Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.greenbergcls.cls #KO_GAQ_versus_KO_NA.greenbergcls.cls #KO_GAQ_versus_KO_NA_repos |
| Phenotype | greenbergcls.cls#KO_GAQ_versus_KO_NA_repos |
| Upregulated in class | KO_NA |
| GeneSet | PUJANA_BRCA_CENTERED_NETWORK |
| Enrichment Score (ES) | -0.7630976 |
| Normalized Enrichment Score (NES) | -1.654003 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.004825826 |
| FWER p-Value | 0.11 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | SLC7A1 | solute carrier family 7 member 1 [Source:HGNC Symbol;Acc:HGNC:11057] | 627 | 1.822 | -0.0059 | No |
| 2 | MAT2A | methionine adenosyltransferase 2A [Source:HGNC Symbol;Acc:HGNC:6904] | 1147 | 1.299 | -0.0120 | No |
| 3 | DCP2 | decapping mRNA 2 [Source:HGNC Symbol;Acc:HGNC:24452] | 1336 | 1.182 | -0.0099 | No |
| 4 | TOP1 | DNA topoisomerase I [Source:HGNC Symbol;Acc:HGNC:11986] | 1427 | 1.145 | -0.0054 | No |
| 5 | DDX39A | DExD-box helicase 39A [Source:HGNC Symbol;Acc:HGNC:17821] | 2210 | 0.817 | -0.0216 | No |
| 6 | ZNF330 | zinc finger protein 330 [Source:HGNC Symbol;Acc:HGNC:15462] | 2455 | 0.737 | -0.0237 | No |
| 7 | SRSF11 | serine and arginine rich splicing factor 11 [Source:HGNC Symbol;Acc:HGNC:10782] | 2723 | 0.661 | -0.0269 | No |
| 8 | SNRPA1 | small nuclear ribonucleoprotein polypeptide A' [Source:HGNC Symbol;Acc:HGNC:11152] | 2757 | 0.652 | -0.0239 | No |
| 9 | NCK1 | NCK adaptor protein 1 [Source:HGNC Symbol;Acc:HGNC:7664] | 3015 | 0.586 | -0.0272 | No |
| 10 | AATF | apoptosis antagonizing transcription factor [Source:HGNC Symbol;Acc:HGNC:19235] | 3086 | 0.575 | -0.0256 | No |
| 11 | METAP1 | methionyl aminopeptidase 1 [Source:HGNC Symbol;Acc:HGNC:15789] | 3090 | 0.575 | -0.0222 | No |
| 12 | STAT5A | signal transducer and activator of transcription 5A [Source:HGNC Symbol;Acc:HGNC:11366] | 3176 | 0.556 | -0.0212 | No |
| 13 | SNRPB | small nuclear ribonucleoprotein polypeptides B and B1 [Source:HGNC Symbol;Acc:HGNC:11153] | 3229 | 0.545 | -0.0193 | No |
| 14 | ZNHIT3 | zinc finger HIT-type containing 3 [Source:HGNC Symbol;Acc:HGNC:12309] | 3626 | 0.467 | -0.0271 | No |
| 15 | MED20 | mediator complex subunit 20 [Source:HGNC Symbol;Acc:HGNC:16840] | 3662 | 0.461 | -0.0253 | No |
| 16 | CSNK2A1 | casein kinase 2 alpha 1 [Source:HGNC Symbol;Acc:HGNC:2457] | 4356 | 0.336 | -0.0420 | No |
| 17 | PRPF4 | pre-mRNA processing factor 4 [Source:HGNC Symbol;Acc:HGNC:17349] | 4746 | 0.272 | -0.0508 | No |
| 18 | SNRPA | small nuclear ribonucleoprotein polypeptide A [Source:HGNC Symbol;Acc:HGNC:11151] | 4960 | 0.238 | -0.0552 | No |
| 19 | PPP1CC | protein phosphatase 1 catalytic subunit gamma [Source:HGNC Symbol;Acc:HGNC:9283] | 5004 | 0.232 | -0.0549 | No |
| 20 | DDX39B | DExD-box helicase 39B [Source:HGNC Symbol;Acc:HGNC:13917] | 5017 | 0.230 | -0.0538 | No |
| 21 | PRPS1 | phosphoribosyl pyrophosphate synthetase 1 [Source:HGNC Symbol;Acc:HGNC:9462] | 5018 | 0.230 | -0.0524 | No |
| 22 | SSBP2 | single stranded DNA binding protein 2 [Source:HGNC Symbol;Acc:HGNC:15831] | 5576 | 0.149 | -0.0666 | No |
| 23 | POLR2B | RNA polymerase II subunit B [Source:HGNC Symbol;Acc:HGNC:9188] | 5589 | 0.148 | -0.0660 | No |
| 24 | CPSF4 | cleavage and polyadenylation specific factor 4 [Source:HGNC Symbol;Acc:HGNC:2327] | 5705 | 0.131 | -0.0683 | No |
| 25 | NAE1 | NEDD8 activating enzyme E1 subunit 1 [Source:HGNC Symbol;Acc:HGNC:621] | 6150 | 0.073 | -0.0799 | No |
| 26 | TBCA | tubulin folding cofactor A [Source:HGNC Symbol;Acc:HGNC:11579] | 6360 | 0.047 | -0.0853 | No |
| 27 | DHFR | dihydrofolate reductase [Source:HGNC Symbol;Acc:HGNC:2861] | 27652 | -0.021 | -0.6610 | No |
| 28 | DDX46 | DEAD-box helicase 46 [Source:HGNC Symbol;Acc:HGNC:18681] | 27694 | -0.025 | -0.6620 | No |
| 29 | TCERG1 | transcription elongation regulator 1 [Source:HGNC Symbol;Acc:HGNC:15630] | 27806 | -0.038 | -0.6647 | No |
| 30 | SEC31A | SEC31 homolog A, COPII coat complex component [Source:HGNC Symbol;Acc:HGNC:17052] | 27874 | -0.047 | -0.6663 | No |
| 31 | CDK1 | cyclin dependent kinase 1 [Source:HGNC Symbol;Acc:HGNC:1722] | 27890 | -0.049 | -0.6664 | No |
| 32 | RPIA | ribose 5-phosphate isomerase A [Source:HGNC Symbol;Acc:HGNC:10297] | 28039 | -0.066 | -0.6700 | No |
| 33 | CNOT3 | CCR4-NOT transcription complex subunit 3 [Source:HGNC Symbol;Acc:HGNC:7879] | 28634 | -0.135 | -0.6852 | No |
| 34 | TAF11 | TATA-box binding protein associated factor 11 [Source:HGNC Symbol;Acc:HGNC:11544] | 28689 | -0.141 | -0.6858 | No |
| 35 | RAD1 | RAD1 checkpoint DNA exonuclease [Source:HGNC Symbol;Acc:HGNC:9806] | 30245 | -0.336 | -0.7258 | No |
| 36 | KATNA1 | katanin catalytic subunit A1 [Source:HGNC Symbol;Acc:HGNC:6216] | 30350 | -0.348 | -0.7265 | No |
| 37 | BUB3 | BUB3 mitotic checkpoint protein [Source:HGNC Symbol;Acc:HGNC:1151] | 30602 | -0.382 | -0.7310 | No |
| 38 | CNOT9 | CCR4-NOT transcription complex subunit 9 [Source:HGNC Symbol;Acc:HGNC:10445] | 30833 | -0.416 | -0.7347 | No |
| 39 | COPS3 | COP9 signalosome subunit 3 [Source:HGNC Symbol;Acc:HGNC:2239] | 30900 | -0.427 | -0.7339 | No |
| 40 | NFYB | nuclear transcription factor Y subunit beta [Source:HGNC Symbol;Acc:HGNC:7805] | 31276 | -0.481 | -0.7411 | No |
| 41 | ASF1A | anti-silencing function 1A histone chaperone [Source:HGNC Symbol;Acc:HGNC:20995] | 31404 | -0.506 | -0.7415 | No |
| 42 | ABCB7 | ATP binding cassette subfamily B member 7 [Source:HGNC Symbol;Acc:HGNC:48] | 31737 | -0.565 | -0.7470 | No |
| 43 | CAD | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase [Source:HGNC Symbol;Acc:HGNC:1424] | 31842 | -0.582 | -0.7463 | No |
| 44 | EIF3H | eukaryotic translation initiation factor 3 subunit H [Source:HGNC Symbol;Acc:HGNC:3273] | 32231 | -0.660 | -0.7528 | No |
| 45 | DNA2 | DNA replication helicase/nuclease 2 [Source:HGNC Symbol;Acc:HGNC:2939] | 32315 | -0.677 | -0.7509 | No |
| 46 | SKP2 | S-phase kinase associated protein 2 [Source:HGNC Symbol;Acc:HGNC:10901] | 32767 | -0.774 | -0.7584 | Yes |
| 47 | LMNB1 | lamin B1 [Source:HGNC Symbol;Acc:HGNC:6637] | 32873 | -0.802 | -0.7564 | Yes |
| 48 | IDH3B | isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta [Source:HGNC Symbol;Acc:HGNC:5385] | 32876 | -0.803 | -0.7515 | Yes |
| 49 | TFDP1 | transcription factor Dp-1 [Source:HGNC Symbol;Acc:HGNC:11749] | 33225 | -0.893 | -0.7555 | Yes |
| 50 | AURKA | aurora kinase A [Source:HGNC Symbol;Acc:HGNC:11393] | 33435 | -0.948 | -0.7554 | Yes |
| 51 | RBBP4 | RB binding protein 4, chromatin remodeling factor [Source:HGNC Symbol;Acc:HGNC:9887] | 33691 | -1.029 | -0.7561 | Yes |
| 52 | HMGB2 | high mobility group box 2 [Source:HGNC Symbol;Acc:HGNC:5000] | 33703 | -1.035 | -0.7501 | Yes |
| 53 | RBBP8 | RB binding protein 8, endonuclease [Source:HGNC Symbol;Acc:HGNC:9891] | 33843 | -1.077 | -0.7473 | Yes |
| 54 | XPO1 | exportin 1 [Source:HGNC Symbol;Acc:HGNC:12825] | 33906 | -1.097 | -0.7423 | Yes |
| 55 | CDC7 | cell division cycle 7 [Source:HGNC Symbol;Acc:HGNC:1745] | 33908 | -1.097 | -0.7357 | Yes |
| 56 | PRKDC | protein kinase, DNA-activated, catalytic subunit [Source:HGNC Symbol;Acc:HGNC:9413] | 33969 | -1.119 | -0.7305 | Yes |
| 57 | RFC3 | replication factor C subunit 3 [Source:HGNC Symbol;Acc:HGNC:9971] | 33988 | -1.124 | -0.7241 | Yes |
| 58 | RNASEH2B | ribonuclease H2 subunit B [Source:HGNC Symbol;Acc:HGNC:25671] | 34020 | -1.136 | -0.7181 | Yes |
| 59 | PCNA | proliferating cell nuclear antigen [Source:HGNC Symbol;Acc:HGNC:8729] | 34299 | -1.231 | -0.7181 | Yes |
| 60 | SUZ12 | SUZ12 polycomb repressive complex 2 subunit [Source:HGNC Symbol;Acc:HGNC:17101] | 34472 | -1.302 | -0.7149 | Yes |
| 61 | TIMELESS | timeless circadian regulator [Source:HGNC Symbol;Acc:HGNC:11813] | 34549 | -1.332 | -0.7088 | Yes |
| 62 | TCF3 | transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:11633] | 34637 | -1.369 | -0.7029 | Yes |
| 63 | SMC4 | structural maintenance of chromosomes 4 [Source:HGNC Symbol;Acc:HGNC:14013] | 34692 | -1.386 | -0.6959 | Yes |
| 64 | MCM4 | minichromosome maintenance complex component 4 [Source:HGNC Symbol;Acc:HGNC:6947] | 34760 | -1.422 | -0.6891 | Yes |
| 65 | NEMP1 | nuclear envelope integral membrane protein 1 [Source:HGNC Symbol;Acc:HGNC:29001] | 34860 | -1.456 | -0.6829 | Yes |
| 66 | CDC20 | cell division cycle 20 [Source:HGNC Symbol;Acc:HGNC:1723] | 34948 | -1.490 | -0.6762 | Yes |
| 67 | MRE11 | MRE11 homolog, double strand break repair nuclease [Source:HGNC Symbol;Acc:HGNC:7230] | 34986 | -1.510 | -0.6680 | Yes |
| 68 | MAD2L1 | mitotic arrest deficient 2 like 1 [Source:HGNC Symbol;Acc:HGNC:6763] | 35065 | -1.544 | -0.6608 | Yes |
| 69 | FANCI | FA complementation group I [Source:HGNC Symbol;Acc:HGNC:25568] | 35150 | -1.587 | -0.6534 | Yes |
| 70 | RAD21 | RAD21 cohesin complex component [Source:HGNC Symbol;Acc:HGNC:9811] | 35190 | -1.608 | -0.6447 | Yes |
| 71 | UNG | uracil DNA glycosylase [Source:HGNC Symbol;Acc:HGNC:12572] | 35303 | -1.677 | -0.6375 | Yes |
| 72 | SMC1A | structural maintenance of chromosomes 1A [Source:HGNC Symbol;Acc:HGNC:11111] | 35336 | -1.691 | -0.6281 | Yes |
| 73 | PPP2R5C | protein phosphatase 2 regulatory subunit B'gamma [Source:HGNC Symbol;Acc:HGNC:9311] | 35407 | -1.730 | -0.6195 | Yes |
| 74 | SMC3 | structural maintenance of chromosomes 3 [Source:HGNC Symbol;Acc:HGNC:2468] | 35412 | -1.731 | -0.6091 | Yes |
| 75 | DUT | deoxyuridine triphosphatase [Source:HGNC Symbol;Acc:HGNC:3078] | 35438 | -1.743 | -0.5992 | Yes |
| 76 | NASP | nuclear autoantigenic sperm protein [Source:HGNC Symbol;Acc:HGNC:7644] | 35440 | -1.743 | -0.5886 | Yes |
| 77 | UBE2C | ubiquitin conjugating enzyme E2 C [Source:HGNC Symbol;Acc:HGNC:15937] | 35447 | -1.747 | -0.5781 | Yes |
| 78 | ESPL1 | extra spindle pole bodies like 1, separase [Source:HGNC Symbol;Acc:HGNC:16856] | 35469 | -1.759 | -0.5680 | Yes |
| 79 | KIFC1 | kinesin family member C1 [Source:HGNC Symbol;Acc:HGNC:6389] | 35510 | -1.778 | -0.5583 | Yes |
| 80 | BRCA2 | BRCA2 DNA repair associated [Source:HGNC Symbol;Acc:HGNC:1101] | 35535 | -1.800 | -0.5480 | Yes |
| 81 | SMC2 | structural maintenance of chromosomes 2 [Source:HGNC Symbol;Acc:HGNC:14011] | 35602 | -1.838 | -0.5386 | Yes |
| 82 | POLA1 | DNA polymerase alpha 1, catalytic subunit [Source:HGNC Symbol;Acc:HGNC:9173] | 35623 | -1.850 | -0.5279 | Yes |
| 83 | DEK | DEK proto-oncogene [Source:HGNC Symbol;Acc:HGNC:2768] | 35633 | -1.861 | -0.5169 | Yes |
| 84 | ATM | ATM serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:795] | 35703 | -1.908 | -0.5071 | Yes |
| 85 | RRM1 | ribonucleotide reductase catalytic subunit M1 [Source:HGNC Symbol;Acc:HGNC:10451] | 35769 | -1.949 | -0.4971 | Yes |
| 86 | RECQL | RecQ like helicase [Source:HGNC Symbol;Acc:HGNC:9948] | 35786 | -1.963 | -0.4856 | Yes |
| 87 | EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit [Source:HGNC Symbol;Acc:HGNC:3527] | 35806 | -1.978 | -0.4741 | Yes |
| 88 | HMMR | hyaluronan mediated motility receptor [Source:HGNC Symbol;Acc:HGNC:5012] | 35808 | -1.979 | -0.4621 | Yes |
| 89 | MCM5 | minichromosome maintenance complex component 5 [Source:HGNC Symbol;Acc:HGNC:6948] | 35939 | -2.080 | -0.4529 | Yes |
| 90 | TOP2A | DNA topoisomerase II alpha [Source:HGNC Symbol;Acc:HGNC:11989] | 35971 | -2.105 | -0.4410 | Yes |
| 91 | LBR | lamin B receptor [Source:HGNC Symbol;Acc:HGNC:6518] | 35988 | -2.120 | -0.4285 | Yes |
| 92 | RAD51C | RAD51 paralog C [Source:HGNC Symbol;Acc:HGNC:9820] | 36002 | -2.139 | -0.4159 | Yes |
| 93 | BLM | BLM RecQ like helicase [Source:HGNC Symbol;Acc:HGNC:1058] | 36023 | -2.156 | -0.4033 | Yes |
| 94 | CHAF1A | chromatin assembly factor 1 subunit A [Source:HGNC Symbol;Acc:HGNC:1910] | 36039 | -2.167 | -0.3906 | Yes |
| 95 | PSIP1 | PC4 and SFRS1 interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:9527] | 36040 | -2.168 | -0.3774 | Yes |
| 96 | RFC4 | replication factor C subunit 4 [Source:HGNC Symbol;Acc:HGNC:9972] | 36061 | -2.182 | -0.3647 | Yes |
| 97 | MCM2 | minichromosome maintenance complex component 2 [Source:HGNC Symbol;Acc:HGNC:6944] | 36147 | -2.266 | -0.3532 | Yes |
| 98 | TMPO | thymopoietin [Source:HGNC Symbol;Acc:HGNC:11875] | 36174 | -2.293 | -0.3400 | Yes |
| 99 | RAD54L | RAD54 like [Source:HGNC Symbol;Acc:HGNC:9826] | 36182 | -2.302 | -0.3262 | Yes |
| 100 | POLE | DNA polymerase epsilon, catalytic subunit [Source:HGNC Symbol;Acc:HGNC:9177] | 36229 | -2.343 | -0.3132 | Yes |
| 101 | GINS1 | GINS complex subunit 1 [Source:HGNC Symbol;Acc:HGNC:28980] | 36323 | -2.430 | -0.3010 | Yes |
| 102 | TOPBP1 | DNA topoisomerase II binding protein 1 [Source:HGNC Symbol;Acc:HGNC:17008] | 36331 | -2.436 | -0.2864 | Yes |
| 103 | CCNA2 | cyclin A2 [Source:HGNC Symbol;Acc:HGNC:1578] | 36418 | -2.536 | -0.2733 | Yes |
| 104 | RPA1 | replication protein A1 [Source:HGNC Symbol;Acc:HGNC:10289] | 36442 | -2.562 | -0.2583 | Yes |
| 105 | TTF2 | transcription termination factor 2 [Source:HGNC Symbol;Acc:HGNC:12398] | 36452 | -2.576 | -0.2429 | Yes |
| 106 | MCM6 | minichromosome maintenance complex component 6 [Source:HGNC Symbol;Acc:HGNC:6949] | 36468 | -2.596 | -0.2276 | Yes |
| 107 | NDC80 | NDC80 kinetochore complex component [Source:HGNC Symbol;Acc:HGNC:16909] | 36492 | -2.640 | -0.2121 | Yes |
| 108 | NCAPD2 | non-SMC condensin I complex subunit D2 [Source:HGNC Symbol;Acc:HGNC:24305] | 36642 | -2.836 | -0.1989 | Yes |
| 109 | PAICS | phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase [Source:HGNC Symbol;Acc:HGNC:8587] | 36657 | -2.858 | -0.1819 | Yes |
| 110 | RAD51AP1 | RAD51 associated protein 1 [Source:HGNC Symbol;Acc:HGNC:16956] | 36707 | -2.964 | -0.1653 | Yes |
| 111 | MYBL2 | MYB proto-oncogene like 2 [Source:HGNC Symbol;Acc:HGNC:7548] | 36799 | -3.202 | -0.1483 | Yes |
| 112 | CHEK2 | checkpoint kinase 2 [Source:HGNC Symbol;Acc:HGNC:16627] | 36816 | -3.242 | -0.1290 | Yes |
| 113 | DNMT1 | DNA methyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:2976] | 36818 | -3.244 | -0.1093 | Yes |
| 114 | BRCA1 | BRCA1 DNA repair associated [Source:HGNC Symbol;Acc:HGNC:1100] | 36824 | -3.259 | -0.0897 | Yes |
| 115 | RB1 | RB transcriptional corepressor 1 [Source:HGNC Symbol;Acc:HGNC:9884] | 36972 | -3.766 | -0.0708 | Yes |
| 116 | H2AZ2 | H2A.Z variant histone 2 [Source:HGNC Symbol;Acc:HGNC:20664] | 36977 | -3.801 | -0.0478 | Yes |
| 117 | MSH2 | mutS homolog 2 [Source:HGNC Symbol;Acc:HGNC:7325] | 37028 | -4.011 | -0.0248 | Yes |
| 118 | TFDP2 | transcription factor Dp-2 [Source:HGNC Symbol;Acc:HGNC:11751] | 37064 | -4.346 | 0.0007 | Yes |
