-SMC condensin I complex subunit H [Source:HGNC Symbol;Acc:HGNC:1112] | 36203 | -2.318 | -0.3742 | Yes |
| 54 | CCNB2 | cyclin B2 [Source:HGNC Symbol;Acc:HGNC:1580] | 36291 | -2.397 | -0.3567 | Yes |
| 55 | GINS1 | GINS complex subunit 1 [Source:HGNC Symbol;Acc:HGNC:28980] | 36323 | -2.430 | -0.3373 | Yes |
| 56 | AURKB | aurora kinase B [Source:HGNC Symbol;Acc:HGNC:11390] | 36338 | -2.450 | -0.3173 | Yes |
| 57 | PTP4A3 | protein tyrosine phosphatase 4A3 [Source:HGNC Symbol;Acc:HGNC:9636] | 36351 | -2.462 | -0.2972 | Yes |
| 58 | STMN1 | stathmin 1 [Source:HGNC Symbol;Acc:HGNC:6510] | 36377 | -2.484 | -0.2772 | Yes |
| 59 | CCNA2 | cyclin A2 [Source:HGNC Symbol;Acc:HGNC:1578] | 36418 | -2.536 | -0.2572 | Yes |
| 60 | MKI67 | marker of proliferation Ki-67 [Source:HGNC Symbol;Acc:HGNC:7107] | 36474 | -2.605 | -0.2371 | Yes |
| 61 | NDC80 | NDC80 kinetochore complex component [Source:HGNC Symbol;Acc:HGNC:16909] | 36492 | -2.640 | -0.2156 | Yes |
| 62 | H2AX | H2A.X variant histone [Source:HGNC Symbol;Acc:HGNC:4739] | 36530 | -2.698 | -0.1942 | Yes |
| 63 | WEE1 | WEE1 G2 checkpoint kinase [Source:HGNC Symbol;Acc:HGNC:12761] | 36533 | -2.702 | -0.1718 | Yes |
| 64 | FOXM1 | forkhead box M1 [Source:HGNC Symbol;Acc:HGNC:3818] | 36641 | -2.835 | -0.1511 | Yes |
| 65 | MCM7 | minichromosome maintenance complex component 7 [Source:HGNC Symbol;Acc:HGNC:6950] | 36694 | -2.936 | -0.1282 | Yes |
| 66 | POLD1 | DNA polymerase delta 1, catalytic subunit [Source:HGNC Symbol;Acc:HGNC:9175] | 36708 | -2.969 | -0.1038 | Yes |
| 67 | GPX4 | glutathione peroxidase 4 [Source:HGNC Symbol;Acc:HGNC:4556] | 36767 | -3.101 | -0.0796 | Yes |
| 68 | MYBL2 | MYB proto-oncogene like 2 [Source:HGNC Symbol;Acc:HGNC:7548] | 36799 | -3.202 | -0.0539 | Yes |
| 69 | CHEK2 | checkpoint kinase 2 [Source:HGNC Symbol;Acc:HGNC:16627] | 36816 | -3.242 | -0.0274 | Yes |
| 70 | TK1 | thymidine kinase 1 [Source:HGNC Symbol;Acc:HGNC:11830] | 37048 | -4.181 | 0.0011 | Yes |
