Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.greenbergcls.cls #KO_GAQ_versus_KO_NA.greenbergcls.cls #KO_GAQ_versus_KO_NA_repos |
| Phenotype | greenbergcls.cls#KO_GAQ_versus_KO_NA_repos |
| Upregulated in class | KO_GAQ |
| GeneSet | HALLMARK_IL6_JAK_STAT3_SIGNALING |
| Enrichment Score (ES) | 0.751428 |
| Normalized Enrichment Score (NES) | 1.8819551 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.001469606 |
| FWER p-Value | 0.001 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | IL1B | interleukin 1 beta [Source:HGNC Symbol;Acc:HGNC:5992] | 0 | 4.990 | 0.0597 | Yes |
| 2 | SOCS3 | suppressor of cytokine signaling 3 [Source:HGNC Symbol;Acc:HGNC:19391] | 12 | 4.738 | 0.1161 | Yes |
| 3 | TNFRSF1B | TNF receptor superfamily member 1B [Source:HGNC Symbol;Acc:HGNC:11917] | 16 | 4.671 | 0.1719 | Yes |
| 4 | TNF | tumor necrosis factor [Source:HGNC Symbol;Acc:HGNC:11892] | 39 | 4.237 | 0.2220 | Yes |
| 5 | PIM1 | Pim-1 proto-oncogene, serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:8986] | 163 | 3.091 | 0.2557 | Yes |
| 6 | PIK3R5 | phosphoinositide-3-kinase regulatory subunit 5 [Source:HGNC Symbol;Acc:HGNC:30035] | 191 | 2.963 | 0.2904 | Yes |
| 7 | CD44 | CD44 molecule (Indian blood group) [Source:HGNC Symbol;Acc:HGNC:1681] | 218 | 2.817 | 0.3234 | Yes |
| 8 | STAT3 | signal transducer and activator of transcription 3 [Source:HGNC Symbol;Acc:HGNC:11364] | 244 | 2.715 | 0.3552 | Yes |
| 9 | CD14 | CD14 molecule [Source:HGNC Symbol;Acc:HGNC:1628] | 285 | 2.574 | 0.3849 | Yes |
| 10 | STAT1 | signal transducer and activator of transcription 1 [Source:HGNC Symbol;Acc:HGNC:11362] | 305 | 2.496 | 0.4143 | Yes |
| 11 | SOCS1 | suppressor of cytokine signaling 1 [Source:HGNC Symbol;Acc:HGNC:19383] | 307 | 2.492 | 0.4441 | Yes |
| 12 | CD36 | CD36 molecule [Source:HGNC Symbol;Acc:HGNC:1663] | 342 | 2.415 | 0.4721 | Yes |
| 13 | TGFB1 | transforming growth factor beta 1 [Source:HGNC Symbol;Acc:HGNC:11766] | 425 | 2.208 | 0.4963 | Yes |
| 14 | STAT2 | signal transducer and activator of transcription 2 [Source:HGNC Symbol;Acc:HGNC:11363] | 446 | 2.147 | 0.5214 | Yes |
| 15 | MYD88 | MYD88 innate immune signal transduction adaptor [Source:HGNC Symbol;Acc:HGNC:7562] | 452 | 2.143 | 0.5469 | Yes |
| 16 | HAX1 | HCLS1 associated protein X-1 [Source:HGNC Symbol;Acc:HGNC:16915] | 576 | 1.921 | 0.5666 | Yes |
| 17 | IRF9 | interferon regulatory factor 9 [Source:HGNC Symbol;Acc:HGNC:6131] | 684 | 1.737 | 0.5845 | Yes |
| 18 | TNFRSF1A | TNF receptor superfamily member 1A [Source:HGNC Symbol;Acc:HGNC:11916] | 720 | 1.690 | 0.6037 | Yes |
| 19 | PTPN11 | protein tyrosine phosphatase non-receptor type 11 [Source:HGNC Symbol;Acc:HGNC:9644] | 985 | 1.428 | 0.6137 | Yes |
| 20 | TLR2 | toll like receptor 2 [Source:HGNC Symbol;Acc:HGNC:11848] | 1022 | 1.395 | 0.6294 | Yes |
| 21 | MAP3K8 | mitogen-activated protein kinase kinase kinase 8 [Source:HGNC Symbol;Acc:HGNC:6860] | 1034 | 1.387 | 0.6457 | Yes |
| 22 | CD9 | CD9 molecule [Source:HGNC Symbol;Acc:HGNC:1709] | 1076 | 1.351 | 0.6608 | Yes |
| 23 | IL2RG | interleukin 2 receptor subunit gamma [Source:HGNC Symbol;Acc:HGNC:6010] | 1180 | 1.276 | 0.6732 | Yes |
| 24 | BAK1 | BCL2 antagonist/killer 1 [Source:HGNC Symbol;Acc:HGNC:949] | 1648 | 1.040 | 0.6731 | Yes |
| 25 | ACVR1B | activin A receptor type 1B [Source:HGNC Symbol;Acc:HGNC:172] | 1791 | 0.966 | 0.6808 | Yes |
| 26 | PTPN1 | protein tyrosine phosphatase non-receptor type 1 [Source:HGNC Symbol;Acc:HGNC:9642] | 1843 | 0.946 | 0.6907 | Yes |
| 27 | STAM2 | signal transducing adaptor molecule 2 [Source:HGNC Symbol;Acc:HGNC:11358] | 1846 | 0.945 | 0.7020 | Yes |
| 28 | IL17RA | interleukin 17 receptor A [Source:HGNC Symbol;Acc:HGNC:5985] | 1914 | 0.925 | 0.7112 | Yes |
| 29 | HMOX1 | heme oxygenase 1 [Source:HGNC Symbol;Acc:HGNC:5013] | 2034 | 0.880 | 0.7185 | Yes |
| 30 | CXCL10 | C-X-C motif chemokine ligand 10 [Source:HGNC Symbol;Acc:HGNC:10637] | 2056 | 0.871 | 0.7284 | Yes |
| 31 | GRB2 | growth factor receptor bound protein 2 [Source:HGNC Symbol;Acc:HGNC:4566] | 2272 | 0.793 | 0.7321 | Yes |
| 32 | CCR1 | C-C motif chemokine receptor 1 [Source:HGNC Symbol;Acc:HGNC:1602] | 2506 | 0.720 | 0.7344 | Yes |
| 33 | TNFRSF12A | TNF receptor superfamily member 12A [Source:HGNC Symbol;Acc:HGNC:18152] | 2678 | 0.671 | 0.7378 | Yes |
| 34 | JUN | Jun proto-oncogene, AP-1 transcription factor subunit [Source:HGNC Symbol;Acc:HGNC:6204] | 2706 | 0.664 | 0.7450 | Yes |
| 35 | ITGB3 | integrin subunit beta 3 [Source:HGNC Symbol;Acc:HGNC:6156] | 2801 | 0.639 | 0.7501 | Yes |
| 36 | FAS | Fas cell surface death receptor [Source:HGNC Symbol;Acc:HGNC:11920] | 3013 | 0.586 | 0.7514 | Yes |
| 37 | LTBR | lymphotoxin beta receptor [Source:HGNC Symbol;Acc:HGNC:6718] | 3809 | 0.437 | 0.7352 | No |
| 38 | IL6 | interleukin 6 [Source:HGNC Symbol;Acc:HGNC:6018] | 4084 | 0.383 | 0.7323 | No |
| 39 | CXCL3 | C-X-C motif chemokine ligand 3 [Source:HGNC Symbol;Acc:HGNC:4604] | 4411 | 0.326 | 0.7274 | No |
| 40 | IL7 | interleukin 7 [Source:HGNC Symbol;Acc:HGNC:6023] | 4678 | 0.282 | 0.7236 | No |
| 41 | CSF1 | colony stimulating factor 1 [Source:HGNC Symbol;Acc:HGNC:2432] | 4753 | 0.271 | 0.7249 | No |
| 42 | IL13RA1 | interleukin 13 receptor subunit alpha 1 [Source:HGNC Symbol;Acc:HGNC:5974] | 5300 | 0.188 | 0.7124 | No |
| 43 | LEPR | leptin receptor [Source:HGNC Symbol;Acc:HGNC:6554] | 6132 | 0.076 | 0.6908 | No |
| 44 | CBL | Cbl proto-oncogene [Source:HGNC Symbol;Acc:HGNC:1541] | 6320 | 0.052 | 0.6864 | No |
| 45 | TNFRSF21 | TNF receptor superfamily member 21 [Source:HGNC Symbol;Acc:HGNC:13469] | 9520 | 0.000 | 0.5999 | No |
| 46 | CRLF2 | cytokine receptor like factor 2 [Source:HGNC Symbol;Acc:HGNC:14281] | 11153 | 0.000 | 0.5558 | No |
| 47 | PLA2G2A | phospholipase A2 group IIA [Source:HGNC Symbol;Acc:HGNC:9031] | 11876 | 0.000 | 0.5363 | No |
| 48 | CSF2RA | colony stimulating factor 2 receptor subunit alpha [Source:HGNC Symbol;Acc:HGNC:2435] | 12160 | 0.000 | 0.5287 | No |
| 49 | PDGFC | platelet derived growth factor C [Source:HGNC Symbol;Acc:HGNC:8801] | 13723 | 0.000 | 0.4865 | No |
| 50 | IL4R | interleukin 4 receptor [Source:HGNC Symbol;Acc:HGNC:6015] | 14035 | 0.000 | 0.4781 | No |
| 51 | IL9R | interleukin 9 receptor [Source:HGNC Symbol;Acc:HGNC:6030] | 14103 | 0.000 | 0.4763 | No |
| 52 | IL15RA | interleukin 15 receptor subunit alpha [Source:HGNC Symbol;Acc:HGNC:5978] | 14330 | 0.000 | 0.4701 | No |
| 53 | EBI3 | Epstein-Barr virus induced 3 [Source:HGNC Symbol;Acc:HGNC:3129] | 15171 | 0.000 | 0.4474 | No |
| 54 | IL17RB | interleukin 17 receptor B [Source:HGNC Symbol;Acc:HGNC:18015] | 15221 | 0.000 | 0.4461 | No |
| 55 | IL18R1 | interleukin 18 receptor 1 [Source:HGNC Symbol;Acc:HGNC:5988] | 15560 | 0.000 | 0.4370 | No |
| 56 | IL2RA | interleukin 2 receptor subunit alpha [Source:HGNC Symbol;Acc:HGNC:6008] | 15735 | 0.000 | 0.4323 | No |
| 57 | IL1R1 | interleukin 1 receptor type 1 [Source:HGNC Symbol;Acc:HGNC:5993] | 15992 | 0.000 | 0.4254 | No |
| 58 | IL1R2 | interleukin 1 receptor type 2 [Source:HGNC Symbol;Acc:HGNC:5994] | 15993 | 0.000 | 0.4254 | No |
| 59 | IL3RA | interleukin 3 receptor subunit alpha [Source:HGNC Symbol;Acc:HGNC:6012] | 16599 | 0.000 | 0.4090 | No |
| 60 | IFNAR1 | interferon alpha and beta receptor subunit 1 [Source:HGNC Symbol;Acc:HGNC:5432] | 18473 | 0.000 | 0.3584 | No |
| 61 | CXCL13 | C-X-C motif chemokine ligand 13 [Source:HGNC Symbol;Acc:HGNC:10639] | 18871 | 0.000 | 0.3477 | No |
| 62 | CXCL11 | C-X-C motif chemokine ligand 11 [Source:HGNC Symbol;Acc:HGNC:10638] | 18906 | 0.000 | 0.3468 | No |
| 63 | OSMR | oncostatin M receptor [Source:HGNC Symbol;Acc:HGNC:8507] | 18985 | 0.000 | 0.3446 | No |
| 64 | CXCL9 | C-X-C motif chemokine ligand 9 [Source:HGNC Symbol;Acc:HGNC:7098] | 19421 | 0.000 | 0.3329 | No |
| 65 | CXCL1 | C-X-C motif chemokine ligand 1 [Source:HGNC Symbol;Acc:HGNC:4602] | 19433 | 0.000 | 0.3326 | No |
| 66 | IL12RB1 | interleukin 12 receptor subunit beta 1 [Source:HGNC Symbol;Acc:HGNC:5971] | 19596 | 0.000 | 0.3282 | No |
| 67 | PF4 | platelet factor 4 [Source:HGNC Symbol;Acc:HGNC:8861] | 19965 | 0.000 | 0.3183 | No |
| 68 | IFNGR1 | interferon gamma receptor 1 [Source:HGNC Symbol;Acc:HGNC:5439] | 20475 | 0.000 | 0.3045 | No |
| 69 | IFNGR2 | interferon gamma receptor 2 [Source:HGNC Symbol;Acc:HGNC:5440] | 20477 | 0.000 | 0.3045 | No |
| 70 | CCL7 | C-C motif chemokine ligand 7 [Source:HGNC Symbol;Acc:HGNC:10634] | 22932 | 0.000 | 0.2382 | No |
| 71 | CD38 | CD38 molecule [Source:HGNC Symbol;Acc:HGNC:1667] | 23027 | 0.000 | 0.2356 | No |
| 72 | CSF2 | colony stimulating factor 2 [Source:HGNC Symbol;Acc:HGNC:2434] | 24555 | 0.000 | 0.1944 | No |
| 73 | REG1A | regenerating family member 1 alpha [Source:HGNC Symbol;Acc:HGNC:9951] | 26414 | 0.000 | 0.1442 | No |
| 74 | A2M | alpha-2-macroglobulin [Source:HGNC Symbol;Acc:HGNC:7] | 27010 | 0.000 | 0.1281 | No |
| 75 | PTPN2 | protein tyrosine phosphatase non-receptor type 2 [Source:HGNC Symbol;Acc:HGNC:9650] | 28422 | -0.110 | 0.0913 | No |
| 76 | ACVRL1 | activin A receptor like type 1 [Source:HGNC Symbol;Acc:HGNC:175] | 29147 | -0.198 | 0.0741 | No |
| 77 | LTB | lymphotoxin beta [Source:HGNC Symbol;Acc:HGNC:6711] | 29173 | -0.202 | 0.0758 | No |
| 78 | CNTFR | ciliary neurotrophic factor receptor [Source:HGNC Symbol;Acc:HGNC:2170] | 29354 | -0.223 | 0.0736 | No |
| 79 | DNTT | DNA nucleotidylexotransferase [Source:HGNC Symbol;Acc:HGNC:2983] | 31010 | -0.441 | 0.0342 | No |
| 80 | IRF1 | interferon regulatory factor 1 [Source:HGNC Symbol;Acc:HGNC:6116] | 31046 | -0.447 | 0.0386 | No |
| 81 | TYK2 | tyrosine kinase 2 [Source:HGNC Symbol;Acc:HGNC:12440] | 31501 | -0.521 | 0.0325 | No |
| 82 | CSF2RB | colony stimulating factor 2 receptor subunit beta [Source:HGNC Symbol;Acc:HGNC:2436] | 31839 | -0.581 | 0.0304 | No |
| 83 | INHBE | inhibin subunit beta E [Source:HGNC Symbol;Acc:HGNC:24029] | 33148 | -0.870 | 0.0054 | No |
| 84 | IL10RB | interleukin 10 receptor subunit beta [Source:HGNC Symbol;Acc:HGNC:5965] | 33741 | -1.046 | 0.0020 | No |
| 85 | CSF3R | colony stimulating factor 3 receptor [Source:HGNC Symbol;Acc:HGNC:2439] | 34209 | -1.200 | 0.0037 | No |
| 86 | IL6ST | interleukin 6 signal transducer [Source:HGNC Symbol;Acc:HGNC:6021] | 35934 | -2.077 | -0.0180 | No |
| 87 | ITGA4 | integrin subunit alpha 4 [Source:HGNC Symbol;Acc:HGNC:6140] | 37042 | -4.117 | 0.0013 | No |
