Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.greenbergcls.cls #KO_GAQ_versus_KO_NA.greenbergcls.cls #KO_GAQ_versus_KO_NA_repos |
| Phenotype | greenbergcls.cls#KO_GAQ_versus_KO_NA_repos |
| Upregulated in class | KO_GAQ |
| GeneSet | REACTOME_INTERLEUKIN_10_SIGNALING |
| Enrichment Score (ES) | 0.87138397 |
| Normalized Enrichment Score (NES) | 1.9784863 |
| Nominal p-value | 0.0 |
| FDR q-value | 1.4145079E-4 |
| FWER p-Value | 0.001 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | IL1B | interleukin 1 beta [Source:HGNC Symbol;Acc:HGNC:5992] | 0 | 4.990 | 0.0771 | Yes |
| 2 | IL1RN | interleukin 1 receptor antagonist [Source:HGNC Symbol;Acc:HGNC:6000] | 2 | 4.934 | 0.1532 | Yes |
| 3 | PTGS2 | prostaglandin-endoperoxide synthase 2 [Source:HGNC Symbol;Acc:HGNC:9605] | 3 | 4.934 | 0.2294 | Yes |
| 4 | CSF3 | colony stimulating factor 3 [Source:HGNC Symbol;Acc:HGNC:2438] | 4 | 4.930 | 0.3055 | Yes |
| 5 | CCL5 | C-C motif chemokine ligand 5 [Source:HGNC Symbol;Acc:HGNC:10632] | 6 | 4.903 | 0.3812 | Yes |
| 6 | CCL4 | C-C motif chemokine ligand 4 [Source:HGNC Symbol;Acc:HGNC:10630] | 13 | 4.731 | 0.4540 | Yes |
| 7 | TNFRSF1B | TNF receptor superfamily member 1B [Source:HGNC Symbol;Acc:HGNC:11917] | 16 | 4.671 | 0.5261 | Yes |
| 8 | TNF | tumor necrosis factor [Source:HGNC Symbol;Acc:HGNC:11892] | 39 | 4.237 | 0.5909 | Yes |
| 9 | IL1A | interleukin 1 alpha [Source:HGNC Symbol;Acc:HGNC:5991] | 57 | 4.035 | 0.6528 | Yes |
| 10 | IL10 | interleukin 10 [Source:HGNC Symbol;Acc:HGNC:5962] | 174 | 3.043 | 0.6966 | Yes |
| 11 | STAT3 | signal transducer and activator of transcription 3 [Source:HGNC Symbol;Acc:HGNC:11364] | 244 | 2.715 | 0.7367 | Yes |
| 12 | LIF | LIF interleukin 6 family cytokine [Source:HGNC Symbol;Acc:HGNC:6596] | 284 | 2.578 | 0.7754 | Yes |
| 13 | CCR5 | C-C motif chemokine receptor 5 (gene/pseudogene) [Source:HGNC Symbol;Acc:HGNC:1606] | 472 | 2.099 | 0.8028 | Yes |
| 14 | TNFRSF1A | TNF receptor superfamily member 1A [Source:HGNC Symbol;Acc:HGNC:11916] | 720 | 1.690 | 0.8222 | Yes |
| 15 | TIMP1 | TIMP metallopeptidase inhibitor 1 [Source:HGNC Symbol;Acc:HGNC:11820] | 819 | 1.576 | 0.8439 | Yes |
| 16 | FPR1 | formyl peptide receptor 1 [Source:HGNC Symbol;Acc:HGNC:3826] | 1808 | 0.959 | 0.8320 | Yes |
| 17 | CXCL10 | C-X-C motif chemokine ligand 10 [Source:HGNC Symbol;Acc:HGNC:10637] | 2056 | 0.871 | 0.8388 | Yes |
| 18 | CCR2 | C-C motif chemokine receptor 2 [Source:HGNC Symbol;Acc:HGNC:1603] | 2084 | 0.861 | 0.8514 | Yes |
| 19 | CCR1 | C-C motif chemokine receptor 1 [Source:HGNC Symbol;Acc:HGNC:1602] | 2506 | 0.720 | 0.8511 | Yes |
| 20 | PTAFR | platelet activating factor receptor [Source:HGNC Symbol;Acc:HGNC:9582] | 2511 | 0.717 | 0.8621 | Yes |
| 21 | CXCL2 | C-X-C motif chemokine ligand 2 [Source:HGNC Symbol;Acc:HGNC:4603] | 2775 | 0.646 | 0.8650 | Yes |
| 22 | IL12B | interleukin 12B [Source:HGNC Symbol;Acc:HGNC:5970] | 2892 | 0.618 | 0.8714 | Yes |
| 23 | IL6 | interleukin 6 [Source:HGNC Symbol;Acc:HGNC:6018] | 4084 | 0.383 | 0.8451 | No |
| 24 | CCL20 | C-C motif chemokine ligand 20 [Source:HGNC Symbol;Acc:HGNC:10619] | 4513 | 0.310 | 0.8384 | No |
| 25 | CCL2 | C-C motif chemokine ligand 2 [Source:HGNC Symbol;Acc:HGNC:10618] | 4624 | 0.294 | 0.8399 | No |
| 26 | CSF1 | colony stimulating factor 1 [Source:HGNC Symbol;Acc:HGNC:2432] | 4753 | 0.271 | 0.8407 | No |
| 27 | JAK1 | Janus kinase 1 [Source:HGNC Symbol;Acc:HGNC:6190] | 4831 | 0.259 | 0.8426 | No |
| 28 | CCL19 | C-C motif chemokine ligand 19 [Source:HGNC Symbol;Acc:HGNC:10617] | 6731 | 0.000 | 0.7913 | No |
| 29 | CCL22 | C-C motif chemokine ligand 22 [Source:HGNC Symbol;Acc:HGNC:10621] | 6742 | 0.000 | 0.7911 | No |
| 30 | IL18 | interleukin 18 [Source:HGNC Symbol;Acc:HGNC:5986] | 13970 | 0.000 | 0.5960 | No |
| 31 | CCL3L1 | C-C motif chemokine ligand 3 like 1 [Source:HGNC Symbol;Acc:HGNC:10628] | 14914 | 0.000 | 0.5705 | No |
| 32 | CCL3L3 | C-C motif chemokine ligand 3 like 3 [Source:HGNC Symbol;Acc:HGNC:30554] | 14915 | 0.000 | 0.5705 | No |
| 33 | IL1R1 | interleukin 1 receptor type 1 [Source:HGNC Symbol;Acc:HGNC:5993] | 15992 | 0.000 | 0.5415 | No |
| 34 | IL1R2 | interleukin 1 receptor type 2 [Source:HGNC Symbol;Acc:HGNC:5994] | 15993 | 0.000 | 0.5415 | No |
| 35 | ICAM1 | intercellular adhesion molecule 1 [Source:HGNC Symbol;Acc:HGNC:5344] | 18266 | 0.000 | 0.4801 | No |
| 36 | CXCL8 | C-X-C motif chemokine ligand 8 [Source:HGNC Symbol;Acc:HGNC:6025] | 19424 | 0.000 | 0.4489 | No |
| 37 | CXCL1 | C-X-C motif chemokine ligand 1 [Source:HGNC Symbol;Acc:HGNC:4602] | 19433 | 0.000 | 0.4487 | No |
| 38 | CD80 | CD80 molecule [Source:HGNC Symbol;Acc:HGNC:1700] | 23109 | 0.000 | 0.3495 | No |
| 39 | CSF2 | colony stimulating factor 2 [Source:HGNC Symbol;Acc:HGNC:2434] | 24555 | 0.000 | 0.3105 | No |
| 40 | FCER2 | Fc fragment of IgE receptor II [Source:HGNC Symbol;Acc:HGNC:3612] | 26077 | 0.000 | 0.2694 | No |
| 41 | IL12A | interleukin 12A [Source:HGNC Symbol;Acc:HGNC:5969] | 26991 | 0.000 | 0.2448 | No |
| 42 | CCL3 | C-C motif chemokine ligand 3 [Source:HGNC Symbol;Acc:HGNC:10627] | 27677 | -0.024 | 0.2266 | No |
| 43 | CD86 | CD86 molecule [Source:HGNC Symbol;Acc:HGNC:1705] | 27938 | -0.056 | 0.2205 | No |
| 44 | IL10RA | interleukin 10 receptor subunit alpha [Source:HGNC Symbol;Acc:HGNC:5964] | 28738 | -0.147 | 0.2012 | No |
| 45 | TYK2 | tyrosine kinase 2 [Source:HGNC Symbol;Acc:HGNC:12440] | 31501 | -0.521 | 0.1347 | No |
| 46 | IL10RB | interleukin 10 receptor subunit beta [Source:HGNC Symbol;Acc:HGNC:5965] | 33741 | -1.046 | 0.0904 | No |
