Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.greenbergcls.cls #KO_GAQ_versus_KO_NA.greenbergcls.cls #KO_GAQ_versus_KO_NA_repos |
| Phenotype | greenbergcls.cls#KO_GAQ_versus_KO_NA_repos |
| Upregulated in class | KO_GAQ |
| GeneSet | HALLMARK_PI3K_AKT_MTOR_SIGNALING |
| Enrichment Score (ES) | 0.3967361 |
| Normalized Enrichment Score (NES) | 1.0168518 |
| Nominal p-value | 0.43356642 |
| FDR q-value | 0.4021053 |
| FWER p-Value | 0.891 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | MAP2K3 | mitogen-activated protein kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6843] | 262 | 2.647 | 0.0240 | Yes |
| 2 | SQSTM1 | sequestosome 1 [Source:HGNC Symbol;Acc:HGNC:11280] | 286 | 2.573 | 0.0535 | Yes |
| 3 | STAT2 | signal transducer and activator of transcription 2 [Source:HGNC Symbol;Acc:HGNC:11363] | 446 | 2.147 | 0.0744 | Yes |
| 4 | MYD88 | MYD88 innate immune signal transduction adaptor [Source:HGNC Symbol;Acc:HGNC:7562] | 452 | 2.143 | 0.0994 | Yes |
| 5 | NFKBIB | NFKB inhibitor beta [Source:HGNC Symbol;Acc:HGNC:7798] | 499 | 2.048 | 0.1222 | Yes |
| 6 | ADCY2 | adenylate cyclase 2 [Source:HGNC Symbol;Acc:HGNC:233] | 600 | 1.877 | 0.1415 | Yes |
| 7 | TNFRSF1A | TNF receptor superfamily member 1A [Source:HGNC Symbol;Acc:HGNC:11916] | 720 | 1.690 | 0.1581 | Yes |
| 8 | PFN1 | profilin 1 [Source:HGNC Symbol;Acc:HGNC:8881] | 790 | 1.606 | 0.1750 | Yes |
| 9 | ACTR3 | actin related protein 3 [Source:HGNC Symbol;Acc:HGNC:170] | 851 | 1.548 | 0.1916 | Yes |
| 10 | CFL1 | cofilin 1 [Source:HGNC Symbol;Acc:HGNC:1874] | 914 | 1.491 | 0.2074 | Yes |
| 11 | PIN1 | peptidylprolyl cis/trans isomerase, NIMA-interacting 1 [Source:HGNC Symbol;Acc:HGNC:8988] | 916 | 1.491 | 0.2248 | Yes |
| 12 | PTPN11 | protein tyrosine phosphatase non-receptor type 11 [Source:HGNC Symbol;Acc:HGNC:9644] | 985 | 1.428 | 0.2397 | Yes |
| 13 | UBE2D3 | ubiquitin conjugating enzyme E2 D3 [Source:HGNC Symbol;Acc:HGNC:12476] | 1139 | 1.302 | 0.2509 | Yes |
| 14 | IL2RG | interleukin 2 receptor subunit gamma [Source:HGNC Symbol;Acc:HGNC:6010] | 1180 | 1.276 | 0.2648 | Yes |
| 15 | ACTR2 | actin related protein 2 [Source:HGNC Symbol;Acc:HGNC:169] | 1203 | 1.254 | 0.2789 | Yes |
| 16 | TRAF2 | TNF receptor associated factor 2 [Source:HGNC Symbol;Acc:HGNC:12032] | 1281 | 1.212 | 0.2910 | Yes |
| 17 | LCK | LCK proto-oncogene, Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:6524] | 1502 | 1.109 | 0.2981 | Yes |
| 18 | SLC2A1 | solute carrier family 2 member 1 [Source:HGNC Symbol;Acc:HGNC:11005] | 1528 | 1.098 | 0.3103 | Yes |
| 19 | UBE2N | ubiquitin conjugating enzyme E2 N [Source:HGNC Symbol;Acc:HGNC:12492] | 1724 | 0.995 | 0.3167 | Yes |
| 20 | CALR | calreticulin [Source:HGNC Symbol;Acc:HGNC:1455] | 1952 | 0.910 | 0.3212 | Yes |
| 21 | PPP2R1B | protein phosphatase 2 scaffold subunit Abeta [Source:HGNC Symbol;Acc:HGNC:9303] | 1980 | 0.900 | 0.3310 | Yes |
| 22 | MAPK10 | mitogen-activated protein kinase 10 [Source:HGNC Symbol;Acc:HGNC:6872] | 2054 | 0.871 | 0.3393 | Yes |
| 23 | GRB2 | growth factor receptor bound protein 2 [Source:HGNC Symbol;Acc:HGNC:4566] | 2272 | 0.793 | 0.3427 | Yes |
| 24 | RIT1 | Ras like without CAAX 1 [Source:HGNC Symbol;Acc:HGNC:10023] | 2570 | 0.701 | 0.3429 | Yes |
| 25 | AP2M1 | adaptor related protein complex 2 subunit mu 1 [Source:HGNC Symbol;Acc:HGNC:564] | 2623 | 0.684 | 0.3495 | Yes |
| 26 | CDKN1A | cyclin dependent kinase inhibitor 1A [Source:HGNC Symbol;Acc:HGNC:1784] | 2691 | 0.668 | 0.3555 | Yes |
| 27 | PAK4 | p21 (RAC1) activated kinase 4 [Source:HGNC Symbol;Acc:HGNC:16059] | 2721 | 0.661 | 0.3625 | Yes |
| 28 | AKT1S1 | AKT1 substrate 1 [Source:HGNC Symbol;Acc:HGNC:28426] | 2768 | 0.648 | 0.3688 | Yes |
| 29 | ARF1 | ADP ribosylation factor 1 [Source:HGNC Symbol;Acc:HGNC:652] | 2816 | 0.636 | 0.3750 | Yes |
| 30 | CAB39 | calcium binding protein 39 [Source:HGNC Symbol;Acc:HGNC:20292] | 2923 | 0.607 | 0.3793 | Yes |
| 31 | NCK1 | NCK adaptor protein 1 [Source:HGNC Symbol;Acc:HGNC:7664] | 3015 | 0.586 | 0.3837 | Yes |
| 32 | YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta [Source:HGNC Symbol;Acc:HGNC:12849] | 3218 | 0.547 | 0.3846 | Yes |
| 33 | RPTOR | regulatory associated protein of MTOR complex 1 [Source:HGNC Symbol;Acc:HGNC:30287] | 3302 | 0.528 | 0.3886 | Yes |
| 34 | ATF1 | activating transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:783] | 3689 | 0.457 | 0.3835 | Yes |
| 35 | ARPC3 | actin related protein 2/3 complex subunit 3 [Source:HGNC Symbol;Acc:HGNC:706] | 3786 | 0.440 | 0.3861 | Yes |
| 36 | CAB39L | calcium binding protein 39 like [Source:HGNC Symbol;Acc:HGNC:20290] | 3792 | 0.439 | 0.3911 | Yes |
| 37 | EIF4E | eukaryotic translation initiation factor 4E [Source:HGNC Symbol;Acc:HGNC:3287] | 3865 | 0.426 | 0.3941 | Yes |
| 38 | TBK1 | TANK binding kinase 1 [Source:HGNC Symbol;Acc:HGNC:11584] | 4131 | 0.372 | 0.3913 | Yes |
| 39 | PPP1CA | protein phosphatase 1 catalytic subunit alpha [Source:HGNC Symbol;Acc:HGNC:9281] | 4216 | 0.358 | 0.3933 | Yes |
| 40 | SMAD2 | SMAD family member 2 [Source:HGNC Symbol;Acc:HGNC:6768] | 4330 | 0.340 | 0.3942 | Yes |
| 41 | HRAS | HRas proto-oncogene, GTPase [Source:HGNC Symbol;Acc:HGNC:5173] | 4381 | 0.332 | 0.3967 | Yes |
| 42 | ARHGDIA | Rho GDP dissociation inhibitor alpha [Source:HGNC Symbol;Acc:HGNC:678] | 4676 | 0.283 | 0.3921 | No |
| 43 | CSNK2B | casein kinase 2 beta [Source:HGNC Symbol;Acc:HGNC:2460] | 5020 | 0.229 | 0.3855 | No |
| 44 | CLTC | clathrin heavy chain [Source:HGNC Symbol;Acc:HGNC:2092] | 5358 | 0.179 | 0.3785 | No |
| 45 | GSK3B | glycogen synthase kinase 3 beta [Source:HGNC Symbol;Acc:HGNC:4617] | 5864 | 0.112 | 0.3662 | No |
| 46 | TRIB3 | tribbles pseudokinase 3 [Source:HGNC Symbol;Acc:HGNC:16228] | 5916 | 0.105 | 0.3660 | No |
| 47 | AKT1 | AKT serine/threonine kinase 1 [Source:HGNC Symbol;Acc:HGNC:391] | 6399 | 0.042 | 0.3535 | No |
| 48 | FGF22 | fibroblast growth factor 22 [Source:HGNC Symbol;Acc:HGNC:3679] | 7225 | 0.000 | 0.3312 | No |
| 49 | FGF17 | fibroblast growth factor 17 [Source:HGNC Symbol;Acc:HGNC:3673] | 7228 | 0.000 | 0.3311 | No |
| 50 | PITX2 | paired like homeodomain 2 [Source:HGNC Symbol;Acc:HGNC:9005] | 7661 | 0.000 | 0.3194 | No |
| 51 | CAMK4 | calcium/calmodulin dependent protein kinase IV [Source:HGNC Symbol;Acc:HGNC:1464] | 9340 | 0.000 | 0.2741 | No |
| 52 | GNGT1 | G protein subunit gamma transducin 1 [Source:HGNC Symbol;Acc:HGNC:4411] | 16355 | 0.000 | 0.0844 | No |
| 53 | IL4 | interleukin 4 [Source:HGNC Symbol;Acc:HGNC:6014] | 17753 | 0.000 | 0.0467 | No |
| 54 | NGF | nerve growth factor [Source:HGNC Symbol;Acc:HGNC:7808] | 19260 | 0.000 | 0.0059 | No |
| 55 | FASLG | Fas ligand [Source:HGNC Symbol;Acc:HGNC:11936] | 20237 | 0.000 | -0.0204 | No |
| 56 | EGFR | epidermal growth factor receptor [Source:HGNC Symbol;Acc:HGNC:3236] | 22165 | 0.000 | -0.0725 | No |
| 57 | THEM4 | thioesterase superfamily member 4 [Source:HGNC Symbol;Acc:HGNC:17947] | 22872 | 0.000 | -0.0916 | No |
| 58 | FGF6 | fibroblast growth factor 6 [Source:HGNC Symbol;Acc:HGNC:3684] | 25439 | 0.000 | -0.1610 | No |
| 59 | GNA14 | G protein subunit alpha 14 [Source:HGNC Symbol;Acc:HGNC:4382] | 26821 | 0.000 | -0.1984 | No |
| 60 | PRKAA2 | protein kinase AMP-activated catalytic subunit alpha 2 [Source:HGNC Symbol;Acc:HGNC:9377] | 27699 | -0.026 | -0.2218 | No |
| 61 | CDK1 | cyclin dependent kinase 1 [Source:HGNC Symbol;Acc:HGNC:1722] | 27890 | -0.049 | -0.2263 | No |
| 62 | PLCB1 | phospholipase C beta 1 [Source:HGNC Symbol;Acc:HGNC:15917] | 28076 | -0.070 | -0.2305 | No |
| 63 | DDIT3 | DNA damage inducible transcript 3 [Source:HGNC Symbol;Acc:HGNC:2726] | 28219 | -0.086 | -0.2333 | No |
| 64 | RALB | RAS like proto-oncogene B [Source:HGNC Symbol;Acc:HGNC:9840] | 28348 | -0.102 | -0.2356 | No |
| 65 | PRKAG1 | protein kinase AMP-activated non-catalytic subunit gamma 1 [Source:HGNC Symbol;Acc:HGNC:9385] | 28421 | -0.110 | -0.2363 | No |
| 66 | RIPK1 | receptor interacting serine/threonine kinase 1 [Source:HGNC Symbol;Acc:HGNC:10019] | 28486 | -0.116 | -0.2366 | No |
| 67 | MAP3K7 | mitogen-activated protein kinase kinase kinase 7 [Source:HGNC Symbol;Acc:HGNC:6859] | 28898 | -0.167 | -0.2458 | No |
| 68 | PIKFYVE | phosphoinositide kinase, FYVE-type zinc finger containing [Source:HGNC Symbol;Acc:HGNC:23785] | 28923 | -0.169 | -0.2444 | No |
| 69 | TIAM1 | TIAM Rac1 associated GEF 1 [Source:HGNC Symbol;Acc:HGNC:11805] | 29145 | -0.198 | -0.2481 | No |
| 70 | HSP90B1 | heat shock protein 90 beta family member 1 [Source:HGNC Symbol;Acc:HGNC:12028] | 29325 | -0.220 | -0.2504 | No |
| 71 | MKNK1 | MAPK interacting serine/threonine kinase 1 [Source:HGNC Symbol;Acc:HGNC:7110] | 29371 | -0.225 | -0.2489 | No |
| 72 | RPS6KA1 | ribosomal protein S6 kinase A1 [Source:HGNC Symbol;Acc:HGNC:10430] | 29541 | -0.245 | -0.2506 | No |
| 73 | MAPK1 | mitogen-activated protein kinase 1 [Source:HGNC Symbol;Acc:HGNC:6871] | 29630 | -0.257 | -0.2500 | No |
| 74 | RPS6KA3 | ribosomal protein S6 kinase A3 [Source:HGNC Symbol;Acc:HGNC:10432] | 30000 | -0.306 | -0.2564 | No |
| 75 | SLA | Src like adaptor [Source:HGNC Symbol;Acc:HGNC:10902] | 30138 | -0.322 | -0.2563 | No |
| 76 | RAC1 | Rac family small GTPase 1 [Source:HGNC Symbol;Acc:HGNC:9801] | 30212 | -0.332 | -0.2544 | No |
| 77 | MAPK8 | mitogen-activated protein kinase 8 [Source:HGNC Symbol;Acc:HGNC:6881] | 30629 | -0.386 | -0.2611 | No |
| 78 | RAF1 | Raf-1 proto-oncogene, serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:9829] | 31097 | -0.454 | -0.2684 | No |
| 79 | TSC2 | TSC complex subunit 2 [Source:HGNC Symbol;Acc:HGNC:12363] | 31274 | -0.481 | -0.2675 | No |
| 80 | MAPK9 | mitogen-activated protein kinase 9 [Source:HGNC Symbol;Acc:HGNC:6886] | 31821 | -0.579 | -0.2755 | No |
| 81 | PLA2G12A | phospholipase A2 group XIIA [Source:HGNC Symbol;Acc:HGNC:18554] | 31914 | -0.592 | -0.2711 | No |
| 82 | MAPKAP1 | MAPK associated protein 1 [Source:HGNC Symbol;Acc:HGNC:18752] | 31935 | -0.596 | -0.2646 | No |
| 83 | PRKAR2A | protein kinase cAMP-dependent type II regulatory subunit alpha [Source:HGNC Symbol;Acc:HGNC:9391] | 32216 | -0.658 | -0.2645 | No |
| 84 | NOD1 | nucleotide binding oligomerization domain containing 1 [Source:HGNC Symbol;Acc:HGNC:16390] | 32326 | -0.679 | -0.2594 | No |
| 85 | GRK2 | G protein-coupled receptor kinase 2 [Source:HGNC Symbol;Acc:HGNC:289] | 32986 | -0.826 | -0.2676 | No |
| 86 | PIK3R3 | phosphoinositide-3-kinase regulatory subunit 3 [Source:HGNC Symbol;Acc:HGNC:8981] | 32995 | -0.830 | -0.2581 | No |
| 87 | PTEN | phosphatase and tensin homolog [Source:HGNC Symbol;Acc:HGNC:9588] | 33052 | -0.845 | -0.2497 | No |
| 88 | SFN | stratifin [Source:HGNC Symbol;Acc:HGNC:10773] | 33221 | -0.892 | -0.2438 | No |
| 89 | CXCR4 | C-X-C motif chemokine receptor 4 [Source:HGNC Symbol;Acc:HGNC:2561] | 33466 | -0.958 | -0.2391 | No |
| 90 | PRKCB | protein kinase C beta [Source:HGNC Symbol;Acc:HGNC:9395] | 33485 | -0.962 | -0.2283 | No |
| 91 | ACACA | acetyl-CoA carboxylase alpha [Source:HGNC Symbol;Acc:HGNC:84] | 33550 | -0.983 | -0.2185 | No |
| 92 | MAP2K6 | mitogen-activated protein kinase kinase 6 [Source:HGNC Symbol;Acc:HGNC:6846] | 33584 | -0.993 | -0.2078 | No |
| 93 | IRAK4 | interleukin 1 receptor associated kinase 4 [Source:HGNC Symbol;Acc:HGNC:17967] | 34008 | -1.131 | -0.2060 | No |
| 94 | DUSP3 | dual specificity phosphatase 3 [Source:HGNC Symbol;Acc:HGNC:3069] | 34033 | -1.141 | -0.1932 | No |
| 95 | CDK4 | cyclin dependent kinase 4 [Source:HGNC Symbol;Acc:HGNC:1773] | 34498 | -1.311 | -0.1904 | No |
| 96 | ITPR2 | inositol 1,4,5-trisphosphate receptor type 2 [Source:HGNC Symbol;Acc:HGNC:6181] | 34723 | -1.404 | -0.1800 | No |
| 97 | DAPP1 | dual adaptor of phosphotyrosine and 3-phosphoinositides 1 [Source:HGNC Symbol;Acc:HGNC:16500] | 35242 | -1.642 | -0.1747 | No |
| 98 | MKNK2 | MAPK interacting serine/threonine kinase 2 [Source:HGNC Symbol;Acc:HGNC:7111] | 35260 | -1.650 | -0.1558 | No |
| 99 | CDK2 | cyclin dependent kinase 2 [Source:HGNC Symbol;Acc:HGNC:1771] | 35470 | -1.760 | -0.1409 | No |
| 100 | ECSIT | ECSIT signaling integrator [Source:HGNC Symbol;Acc:HGNC:29548] | 35577 | -1.825 | -0.1223 | No |
| 101 | VAV3 | vav guanine nucleotide exchange factor 3 [Source:HGNC Symbol;Acc:HGNC:12659] | 35957 | -2.094 | -0.1080 | No |
| 102 | CDKN1B | cyclin dependent kinase inhibitor 1B [Source:HGNC Symbol;Acc:HGNC:1785] | 35972 | -2.105 | -0.0837 | No |
| 103 | PLCG1 | phospholipase C gamma 1 [Source:HGNC Symbol;Acc:HGNC:9065] | 36448 | -2.568 | -0.0664 | No |
| 104 | E2F1 | E2F transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:3113] | 36801 | -3.209 | -0.0383 | No |
| 105 | PDK1 | pyruvate dehydrogenase kinase 1 [Source:HGNC Symbol;Acc:HGNC:8809] | 37010 | -3.931 | 0.0022 | No |
