Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.greenbergcls.cls #KO_GAQ_versus_KO_NA.greenbergcls.cls #KO_GAQ_versus_KO_NA_repos |
| Phenotype | greenbergcls.cls#KO_GAQ_versus_KO_NA_repos |
| Upregulated in class | KO_GAQ |
| GeneSet | HALLMARK_INTERFERON_ALPHA_RESPONSE |
| Enrichment Score (ES) | 0.7541597 |
| Normalized Enrichment Score (NES) | 1.9306881 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0018370074 |
| FWER p-Value | 0.001 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | USP18 | ubiquitin specific peptidase 18 [Source:HGNC Symbol;Acc:HGNC:12616] | 34 | 4.337 | 0.0324 | Yes |
| 2 | IFI44 | interferon induced protein 44 [Source:HGNC Symbol;Acc:HGNC:16938] | 63 | 3.976 | 0.0622 | Yes |
| 3 | DHX58 | DExH-box helicase 58 [Source:HGNC Symbol;Acc:HGNC:29517] | 121 | 3.365 | 0.0865 | Yes |
| 4 | OAS1 | 2'-5'-oligoadenylate synthetase 1 [Source:HGNC Symbol;Acc:HGNC:8086] | 143 | 3.206 | 0.1106 | Yes |
| 5 | IRF7 | interferon regulatory factor 7 [Source:HGNC Symbol;Acc:HGNC:6122] | 154 | 3.130 | 0.1343 | Yes |
| 6 | PARP12 | poly(ADP-ribose) polymerase family member 12 [Source:HGNC Symbol;Acc:HGNC:21919] | 168 | 3.071 | 0.1576 | Yes |
| 7 | IFI35 | interferon induced protein 35 [Source:HGNC Symbol;Acc:HGNC:5399] | 173 | 3.047 | 0.1809 | Yes |
| 8 | IFIH1 | interferon induced with helicase C domain 1 [Source:HGNC Symbol;Acc:HGNC:18873] | 177 | 3.033 | 0.2041 | Yes |
| 9 | PARP14 | poly(ADP-ribose) polymerase family member 14 [Source:HGNC Symbol;Acc:HGNC:29232] | 178 | 3.031 | 0.2274 | Yes |
| 10 | EIF2AK2 | eukaryotic translation initiation factor 2 alpha kinase 2 [Source:HGNC Symbol;Acc:HGNC:9437] | 181 | 3.025 | 0.2506 | Yes |
| 11 | OASL | 2'-5'-oligoadenylate synthetase like [Source:HGNC Symbol;Acc:HGNC:8090] | 184 | 3.012 | 0.2737 | Yes |
| 12 | TRAFD1 | TRAF-type zinc finger domain containing 1 [Source:HGNC Symbol;Acc:HGNC:24808] | 185 | 3.011 | 0.2968 | Yes |
| 13 | HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 [Source:HGNC Symbol;Acc:HGNC:26072] | 211 | 2.872 | 0.3182 | Yes |
| 14 | SAMD9 | sterile alpha motif domain containing 9 [Source:HGNC Symbol;Acc:HGNC:1348] | 214 | 2.849 | 0.3400 | Yes |
| 15 | HELZ2 | helicase with zinc finger 2 [Source:HGNC Symbol;Acc:HGNC:30021] | 234 | 2.745 | 0.3606 | Yes |
| 16 | DDX60 | DExD/H-box helicase 60 [Source:HGNC Symbol;Acc:HGNC:25942] | 235 | 2.744 | 0.3817 | Yes |
| 17 | SAMD9L | sterile alpha motif domain containing 9 like [Source:HGNC Symbol;Acc:HGNC:1349] | 258 | 2.666 | 0.4016 | Yes |
| 18 | ISG20 | interferon stimulated exonuclease gene 20 [Source:HGNC Symbol;Acc:HGNC:6130] | 277 | 2.597 | 0.4210 | Yes |
| 19 | TRIM25 | tripartite motif containing 25 [Source:HGNC Symbol;Acc:HGNC:12932] | 325 | 2.450 | 0.4386 | Yes |
| 20 | MX1 | MX dynamin like GTPase 1 [Source:HGNC Symbol;Acc:HGNC:7532] | 391 | 2.293 | 0.4544 | Yes |
| 21 | CMPK2 | cytidine/uridine monophosphate kinase 2 [Source:HGNC Symbol;Acc:HGNC:27015] | 421 | 2.219 | 0.4707 | Yes |
| 22 | RIPK2 | receptor interacting serine/threonine kinase 2 [Source:HGNC Symbol;Acc:HGNC:10020] | 435 | 2.177 | 0.4871 | Yes |
| 23 | STAT2 | signal transducer and activator of transcription 2 [Source:HGNC Symbol;Acc:HGNC:11363] | 446 | 2.147 | 0.5033 | Yes |
| 24 | ADAR | adenosine deaminase RNA specific [Source:HGNC Symbol;Acc:HGNC:225] | 482 | 2.080 | 0.5183 | Yes |
| 25 | LGALS3BP | galectin 3 binding protein [Source:HGNC Symbol;Acc:HGNC:6564] | 506 | 2.036 | 0.5334 | Yes |
| 26 | PNPT1 | polyribonucleotide nucleotidyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:23166] | 509 | 2.033 | 0.5489 | Yes |
| 27 | IFITM3 | interferon induced transmembrane protein 3 [Source:HGNC Symbol;Acc:HGNC:5414] | 587 | 1.904 | 0.5615 | Yes |
| 28 | RSAD2 | radical S-adenosyl methionine domain containing 2 [Source:HGNC Symbol;Acc:HGNC:30908] | 595 | 1.883 | 0.5757 | Yes |
| 29 | EPSTI1 | epithelial stromal interaction 1 [Source:HGNC Symbol;Acc:HGNC:16465] | 613 | 1.855 | 0.5895 | Yes |
| 30 | IFITM2 | interferon induced transmembrane protein 2 [Source:HGNC Symbol;Acc:HGNC:5413] | 661 | 1.774 | 0.6019 | Yes |
| 31 | IRF9 | interferon regulatory factor 9 [Source:HGNC Symbol;Acc:HGNC:6131] | 684 | 1.737 | 0.6147 | Yes |
| 32 | GBP4 | guanylate binding protein 4 [Source:HGNC Symbol;Acc:HGNC:20480] | 900 | 1.503 | 0.6204 | Yes |
| 33 | UBE2L6 | ubiquitin conjugating enzyme E2 L6 [Source:HGNC Symbol;Acc:HGNC:12490] | 954 | 1.453 | 0.6301 | Yes |
| 34 | PARP9 | poly(ADP-ribose) polymerase family member 9 [Source:HGNC Symbol;Acc:HGNC:24118] | 981 | 1.431 | 0.6404 | Yes |
| 35 | PROCR | protein C receptor [Source:HGNC Symbol;Acc:HGNC:9452] | 1019 | 1.399 | 0.6502 | Yes |
| 36 | CASP8 | caspase 8 [Source:HGNC Symbol;Acc:HGNC:1509] | 1102 | 1.329 | 0.6581 | Yes |
| 37 | TRIM21 | tripartite motif containing 21 [Source:HGNC Symbol;Acc:HGNC:11312] | 1106 | 1.324 | 0.6682 | Yes |
| 38 | GBP2 | guanylate binding protein 2 [Source:HGNC Symbol;Acc:HGNC:4183] | 1169 | 1.286 | 0.6764 | Yes |
| 39 | PSME2 | proteasome activator subunit 2 [Source:HGNC Symbol;Acc:HGNC:9569] | 1187 | 1.267 | 0.6857 | Yes |
| 40 | IFIT2 | interferon induced protein with tetratricopeptide repeats 2 [Source:HGNC Symbol;Acc:HGNC:5409] | 1201 | 1.255 | 0.6950 | Yes |
| 41 | CMTR1 | cap methyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:21077] | 1241 | 1.229 | 0.7034 | Yes |
| 42 | UBA7 | ubiquitin like modifier activating enzyme 7 [Source:HGNC Symbol;Acc:HGNC:12471] | 1375 | 1.169 | 0.7088 | Yes |
| 43 | CD47 | CD47 molecule [Source:HGNC Symbol;Acc:HGNC:1682] | 1409 | 1.154 | 0.7168 | Yes |
| 44 | OGFR | opioid growth factor receptor [Source:HGNC Symbol;Acc:HGNC:15768] | 1437 | 1.139 | 0.7248 | Yes |
| 45 | TDRD7 | tudor domain containing 7 [Source:HGNC Symbol;Acc:HGNC:30831] | 1445 | 1.135 | 0.7333 | Yes |
| 46 | MOV10 | Mov10 RISC complex RNA helicase [Source:HGNC Symbol;Acc:HGNC:7200] | 1563 | 1.081 | 0.7385 | Yes |
| 47 | PSMA3 | proteasome 20S subunit alpha 3 [Source:HGNC Symbol;Acc:HGNC:9532] | 1575 | 1.075 | 0.7464 | Yes |
| 48 | TAP1 | transporter 1, ATP binding cassette subfamily B member [Source:HGNC Symbol;Acc:HGNC:43] | 1593 | 1.067 | 0.7542 | Yes |
| 49 | CXCL10 | C-X-C motif chemokine ligand 10 [Source:HGNC Symbol;Acc:HGNC:10637] | 2056 | 0.871 | 0.7484 | No |
| 50 | TRIM14 | tripartite motif containing 14 [Source:HGNC Symbol;Acc:HGNC:16283] | 2359 | 0.767 | 0.7461 | No |
| 51 | PSME1 | proteasome activator subunit 1 [Source:HGNC Symbol;Acc:HGNC:9568] | 2661 | 0.674 | 0.7431 | No |
| 52 | WARS1 | tryptophanyl-tRNA synthetase 1 [Source:HGNC Symbol;Acc:HGNC:12729] | 2680 | 0.671 | 0.7478 | No |
| 53 | TRIM26 | tripartite motif containing 26 [Source:HGNC Symbol;Acc:HGNC:12962] | 3041 | 0.581 | 0.7425 | No |
| 54 | ISG15 | ISG15 ubiquitin like modifier [Source:HGNC Symbol;Acc:HGNC:4053] | 4002 | 0.397 | 0.7196 | No |
| 55 | CASP1 | caspase 1 [Source:HGNC Symbol;Acc:HGNC:1499] | 4121 | 0.374 | 0.7193 | No |
| 56 | PSMB8 | proteasome 20S subunit beta 8 [Source:HGNC Symbol;Acc:HGNC:9545] | 4173 | 0.366 | 0.7207 | No |
| 57 | HLA-C | major histocompatibility complex, class I, C [Source:HGNC Symbol;Acc:HGNC:4933] | 4332 | 0.340 | 0.7191 | No |
| 58 | BATF2 | basic leucine zipper ATF-like transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:25163] | 4371 | 0.333 | 0.7206 | No |
| 59 | RNF31 | ring finger protein 31 [Source:HGNC Symbol;Acc:HGNC:16031] | 4407 | 0.327 | 0.7222 | No |
| 60 | TENT5A | terminal nucleotidyltransferase 5A [Source:HGNC Symbol;Acc:HGNC:18345] | 4485 | 0.315 | 0.7225 | No |
| 61 | IL7 | interleukin 7 [Source:HGNC Symbol;Acc:HGNC:6023] | 4678 | 0.282 | 0.7195 | No |
| 62 | CSF1 | colony stimulating factor 1 [Source:HGNC Symbol;Acc:HGNC:2432] | 4753 | 0.271 | 0.7196 | No |
| 63 | TRIM5 | tripartite motif containing 5 [Source:HGNC Symbol;Acc:HGNC:16276] | 4912 | 0.246 | 0.7172 | No |
| 64 | IFIT3 | interferon induced protein with tetratricopeptide repeats 3 [Source:HGNC Symbol;Acc:HGNC:5411] | 5571 | 0.150 | 0.7006 | No |
| 65 | NMI | N-myc and STAT interactor [Source:HGNC Symbol;Acc:HGNC:7854] | 5574 | 0.149 | 0.7017 | No |
| 66 | SELL | selectin L [Source:HGNC Symbol;Acc:HGNC:10720] | 7480 | 0.000 | 0.6502 | No |
| 67 | CCRL2 | C-C motif chemokine receptor like 2 [Source:HGNC Symbol;Acc:HGNC:1612] | 9023 | 0.000 | 0.6085 | No |
| 68 | LY6E | lymphocyte antigen 6 family member E [Source:HGNC Symbol;Acc:HGNC:6727] | 9480 | 0.000 | 0.5962 | No |
| 69 | RTP4 | receptor transporter protein 4 [Source:HGNC Symbol;Acc:HGNC:23992] | 10770 | 0.000 | 0.5613 | No |
| 70 | IFI30 | IFI30 lysosomal thiol reductase [Source:HGNC Symbol;Acc:HGNC:5398] | 11722 | 0.000 | 0.5356 | No |
| 71 | BST2 | bone marrow stromal cell antigen 2 [Source:HGNC Symbol;Acc:HGNC:1119] | 12674 | 0.000 | 0.5099 | No |
| 72 | IL4R | interleukin 4 receptor [Source:HGNC Symbol;Acc:HGNC:6015] | 14035 | 0.000 | 0.4731 | No |
| 73 | CXCL11 | C-X-C motif chemokine ligand 11 [Source:HGNC Symbol;Acc:HGNC:10638] | 18906 | 0.000 | 0.3415 | No |
| 74 | IFI44L | interferon induced protein 44 like [Source:HGNC Symbol;Acc:HGNC:17817] | 23719 | 0.000 | 0.2114 | No |
| 75 | LAMP3 | lysosomal associated membrane protein 3 [Source:HGNC Symbol;Acc:HGNC:14582] | 24566 | 0.000 | 0.1885 | No |
| 76 | SP110 | SP110 nuclear body protein [Source:HGNC Symbol;Acc:HGNC:5401] | 27681 | -0.024 | 0.1046 | No |
| 77 | TMEM140 | transmembrane protein 140 [Source:HGNC Symbol;Acc:HGNC:21870] | 27683 | -0.024 | 0.1047 | No |
| 78 | IFITM1 | interferon induced transmembrane protein 1 [Source:HGNC Symbol;Acc:HGNC:5412] | 28206 | -0.085 | 0.0912 | No |
| 79 | B2M | beta-2-microglobulin [Source:HGNC Symbol;Acc:HGNC:914] | 28290 | -0.095 | 0.0897 | No |
| 80 | PLSCR1 | phospholipid scramblase 1 [Source:HGNC Symbol;Acc:HGNC:9092] | 29170 | -0.202 | 0.0675 | No |
| 81 | LAP3 | leucine aminopeptidase 3 [Source:HGNC Symbol;Acc:HGNC:18449] | 29418 | -0.231 | 0.0626 | No |
| 82 | PSMB9 | proteasome 20S subunit beta 9 [Source:HGNC Symbol;Acc:HGNC:9546] | 29970 | -0.303 | 0.0501 | No |
| 83 | C1S | complement C1s [Source:HGNC Symbol;Acc:HGNC:1247] | 30851 | -0.420 | 0.0295 | No |
| 84 | IRF1 | interferon regulatory factor 1 [Source:HGNC Symbol;Acc:HGNC:6116] | 31046 | -0.447 | 0.0277 | No |
| 85 | IFI27 | interferon alpha inducible protein 27 [Source:HGNC Symbol;Acc:HGNC:5397] | 31061 | -0.449 | 0.0308 | No |
| 86 | NCOA7 | nuclear receptor coactivator 7 [Source:HGNC Symbol;Acc:HGNC:21081] | 32037 | -0.616 | 0.0091 | No |
| 87 | IL15 | interleukin 15 [Source:HGNC Symbol;Acc:HGNC:5977] | 32922 | -0.814 | -0.0085 | No |
| 88 | LPAR6 | lysophosphatidic acid receptor 6 [Source:HGNC Symbol;Acc:HGNC:15520] | 33131 | -0.866 | -0.0075 | No |
| 89 | IRF2 | interferon regulatory factor 2 [Source:HGNC Symbol;Acc:HGNC:6117] | 33265 | -0.907 | -0.0041 | No |
| 90 | SLC25A28 | solute carrier family 25 member 28 [Source:HGNC Symbol;Acc:HGNC:23472] | 33357 | -0.928 | 0.0006 | No |
| 91 | MVB12A | multivesicular body subunit 12A [Source:HGNC Symbol;Acc:HGNC:25153] | 33398 | -0.941 | 0.0067 | No |
| 92 | NUB1 | negative regulator of ubiquitin like proteins 1 [Source:HGNC Symbol;Acc:HGNC:17623] | 33541 | -0.980 | 0.0104 | No |
| 93 | ELF1 | E74 like ETS transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:3316] | 34459 | -1.297 | -0.0044 | No |
| 94 | CD74 | CD74 molecule [Source:HGNC Symbol;Acc:HGNC:1697] | 35245 | -1.643 | -0.0130 | No |
| 95 | CNP | 2',3'-cyclic nucleotide 3' phosphodiesterase [Source:HGNC Symbol;Acc:HGNC:2158] | 35851 | -2.009 | -0.0139 | No |
| 96 | TXNIP | thioredoxin interacting protein [Source:HGNC Symbol;Acc:HGNC:16952] | 36389 | -2.502 | -0.0092 | No |
| 97 | GMPR | guanosine monophosphate reductase [Source:HGNC Symbol;Acc:HGNC:4376] | 36949 | -3.665 | 0.0038 | No |
