Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.greenbergcls.cls #KO_GAQ_versus_KO_NA.greenbergcls.cls #KO_GAQ_versus_KO_NA_repos |
| Phenotype | greenbergcls.cls#KO_GAQ_versus_KO_NA_repos |
| Upregulated in class | KO_NA |
| GeneSet | WP_MONOAMINE_GPCRS |
| Enrichment Score (ES) | -0.9181416 |
| Normalized Enrichment Score (NES) | -1.6817582 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.002308171 |
| FWER p-Value | 0.042 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | CHRM1 | cholinergic receptor muscarinic 1 [Source:HGNC Symbol;Acc:HGNC:1950] | 5724 | 0.128 | -0.1400 | No |
| 2 | HRH1 | histamine receptor H1 [Source:HGNC Symbol;Acc:HGNC:5182] | 5957 | 0.100 | -0.1349 | No |
| 3 | HTR7 | 5-hydroxytryptamine receptor 7 [Source:HGNC Symbol;Acc:HGNC:5302] | 6191 | 0.071 | -0.1332 | No |
| 4 | HTR4 | 5-hydroxytryptamine receptor 4 [Source:HGNC Symbol;Acc:HGNC:5299] | 15644 | 0.000 | -0.3883 | No |
| 5 | HTR6 | 5-hydroxytryptamine receptor 6 [Source:HGNC Symbol;Acc:HGNC:5301] | 15646 | 0.000 | -0.3883 | No |
| 6 | HTR1E | 5-hydroxytryptamine receptor 1E [Source:HGNC Symbol;Acc:HGNC:5291] | 15703 | 0.000 | -0.3898 | No |
| 7 | HTR1F | 5-hydroxytryptamine receptor 1F [Source:HGNC Symbol;Acc:HGNC:5292] | 15705 | 0.000 | -0.3898 | No |
| 8 | HTR1D | 5-hydroxytryptamine receptor 1D [Source:HGNC Symbol;Acc:HGNC:5289] | 15706 | 0.000 | -0.3898 | No |
| 9 | HTR1A | 5-hydroxytryptamine receptor 1A [Source:HGNC Symbol;Acc:HGNC:5286] | 15707 | 0.000 | -0.3898 | No |
| 10 | HTR2B | 5-hydroxytryptamine receptor 2B [Source:HGNC Symbol;Acc:HGNC:5294] | 15714 | 0.000 | -0.3900 | No |
| 11 | HTR2C | 5-hydroxytryptamine receptor 2C [Source:HGNC Symbol;Acc:HGNC:5295] | 15715 | 0.000 | -0.3900 | No |
| 12 | HTR2A | 5-hydroxytryptamine receptor 2A [Source:HGNC Symbol;Acc:HGNC:5293] | 15716 | 0.000 | -0.3900 | No |
| 13 | HTR5A | 5-hydroxytryptamine receptor 5A [Source:HGNC Symbol;Acc:HGNC:5300] | 15734 | 0.000 | -0.3905 | No |
| 14 | ADRA1D | adrenoceptor alpha 1D [Source:HGNC Symbol;Acc:HGNC:280] | 16587 | 0.000 | -0.4134 | No |
| 15 | ADRA1B | adrenoceptor alpha 1B [Source:HGNC Symbol;Acc:HGNC:278] | 16588 | 0.000 | -0.4134 | No |
| 16 | ADRA1A | adrenoceptor alpha 1A [Source:HGNC Symbol;Acc:HGNC:277] | 16590 | 0.000 | -0.4135 | No |
| 17 | ADRA2C | adrenoceptor alpha 2C [Source:HGNC Symbol;Acc:HGNC:283] | 16596 | 0.000 | -0.4136 | No |
| 18 | ADRA2B | adrenoceptor alpha 2B [Source:HGNC Symbol;Acc:HGNC:282] | 16597 | 0.000 | -0.4136 | No |
| 19 | CHRM2 | cholinergic receptor muscarinic 2 [Source:HGNC Symbol;Acc:HGNC:1951] | 17853 | 0.000 | -0.4475 | No |
| 20 | CHRM3 | cholinergic receptor muscarinic 3 [Source:HGNC Symbol;Acc:HGNC:1952] | 17855 | 0.000 | -0.4475 | No |
| 21 | CHRM5 | cholinergic receptor muscarinic 5 [Source:HGNC Symbol;Acc:HGNC:1954] | 17856 | 0.000 | -0.4475 | No |
| 22 | ADRB3 | adrenoceptor beta 3 [Source:HGNC Symbol;Acc:HGNC:288] | 17915 | 0.000 | -0.4491 | No |
| 23 | ADRB1 | adrenoceptor beta 1 [Source:HGNC Symbol;Acc:HGNC:285] | 17958 | 0.000 | -0.4502 | No |
| 24 | DRD1 | dopamine receptor D1 [Source:HGNC Symbol;Acc:HGNC:3020] | 18481 | 0.000 | -0.4643 | No |
| 25 | DRD2 | dopamine receptor D2 [Source:HGNC Symbol;Acc:HGNC:3023] | 18482 | 0.000 | -0.4643 | No |
| 26 | DRD3 | dopamine receptor D3 [Source:HGNC Symbol;Acc:HGNC:3024] | 18484 | 0.000 | -0.4643 | No |
| 27 | DRD4 | dopamine receptor D4 [Source:HGNC Symbol;Acc:HGNC:3025] | 18485 | 0.000 | -0.4643 | No |
| 28 | DRD5 | dopamine receptor D5 [Source:HGNC Symbol;Acc:HGNC:3026] | 18486 | 0.000 | -0.4643 | No |
| 29 | HRH2 | histamine receptor H2 [Source:HGNC Symbol;Acc:HGNC:5183] | 26803 | 0.000 | -0.6887 | No |
| 30 | ADRA2A | adrenoceptor alpha 2A [Source:HGNC Symbol;Acc:HGNC:281] | 27670 | -0.023 | -0.7094 | No |
| 31 | CHRM4 | cholinergic receptor muscarinic 4 [Source:HGNC Symbol;Acc:HGNC:1953] | 30608 | -0.383 | -0.7455 | Yes |
| 32 | HTR1B | 5-hydroxytryptamine receptor 1B [Source:HGNC Symbol;Acc:HGNC:5287] | 37008 | -3.913 | -0.4766 | Yes |
| 33 | ADRB2 | adrenoceptor beta 2 [Source:HGNC Symbol;Acc:HGNC:286] | 37054 | -4.242 | 0.0010 | Yes |
