Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.greenbergcls.cls #KO_GAQ_versus_KO_NA.greenbergcls.cls #KO_GAQ_versus_KO_NA_repos |
| Phenotype | greenbergcls.cls#KO_GAQ_versus_KO_NA_repos |
| Upregulated in class | KO_GAQ |
| GeneSet | HALLMARK_UNFOLDED_PROTEIN_RESPONSE |
| Enrichment Score (ES) | 0.51672673 |
| Normalized Enrichment Score (NES) | 1.330243 |
| Nominal p-value | 0.023622047 |
| FDR q-value | 0.07084364 |
| FWER p-Value | 0.15 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | HERPUD1 | homocysteine inducible ER protein with ubiquitin like domain 1 [Source:HGNC Symbol;Acc:HGNC:13744] | 445 | 2.152 | 0.0117 | Yes |
| 2 | SDAD1 | SDA1 domain containing 1 [Source:HGNC Symbol;Acc:HGNC:25537] | 451 | 2.143 | 0.0352 | Yes |
| 3 | DNAJB9 | DnaJ heat shock protein family (Hsp40) member B9 [Source:HGNC Symbol;Acc:HGNC:6968] | 462 | 2.114 | 0.0582 | Yes |
| 4 | RRP9 | ribosomal RNA processing 9, U3 small nucleolar RNA binding protein [Source:HGNC Symbol;Acc:HGNC:16829] | 466 | 2.111 | 0.0814 | Yes |
| 5 | HSPA5 | heat shock protein family A (Hsp70) member 5 [Source:HGNC Symbol;Acc:HGNC:5238] | 529 | 2.006 | 0.1018 | Yes |
| 6 | SRPRA | SRP receptor subunit alpha [Source:HGNC Symbol;Acc:HGNC:11307] | 554 | 1.960 | 0.1228 | Yes |
| 7 | ATF3 | activating transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:785] | 582 | 1.916 | 0.1432 | Yes |
| 8 | CHAC1 | ChaC glutathione specific gamma-glutamylcyclotransferase 1 [Source:HGNC Symbol;Acc:HGNC:28680] | 682 | 1.742 | 0.1597 | Yes |
| 9 | NABP1 | nucleic acid binding protein 1 [Source:HGNC Symbol;Acc:HGNC:26232] | 728 | 1.682 | 0.1770 | Yes |
| 10 | FUS | FUS RNA binding protein [Source:HGNC Symbol;Acc:HGNC:4010] | 754 | 1.645 | 0.1945 | Yes |
| 11 | TATDN2 | TatD DNase domain containing 2 [Source:HGNC Symbol;Acc:HGNC:28988] | 814 | 1.580 | 0.2103 | Yes |
| 12 | ASNS | asparagine synthetase (glutamine-hydrolyzing) [Source:HGNC Symbol;Acc:HGNC:753] | 848 | 1.549 | 0.2265 | Yes |
| 13 | CEBPB | CCAAT enhancer binding protein beta [Source:HGNC Symbol;Acc:HGNC:1834] | 973 | 1.438 | 0.2390 | Yes |
| 14 | IFIT1 | interferon induced protein with tetratricopeptide repeats 1 [Source:HGNC Symbol;Acc:HGNC:5407] | 977 | 1.436 | 0.2547 | Yes |
| 15 | LSM1 | LSM1 homolog, mRNA degradation associated [Source:HGNC Symbol;Acc:HGNC:20472] | 1063 | 1.364 | 0.2675 | Yes |
| 16 | DKC1 | dyskerin pseudouridine synthase 1 [Source:HGNC Symbol;Acc:HGNC:2890] | 1160 | 1.291 | 0.2791 | Yes |
| 17 | ATF4 | activating transcription factor 4 [Source:HGNC Symbol;Acc:HGNC:786] | 1257 | 1.220 | 0.2899 | Yes |
| 18 | YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta [Source:HGNC Symbol;Acc:HGNC:12855] | 1273 | 1.215 | 0.3029 | Yes |
| 19 | DCP2 | decapping mRNA 2 [Source:HGNC Symbol;Acc:HGNC:24452] | 1336 | 1.182 | 0.3143 | Yes |
| 20 | NOP14 | NOP14 nucleolar protein [Source:HGNC Symbol;Acc:HGNC:16821] | 1391 | 1.160 | 0.3256 | Yes |
| 21 | EIF2S1 | eukaryotic translation initiation factor 2 subunit alpha [Source:HGNC Symbol;Acc:HGNC:3265] | 1461 | 1.129 | 0.3362 | Yes |
| 22 | DCP1A | decapping mRNA 1A [Source:HGNC Symbol;Acc:HGNC:18714] | 1484 | 1.118 | 0.3479 | Yes |
| 23 | SLC1A4 | solute carrier family 1 member 4 [Source:HGNC Symbol;Acc:HGNC:10942] | 1753 | 0.983 | 0.3515 | Yes |
| 24 | SLC7A5 | solute carrier family 7 member 5 [Source:HGNC Symbol;Acc:HGNC:11063] | 1767 | 0.978 | 0.3619 | Yes |
| 25 | KIF5B | kinesin family member 5B [Source:HGNC Symbol;Acc:HGNC:6324] | 1902 | 0.927 | 0.3685 | Yes |
| 26 | SERP1 | stress associated endoplasmic reticulum protein 1 [Source:HGNC Symbol;Acc:HGNC:10759] | 1937 | 0.916 | 0.3777 | Yes |
| 27 | BAG3 | BAG cochaperone 3 [Source:HGNC Symbol;Acc:HGNC:939] | 1944 | 0.914 | 0.3876 | Yes |
| 28 | CNOT4 | CCR4-NOT transcription complex subunit 4 [Source:HGNC Symbol;Acc:HGNC:7880] | 1946 | 0.913 | 0.3976 | Yes |
| 29 | CALR | calreticulin [Source:HGNC Symbol;Acc:HGNC:1455] | 1952 | 0.910 | 0.4075 | Yes |
| 30 | NOP56 | NOP56 ribonucleoprotein [Source:HGNC Symbol;Acc:HGNC:15911] | 1979 | 0.900 | 0.4168 | Yes |
| 31 | EXOSC4 | exosome component 4 [Source:HGNC Symbol;Acc:HGNC:18189] | 2050 | 0.872 | 0.4245 | Yes |
| 32 | SRPRB | SRP receptor subunit beta [Source:HGNC Symbol;Acc:HGNC:24085] | 2093 | 0.857 | 0.4328 | Yes |
| 33 | HYOU1 | hypoxia up-regulated 1 [Source:HGNC Symbol;Acc:HGNC:16931] | 2177 | 0.826 | 0.4396 | Yes |
| 34 | EXOSC1 | exosome component 1 [Source:HGNC Symbol;Acc:HGNC:17286] | 2208 | 0.818 | 0.4479 | Yes |
| 35 | TARS1 | threonyl-tRNA synthetase 1 [Source:HGNC Symbol;Acc:HGNC:11572] | 2275 | 0.792 | 0.4548 | Yes |
| 36 | NOLC1 | nucleolar and coiled-body phosphoprotein 1 [Source:HGNC Symbol;Acc:HGNC:15608] | 2292 | 0.786 | 0.4630 | Yes |
| 37 | LSM4 | LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated [Source:HGNC Symbol;Acc:HGNC:17259] | 2745 | 0.654 | 0.4580 | Yes |
| 38 | TTC37 | tetratricopeptide repeat domain 37 [Source:HGNC Symbol;Acc:HGNC:23639] | 2752 | 0.653 | 0.4651 | Yes |
| 39 | TSPYL2 | TSPY like 2 [Source:HGNC Symbol;Acc:HGNC:24358] | 2760 | 0.651 | 0.4720 | Yes |
| 40 | SEC11A | SEC11 homolog A, signal peptidase complex subunit [Source:HGNC Symbol;Acc:HGNC:17718] | 3008 | 0.587 | 0.4718 | Yes |
| 41 | EIF4EBP1 | eukaryotic translation initiation factor 4E binding protein 1 [Source:HGNC Symbol;Acc:HGNC:3288] | 3253 | 0.540 | 0.4712 | Yes |
| 42 | BANF1 | BAF nuclear assembly factor 1 [Source:HGNC Symbol;Acc:HGNC:17397] | 3373 | 0.513 | 0.4736 | Yes |
| 43 | PAIP1 | poly(A) binding protein interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:16945] | 3516 | 0.488 | 0.4751 | Yes |
| 44 | EIF4G1 | eukaryotic translation initiation factor 4 gamma 1 [Source:HGNC Symbol;Acc:HGNC:3296] | 3591 | 0.474 | 0.4784 | Yes |
| 45 | EIF4E | eukaryotic translation initiation factor 4E [Source:HGNC Symbol;Acc:HGNC:3287] | 3865 | 0.426 | 0.4757 | Yes |
| 46 | EIF4A1 | eukaryotic translation initiation factor 4A1 [Source:HGNC Symbol;Acc:HGNC:3282] | 3956 | 0.405 | 0.4777 | Yes |
| 47 | MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase [Source:HGNC Symbol;Acc:HGNC:7434] | 3961 | 0.404 | 0.4821 | Yes |
| 48 | DDIT4 | DNA damage inducible transcript 4 [Source:HGNC Symbol;Acc:HGNC:24944] | 3986 | 0.399 | 0.4858 | Yes |
| 49 | WFS1 | wolframin ER transmembrane glycoprotein [Source:HGNC Symbol;Acc:HGNC:12762] | 4182 | 0.364 | 0.4845 | Yes |
| 50 | YIF1A | Yip1 interacting factor homolog A, membrane trafficking protein [Source:HGNC Symbol;Acc:HGNC:16688] | 4188 | 0.363 | 0.4884 | Yes |
| 51 | SPCS1 | signal peptidase complex subunit 1 [Source:HGNC Symbol;Acc:HGNC:23401] | 4252 | 0.352 | 0.4906 | Yes |
| 52 | SSR1 | signal sequence receptor subunit 1 [Source:HGNC Symbol;Acc:HGNC:11323] | 4267 | 0.350 | 0.4941 | Yes |
| 53 | CNOT6 | CCR4-NOT transcription complex subunit 6 [Source:HGNC Symbol;Acc:HGNC:14099] | 4425 | 0.324 | 0.4934 | Yes |
| 54 | EXOSC2 | exosome component 2 [Source:HGNC Symbol;Acc:HGNC:17097] | 4426 | 0.324 | 0.4970 | Yes |
| 55 | ARFGAP1 | ADP ribosylation factor GTPase activating protein 1 [Source:HGNC Symbol;Acc:HGNC:15852] | 4475 | 0.317 | 0.4992 | Yes |
| 56 | NPM1 | nucleophosmin 1 [Source:HGNC Symbol;Acc:HGNC:7910] | 4477 | 0.317 | 0.5026 | Yes |
| 57 | EDC4 | enhancer of mRNA decapping 4 [Source:HGNC Symbol;Acc:HGNC:17157] | 4582 | 0.300 | 0.5031 | Yes |
| 58 | DNAJC3 | DnaJ heat shock protein family (Hsp40) member C3 [Source:HGNC Symbol;Acc:HGNC:9439] | 4604 | 0.296 | 0.5058 | Yes |
| 59 | CCL2 | C-C motif chemokine ligand 2 [Source:HGNC Symbol;Acc:HGNC:10618] | 4624 | 0.294 | 0.5085 | Yes |
| 60 | CXXC1 | CXXC finger protein 1 [Source:HGNC Symbol;Acc:HGNC:24343] | 4652 | 0.289 | 0.5110 | Yes |
| 61 | IARS1 | isoleucyl-tRNA synthetase 1 [Source:HGNC Symbol;Acc:HGNC:5330] | 4681 | 0.282 | 0.5133 | Yes |
| 62 | PREB | prolactin regulatory element binding [Source:HGNC Symbol;Acc:HGNC:9356] | 4719 | 0.277 | 0.5154 | Yes |
| 63 | XPOT | exportin for tRNA [Source:HGNC Symbol;Acc:HGNC:12826] | 4780 | 0.267 | 0.5167 | Yes |
| 64 | GEMIN4 | gem nuclear organelle associated protein 4 [Source:HGNC Symbol;Acc:HGNC:15717] | 4918 | 0.245 | 0.5157 | No |
| 65 | EXOSC10 | exosome component 10 [Source:HGNC Symbol;Acc:HGNC:9138] | 5019 | 0.229 | 0.5155 | No |
| 66 | DNAJA4 | DnaJ heat shock protein family (Hsp40) member A4 [Source:HGNC Symbol;Acc:HGNC:14885] | 5115 | 0.216 | 0.5154 | No |
| 67 | HSPA9 | heat shock protein family A (Hsp70) member 9 [Source:HGNC Symbol;Acc:HGNC:5244] | 5256 | 0.195 | 0.5137 | No |
| 68 | CNOT2 | CCR4-NOT transcription complex subunit 2 [Source:HGNC Symbol;Acc:HGNC:7878] | 5318 | 0.186 | 0.5141 | No |
| 69 | NFYA | nuclear transcription factor Y subunit alpha [Source:HGNC Symbol;Acc:HGNC:7804] | 5422 | 0.171 | 0.5132 | No |
| 70 | EIF4A2 | eukaryotic translation initiation factor 4A2 [Source:HGNC Symbol;Acc:HGNC:3284] | 5455 | 0.165 | 0.5142 | No |
| 71 | DDX10 | DEAD-box helicase 10 [Source:HGNC Symbol;Acc:HGNC:2735] | 5495 | 0.160 | 0.5149 | No |
| 72 | SPCS3 | signal peptidase complex subunit 3 [Source:HGNC Symbol;Acc:HGNC:26212] | 5549 | 0.153 | 0.5151 | No |
| 73 | EIF4A3 | eukaryotic translation initiation factor 4A3 [Source:HGNC Symbol;Acc:HGNC:18683] | 5776 | 0.121 | 0.5104 | No |
| 74 | PDIA5 | protein disulfide isomerase family A member 5 [Source:HGNC Symbol;Acc:HGNC:24811] | 6629 | 0.008 | 0.4874 | No |
| 75 | IGFBP1 | insulin like growth factor binding protein 1 [Source:HGNC Symbol;Acc:HGNC:5469] | 11990 | 0.000 | 0.3425 | No |
| 76 | SEC31A | SEC31 homolog A, COPII coat complex component [Source:HGNC Symbol;Acc:HGNC:17052] | 27874 | -0.047 | -0.0866 | No |
| 77 | GOSR2 | golgi SNAP receptor complex member 2 [Source:HGNC Symbol;Acc:HGNC:4431] | 27925 | -0.054 | -0.0873 | No |
| 78 | MTREX | Mtr4 exosome RNA helicase [Source:HGNC Symbol;Acc:HGNC:18734] | 28018 | -0.064 | -0.0891 | No |
| 79 | SHC1 | SHC adaptor protein 1 [Source:HGNC Symbol;Acc:HGNC:10840] | 28156 | -0.079 | -0.0919 | No |
| 80 | XBP1 | X-box binding protein 1 [Source:HGNC Symbol;Acc:HGNC:12801] | 28236 | -0.088 | -0.0931 | No |
| 81 | ZBTB17 | zinc finger and BTB domain containing 17 [Source:HGNC Symbol;Acc:HGNC:12936] | 28318 | -0.098 | -0.0942 | No |
| 82 | NHP2 | NHP2 ribonucleoprotein [Source:HGNC Symbol;Acc:HGNC:14377] | 28517 | -0.122 | -0.0982 | No |
| 83 | PDIA6 | protein disulfide isomerase family A member 6 [Source:HGNC Symbol;Acc:HGNC:30168] | 28801 | -0.155 | -0.1042 | No |
| 84 | HSP90B1 | heat shock protein 90 beta family member 1 [Source:HGNC Symbol;Acc:HGNC:12028] | 29325 | -0.220 | -0.1159 | No |
| 85 | EXOC2 | exocyst complex component 2 [Source:HGNC Symbol;Acc:HGNC:24968] | 29529 | -0.244 | -0.1187 | No |
| 86 | POP4 | POP4 homolog, ribonuclease P/MRP subunit [Source:HGNC Symbol;Acc:HGNC:30081] | 29840 | -0.286 | -0.1239 | No |
| 87 | VEGFA | vascular endothelial growth factor A [Source:HGNC Symbol;Acc:HGNC:12680] | 30198 | -0.330 | -0.1299 | No |
| 88 | RPS14 | ribosomal protein S14 [Source:HGNC Symbol;Acc:HGNC:10387] | 30800 | -0.410 | -0.1417 | No |
| 89 | ATF6 | activating transcription factor 6 [Source:HGNC Symbol;Acc:HGNC:791] | 31221 | -0.473 | -0.1478 | No |
| 90 | NFYB | nuclear transcription factor Y subunit beta [Source:HGNC Symbol;Acc:HGNC:7805] | 31276 | -0.481 | -0.1440 | No |
| 91 | EXOSC9 | exosome component 9 [Source:HGNC Symbol;Acc:HGNC:9137] | 31331 | -0.491 | -0.1400 | No |
| 92 | DCTN1 | dynactin subunit 1 [Source:HGNC Symbol;Acc:HGNC:2711] | 31344 | -0.493 | -0.1349 | No |
| 93 | CEBPG | CCAAT enhancer binding protein gamma [Source:HGNC Symbol;Acc:HGNC:1837] | 31621 | -0.543 | -0.1364 | No |
| 94 | ALDH18A1 | aldehyde dehydrogenase 18 family member A1 [Source:HGNC Symbol;Acc:HGNC:9722] | 31630 | -0.546 | -0.1306 | No |
| 95 | ATP6V0D1 | ATPase H+ transporting V0 subunit d1 [Source:HGNC Symbol;Acc:HGNC:13724] | 31694 | -0.559 | -0.1261 | No |
| 96 | STC2 | stanniocalcin 2 [Source:HGNC Symbol;Acc:HGNC:11374] | 31950 | -0.599 | -0.1264 | No |
| 97 | EEF2 | eukaryotic translation elongation factor 2 [Source:HGNC Symbol;Acc:HGNC:3214] | 32102 | -0.632 | -0.1235 | No |
| 98 | PSAT1 | phosphoserine aminotransferase 1 [Source:HGNC Symbol;Acc:HGNC:19129] | 32167 | -0.646 | -0.1182 | No |
| 99 | KDELR3 | KDEL endoplasmic reticulum protein retention receptor 3 [Source:HGNC Symbol;Acc:HGNC:6306] | 32487 | -0.712 | -0.1189 | No |
| 100 | CKS1B | CDC28 protein kinase regulatory subunit 1B [Source:HGNC Symbol;Acc:HGNC:19083] | 32738 | -0.765 | -0.1173 | No |
| 101 | IMP3 | IMP U3 small nucleolar ribonucleoprotein 3 [Source:HGNC Symbol;Acc:HGNC:14497] | 32856 | -0.798 | -0.1116 | No |
| 102 | EIF2AK3 | eukaryotic translation initiation factor 2 alpha kinase 3 [Source:HGNC Symbol;Acc:HGNC:3255] | 32905 | -0.810 | -0.1040 | No |
| 103 | KHSRP | KH-type splicing regulatory protein [Source:HGNC Symbol;Acc:HGNC:6316] | 32923 | -0.814 | -0.0955 | No |
| 104 | SLC30A5 | solute carrier family 30 member 5 [Source:HGNC Symbol;Acc:HGNC:19089] | 33457 | -0.955 | -0.0994 | No |
| 105 | PARN | poly(A)-specific ribonuclease [Source:HGNC Symbol;Acc:HGNC:8609] | 33559 | -0.985 | -0.0912 | No |
| 106 | TUBB2A | tubulin beta 2A class IIa [Source:HGNC Symbol;Acc:HGNC:12412] | 33749 | -1.047 | -0.0848 | No |
| 107 | ERN1 | endoplasmic reticulum to nucleus signaling 1 [Source:HGNC Symbol;Acc:HGNC:3449] | 35176 | -1.602 | -0.1057 | No |
| 108 | FKBP14 | FKBP prolyl isomerase 14 [Source:HGNC Symbol;Acc:HGNC:18625] | 35218 | -1.624 | -0.0889 | No |
| 109 | EXOSC5 | exosome component 5 [Source:HGNC Symbol;Acc:HGNC:24662] | 35339 | -1.693 | -0.0735 | No |
| 110 | EDEM1 | ER degradation enhancing alpha-mannosidase like protein 1 [Source:HGNC Symbol;Acc:HGNC:18967] | 35917 | -2.063 | -0.0664 | No |
| 111 | ERO1A | endoplasmic reticulum oxidoreductase 1 alpha [Source:HGNC Symbol;Acc:HGNC:13280] | 36113 | -2.235 | -0.0470 | No |
| 112 | H2AX | H2A.X variant histone [Source:HGNC Symbol;Acc:HGNC:4739] | 36530 | -2.698 | -0.0285 | No |
| 113 | WIPI1 | WD repeat domain, phosphoinositide interacting 1 [Source:HGNC Symbol;Acc:HGNC:25471] | 37018 | -3.961 | 0.0019 | No |
