Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.greenbergcls.cls #KO_GAQ_versus_KO_NA.greenbergcls.cls #KO_GAQ_versus_KO_NA_repos |
| Phenotype | greenbergcls.cls#KO_GAQ_versus_KO_NA_repos |
| Upregulated in class | KO_GAQ |
| GeneSet | HALLMARK_COAGULATION |
| Enrichment Score (ES) | 0.40001315 |
| Normalized Enrichment Score (NES) | 1.0704713 |
| Nominal p-value | 0.16666667 |
| FDR q-value | 0.32530648 |
| FWER p-Value | 0.761 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | FURIN | furin, paired basic amino acid cleaving enzyme [Source:HGNC Symbol;Acc:HGNC:8568] | 35 | 4.322 | 0.0457 | Yes |
| 2 | PDGFB | platelet derived growth factor subunit B [Source:HGNC Symbol;Acc:HGNC:8800] | 49 | 4.118 | 0.0898 | Yes |
| 3 | F9 | coagulation factor IX [Source:HGNC Symbol;Acc:HGNC:3551] | 129 | 3.315 | 0.1234 | Yes |
| 4 | PLEK | pleckstrin [Source:HGNC Symbol;Acc:HGNC:9070] | 225 | 2.789 | 0.1510 | Yes |
| 5 | MMP9 | matrix metallopeptidase 9 [Source:HGNC Symbol;Acc:HGNC:7176] | 365 | 2.347 | 0.1725 | Yes |
| 6 | SERPINE1 | serpin family E member 1 [Source:HGNC Symbol;Acc:HGNC:8583] | 402 | 2.272 | 0.1961 | Yes |
| 7 | WDR1 | WD repeat domain 1 [Source:HGNC Symbol;Acc:HGNC:12754] | 406 | 2.258 | 0.2204 | Yes |
| 8 | GNG12 | G protein subunit gamma 12 [Source:HGNC Symbol;Acc:HGNC:19663] | 437 | 2.175 | 0.2430 | Yes |
| 9 | SERPINB2 | serpin family B member 2 [Source:HGNC Symbol;Acc:HGNC:8584] | 512 | 2.028 | 0.2629 | Yes |
| 10 | MAFF | MAF bZIP transcription factor F [Source:HGNC Symbol;Acc:HGNC:6780] | 544 | 1.978 | 0.2835 | Yes |
| 11 | MMP2 | matrix metallopeptidase 2 [Source:HGNC Symbol;Acc:HGNC:7166] | 749 | 1.655 | 0.2958 | Yes |
| 12 | GDA | guanine deaminase [Source:HGNC Symbol;Acc:HGNC:4212] | 755 | 1.643 | 0.3134 | Yes |
| 13 | MMP14 | matrix metallopeptidase 14 [Source:HGNC Symbol;Acc:HGNC:7160] | 776 | 1.617 | 0.3303 | Yes |
| 14 | TIMP1 | TIMP metallopeptidase inhibitor 1 [Source:HGNC Symbol;Acc:HGNC:11820] | 819 | 1.576 | 0.3462 | Yes |
| 15 | CFB | complement factor B [Source:HGNC Symbol;Acc:HGNC:1037] | 888 | 1.514 | 0.3607 | Yes |
| 16 | ANXA1 | annexin A1 [Source:HGNC Symbol;Acc:HGNC:533] | 913 | 1.493 | 0.3761 | Yes |
| 17 | CD9 | CD9 molecule [Source:HGNC Symbol;Acc:HGNC:1709] | 1076 | 1.351 | 0.3863 | Yes |
| 18 | SERPINC1 | serpin family C member 1 [Source:HGNC Symbol;Acc:HGNC:775] | 1194 | 1.260 | 0.3968 | Yes |
| 19 | FBN1 | fibrillin 1 [Source:HGNC Symbol;Acc:HGNC:3603] | 2219 | 0.814 | 0.3778 | Yes |
| 20 | FYN | FYN proto-oncogene, Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:4037] | 2383 | 0.760 | 0.3816 | Yes |
| 21 | KLF7 | Kruppel like factor 7 [Source:HGNC Symbol;Acc:HGNC:6350] | 2496 | 0.723 | 0.3864 | Yes |
| 22 | CTSV | cathepsin V [Source:HGNC Symbol;Acc:HGNC:2538] | 2748 | 0.653 | 0.3867 | Yes |
| 23 | ITGB3 | integrin subunit beta 3 [Source:HGNC Symbol;Acc:HGNC:6156] | 2801 | 0.639 | 0.3922 | Yes |
| 24 | THBS1 | thrombospondin 1 [Source:HGNC Symbol;Acc:HGNC:11785] | 2879 | 0.622 | 0.3968 | Yes |
| 25 | ADAM9 | ADAM metallopeptidase domain 9 [Source:HGNC Symbol;Acc:HGNC:216] | 3033 | 0.582 | 0.3989 | Yes |
| 26 | CPN1 | carboxypeptidase N subunit 1 [Source:HGNC Symbol;Acc:HGNC:2312] | 3245 | 0.541 | 0.3991 | Yes |
| 27 | PREP | prolyl endopeptidase [Source:HGNC Symbol;Acc:HGNC:9358] | 3413 | 0.506 | 0.4000 | Yes |
| 28 | ITIH1 | inter-alpha-trypsin inhibitor heavy chain 1 [Source:HGNC Symbol;Acc:HGNC:6166] | 3629 | 0.467 | 0.3992 | No |
| 29 | BMP1 | bone morphogenetic protein 1 [Source:HGNC Symbol;Acc:HGNC:1067] | 3790 | 0.439 | 0.3996 | No |
| 30 | F10 | coagulation factor X [Source:HGNC Symbol;Acc:HGNC:3528] | 4108 | 0.377 | 0.3951 | No |
| 31 | C2 | complement C2 [Source:HGNC Symbol;Acc:HGNC:1248] | 4220 | 0.357 | 0.3960 | No |
| 32 | RABIF | RAB interacting factor [Source:HGNC Symbol;Acc:HGNC:9797] | 4237 | 0.354 | 0.3994 | No |
| 33 | S100A13 | S100 calcium binding protein A13 [Source:HGNC Symbol;Acc:HGNC:10490] | 4438 | 0.322 | 0.3974 | No |
| 34 | ARF4 | ADP ribosylation factor 4 [Source:HGNC Symbol;Acc:HGNC:655] | 4703 | 0.279 | 0.3933 | No |
| 35 | APOA1 | apolipoprotein A1 [Source:HGNC Symbol;Acc:HGNC:600] | 4990 | 0.234 | 0.3881 | No |
| 36 | GNB2 | G protein subunit beta 2 [Source:HGNC Symbol;Acc:HGNC:4398] | 5136 | 0.212 | 0.3864 | No |
| 37 | CTSK | cathepsin K [Source:HGNC Symbol;Acc:HGNC:2536] | 5336 | 0.183 | 0.3830 | No |
| 38 | MMP8 | matrix metallopeptidase 8 [Source:HGNC Symbol;Acc:HGNC:7175] | 5339 | 0.182 | 0.3849 | No |
| 39 | RGN | regucalcin [Source:HGNC Symbol;Acc:HGNC:9989] | 5524 | 0.156 | 0.3817 | No |
| 40 | MMP3 | matrix metallopeptidase 3 [Source:HGNC Symbol;Acc:HGNC:7173] | 5930 | 0.103 | 0.3718 | No |
| 41 | SH2B2 | SH2B adaptor protein 2 [Source:HGNC Symbol;Acc:HGNC:17381] | 6010 | 0.091 | 0.3707 | No |
| 42 | CLU | clusterin [Source:HGNC Symbol;Acc:HGNC:2095] | 6180 | 0.071 | 0.3669 | No |
| 43 | THBD | thrombomodulin [Source:HGNC Symbol;Acc:HGNC:11784] | 6217 | 0.065 | 0.3666 | No |
| 44 | CTSH | cathepsin H [Source:HGNC Symbol;Acc:HGNC:2535] | 6657 | 0.003 | 0.3547 | No |
| 45 | PLAT | plasminogen activator, tissue type [Source:HGNC Symbol;Acc:HGNC:9051] | 10184 | 0.000 | 0.2593 | No |
| 46 | APOC3 | apolipoprotein C3 [Source:HGNC Symbol;Acc:HGNC:610] | 10409 | 0.000 | 0.2533 | No |
| 47 | APOC2 | apolipoprotein C2 [Source:HGNC Symbol;Acc:HGNC:609] | 10411 | 0.000 | 0.2532 | No |
| 48 | APOC1 | apolipoprotein C1 [Source:HGNC Symbol;Acc:HGNC:607] | 10412 | 0.000 | 0.2532 | No |
| 49 | F13B | coagulation factor XIII B chain [Source:HGNC Symbol;Acc:HGNC:3534] | 11113 | 0.000 | 0.2343 | No |
| 50 | KLKB1 | kallikrein B1 [Source:HGNC Symbol;Acc:HGNC:6371] | 11375 | 0.000 | 0.2272 | No |
| 51 | TMPRSS6 | transmembrane serine protease 6 [Source:HGNC Symbol;Acc:HGNC:16517] | 11767 | 0.000 | 0.2166 | No |
| 52 | PROZ | protein Z, vitamin K dependent plasma glycoprotein [Source:HGNC Symbol;Acc:HGNC:9460] | 11813 | 0.000 | 0.2154 | No |
| 53 | PROC | protein C, inactivator of coagulation factors Va and VIIIa [Source:HGNC Symbol;Acc:HGNC:9451] | 11831 | 0.000 | 0.2150 | No |
| 54 | ACOX2 | acyl-CoA oxidase 2 [Source:HGNC Symbol;Acc:HGNC:120] | 12522 | 0.000 | 0.1963 | No |
| 55 | P2RY1 | purinergic receptor P2Y1 [Source:HGNC Symbol;Acc:HGNC:8539] | 14290 | 0.000 | 0.1485 | No |
| 56 | MBL2 | mannose binding lectin 2 [Source:HGNC Symbol;Acc:HGNC:6922] | 15718 | 0.000 | 0.1099 | No |
| 57 | C8B | complement C8 beta chain [Source:HGNC Symbol;Acc:HGNC:1353] | 15783 | 0.000 | 0.1081 | No |
| 58 | C8A | complement C8 alpha chain [Source:HGNC Symbol;Acc:HGNC:1352] | 15784 | 0.000 | 0.1081 | No |
| 59 | C8G | complement C8 gamma chain [Source:HGNC Symbol;Acc:HGNC:1354] | 15786 | 0.000 | 0.1081 | No |
| 60 | HTRA1 | HtrA serine peptidase 1 [Source:HGNC Symbol;Acc:HGNC:9476] | 15808 | 0.000 | 0.1075 | No |
| 61 | CFD | complement factor D [Source:HGNC Symbol;Acc:HGNC:2771] | 15883 | 0.000 | 0.1055 | No |
| 62 | CFI | complement factor I [Source:HGNC Symbol;Acc:HGNC:5394] | 15884 | 0.000 | 0.1055 | No |
| 63 | DCT | dopachrome tautomerase [Source:HGNC Symbol;Acc:HGNC:2709] | 16122 | 0.000 | 0.0991 | No |
| 64 | C9 | complement C9 [Source:HGNC Symbol;Acc:HGNC:1358] | 16193 | 0.000 | 0.0972 | No |
| 65 | F2 | coagulation factor II, thrombin [Source:HGNC Symbol;Acc:HGNC:3535] | 16235 | 0.000 | 0.0961 | No |
| 66 | F12 | coagulation factor XII [Source:HGNC Symbol;Acc:HGNC:3530] | 16532 | 0.000 | 0.0881 | No |
| 67 | F11 | coagulation factor XI [Source:HGNC Symbol;Acc:HGNC:3529] | 16533 | 0.000 | 0.0881 | No |
| 68 | FGA | fibrinogen alpha chain [Source:HGNC Symbol;Acc:HGNC:3661] | 16752 | 0.000 | 0.0822 | No |
| 69 | FGG | fibrinogen gamma chain [Source:HGNC Symbol;Acc:HGNC:3694] | 16753 | 0.000 | 0.0822 | No |
| 70 | OLR1 | oxidized low density lipoprotein receptor 1 [Source:HGNC Symbol;Acc:HGNC:8133] | 16800 | 0.000 | 0.0810 | No |
| 71 | GP9 | glycoprotein IX platelet [Source:HGNC Symbol;Acc:HGNC:4444] | 17186 | 0.000 | 0.0705 | No |
| 72 | TIMP3 | TIMP metallopeptidase inhibitor 3 [Source:HGNC Symbol;Acc:HGNC:11822] | 17194 | 0.000 | 0.0704 | No |
| 73 | HRG | histidine rich glycoprotein [Source:HGNC Symbol;Acc:HGNC:5181] | 17525 | 0.000 | 0.0614 | No |
| 74 | HNF4A | hepatocyte nuclear factor 4 alpha [Source:HGNC Symbol;Acc:HGNC:5024] | 17695 | 0.000 | 0.0569 | No |
| 75 | SERPING1 | serpin family G member 1 [Source:HGNC Symbol;Acc:HGNC:1228] | 17806 | 0.000 | 0.0539 | No |
| 76 | SERPINA1 | serpin family A member 1 [Source:HGNC Symbol;Acc:HGNC:8941] | 17817 | 0.000 | 0.0536 | No |
| 77 | DPP4 | dipeptidyl peptidase 4 [Source:HGNC Symbol;Acc:HGNC:3009] | 17960 | 0.000 | 0.0498 | No |
| 78 | MMP7 | matrix metallopeptidase 7 [Source:HGNC Symbol;Acc:HGNC:7174] | 19084 | 0.000 | 0.0194 | No |
| 79 | MMP1 | matrix metallopeptidase 1 [Source:HGNC Symbol;Acc:HGNC:7155] | 19087 | 0.000 | 0.0193 | No |
| 80 | PF4 | platelet factor 4 [Source:HGNC Symbol;Acc:HGNC:8861] | 19965 | 0.000 | -0.0044 | No |
| 81 | HMGCS2 | 3-hydroxy-3-methylglutaryl-CoA synthase 2 [Source:HGNC Symbol;Acc:HGNC:5008] | 20006 | 0.000 | -0.0055 | No |
| 82 | PLG | plasminogen [Source:HGNC Symbol;Acc:HGNC:9071] | 20039 | 0.000 | -0.0064 | No |
| 83 | C1QA | complement C1q A chain [Source:HGNC Symbol;Acc:HGNC:1241] | 20095 | 0.000 | -0.0078 | No |
| 84 | LEFTY2 | left-right determination factor 2 [Source:HGNC Symbol;Acc:HGNC:3122] | 20206 | 0.000 | -0.0108 | No |
| 85 | KLK8 | kallikrein related peptidase 8 [Source:HGNC Symbol;Acc:HGNC:6369] | 20641 | 0.000 | -0.0226 | No |
| 86 | MMP10 | matrix metallopeptidase 10 [Source:HGNC Symbol;Acc:HGNC:7156] | 20866 | 0.000 | -0.0286 | No |
| 87 | F2RL2 | coagulation factor II thrombin receptor like 2 [Source:HGNC Symbol;Acc:HGNC:3539] | 21195 | 0.000 | -0.0375 | No |
| 88 | MEP1A | meprin A subunit alpha [Source:HGNC Symbol;Acc:HGNC:7015] | 23291 | 0.000 | -0.0942 | No |
| 89 | GP1BA | glycoprotein Ib platelet subunit alpha [Source:HGNC Symbol;Acc:HGNC:4439] | 23352 | 0.000 | -0.0958 | No |
| 90 | TFPI2 | tissue factor pathway inhibitor 2 [Source:HGNC Symbol;Acc:HGNC:11761] | 25008 | 0.000 | -0.1406 | No |
| 91 | PRSS23 | serine protease 23 [Source:HGNC Symbol;Acc:HGNC:14370] | 25272 | 0.000 | -0.1477 | No |
| 92 | ITGA2 | integrin subunit alpha 2 [Source:HGNC Symbol;Acc:HGNC:6137] | 26459 | 0.000 | -0.1798 | No |
| 93 | A2M | alpha-2-macroglobulin [Source:HGNC Symbol;Acc:HGNC:7] | 27010 | 0.000 | -0.1947 | No |
| 94 | SPARC | secreted protein acidic and cysteine rich [Source:HGNC Symbol;Acc:HGNC:11219] | 27359 | 0.000 | -0.2041 | No |
| 95 | MASP2 | mannan binding lectin serine peptidase 2 [Source:HGNC Symbol;Acc:HGNC:6902] | 27887 | -0.049 | -0.2179 | No |
| 96 | MMP15 | matrix metallopeptidase 15 [Source:HGNC Symbol;Acc:HGNC:7161] | 27966 | -0.058 | -0.2193 | No |
| 97 | CPB2 | carboxypeptidase B2 [Source:HGNC Symbol;Acc:HGNC:2300] | 28489 | -0.117 | -0.2322 | No |
| 98 | C3 | complement C3 [Source:HGNC Symbol;Acc:HGNC:1318] | 29098 | -0.192 | -0.2466 | No |
| 99 | TF | transferrin [Source:HGNC Symbol;Acc:HGNC:11740] | 29300 | -0.217 | -0.2497 | No |
| 100 | RAPGEF3 | Rap guanine nucleotide exchange factor 3 [Source:HGNC Symbol;Acc:HGNC:16629] | 29369 | -0.225 | -0.2491 | No |
| 101 | FN1 | fibronectin 1 [Source:HGNC Symbol;Acc:HGNC:3778] | 29713 | -0.269 | -0.2555 | No |
| 102 | F3 | coagulation factor III, tissue factor [Source:HGNC Symbol;Acc:HGNC:3541] | 29759 | -0.275 | -0.2537 | No |
| 103 | HPN | hepsin [Source:HGNC Symbol;Acc:HGNC:5155] | 29924 | -0.298 | -0.2549 | No |
| 104 | DUSP14 | dual specificity phosphatase 14 [Source:HGNC Symbol;Acc:HGNC:17007] | 29944 | -0.300 | -0.2522 | No |
| 105 | RAC1 | Rac family small GTPase 1 [Source:HGNC Symbol;Acc:HGNC:9801] | 30212 | -0.332 | -0.2559 | No |
| 106 | PEF1 | penta-EF-hand domain containing 1 [Source:HGNC Symbol;Acc:HGNC:30009] | 30294 | -0.342 | -0.2544 | No |
| 107 | LAMP2 | lysosomal associated membrane protein 2 [Source:HGNC Symbol;Acc:HGNC:6501] | 30485 | -0.365 | -0.2556 | No |
| 108 | MMP11 | matrix metallopeptidase 11 [Source:HGNC Symbol;Acc:HGNC:7157] | 30623 | -0.384 | -0.2551 | No |
| 109 | C1S | complement C1s [Source:HGNC Symbol;Acc:HGNC:1247] | 30851 | -0.420 | -0.2567 | No |
| 110 | CTSO | cathepsin O [Source:HGNC Symbol;Acc:HGNC:2542] | 32021 | -0.613 | -0.2818 | No |
| 111 | USP11 | ubiquitin specific peptidase 11 [Source:HGNC Symbol;Acc:HGNC:12609] | 32054 | -0.619 | -0.2759 | No |
| 112 | CRIP2 | cysteine rich protein 2 [Source:HGNC Symbol;Acc:HGNC:2361] | 32134 | -0.639 | -0.2712 | No |
| 113 | VWF | von Willebrand factor [Source:HGNC Symbol;Acc:HGNC:12726] | 32259 | -0.666 | -0.2674 | No |
| 114 | SIRT2 | sirtuin 2 [Source:HGNC Symbol;Acc:HGNC:10886] | 32395 | -0.693 | -0.2635 | No |
| 115 | ISCU | iron-sulfur cluster assembly enzyme [Source:HGNC Symbol;Acc:HGNC:29882] | 32650 | -0.746 | -0.2623 | No |
| 116 | COMP | cartilage oligomeric matrix protein [Source:HGNC Symbol;Acc:HGNC:2227] | 32716 | -0.762 | -0.2559 | No |
| 117 | MST1 | macrophage stimulating 1 [Source:HGNC Symbol;Acc:HGNC:7380] | 33180 | -0.879 | -0.2589 | No |
| 118 | S100A1 | S100 calcium binding protein A1 [Source:HGNC Symbol;Acc:HGNC:10486] | 33433 | -0.947 | -0.2555 | No |
| 119 | CTSB | cathepsin B [Source:HGNC Symbol;Acc:HGNC:2527] | 33586 | -0.993 | -0.2489 | No |
| 120 | MSRB2 | methionine sulfoxide reductase B2 [Source:HGNC Symbol;Acc:HGNC:17061] | 34129 | -1.173 | -0.2509 | No |
| 121 | CAPN2 | calpain 2 [Source:HGNC Symbol;Acc:HGNC:1479] | 34154 | -1.181 | -0.2388 | No |
| 122 | CASP9 | caspase 9 [Source:HGNC Symbol;Acc:HGNC:1511] | 34275 | -1.224 | -0.2288 | No |
| 123 | CTSE | cathepsin E [Source:HGNC Symbol;Acc:HGNC:2530] | 34277 | -1.225 | -0.2157 | No |
| 124 | PROS1 | protein S [Source:HGNC Symbol;Acc:HGNC:9456] | 34322 | -1.241 | -0.2035 | No |
| 125 | CPQ | carboxypeptidase Q [Source:HGNC Symbol;Acc:HGNC:16910] | 34513 | -1.316 | -0.1944 | No |
| 126 | LTA4H | leukotriene A4 hydrolase [Source:HGNC Symbol;Acc:HGNC:6710] | 34662 | -1.376 | -0.1835 | No |
| 127 | DUSP6 | dual specificity phosphatase 6 [Source:HGNC Symbol;Acc:HGNC:3072] | 34816 | -1.442 | -0.1721 | No |
| 128 | CAPN5 | calpain 5 [Source:HGNC Symbol;Acc:HGNC:1482] | 35291 | -1.672 | -0.1669 | No |
| 129 | CFH | complement factor H [Source:HGNC Symbol;Acc:HGNC:4883] | 35327 | -1.688 | -0.1496 | No |
| 130 | C1R | complement C1r [Source:HGNC Symbol;Acc:HGNC:1246] | 35404 | -1.729 | -0.1330 | No |
| 131 | CSRP1 | cysteine and glycine rich protein 1 [Source:HGNC Symbol;Acc:HGNC:2469] | 35409 | -1.730 | -0.1145 | No |
| 132 | ANG | angiogenin [Source:HGNC Symbol;Acc:HGNC:483] | 35457 | -1.752 | -0.0968 | No |
| 133 | LRP1 | LDL receptor related protein 1 [Source:HGNC Symbol;Acc:HGNC:6692] | 35671 | -1.882 | -0.0823 | No |
| 134 | F8 | coagulation factor VIII [Source:HGNC Symbol;Acc:HGNC:3546] | 35743 | -1.929 | -0.0634 | No |
| 135 | LGMN | legumain [Source:HGNC Symbol;Acc:HGNC:9472] | 36140 | -2.261 | -0.0497 | No |
| 136 | GSN | gelsolin [Source:HGNC Symbol;Acc:HGNC:4620] | 36669 | -2.887 | -0.0328 | No |
| 137 | PLAU | plasminogen activator, urokinase [Source:HGNC Symbol;Acc:HGNC:9052] | 37041 | -4.092 | 0.0013 | No |
