Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.greenbergcls.cls #KO_GAQ_versus_KO_NA.greenbergcls.cls #KO_GAQ_versus_KO_NA_repos |
| Phenotype | greenbergcls.cls#KO_GAQ_versus_KO_NA_repos |
| Upregulated in class | KO_NA |
| GeneSet | GOCC_LYSOSOMAL_LUMEN |
| Enrichment Score (ES) | -0.7862334 |
| Normalized Enrichment Score (NES) | -1.6464998 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.02250518 |
| FWER p-Value | 0.201 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | PLD3 | phospholipase D family member 3 [Source:HGNC Symbol;Acc:HGNC:17158] | 994 | 1.419 | -0.0120 | No |
| 2 | HSP90AA1 | heat shock protein 90 alpha family class A member 1 [Source:HGNC Symbol;Acc:HGNC:5253] | 1619 | 1.054 | -0.0178 | No |
| 3 | CTSV | cathepsin V [Source:HGNC Symbol;Acc:HGNC:2538] | 2748 | 0.653 | -0.0415 | No |
| 4 | CSPG4 | chondroitin sulfate proteoglycan 4 [Source:HGNC Symbol;Acc:HGNC:2466] | 4124 | 0.373 | -0.0747 | No |
| 5 | CTSD | cathepsin D [Source:HGNC Symbol;Acc:HGNC:2529] | 4239 | 0.353 | -0.0741 | No |
| 6 | AGRN | agrin [Source:HGNC Symbol;Acc:HGNC:329] | 4462 | 0.319 | -0.0768 | No |
| 7 | SDC4 | syndecan 4 [Source:HGNC Symbol;Acc:HGNC:10661] | 4470 | 0.318 | -0.0736 | No |
| 8 | CTSK | cathepsin K [Source:HGNC Symbol;Acc:HGNC:2536] | 5336 | 0.183 | -0.0951 | No |
| 9 | NPC2 | NPC intracellular cholesterol transporter 2 [Source:HGNC Symbol;Acc:HGNC:14537] | 5621 | 0.142 | -0.1013 | No |
| 10 | GPC1 | glypican 1 [Source:HGNC Symbol;Acc:HGNC:4449] | 6254 | 0.060 | -0.1177 | No |
| 11 | GUSB | glucuronidase beta [Source:HGNC Symbol;Acc:HGNC:4696] | 6452 | 0.034 | -0.1227 | No |
| 12 | EPDR1 | ependymin related 1 [Source:HGNC Symbol;Acc:HGNC:17572] | 6875 | 0.000 | -0.1341 | No |
| 13 | RNASET2 | ribonuclease T2 [Source:HGNC Symbol;Acc:HGNC:21686] | 7083 | 0.000 | -0.1397 | No |
| 14 | SDC2 | syndecan 2 [Source:HGNC Symbol;Acc:HGNC:10659] | 7152 | 0.000 | -0.1415 | No |
| 15 | APOB | apolipoprotein B [Source:HGNC Symbol;Acc:HGNC:603] | 7157 | 0.000 | -0.1416 | No |
| 16 | NEU4 | neuraminidase 4 [Source:HGNC Symbol;Acc:HGNC:21328] | 10138 | 0.000 | -0.2222 | No |
| 17 | HSPG2 | heparan sulfate proteoglycan 2 [Source:HGNC Symbol;Acc:HGNC:5273] | 10582 | 0.000 | -0.2342 | No |
| 18 | ACAN | aggrecan [Source:HGNC Symbol;Acc:HGNC:319] | 11067 | 0.000 | -0.2472 | No |
| 19 | IFI30 | IFI30 lysosomal thiol reductase [Source:HGNC Symbol;Acc:HGNC:5398] | 11722 | 0.000 | -0.2649 | No |
| 20 | CBLIF | cobalamin binding intrinsic factor [Source:HGNC Symbol;Acc:HGNC:4268] | 13596 | 0.000 | -0.3155 | No |
| 21 | BCAN | brevican [Source:HGNC Symbol;Acc:HGNC:23059] | 15875 | 0.000 | -0.3771 | No |
| 22 | DCN | decorin [Source:HGNC Symbol;Acc:HGNC:2705] | 16118 | 0.000 | -0.3837 | No |
| 23 | GC | GC vitamin D binding protein [Source:HGNC Symbol;Acc:HGNC:4187] | 16258 | 0.000 | -0.3874 | No |
| 24 | KERA | keratocan [Source:HGNC Symbol;Acc:HGNC:6309] | 18466 | 0.000 | -0.4471 | No |
| 25 | LUM | lumican [Source:HGNC Symbol;Acc:HGNC:6724] | 18759 | 0.000 | -0.4550 | No |
| 26 | OGN | osteoglycin [Source:HGNC Symbol;Acc:HGNC:8126] | 19651 | 0.000 | -0.4790 | No |
| 27 | OMD | osteomodulin [Source:HGNC Symbol;Acc:HGNC:8134] | 19718 | 0.000 | -0.4808 | No |
| 28 | FASLG | Fas ligand [Source:HGNC Symbol;Acc:HGNC:11936] | 20237 | 0.000 | -0.4948 | No |
| 29 | NCAN | neurocan [Source:HGNC Symbol;Acc:HGNC:2465] | 22787 | 0.000 | -0.5637 | No |
| 30 | SERPINB13 | serpin family B member 13 [Source:HGNC Symbol;Acc:HGNC:8944] | 22813 | 0.000 | -0.5644 | No |
| 31 | CD1E | CD1e molecule [Source:HGNC Symbol;Acc:HGNC:1638] | 22987 | 0.000 | -0.5691 | No |
| 32 | GPC3 | glypican 3 [Source:HGNC Symbol;Acc:HGNC:4451] | 23074 | 0.000 | -0.5714 | No |
| 33 | GPC2 | glypican 2 [Source:HGNC Symbol;Acc:HGNC:4450] | 23076 | 0.000 | -0.5714 | No |
| 34 | GPC5 | glypican 5 [Source:HGNC Symbol;Acc:HGNC:4453] | 23078 | 0.000 | -0.5715 | No |
| 35 | GPC4 | glypican 4 [Source:HGNC Symbol;Acc:HGNC:4452] | 23080 | 0.000 | -0.5715 | No |
| 36 | GPC6 | glypican 6 [Source:HGNC Symbol;Acc:HGNC:4454] | 23082 | 0.000 | -0.5715 | No |
| 37 | PRELP | proline and arginine rich end leucine rich repeat protein [Source:HGNC Symbol;Acc:HGNC:9357] | 24019 | 0.000 | -0.5968 | No |
| 38 | SPACA7 | sperm acrosome associated 7 [Source:HGNC Symbol;Acc:HGNC:29575] | 24230 | 0.000 | -0.6025 | No |
| 39 | CTSL | cathepsin L [Source:HGNC Symbol;Acc:HGNC:2537] | 25093 | 0.000 | -0.6258 | No |
| 40 | FMOD | fibromodulin [Source:HGNC Symbol;Acc:HGNC:3774] | 27174 | 0.000 | -0.6820 | No |
| 41 | CUBN | cubilin [Source:HGNC Symbol;Acc:HGNC:2548] | 27627 | -0.017 | -0.6940 | No |
| 42 | ACP2 | acid phosphatase 2, lysosomal [Source:HGNC Symbol;Acc:HGNC:123] | 27691 | -0.025 | -0.6955 | No |
| 43 | PDGFRB | platelet derived growth factor receptor beta [Source:HGNC Symbol;Acc:HGNC:8804] | 28543 | -0.124 | -0.7172 | No |
| 44 | LAMP2 | lysosomal associated membrane protein 2 [Source:HGNC Symbol;Acc:HGNC:6501] | 30485 | -0.365 | -0.7658 | No |
| 45 | BGN | biglycan [Source:HGNC Symbol;Acc:HGNC:1044] | 30492 | -0.365 | -0.7622 | No |
| 46 | GBA | glucosylceramidase beta [Source:HGNC Symbol;Acc:HGNC:4177] | 30707 | -0.397 | -0.7638 | No |
| 47 | HSPA8 | heat shock protein family A (Hsp70) member 8 [Source:HGNC Symbol;Acc:HGNC:5241] | 30969 | -0.434 | -0.7663 | No |
| 48 | CHID1 | chitinase domain containing 1 [Source:HGNC Symbol;Acc:HGNC:28474] | 31688 | -0.557 | -0.7799 | No |
| 49 | VCAN | versican [Source:HGNC Symbol;Acc:HGNC:2464] | 31925 | -0.594 | -0.7800 | Yes |
| 50 | HPSE | heparanase [Source:HGNC Symbol;Acc:HGNC:5164] | 31965 | -0.602 | -0.7748 | Yes |
| 51 | CSPG5 | chondroitin sulfate proteoglycan 5 [Source:HGNC Symbol;Acc:HGNC:2467] | 32212 | -0.657 | -0.7745 | Yes |
| 52 | TXNDC5 | thioredoxin domain containing 5 [Source:HGNC Symbol;Acc:HGNC:21073] | 32406 | -0.695 | -0.7724 | Yes |
| 53 | NEU1 | neuraminidase 1 [Source:HGNC Symbol;Acc:HGNC:7758] | 32726 | -0.764 | -0.7731 | Yes |
| 54 | CTSS | cathepsin S [Source:HGNC Symbol;Acc:HGNC:2545] | 32978 | -0.824 | -0.7712 | Yes |
| 55 | TCN2 | transcobalamin 2 [Source:HGNC Symbol;Acc:HGNC:11653] | 33085 | -0.855 | -0.7651 | Yes |
| 56 | PLBD2 | phospholipase B domain containing 2 [Source:HGNC Symbol;Acc:HGNC:27283] | 33452 | -0.954 | -0.7650 | Yes |
| 57 | CTSB | cathepsin B [Source:HGNC Symbol;Acc:HGNC:2527] | 33586 | -0.993 | -0.7582 | Yes |
| 58 | GNS | glucosamine (N-acetyl)-6-sulfatase [Source:HGNC Symbol;Acc:HGNC:4422] | 33646 | -1.014 | -0.7492 | Yes |
| 59 | SMPD1 | sphingomyelin phosphodiesterase 1 [Source:HGNC Symbol;Acc:HGNC:11120] | 33695 | -1.029 | -0.7397 | Yes |
| 60 | SDC1 | syndecan 1 [Source:HGNC Symbol;Acc:HGNC:10658] | 33876 | -1.087 | -0.7332 | Yes |
| 61 | ASAH1 | N-acylsphingosine amidohydrolase 1 [Source:HGNC Symbol;Acc:HGNC:735] | 34003 | -1.128 | -0.7247 | Yes |
| 62 | MAN2B2 | mannosidase alpha class 2B member 2 [Source:HGNC Symbol;Acc:HGNC:29623] | 34009 | -1.132 | -0.7130 | Yes |
| 63 | PPT2 | palmitoyl-protein thioesterase 2 [Source:HGNC Symbol;Acc:HGNC:9326] | 34135 | -1.176 | -0.7041 | Yes |
| 64 | LIPA | lipase A, lysosomal acid type [Source:HGNC Symbol;Acc:HGNC:6617] | 34582 | -1.346 | -0.7020 | Yes |
| 65 | GALNS | galactosamine (N-acetyl)-6-sulfatase [Source:HGNC Symbol;Acc:HGNC:4122] | 34667 | -1.378 | -0.6899 | Yes |
| 66 | GAA | glucosidase alpha, acid [Source:HGNC Symbol;Acc:HGNC:4065] | 34772 | -1.426 | -0.6777 | Yes |
| 67 | GLA | galactosidase alpha [Source:HGNC Symbol;Acc:HGNC:4296] | 34933 | -1.483 | -0.6665 | Yes |
| 68 | MANBA | mannosidase beta [Source:HGNC Symbol;Acc:HGNC:6831] | 35079 | -1.551 | -0.6542 | Yes |
| 69 | PPT1 | palmitoyl-protein thioesterase 1 [Source:HGNC Symbol;Acc:HGNC:9325] | 35105 | -1.567 | -0.6384 | Yes |
| 70 | CD74 | CD74 molecule [Source:HGNC Symbol;Acc:HGNC:1697] | 35245 | -1.643 | -0.6250 | Yes |
| 71 | GYG1 | glycogenin 1 [Source:HGNC Symbol;Acc:HGNC:4699] | 35532 | -1.798 | -0.6139 | Yes |
| 72 | CTSA | cathepsin A [Source:HGNC Symbol;Acc:HGNC:9251] | 35773 | -1.951 | -0.5999 | Yes |
| 73 | GALC | galactosylceramidase [Source:HGNC Symbol;Acc:HGNC:4115] | 35780 | -1.959 | -0.5795 | Yes |
| 74 | FUCA1 | alpha-L-fucosidase 1 [Source:HGNC Symbol;Acc:HGNC:4006] | 35822 | -1.993 | -0.5598 | Yes |
| 75 | GLB1 | galactosidase beta 1 [Source:HGNC Symbol;Acc:HGNC:4298] | 35893 | -2.039 | -0.5403 | Yes |
| 76 | IDS | iduronate 2-sulfatase [Source:HGNC Symbol;Acc:HGNC:5389] | 35916 | -2.062 | -0.5193 | Yes |
| 77 | IDUA | alpha-L-iduronidase [Source:HGNC Symbol;Acc:HGNC:5391] | 35931 | -2.076 | -0.4979 | Yes |
| 78 | LGMN | legumain [Source:HGNC Symbol;Acc:HGNC:9472] | 36140 | -2.261 | -0.4798 | Yes |
| 79 | TPP1 | tripeptidyl peptidase 1 [Source:HGNC Symbol;Acc:HGNC:2073] | 36144 | -2.264 | -0.4562 | Yes |
| 80 | HEXA | hexosaminidase subunit alpha [Source:HGNC Symbol;Acc:HGNC:4878] | 36146 | -2.266 | -0.4325 | Yes |
| 81 | SCARB2 | scavenger receptor class B member 2 [Source:HGNC Symbol;Acc:HGNC:1665] | 36396 | -2.508 | -0.4129 | Yes |
| 82 | ARSB | arylsulfatase B [Source:HGNC Symbol;Acc:HGNC:714] | 36419 | -2.536 | -0.3869 | Yes |
| 83 | CTSF | cathepsin F [Source:HGNC Symbol;Acc:HGNC:2531] | 36494 | -2.644 | -0.3612 | Yes |
| 84 | ARSA | arylsulfatase A [Source:HGNC Symbol;Acc:HGNC:713] | 36501 | -2.649 | -0.3336 | Yes |
| 85 | NAAA | N-acylethanolamine acid amidase [Source:HGNC Symbol;Acc:HGNC:736] | 36582 | -2.760 | -0.3069 | Yes |
| 86 | SDC3 | syndecan 3 [Source:HGNC Symbol;Acc:HGNC:10660] | 36604 | -2.781 | -0.2783 | Yes |
| 87 | MAN2B1 | mannosidase alpha class 2B member 1 [Source:HGNC Symbol;Acc:HGNC:6826] | 36728 | -3.002 | -0.2502 | Yes |
| 88 | PSAP | prosaposin [Source:HGNC Symbol;Acc:HGNC:9498] | 36737 | -3.024 | -0.2187 | Yes |
| 89 | NAGLU | N-acetyl-alpha-glucosaminidase [Source:HGNC Symbol;Acc:HGNC:7632] | 36743 | -3.042 | -0.1870 | Yes |
| 90 | HEXB | hexosaminidase subunit beta [Source:HGNC Symbol;Acc:HGNC:4879] | 36811 | -3.226 | -0.1550 | Yes |
| 91 | ATP13A2 | ATPase cation transporting 13A2 [Source:HGNC Symbol;Acc:HGNC:30213] | 36864 | -3.357 | -0.1212 | Yes |
| 92 | SGSH | N-sulfoglucosamine sulfohydrolase [Source:HGNC Symbol;Acc:HGNC:10818] | 36990 | -3.857 | -0.0842 | Yes |
| 93 | GM2A | GM2 ganglioside activator [Source:HGNC Symbol;Acc:HGNC:4367] | 37020 | -3.975 | -0.0433 | Yes |
| 94 | HYAL1 | hyaluronidase 1 [Source:HGNC Symbol;Acc:HGNC:5320] | 37061 | -4.309 | 0.0008 | Yes |
