Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.greenbergcls.cls #KO_GAQ_versus_KO_NA.greenbergcls.cls #KO_GAQ_versus_KO_NA_repos |
| Phenotype | greenbergcls.cls#KO_GAQ_versus_KO_NA_repos |
| Upregulated in class | KO_GAQ |
| GeneSet | REACTOME_INTERFERON_ALPHA_BETA_SIGNALING |
| Enrichment Score (ES) | 0.8063346 |
| Normalized Enrichment Score (NES) | 1.9987094 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0 |
| FWER p-Value | 0.0 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | SOCS3 | suppressor of cytokine signaling 3 [Source:HGNC Symbol;Acc:HGNC:19391] | 12 | 4.738 | 0.0668 | Yes |
| 2 | USP18 | ubiquitin specific peptidase 18 [Source:HGNC Symbol;Acc:HGNC:12616] | 34 | 4.337 | 0.1277 | Yes |
| 3 | OAS1 | 2'-5'-oligoadenylate synthetase 1 [Source:HGNC Symbol;Acc:HGNC:8086] | 143 | 3.206 | 0.1702 | Yes |
| 4 | IRF7 | interferon regulatory factor 7 [Source:HGNC Symbol;Acc:HGNC:6122] | 154 | 3.130 | 0.2143 | Yes |
| 5 | IFI35 | interferon induced protein 35 [Source:HGNC Symbol;Acc:HGNC:5399] | 173 | 3.047 | 0.2570 | Yes |
| 6 | OAS3 | 2'-5'-oligoadenylate synthetase 3 [Source:HGNC Symbol;Acc:HGNC:8088] | 183 | 3.012 | 0.2995 | Yes |
| 7 | OASL | 2'-5'-oligoadenylate synthetase like [Source:HGNC Symbol;Acc:HGNC:8090] | 184 | 3.012 | 0.3421 | Yes |
| 8 | OAS2 | 2'-5'-oligoadenylate synthetase 2 [Source:HGNC Symbol;Acc:HGNC:8087] | 272 | 2.610 | 0.3768 | Yes |
| 9 | ISG20 | interferon stimulated exonuclease gene 20 [Source:HGNC Symbol;Acc:HGNC:6130] | 277 | 2.597 | 0.4135 | Yes |
| 10 | STAT1 | signal transducer and activator of transcription 1 [Source:HGNC Symbol;Acc:HGNC:11362] | 305 | 2.496 | 0.4481 | Yes |
| 11 | SOCS1 | suppressor of cytokine signaling 1 [Source:HGNC Symbol;Acc:HGNC:19383] | 307 | 2.492 | 0.4834 | Yes |
| 12 | MX1 | MX dynamin like GTPase 1 [Source:HGNC Symbol;Acc:HGNC:7532] | 391 | 2.293 | 0.5137 | Yes |
| 13 | STAT2 | signal transducer and activator of transcription 2 [Source:HGNC Symbol;Acc:HGNC:11363] | 446 | 2.147 | 0.5426 | Yes |
| 14 | ADAR | adenosine deaminase RNA specific [Source:HGNC Symbol;Acc:HGNC:225] | 482 | 2.080 | 0.5712 | Yes |
| 15 | IFITM3 | interferon induced transmembrane protein 3 [Source:HGNC Symbol;Acc:HGNC:5414] | 587 | 1.904 | 0.5953 | Yes |
| 16 | RSAD2 | radical S-adenosyl methionine domain containing 2 [Source:HGNC Symbol;Acc:HGNC:30908] | 595 | 1.883 | 0.6218 | Yes |
| 17 | MX2 | MX dynamin like GTPase 2 [Source:HGNC Symbol;Acc:HGNC:7533] | 658 | 1.777 | 0.6454 | Yes |
| 18 | IFITM2 | interferon induced transmembrane protein 2 [Source:HGNC Symbol;Acc:HGNC:5413] | 661 | 1.774 | 0.6704 | Yes |
| 19 | IRF9 | interferon regulatory factor 9 [Source:HGNC Symbol;Acc:HGNC:6131] | 684 | 1.737 | 0.6945 | Yes |
| 20 | IFIT1 | interferon induced protein with tetratricopeptide repeats 1 [Source:HGNC Symbol;Acc:HGNC:5407] | 977 | 1.436 | 0.7069 | Yes |
| 21 | PTPN11 | protein tyrosine phosphatase non-receptor type 11 [Source:HGNC Symbol;Acc:HGNC:9644] | 985 | 1.428 | 0.7270 | Yes |
| 22 | IRF8 | interferon regulatory factor 8 [Source:HGNC Symbol;Acc:HGNC:5358] | 999 | 1.414 | 0.7467 | Yes |
| 23 | IP6K2 | inositol hexakisphosphate kinase 2 [Source:HGNC Symbol;Acc:HGNC:17313] | 1027 | 1.394 | 0.7657 | Yes |
| 24 | GBP2 | guanylate binding protein 2 [Source:HGNC Symbol;Acc:HGNC:4183] | 1169 | 1.286 | 0.7801 | Yes |
| 25 | IFIT2 | interferon induced protein with tetratricopeptide repeats 2 [Source:HGNC Symbol;Acc:HGNC:5409] | 1201 | 1.255 | 0.7970 | Yes |
| 26 | PTPN1 | protein tyrosine phosphatase non-receptor type 1 [Source:HGNC Symbol;Acc:HGNC:9642] | 1843 | 0.946 | 0.7931 | Yes |
| 27 | HLA-B | major histocompatibility complex, class I, B [Source:HGNC Symbol;Acc:HGNC:4932] | 1962 | 0.906 | 0.8028 | Yes |
| 28 | HLA-E | major histocompatibility complex, class I, E [Source:HGNC Symbol;Acc:HGNC:4962] | 2943 | 0.602 | 0.7849 | Yes |
| 29 | EGR1 | early growth response 1 [Source:HGNC Symbol;Acc:HGNC:3238] | 2983 | 0.590 | 0.7922 | Yes |
| 30 | IRF5 | interferon regulatory factor 5 [Source:HGNC Symbol;Acc:HGNC:6120] | 3350 | 0.518 | 0.7896 | Yes |
| 31 | IRF6 | interferon regulatory factor 6 [Source:HGNC Symbol;Acc:HGNC:6121] | 3401 | 0.508 | 0.7955 | Yes |
| 32 | ABCE1 | ATP binding cassette subfamily E member 1 [Source:HGNC Symbol;Acc:HGNC:69] | 3577 | 0.476 | 0.7975 | Yes |
| 33 | KPNA1 | karyopherin subunit alpha 1 [Source:HGNC Symbol;Acc:HGNC:6394] | 3694 | 0.456 | 0.8008 | Yes |
| 34 | ISG15 | ISG15 ubiquitin like modifier [Source:HGNC Symbol;Acc:HGNC:4053] | 4002 | 0.397 | 0.7981 | Yes |
| 35 | PSMB8 | proteasome 20S subunit beta 8 [Source:HGNC Symbol;Acc:HGNC:9545] | 4173 | 0.366 | 0.7987 | Yes |
| 36 | HLA-C | major histocompatibility complex, class I, C [Source:HGNC Symbol;Acc:HGNC:4933] | 4332 | 0.340 | 0.7993 | Yes |
| 37 | HLA-A | major histocompatibility complex, class I, A [Source:HGNC Symbol;Acc:HGNC:4931] | 4396 | 0.329 | 0.8022 | Yes |
| 38 | HLA-F | major histocompatibility complex, class I, F [Source:HGNC Symbol;Acc:HGNC:4963] | 4416 | 0.325 | 0.8063 | Yes |
| 39 | JAK1 | Janus kinase 1 [Source:HGNC Symbol;Acc:HGNC:6190] | 4831 | 0.259 | 0.7988 | No |
| 40 | IRF4 | interferon regulatory factor 4 [Source:HGNC Symbol;Acc:HGNC:6119] | 4996 | 0.233 | 0.7977 | No |
| 41 | KPNB1 | karyopherin subunit beta 1 [Source:HGNC Symbol;Acc:HGNC:6400] | 5229 | 0.199 | 0.7942 | No |
| 42 | IFIT3 | interferon induced protein with tetratricopeptide repeats 3 [Source:HGNC Symbol;Acc:HGNC:5411] | 5571 | 0.150 | 0.7872 | No |
| 43 | IRF3 | interferon regulatory factor 3 [Source:HGNC Symbol;Acc:HGNC:6118] | 5665 | 0.137 | 0.7866 | No |
| 44 | SAMHD1 | SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 [Source:HGNC Symbol;Acc:HGNC:15925] | 6076 | 0.084 | 0.7767 | No |
| 45 | BST2 | bone marrow stromal cell antigen 2 [Source:HGNC Symbol;Acc:HGNC:1119] | 12674 | 0.000 | 0.5985 | No |
| 46 | IFNA13 | interferon alpha 13 [Source:HGNC Symbol;Acc:HGNC:5419] | 18192 | 0.000 | 0.4495 | No |
| 47 | IFNA14 | interferon alpha 14 [Source:HGNC Symbol;Acc:HGNC:5420] | 18193 | 0.000 | 0.4495 | No |
| 48 | IFNA16 | interferon alpha 16 [Source:HGNC Symbol;Acc:HGNC:5421] | 18195 | 0.000 | 0.4494 | No |
| 49 | IFNA17 | interferon alpha 17 [Source:HGNC Symbol;Acc:HGNC:5422] | 18197 | 0.000 | 0.4494 | No |
| 50 | IFNA10 | interferon alpha 10 [Source:HGNC Symbol;Acc:HGNC:5418] | 18204 | 0.000 | 0.4492 | No |
| 51 | IFNA21 | interferon alpha 21 [Source:HGNC Symbol;Acc:HGNC:5424] | 18211 | 0.000 | 0.4491 | No |
| 52 | IFNAR2 | interferon alpha and beta receptor subunit 2 [Source:HGNC Symbol;Acc:HGNC:5433] | 18465 | 0.000 | 0.4422 | No |
| 53 | IFNAR1 | interferon alpha and beta receptor subunit 1 [Source:HGNC Symbol;Acc:HGNC:5432] | 18473 | 0.000 | 0.4421 | No |
| 54 | IFI6 | interferon alpha inducible protein 6 [Source:HGNC Symbol;Acc:HGNC:4054] | 20673 | 0.000 | 0.3827 | No |
| 55 | IFIT5 | interferon induced protein with tetratricopeptide repeats 5 [Source:HGNC Symbol;Acc:HGNC:13328] | 23308 | 0.000 | 0.3115 | No |
| 56 | IFNA5 | interferon alpha 5 [Source:HGNC Symbol;Acc:HGNC:5426] | 24727 | 0.000 | 0.2732 | No |
| 57 | IFNA4 | interferon alpha 4 [Source:HGNC Symbol;Acc:HGNC:5425] | 24728 | 0.000 | 0.2732 | No |
| 58 | IFNA7 | interferon alpha 7 [Source:HGNC Symbol;Acc:HGNC:5428] | 24730 | 0.000 | 0.2732 | No |
| 59 | IFNA6 | interferon alpha 6 [Source:HGNC Symbol;Acc:HGNC:5427] | 24731 | 0.000 | 0.2732 | No |
| 60 | IFNA1 | interferon alpha 1 [Source:HGNC Symbol;Acc:HGNC:5417] | 24732 | 0.000 | 0.2732 | No |
| 61 | IFNA2 | interferon alpha 2 [Source:HGNC Symbol;Acc:HGNC:5423] | 24733 | 0.000 | 0.2732 | No |
| 62 | IFNA8 | interferon alpha 8 [Source:HGNC Symbol;Acc:HGNC:5429] | 24736 | 0.000 | 0.2731 | No |
| 63 | IFNB1 | interferon beta 1 [Source:HGNC Symbol;Acc:HGNC:5434] | 24765 | 0.000 | 0.2724 | No |
| 64 | XAF1 | XIAP associated factor 1 [Source:HGNC Symbol;Acc:HGNC:30932] | 27277 | 0.000 | 0.2045 | No |
| 65 | IFITM1 | interferon induced transmembrane protein 1 [Source:HGNC Symbol;Acc:HGNC:5412] | 28206 | -0.085 | 0.1807 | No |
| 66 | HLA-G | major histocompatibility complex, class I, G [Source:HGNC Symbol;Acc:HGNC:4964] | 29308 | -0.218 | 0.1540 | No |
| 67 | IRF1 | interferon regulatory factor 1 [Source:HGNC Symbol;Acc:HGNC:6116] | 31046 | -0.447 | 0.1134 | No |
| 68 | IFI27 | interferon alpha inducible protein 27 [Source:HGNC Symbol;Acc:HGNC:5397] | 31061 | -0.449 | 0.1194 | No |
| 69 | HLA-H | major histocompatibility complex, class I, H (pseudogene) [Source:HGNC Symbol;Acc:HGNC:4965] | 31272 | -0.481 | 0.1205 | No |
| 70 | RNASEL | ribonuclease L [Source:HGNC Symbol;Acc:HGNC:10050] | 31483 | -0.519 | 0.1222 | No |
| 71 | TYK2 | tyrosine kinase 2 [Source:HGNC Symbol;Acc:HGNC:12440] | 31501 | -0.521 | 0.1292 | No |
| 72 | PTPN6 | protein tyrosine phosphatase non-receptor type 6 [Source:HGNC Symbol;Acc:HGNC:9658] | 32090 | -0.629 | 0.1222 | No |
| 73 | IRF2 | interferon regulatory factor 2 [Source:HGNC Symbol;Acc:HGNC:6117] | 33265 | -0.907 | 0.1033 | No |
