Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.greenbergcls.cls #KO_LPS_versus_KO_NA.greenbergcls.cls #KO_LPS_versus_KO_NA_repos |
| Phenotype | greenbergcls.cls#KO_LPS_versus_KO_NA_repos |
| Upregulated in class | KO_LPS |
| GeneSet | REACTOME_INTERFERON_ALPHA_BETA_SIGNALING |
| Enrichment Score (ES) | 0.8946349 |
| Normalized Enrichment Score (NES) | 2.1991231 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0 |
| FWER p-Value | 0.0 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | RSAD2 | radical S-adenosyl methionine domain containing 2 [Source:HGNC Symbol;Acc:HGNC:30908] | 14 | 4.897 | 0.0432 | Yes |
| 2 | IFIT2 | interferon induced protein with tetratricopeptide repeats 2 [Source:HGNC Symbol;Acc:HGNC:5409] | 15 | 4.880 | 0.0866 | Yes |
| 3 | ISG20 | interferon stimulated exonuclease gene 20 [Source:HGNC Symbol;Acc:HGNC:6130] | 17 | 4.860 | 0.1297 | Yes |
| 4 | IFIT1 | interferon induced protein with tetratricopeptide repeats 1 [Source:HGNC Symbol;Acc:HGNC:5407] | 18 | 4.859 | 0.1729 | Yes |
| 5 | MX1 | MX dynamin like GTPase 1 [Source:HGNC Symbol;Acc:HGNC:7532] | 28 | 4.772 | 0.2151 | Yes |
| 6 | MX2 | MX dynamin like GTPase 2 [Source:HGNC Symbol;Acc:HGNC:7533] | 31 | 4.760 | 0.2574 | Yes |
| 7 | OASL | 2'-5'-oligoadenylate synthetase like [Source:HGNC Symbol;Acc:HGNC:8090] | 37 | 4.693 | 0.2990 | Yes |
| 8 | USP18 | ubiquitin specific peptidase 18 [Source:HGNC Symbol;Acc:HGNC:12616] | 40 | 4.680 | 0.3405 | Yes |
| 9 | IRF7 | interferon regulatory factor 7 [Source:HGNC Symbol;Acc:HGNC:6122] | 49 | 4.561 | 0.3809 | Yes |
| 10 | SOCS3 | suppressor of cytokine signaling 3 [Source:HGNC Symbol;Acc:HGNC:19391] | 52 | 4.513 | 0.4210 | Yes |
| 11 | GBP2 | guanylate binding protein 2 [Source:HGNC Symbol;Acc:HGNC:4183] | 86 | 4.166 | 0.4571 | Yes |
| 12 | STAT2 | signal transducer and activator of transcription 2 [Source:HGNC Symbol;Acc:HGNC:11363] | 99 | 4.056 | 0.4929 | Yes |
| 13 | IFI35 | interferon induced protein 35 [Source:HGNC Symbol;Acc:HGNC:5399] | 104 | 4.029 | 0.5286 | Yes |
| 14 | STAT1 | signal transducer and activator of transcription 1 [Source:HGNC Symbol;Acc:HGNC:11362] | 134 | 3.807 | 0.5616 | Yes |
| 15 | OAS1 | 2'-5'-oligoadenylate synthetase 1 [Source:HGNC Symbol;Acc:HGNC:8086] | 142 | 3.728 | 0.5946 | Yes |
| 16 | OAS3 | 2'-5'-oligoadenylate synthetase 3 [Source:HGNC Symbol;Acc:HGNC:8088] | 176 | 3.554 | 0.6253 | Yes |
| 17 | OAS2 | 2'-5'-oligoadenylate synthetase 2 [Source:HGNC Symbol;Acc:HGNC:8087] | 215 | 3.271 | 0.6534 | Yes |
| 18 | ADAR | adenosine deaminase RNA specific [Source:HGNC Symbol;Acc:HGNC:225] | 343 | 2.737 | 0.6743 | Yes |
| 19 | IRF9 | interferon regulatory factor 9 [Source:HGNC Symbol;Acc:HGNC:6131] | 441 | 2.432 | 0.6933 | Yes |
| 20 | SAMHD1 | SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 [Source:HGNC Symbol;Acc:HGNC:15925] | 455 | 2.401 | 0.7143 | Yes |
| 21 | IRF1 | interferon regulatory factor 1 [Source:HGNC Symbol;Acc:HGNC:6116] | 482 | 2.341 | 0.7344 | Yes |
| 22 | IFITM3 | interferon induced transmembrane protein 3 [Source:HGNC Symbol;Acc:HGNC:5414] | 584 | 2.105 | 0.7504 | Yes |
| 23 | PSMB8 | proteasome 20S subunit beta 8 [Source:HGNC Symbol;Acc:HGNC:9545] | 641 | 2.004 | 0.7667 | Yes |
| 24 | IFITM2 | interferon induced transmembrane protein 2 [Source:HGNC Symbol;Acc:HGNC:5413] | 662 | 1.976 | 0.7837 | Yes |
| 25 | IP6K2 | inositol hexakisphosphate kinase 2 [Source:HGNC Symbol;Acc:HGNC:17313] | 678 | 1.953 | 0.8006 | Yes |
| 26 | HLA-E | major histocompatibility complex, class I, E [Source:HGNC Symbol;Acc:HGNC:4962] | 717 | 1.865 | 0.8162 | Yes |
| 27 | SOCS1 | suppressor of cytokine signaling 1 [Source:HGNC Symbol;Acc:HGNC:19383] | 925 | 1.627 | 0.8251 | Yes |
| 28 | HLA-B | major histocompatibility complex, class I, B [Source:HGNC Symbol;Acc:HGNC:4932] | 1074 | 1.457 | 0.8340 | Yes |
| 29 | IRF5 | interferon regulatory factor 5 [Source:HGNC Symbol;Acc:HGNC:6120] | 1220 | 1.329 | 0.8419 | Yes |
| 30 | HLA-A | major histocompatibility complex, class I, A [Source:HGNC Symbol;Acc:HGNC:4931] | 1294 | 1.274 | 0.8513 | Yes |
| 31 | IFIT3 | interferon induced protein with tetratricopeptide repeats 3 [Source:HGNC Symbol;Acc:HGNC:5411] | 1533 | 1.127 | 0.8549 | Yes |
| 32 | HLA-C | major histocompatibility complex, class I, C [Source:HGNC Symbol;Acc:HGNC:4933] | 1587 | 1.094 | 0.8632 | Yes |
| 33 | HLA-F | major histocompatibility complex, class I, F [Source:HGNC Symbol;Acc:HGNC:4963] | 1610 | 1.082 | 0.8722 | Yes |
| 34 | IRF8 | interferon regulatory factor 8 [Source:HGNC Symbol;Acc:HGNC:5358] | 1644 | 1.063 | 0.8807 | Yes |
| 35 | HLA-G | major histocompatibility complex, class I, G [Source:HGNC Symbol;Acc:HGNC:4964] | 1756 | 0.999 | 0.8866 | Yes |
| 36 | PTPN11 | protein tyrosine phosphatase non-receptor type 11 [Source:HGNC Symbol;Acc:HGNC:9644] | 1785 | 0.985 | 0.8946 | Yes |
| 37 | IRF4 | interferon regulatory factor 4 [Source:HGNC Symbol;Acc:HGNC:6119] | 2082 | 0.867 | 0.8943 | No |
| 38 | ISG15 | ISG15 ubiquitin like modifier [Source:HGNC Symbol;Acc:HGNC:4053] | 2551 | 0.693 | 0.8879 | No |
| 39 | TYK2 | tyrosine kinase 2 [Source:HGNC Symbol;Acc:HGNC:12440] | 3023 | 0.559 | 0.8801 | No |
| 40 | PTPN1 | protein tyrosine phosphatase non-receptor type 1 [Source:HGNC Symbol;Acc:HGNC:9642] | 3861 | 0.384 | 0.8609 | No |
| 41 | IFITM1 | interferon induced transmembrane protein 1 [Source:HGNC Symbol;Acc:HGNC:5412] | 4979 | 0.186 | 0.8324 | No |
| 42 | JAK1 | Janus kinase 1 [Source:HGNC Symbol;Acc:HGNC:6190] | 5316 | 0.133 | 0.8245 | No |
| 43 | ABCE1 | ATP binding cassette subfamily E member 1 [Source:HGNC Symbol;Acc:HGNC:69] | 5452 | 0.114 | 0.8219 | No |
| 44 | HLA-H | major histocompatibility complex, class I, H (pseudogene) [Source:HGNC Symbol;Acc:HGNC:4965] | 5511 | 0.108 | 0.8213 | No |
| 45 | KPNA1 | karyopherin subunit alpha 1 [Source:HGNC Symbol;Acc:HGNC:6394] | 5975 | 0.036 | 0.8091 | No |
| 46 | BST2 | bone marrow stromal cell antigen 2 [Source:HGNC Symbol;Acc:HGNC:1119] | 12415 | 0.000 | 0.6351 | No |
| 47 | IFNA13 | interferon alpha 13 [Source:HGNC Symbol;Acc:HGNC:5419] | 18098 | 0.000 | 0.4816 | No |
| 48 | IFNA14 | interferon alpha 14 [Source:HGNC Symbol;Acc:HGNC:5420] | 18099 | 0.000 | 0.4816 | No |
| 49 | IFNA16 | interferon alpha 16 [Source:HGNC Symbol;Acc:HGNC:5421] | 18101 | 0.000 | 0.4816 | No |
| 50 | IFNA17 | interferon alpha 17 [Source:HGNC Symbol;Acc:HGNC:5422] | 18103 | 0.000 | 0.4816 | No |
| 51 | IFNA10 | interferon alpha 10 [Source:HGNC Symbol;Acc:HGNC:5418] | 18110 | 0.000 | 0.4814 | No |
| 52 | IFNA21 | interferon alpha 21 [Source:HGNC Symbol;Acc:HGNC:5424] | 18117 | 0.000 | 0.4813 | No |
| 53 | IFNAR2 | interferon alpha and beta receptor subunit 2 [Source:HGNC Symbol;Acc:HGNC:5433] | 18372 | 0.000 | 0.4744 | No |
| 54 | IFNAR1 | interferon alpha and beta receptor subunit 1 [Source:HGNC Symbol;Acc:HGNC:5432] | 18380 | 0.000 | 0.4742 | No |
| 55 | IFI6 | interferon alpha inducible protein 6 [Source:HGNC Symbol;Acc:HGNC:4054] | 20586 | 0.000 | 0.4146 | No |
| 56 | IFIT5 | interferon induced protein with tetratricopeptide repeats 5 [Source:HGNC Symbol;Acc:HGNC:13328] | 22980 | 0.000 | 0.3500 | No |
| 57 | IFNA5 | interferon alpha 5 [Source:HGNC Symbol;Acc:HGNC:5426] | 24410 | 0.000 | 0.3114 | No |
| 58 | IFNA4 | interferon alpha 4 [Source:HGNC Symbol;Acc:HGNC:5425] | 24411 | 0.000 | 0.3114 | No |
| 59 | IFNA7 | interferon alpha 7 [Source:HGNC Symbol;Acc:HGNC:5428] | 24413 | 0.000 | 0.3114 | No |
| 60 | IFNA6 | interferon alpha 6 [Source:HGNC Symbol;Acc:HGNC:5427] | 24414 | 0.000 | 0.3114 | No |
| 61 | IFNA1 | interferon alpha 1 [Source:HGNC Symbol;Acc:HGNC:5417] | 24415 | 0.000 | 0.3114 | No |
| 62 | IFNA2 | interferon alpha 2 [Source:HGNC Symbol;Acc:HGNC:5423] | 24416 | 0.000 | 0.3114 | No |
| 63 | IFNA8 | interferon alpha 8 [Source:HGNC Symbol;Acc:HGNC:5429] | 24419 | 0.000 | 0.3113 | No |
| 64 | IFNB1 | interferon beta 1 [Source:HGNC Symbol;Acc:HGNC:5434] | 24448 | 0.000 | 0.3106 | No |
| 65 | XAF1 | XIAP associated factor 1 [Source:HGNC Symbol;Acc:HGNC:30932] | 26912 | 0.000 | 0.2440 | No |
| 66 | IRF6 | interferon regulatory factor 6 [Source:HGNC Symbol;Acc:HGNC:6121] | 27417 | -0.048 | 0.2308 | No |
| 67 | IRF3 | interferon regulatory factor 3 [Source:HGNC Symbol;Acc:HGNC:6118] | 27899 | -0.107 | 0.2188 | No |
| 68 | EGR1 | early growth response 1 [Source:HGNC Symbol;Acc:HGNC:3238] | 28521 | -0.185 | 0.2037 | No |
| 69 | IRF2 | interferon regulatory factor 2 [Source:HGNC Symbol;Acc:HGNC:6117] | 28543 | -0.188 | 0.2048 | No |
| 70 | KPNB1 | karyopherin subunit beta 1 [Source:HGNC Symbol;Acc:HGNC:6400] | 30691 | -0.481 | 0.1510 | No |
| 71 | IFI27 | interferon alpha inducible protein 27 [Source:HGNC Symbol;Acc:HGNC:5397] | 30715 | -0.484 | 0.1547 | No |
| 72 | RNASEL | ribonuclease L [Source:HGNC Symbol;Acc:HGNC:10050] | 30930 | -0.519 | 0.1536 | No |
| 73 | PTPN6 | protein tyrosine phosphatase non-receptor type 6 [Source:HGNC Symbol;Acc:HGNC:9658] | 34316 | -1.441 | 0.0749 | No |
