Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.greenbergcls.cls #KO_LPS_versus_KO_NA.greenbergcls.cls #KO_LPS_versus_KO_NA_repos |
| Phenotype | greenbergcls.cls#KO_LPS_versus_KO_NA_repos |
| Upregulated in class | KO_LPS |
| GeneSet | REACTOME_INTERLEUKIN_10_SIGNALING |
| Enrichment Score (ES) | 0.90761065 |
| Normalized Enrichment Score (NES) | 2.024217 |
| Nominal p-value | 0.0 |
| FDR q-value | 9.289872E-5 |
| FWER p-Value | 0.001 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | IL10 | interleukin 10 [Source:HGNC Symbol;Acc:HGNC:5962] | 0 | 5.000 | 0.0653 | Yes |
| 2 | IL1B | interleukin 1 beta [Source:HGNC Symbol;Acc:HGNC:5992] | 1 | 4.995 | 0.1306 | Yes |
| 3 | LIF | LIF interleukin 6 family cytokine [Source:HGNC Symbol;Acc:HGNC:6596] | 2 | 4.994 | 0.1958 | Yes |
| 4 | CCL5 | C-C motif chemokine ligand 5 [Source:HGNC Symbol;Acc:HGNC:10632] | 4 | 4.991 | 0.2610 | Yes |
| 5 | PTGS2 | prostaglandin-endoperoxide synthase 2 [Source:HGNC Symbol;Acc:HGNC:9605] | 6 | 4.961 | 0.3258 | Yes |
| 6 | CSF3 | colony stimulating factor 3 [Source:HGNC Symbol;Acc:HGNC:2438] | 8 | 4.953 | 0.3905 | Yes |
| 7 | IL1A | interleukin 1 alpha [Source:HGNC Symbol;Acc:HGNC:5991] | 9 | 4.938 | 0.4550 | Yes |
| 8 | IL1RN | interleukin 1 receptor antagonist [Source:HGNC Symbol;Acc:HGNC:6000] | 10 | 4.929 | 0.5195 | Yes |
| 9 | CCL4 | C-C motif chemokine ligand 4 [Source:HGNC Symbol;Acc:HGNC:10630] | 36 | 4.695 | 0.5801 | Yes |
| 10 | TNFRSF1B | TNF receptor superfamily member 1B [Source:HGNC Symbol;Acc:HGNC:11917] | 41 | 4.677 | 0.6411 | Yes |
| 11 | TNF | tumor necrosis factor [Source:HGNC Symbol;Acc:HGNC:11892] | 50 | 4.531 | 0.7001 | Yes |
| 12 | PTAFR | platelet activating factor receptor [Source:HGNC Symbol;Acc:HGNC:9582] | 254 | 3.077 | 0.7348 | Yes |
| 13 | CXCL10 | C-X-C motif chemokine ligand 10 [Source:HGNC Symbol;Acc:HGNC:10637] | 410 | 2.520 | 0.7636 | Yes |
| 14 | STAT3 | signal transducer and activator of transcription 3 [Source:HGNC Symbol;Acc:HGNC:11364] | 480 | 2.350 | 0.7924 | Yes |
| 15 | CCR5 | C-C motif chemokine receptor 5 (gene/pseudogene) [Source:HGNC Symbol;Acc:HGNC:1606] | 612 | 2.056 | 0.8158 | Yes |
| 16 | CSF1 | colony stimulating factor 1 [Source:HGNC Symbol;Acc:HGNC:2432] | 698 | 1.916 | 0.8385 | Yes |
| 17 | TNFRSF1A | TNF receptor superfamily member 1A [Source:HGNC Symbol;Acc:HGNC:11916] | 720 | 1.864 | 0.8623 | Yes |
| 18 | TIMP1 | TIMP metallopeptidase inhibitor 1 [Source:HGNC Symbol;Acc:HGNC:11820] | 1145 | 1.391 | 0.8690 | Yes |
| 19 | CCL3 | C-C motif chemokine ligand 3 [Source:HGNC Symbol;Acc:HGNC:10627] | 1419 | 1.192 | 0.8772 | Yes |
| 20 | CD86 | CD86 molecule [Source:HGNC Symbol;Acc:HGNC:1705] | 1615 | 1.080 | 0.8861 | Yes |
| 21 | IL6 | interleukin 6 [Source:HGNC Symbol;Acc:HGNC:6018] | 1761 | 0.996 | 0.8952 | Yes |
| 22 | FPR1 | formyl peptide receptor 1 [Source:HGNC Symbol;Acc:HGNC:3826] | 1840 | 0.965 | 0.9057 | Yes |
| 23 | CXCL2 | C-X-C motif chemokine ligand 2 [Source:HGNC Symbol;Acc:HGNC:4603] | 2170 | 0.828 | 0.9076 | Yes |
| 24 | TYK2 | tyrosine kinase 2 [Source:HGNC Symbol;Acc:HGNC:12440] | 3023 | 0.559 | 0.8919 | No |
| 25 | CCR2 | C-C motif chemokine receptor 2 [Source:HGNC Symbol;Acc:HGNC:1603] | 3669 | 0.417 | 0.8800 | No |
| 26 | IL18 | interleukin 18 [Source:HGNC Symbol;Acc:HGNC:5986] | 4079 | 0.345 | 0.8734 | No |
| 27 | CCL2 | C-C motif chemokine ligand 2 [Source:HGNC Symbol;Acc:HGNC:10618] | 4325 | 0.292 | 0.8706 | No |
| 28 | IL12B | interleukin 12B [Source:HGNC Symbol;Acc:HGNC:5970] | 5016 | 0.181 | 0.8544 | No |
| 29 | JAK1 | Janus kinase 1 [Source:HGNC Symbol;Acc:HGNC:6190] | 5316 | 0.133 | 0.8480 | No |
| 30 | CCR1 | C-C motif chemokine receptor 1 [Source:HGNC Symbol;Acc:HGNC:1602] | 5505 | 0.109 | 0.8444 | No |
| 31 | CCL19 | C-C motif chemokine ligand 19 [Source:HGNC Symbol;Acc:HGNC:10617] | 6253 | 0.000 | 0.8242 | No |
| 32 | CCL22 | C-C motif chemokine ligand 22 [Source:HGNC Symbol;Acc:HGNC:10621] | 6264 | 0.000 | 0.8239 | No |
| 33 | CCL20 | C-C motif chemokine ligand 20 [Source:HGNC Symbol;Acc:HGNC:10619] | 6267 | 0.000 | 0.8239 | No |
| 34 | CCL3L1 | C-C motif chemokine ligand 3 like 1 [Source:HGNC Symbol;Acc:HGNC:10628] | 14646 | 0.000 | 0.5977 | No |
| 35 | CCL3L3 | C-C motif chemokine ligand 3 like 3 [Source:HGNC Symbol;Acc:HGNC:30554] | 14647 | 0.000 | 0.5977 | No |
| 36 | IL1R1 | interleukin 1 receptor type 1 [Source:HGNC Symbol;Acc:HGNC:5993] | 15849 | 0.000 | 0.5653 | No |
| 37 | IL1R2 | interleukin 1 receptor type 2 [Source:HGNC Symbol;Acc:HGNC:5994] | 15850 | 0.000 | 0.5653 | No |
| 38 | ICAM1 | intercellular adhesion molecule 1 [Source:HGNC Symbol;Acc:HGNC:5344] | 18173 | 0.000 | 0.5026 | No |
| 39 | CXCL8 | C-X-C motif chemokine ligand 8 [Source:HGNC Symbol;Acc:HGNC:6025] | 19334 | 0.000 | 0.4713 | No |
| 40 | CXCL1 | C-X-C motif chemokine ligand 1 [Source:HGNC Symbol;Acc:HGNC:4602] | 19343 | 0.000 | 0.4711 | No |
| 41 | CD80 | CD80 molecule [Source:HGNC Symbol;Acc:HGNC:1700] | 22905 | 0.000 | 0.3750 | No |
| 42 | CSF2 | colony stimulating factor 2 [Source:HGNC Symbol;Acc:HGNC:2434] | 24235 | 0.000 | 0.3391 | No |
| 43 | FCER2 | Fc fragment of IgE receptor II [Source:HGNC Symbol;Acc:HGNC:3612] | 25712 | 0.000 | 0.2993 | No |
| 44 | IL12A | interleukin 12A [Source:HGNC Symbol;Acc:HGNC:5969] | 26624 | 0.000 | 0.2747 | No |
| 45 | IL10RA | interleukin 10 receptor subunit alpha [Source:HGNC Symbol;Acc:HGNC:5964] | 29319 | -0.291 | 0.2057 | No |
| 46 | IL10RB | interleukin 10 receptor subunit beta [Source:HGNC Symbol;Acc:HGNC:5965] | 29447 | -0.306 | 0.2063 | No |
