Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.greenbergcls.cls #KO_GAQ_versus_KO_NA.greenbergcls.cls #KO_GAQ_versus_KO_NA_repos |
| Phenotype | greenbergcls.cls#KO_GAQ_versus_KO_NA_repos |
| Upregulated in class | KO_NA |
| GeneSet | REN_BOUND_BY_E2F |
| Enrichment Score (ES) | -0.82874274 |
| Normalized Enrichment Score (NES) | -1.6788598 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0024214103 |
| FWER p-Value | 0.047 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | E2F3 | E2F transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:3115] | 1692 | 1.014 | -0.0349 | No |
| 2 | CDC25A | cell division cycle 25A [Source:HGNC Symbol;Acc:HGNC:1725] | 2842 | 0.631 | -0.0592 | No |
| 3 | BRD2 | bromodomain containing 2 [Source:HGNC Symbol;Acc:HGNC:1103] | 5854 | 0.113 | -0.1393 | No |
| 4 | H2BC21 | H2B clustered histone 21 [Source:HGNC Symbol;Acc:HGNC:4760] | 5941 | 0.102 | -0.1406 | No |
| 5 | SUPT4H1 | SPT4 homolog, DSIF elongation factor subunit [Source:HGNC Symbol;Acc:HGNC:11467] | 6583 | 0.018 | -0.1577 | No |
| 6 | H2AC18 | H2A clustered histone 18 [Source:HGNC Symbol;Acc:HGNC:4736] | 21731 | 0.000 | -0.5667 | No |
| 7 | CENPA | centromere protein A [Source:HGNC Symbol;Acc:HGNC:1851] | 24136 | 0.000 | -0.6317 | No |
| 8 | CDK1 | cyclin dependent kinase 1 [Source:HGNC Symbol;Acc:HGNC:1722] | 27890 | -0.049 | -0.7325 | No |
| 9 | POLA2 | DNA polymerase alpha 2, accessory subunit [Source:HGNC Symbol;Acc:HGNC:30073] | 28663 | -0.138 | -0.7519 | No |
| 10 | PTTG1 | PTTG1 regulator of sister chromatid separation, securin [Source:HGNC Symbol;Acc:HGNC:9690] | 29208 | -0.205 | -0.7644 | No |
| 11 | UMPS | uridine monophosphate synthetase [Source:HGNC Symbol;Acc:HGNC:12563] | 30035 | -0.309 | -0.7834 | No |
| 12 | CSTF1 | cleavage stimulation factor subunit 1 [Source:HGNC Symbol;Acc:HGNC:2483] | 30346 | -0.348 | -0.7881 | No |
| 13 | CKS1BP7 | CDC28 protein kinase regulatory subunit 1B pseudogene 7 [Source:HGNC Symbol;Acc:HGNC:1999] | 30412 | -0.356 | -0.7860 | No |
| 14 | BUB3 | BUB3 mitotic checkpoint protein [Source:HGNC Symbol;Acc:HGNC:1151] | 30602 | -0.382 | -0.7871 | No |
| 15 | MLH1 | mutL homolog 1 [Source:HGNC Symbol;Acc:HGNC:7127] | 31040 | -0.446 | -0.7941 | No |
| 16 | H3C4 | H3 clustered histone 4 [Source:HGNC Symbol;Acc:HGNC:4767] | 31295 | -0.484 | -0.7958 | No |
| 17 | NAP1L4 | nucleosome assembly protein 1 like 4 [Source:HGNC Symbol;Acc:HGNC:7640] | 31525 | -0.526 | -0.7964 | No |
| 18 | FEN1 | flap structure-specific endonuclease 1 [Source:HGNC Symbol;Acc:HGNC:3650] | 32050 | -0.618 | -0.8040 | No |
| 19 | HMGB1 | high mobility group box 1 [Source:HGNC Symbol;Acc:HGNC:4983] | 32463 | -0.708 | -0.8076 | No |
| 20 | RPA3 | replication protein A3 [Source:HGNC Symbol;Acc:HGNC:10291] | 33248 | -0.901 | -0.8192 | Yes |
| 21 | ORC1 | origin recognition complex subunit 1 [Source:HGNC Symbol;Acc:HGNC:8487] | 33416 | -0.944 | -0.8136 | Yes |
| 22 | PRKDC | protein kinase, DNA-activated, catalytic subunit [Source:HGNC Symbol;Acc:HGNC:9413] | 33969 | -1.119 | -0.8166 | Yes |
| 23 | RFC3 | replication factor C subunit 3 [Source:HGNC Symbol;Acc:HGNC:9971] | 33988 | -1.124 | -0.8051 | Yes |
| 24 | H2AZ1 | H2A.Z variant histone 1 [Source:HGNC Symbol;Acc:HGNC:4741] | 34298 | -1.231 | -0.8004 | Yes |
| 25 | PCNA | proliferating cell nuclear antigen [Source:HGNC Symbol;Acc:HGNC:8729] | 34299 | -1.231 | -0.7873 | Yes |
| 26 | H2AC6 | H2A clustered histone 6 [Source:HGNC Symbol;Acc:HGNC:4733] | 34425 | -1.278 | -0.7770 | Yes |
| 27 | TP53 | tumor protein p53 [Source:HGNC Symbol;Acc:HGNC:11998] | 34573 | -1.344 | -0.7667 | Yes |
| 28 | MCM3 | minichromosome maintenance complex component 3 [Source:HGNC Symbol;Acc:HGNC:6945] | 34678 | -1.382 | -0.7548 | Yes |
| 29 | CHEK1 | checkpoint kinase 1 [Source:HGNC Symbol;Acc:HGNC:1925] | 34680 | -1.382 | -0.7401 | Yes |
| 30 | SMC4 | structural maintenance of chromosomes 4 [Source:HGNC Symbol;Acc:HGNC:14013] | 34692 | -1.386 | -0.7257 | Yes |
| 31 | CENPE | centromere protein E [Source:HGNC Symbol;Acc:HGNC:1856] | 34850 | -1.453 | -0.7144 | Yes |
| 32 | MAD2L1 | mitotic arrest deficient 2 like 1 [Source:HGNC Symbol;Acc:HGNC:6763] | 35065 | -1.544 | -0.7038 | Yes |
| 33 | RBL1 | RB transcriptional corepressor like 1 [Source:HGNC Symbol;Acc:HGNC:9893] | 35256 | -1.647 | -0.6914 | Yes |
| 34 | CBX5 | chromobox 5 [Source:HGNC Symbol;Acc:HGNC:1555] | 35296 | -1.675 | -0.6746 | Yes |
| 35 | UNG | uracil DNA glycosylase [Source:HGNC Symbol;Acc:HGNC:12572] | 35303 | -1.677 | -0.6569 | Yes |
| 36 | RAD51 | RAD51 recombinase [Source:HGNC Symbol;Acc:HGNC:9817] | 35380 | -1.712 | -0.6407 | Yes |
| 37 | DUT | deoxyuridine triphosphatase [Source:HGNC Symbol;Acc:HGNC:3078] | 35438 | -1.743 | -0.6237 | Yes |
| 38 | CDK2 | cyclin dependent kinase 2 [Source:HGNC Symbol;Acc:HGNC:1771] | 35470 | -1.760 | -0.6058 | Yes |
| 39 | SMC2 | structural maintenance of chromosomes 2 [Source:HGNC Symbol;Acc:HGNC:14011] | 35602 | -1.838 | -0.5898 | Yes |
| 40 | POLA1 | DNA polymerase alpha 1, catalytic subunit [Source:HGNC Symbol;Acc:HGNC:9173] | 35623 | -1.850 | -0.5706 | Yes |
| 41 | CDC6 | cell division cycle 6 [Source:HGNC Symbol;Acc:HGNC:1744] | 35691 | -1.899 | -0.5522 | Yes |
| 42 | DBF4 | DBF4 zinc finger [Source:HGNC Symbol;Acc:HGNC:17364] | 35707 | -1.910 | -0.5323 | Yes |
| 43 | BARD1 | BRCA1 associated RING domain 1 [Source:HGNC Symbol;Acc:HGNC:952] | 35764 | -1.947 | -0.5131 | Yes |
| 44 | RRM1 | ribonucleotide reductase catalytic subunit M1 [Source:HGNC Symbol;Acc:HGNC:10451] | 35769 | -1.949 | -0.4924 | Yes |
| 45 | MCM5 | minichromosome maintenance complex component 5 [Source:HGNC Symbol;Acc:HGNC:6948] | 35939 | -2.080 | -0.4749 | Yes |
| 46 | TOP2A | DNA topoisomerase II alpha [Source:HGNC Symbol;Acc:HGNC:11989] | 35971 | -2.105 | -0.4533 | Yes |
| 47 | RFC4 | replication factor C subunit 4 [Source:HGNC Symbol;Acc:HGNC:9972] | 36061 | -2.182 | -0.4325 | Yes |
| 48 | TTK | TTK protein kinase [Source:HGNC Symbol;Acc:HGNC:12401] | 36102 | -2.226 | -0.4099 | Yes |
| 49 | RAD54L | RAD54 like [Source:HGNC Symbol;Acc:HGNC:9826] | 36182 | -2.302 | -0.3875 | Yes |
| 50 | PRIM2 | DNA primase subunit 2 [Source:HGNC Symbol;Acc:HGNC:9370] | 36236 | -2.348 | -0.3639 | Yes |
| 51 | HMGB3 | high mobility group box 3 [Source:HGNC Symbol;Acc:HGNC:5004] | 36380 | -2.489 | -0.3413 | Yes |
| 52 | HLTF | helicase like transcription factor [Source:HGNC Symbol;Acc:HGNC:11099] | 36409 | -2.528 | -0.3151 | Yes |
| 53 | CCNA2 | cyclin A2 [Source:HGNC Symbol;Acc:HGNC:1578] | 36418 | -2.536 | -0.2884 | Yes |
| 54 | MCM6 | minichromosome maintenance complex component 6 [Source:HGNC Symbol;Acc:HGNC:6949] | 36468 | -2.596 | -0.2620 | Yes |
| 55 | NDC80 | NDC80 kinetochore complex component [Source:HGNC Symbol;Acc:HGNC:16909] | 36492 | -2.640 | -0.2346 | Yes |
| 56 | H2AX | H2A.X variant histone [Source:HGNC Symbol;Acc:HGNC:4739] | 36530 | -2.698 | -0.2068 | Yes |
| 57 | RFC2 | replication factor C subunit 2 [Source:HGNC Symbol;Acc:HGNC:9970] | 36537 | -2.711 | -0.1782 | Yes |
| 58 | POLD1 | DNA polymerase delta 1, catalytic subunit [Source:HGNC Symbol;Acc:HGNC:9175] | 36708 | -2.969 | -0.1511 | Yes |
| 59 | E2F2 | E2F transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:3114] | 36797 | -3.199 | -0.1195 | Yes |
| 60 | RB1 | RB transcriptional corepressor 1 [Source:HGNC Symbol;Acc:HGNC:9884] | 36972 | -3.766 | -0.0841 | Yes |
| 61 | MSH2 | mutS homolog 2 [Source:HGNC Symbol;Acc:HGNC:7325] | 37028 | -4.011 | -0.0429 | Yes |
| 62 | TK1 | thymidine kinase 1 [Source:HGNC Symbol;Acc:HGNC:11830] | 37048 | -4.181 | 0.0011 | Yes |
