Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.greenbergcls.cls #KO_LPS_versus_KO_NA.greenbergcls.cls #KO_LPS_versus_KO_NA_repos |
| Phenotype | greenbergcls.cls#KO_LPS_versus_KO_NA_repos |
| Upregulated in class | KO_LPS |
| GeneSet | IRF2_01 |
| Enrichment Score (ES) | 0.5334866 |
| Normalized Enrichment Score (NES) | 1.4001683 |
| Nominal p-value | 0.0 |
| FDR q-value | 1.0 |
| FWER p-Value | 1.0 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | LIF | LIF interleukin 6 family cytokine [Source:HGNC Symbol;Acc:HGNC:6596] | 2 | 4.994 | 0.0385 | Yes |
| 2 | USP18 | ubiquitin specific peptidase 18 [Source:HGNC Symbol;Acc:HGNC:12616] | 40 | 4.680 | 0.0737 | Yes |
| 3 | OSM | oncostatin M [Source:HGNC Symbol;Acc:HGNC:8506] | 69 | 4.312 | 0.1063 | Yes |
| 4 | IL27 | interleukin 27 [Source:HGNC Symbol;Acc:HGNC:19157] | 85 | 4.177 | 0.1381 | Yes |
| 5 | DDX58 | DExD/H-box helicase 58 [Source:HGNC Symbol;Acc:HGNC:19102] | 92 | 4.123 | 0.1698 | Yes |
| 6 | NT5C3A | 5'-nucleotidase, cytosolic IIIA [Source:HGNC Symbol;Acc:HGNC:17820] | 157 | 3.660 | 0.1964 | Yes |
| 7 | REL | REL proto-oncogene, NF-kB subunit [Source:HGNC Symbol;Acc:HGNC:9954] | 158 | 3.659 | 0.2246 | Yes |
| 8 | TAP1 | transporter 1, ATP binding cassette subfamily B member [Source:HGNC Symbol;Acc:HGNC:43] | 207 | 3.333 | 0.2491 | Yes |
| 9 | DTX3L | deltex E3 ubiquitin ligase 3L [Source:HGNC Symbol;Acc:HGNC:30323] | 244 | 3.130 | 0.2723 | Yes |
| 10 | TAPBP | TAP binding protein [Source:HGNC Symbol;Acc:HGNC:11566] | 247 | 3.122 | 0.2964 | Yes |
| 11 | PRDX5 | peroxiredoxin 5 [Source:HGNC Symbol;Acc:HGNC:9355] | 402 | 2.539 | 0.3118 | Yes |
| 12 | CXCL10 | C-X-C motif chemokine ligand 10 [Source:HGNC Symbol;Acc:HGNC:10637] | 410 | 2.520 | 0.3311 | Yes |
| 13 | PIGV | phosphatidylinositol glycan anchor biosynthesis class V [Source:HGNC Symbol;Acc:HGNC:26031] | 433 | 2.449 | 0.3494 | Yes |
| 14 | PSME1 | proteasome activator subunit 1 [Source:HGNC Symbol;Acc:HGNC:9568] | 458 | 2.393 | 0.3673 | Yes |
| 15 | ATF3 | activating transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:785] | 526 | 2.244 | 0.3828 | Yes |
| 16 | PSMB9 | proteasome 20S subunit beta 9 [Source:HGNC Symbol;Acc:HGNC:9546] | 579 | 2.125 | 0.3978 | Yes |
| 17 | PSMB8 | proteasome 20S subunit beta 8 [Source:HGNC Symbol;Acc:HGNC:9545] | 641 | 2.004 | 0.4116 | Yes |
| 18 | PGM5 | phosphoglucomutase 5 [Source:HGNC Symbol;Acc:HGNC:8908] | 711 | 1.881 | 0.4243 | Yes |
| 19 | PARP9 | poly(ADP-ribose) polymerase family member 9 [Source:HGNC Symbol;Acc:HGNC:24118] | 774 | 1.781 | 0.4364 | Yes |
| 20 | LRATD2 | LRAT domain containing 2 [Source:HGNC Symbol;Acc:HGNC:24166] | 920 | 1.629 | 0.4450 | Yes |
| 21 | SYNE2 | spectrin repeat containing nuclear envelope protein 2 [Source:HGNC Symbol;Acc:HGNC:17084] | 933 | 1.623 | 0.4573 | Yes |
| 22 | TCIRG1 | T cell immune regulator 1, ATPase H+ transporting V0 subunit a3 [Source:HGNC Symbol;Acc:HGNC:11647] | 960 | 1.593 | 0.4689 | Yes |
| 23 | LSM6 | LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated [Source:HGNC Symbol;Acc:HGNC:17017] | 1112 | 1.418 | 0.4757 | Yes |
| 24 | PSMA3 | proteasome 20S subunit alpha 3 [Source:HGNC Symbol;Acc:HGNC:9532] | 1306 | 1.263 | 0.4803 | Yes |
| 25 | MAP3K11 | mitogen-activated protein kinase kinase kinase 11 [Source:HGNC Symbol;Acc:HGNC:6850] | 1439 | 1.178 | 0.4858 | Yes |
| 26 | SLC38A2 | solute carrier family 38 member 2 [Source:HGNC Symbol;Acc:HGNC:13448] | 1509 | 1.140 | 0.4927 | Yes |
| 27 | CASZ1 | castor zinc finger 1 [Source:HGNC Symbol;Acc:HGNC:26002] | 1625 | 1.074 | 0.4979 | Yes |
| 28 | E2F3 | E2F transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:3115] | 1686 | 1.040 | 0.5043 | Yes |
| 29 | FXYD5 | FXYD domain containing ion transport regulator 5 [Source:HGNC Symbol;Acc:HGNC:4029] | 1861 | 0.960 | 0.5071 | Yes |
| 30 | RAPGEF6 | Rap guanine nucleotide exchange factor 6 [Source:HGNC Symbol;Acc:HGNC:20655] | 1896 | 0.948 | 0.5135 | Yes |
| 31 | ROCK1 | Rho associated coiled-coil containing protein kinase 1 [Source:HGNC Symbol;Acc:HGNC:10251] | 1988 | 0.905 | 0.5180 | Yes |
| 32 | PCGF5 | polycomb group ring finger 5 [Source:HGNC Symbol;Acc:HGNC:28264] | 2064 | 0.875 | 0.5227 | Yes |
| 33 | PRKD3 | protein kinase D3 [Source:HGNC Symbol;Acc:HGNC:9408] | 2281 | 0.785 | 0.5229 | Yes |
| 34 | MED13 | mediator complex subunit 13 [Source:HGNC Symbol;Acc:HGNC:22474] | 2316 | 0.775 | 0.5280 | Yes |
| 35 | CDK6 | cyclin dependent kinase 6 [Source:HGNC Symbol;Acc:HGNC:1777] | 2334 | 0.768 | 0.5335 | Yes |
| 36 | DNASE1L3 | deoxyribonuclease 1 like 3 [Source:HGNC Symbol;Acc:HGNC:2959] | 2579 | 0.686 | 0.5322 | No |
| 37 | UPF2 | UPF2 regulator of nonsense mediated mRNA decay [Source:HGNC Symbol;Acc:HGNC:17854] | 2974 | 0.572 | 0.5259 | No |
| 38 | GSDMD | gasdermin D [Source:HGNC Symbol;Acc:HGNC:25697] | 3566 | 0.440 | 0.5134 | No |
| 39 | B2M | beta-2-microglobulin [Source:HGNC Symbol;Acc:HGNC:914] | 3719 | 0.408 | 0.5124 | No |
| 40 | ASH1L | ASH1 like histone lysine methyltransferase [Source:HGNC Symbol;Acc:HGNC:19088] | 3993 | 0.363 | 0.5078 | No |
| 41 | IL11 | interleukin 11 [Source:HGNC Symbol;Acc:HGNC:5966] | 4154 | 0.328 | 0.5060 | No |
| 42 | TBX1 | T-box transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:11592] | 5057 | 0.174 | 0.4830 | No |
| 43 | KCNE4 | potassium voltage-gated channel subfamily E regulatory subunit 4 [Source:HGNC Symbol;Acc:HGNC:6244] | 5647 | 0.086 | 0.4677 | No |
| 44 | DUSP10 | dual specificity phosphatase 10 [Source:HGNC Symbol;Acc:HGNC:3065] | 5887 | 0.053 | 0.4616 | No |
| 45 | IKZF2 | IKAROS family zinc finger 2 [Source:HGNC Symbol;Acc:HGNC:13177] | 6020 | 0.030 | 0.4583 | No |
| 46 | DLG1 | discs large MAGUK scaffold protein 1 [Source:HGNC Symbol;Acc:HGNC:2900] | 6133 | 0.011 | 0.4554 | No |
| 47 | PRDM16 | PR/SET domain 16 [Source:HGNC Symbol;Acc:HGNC:14000] | 6801 | 0.000 | 0.4373 | No |
| 48 | ASPA | aspartoacylase [Source:HGNC Symbol;Acc:HGNC:756] | 7611 | 0.000 | 0.4154 | No |
| 49 | BHLHE22 | basic helix-loop-helix family member e22 [Source:HGNC Symbol;Acc:HGNC:11963] | 8022 | 0.000 | 0.4043 | No |
| 50 | PROX1 | prospero homeobox 1 [Source:HGNC Symbol;Acc:HGNC:9459] | 8207 | 0.000 | 0.3994 | No |
| 51 | HOXA6 | homeobox A6 [Source:HGNC Symbol;Acc:HGNC:5107] | 8601 | 0.000 | 0.3887 | No |
| 52 | H4C7 | H4 clustered histone 7 [Source:HGNC Symbol;Acc:HGNC:4792] | 10049 | 0.000 | 0.3496 | No |
| 53 | LDB2 | LIM domain binding 2 [Source:HGNC Symbol;Acc:HGNC:6533] | 10907 | 0.000 | 0.3264 | No |
| 54 | TMPRSS5 | transmembrane serine protease 5 [Source:HGNC Symbol;Acc:HGNC:14908] | 11378 | 0.000 | 0.3137 | No |
| 55 | BST2 | bone marrow stromal cell antigen 2 [Source:HGNC Symbol;Acc:HGNC:1119] | 12415 | 0.000 | 0.2857 | No |
| 56 | MSX1 | msh homeobox 1 [Source:HGNC Symbol;Acc:HGNC:7391] | 12453 | 0.000 | 0.2847 | No |
| 57 | UBD | ubiquitin D [Source:HGNC Symbol;Acc:HGNC:18795] | 12735 | 0.000 | 0.2771 | No |
| 58 | GLRA1 | glycine receptor alpha 1 [Source:HGNC Symbol;Acc:HGNC:4326] | 12868 | 0.000 | 0.2735 | No |
| 59 | TMEM108 | transmembrane protein 108 [Source:HGNC Symbol;Acc:HGNC:28451] | 13421 | 0.000 | 0.2585 | No |
| 60 | PDGFC | platelet derived growth factor C [Source:HGNC Symbol;Acc:HGNC:8801] | 13461 | 0.000 | 0.2575 | No |
| 61 | IL15RA | interleukin 15 receptor subunit alpha [Source:HGNC Symbol;Acc:HGNC:5978] | 14065 | 0.000 | 0.2412 | No |
| 62 | FLT3LG | fms related receptor tyrosine kinase 3 ligand [Source:HGNC Symbol;Acc:HGNC:3766] | 14079 | 0.000 | 0.2408 | No |
| 63 | BLK | BLK proto-oncogene, Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:1057] | 15546 | 0.000 | 0.2012 | No |
| 64 | DLX4 | distal-less homeobox 4 [Source:HGNC Symbol;Acc:HGNC:2917] | 16724 | 0.000 | 0.1693 | No |
| 65 | NDN | necdin, MAGE family member [Source:HGNC Symbol;Acc:HGNC:7675] | 19152 | 0.000 | 0.1037 | No |
| 66 | BNC2 | basonuclin 2 [Source:HGNC Symbol;Acc:HGNC:30988] | 19158 | 0.000 | 0.1035 | No |
| 67 | AGBL2 | ATP/GTP binding protein like 2 [Source:HGNC Symbol;Acc:HGNC:26296] | 20450 | 0.000 | 0.0686 | No |
| 68 | BCL11A | BAF chromatin remodeling complex subunit BCL11A [Source:HGNC Symbol;Acc:HGNC:13221] | 20558 | 0.000 | 0.0657 | No |
| 69 | PIGR | polymeric immunoglobulin receptor [Source:HGNC Symbol;Acc:HGNC:8968] | 22583 | 0.000 | 0.0110 | No |
| 70 | NPR3 | natriuretic peptide receptor 3 [Source:HGNC Symbol;Acc:HGNC:7945] | 23414 | 0.000 | -0.0115 | No |
| 71 | EGFL6 | EGF like domain multiple 6 [Source:HGNC Symbol;Acc:HGNC:3235] | 23684 | 0.000 | -0.0188 | No |
| 72 | CCDC68 | coiled-coil domain containing 68 [Source:HGNC Symbol;Acc:HGNC:24350] | 24346 | 0.000 | -0.0367 | No |
| 73 | IFNB1 | interferon beta 1 [Source:HGNC Symbol;Acc:HGNC:5434] | 24448 | 0.000 | -0.0394 | No |
| 74 | IFNL2 | interferon lambda 2 [Source:HGNC Symbol;Acc:HGNC:18364] | 24550 | 0.000 | -0.0421 | No |
| 75 | IFNL3 | interferon lambda 3 [Source:HGNC Symbol;Acc:HGNC:18365] | 24561 | 0.000 | -0.0424 | No |
| 76 | KCNMB3 | potassium calcium-activated channel subfamily M regulatory beta subunit 3 [Source:HGNC Symbol;Acc:HGNC:6287] | 24606 | 0.000 | -0.0436 | No |
| 77 | XAF1 | XIAP associated factor 1 [Source:HGNC Symbol;Acc:HGNC:30932] | 26912 | 0.000 | -0.1059 | No |
| 78 | CUL2 | cullin 2 [Source:HGNC Symbol;Acc:HGNC:2552] | 27257 | -0.022 | -0.1151 | No |
| 79 | RFX4 | regulatory factor X4 [Source:HGNC Symbol;Acc:HGNC:9985] | 27666 | -0.078 | -0.1255 | No |
| 80 | EIF4A2 | eukaryotic translation initiation factor 4A2 [Source:HGNC Symbol;Acc:HGNC:3284] | 27681 | -0.079 | -0.1253 | No |
| 81 | RTL9 | retrotransposon Gag like 9 [Source:HGNC Symbol;Acc:HGNC:29245] | 27720 | -0.085 | -0.1257 | No |
| 82 | TMEM229B | transmembrane protein 229B [Source:HGNC Symbol;Acc:HGNC:20130] | 28087 | -0.128 | -0.1346 | No |
| 83 | CAPRIN1 | cell cycle associated protein 1 [Source:HGNC Symbol;Acc:HGNC:6743] | 28123 | -0.131 | -0.1345 | No |
| 84 | CSAD | cysteine sulfinic acid decarboxylase [Source:HGNC Symbol;Acc:HGNC:18966] | 28347 | -0.161 | -0.1393 | No |
| 85 | RIMS2 | regulating synaptic membrane exocytosis 2 [Source:HGNC Symbol;Acc:HGNC:17283] | 28443 | -0.173 | -0.1405 | No |
| 86 | KARS1 | lysyl-tRNA synthetase 1 [Source:HGNC Symbol;Acc:HGNC:6215] | 28724 | -0.212 | -0.1465 | No |
| 87 | TMBIM4 | transmembrane BAX inhibitor motif containing 4 [Source:HGNC Symbol;Acc:HGNC:24257] | 28882 | -0.230 | -0.1489 | No |
| 88 | TRMT112 | tRNA methyltransferase subunit 11-2 [Source:HGNC Symbol;Acc:HGNC:26940] | 29343 | -0.294 | -0.1591 | No |
| 89 | ME3 | malic enzyme 3 [Source:HGNC Symbol;Acc:HGNC:6985] | 29504 | -0.313 | -0.1610 | No |
| 90 | SREK1 | splicing regulatory glutamic acid and lysine rich protein 1 [Source:HGNC Symbol;Acc:HGNC:17882] | 29671 | -0.333 | -0.1630 | No |
| 91 | MAPK6 | mitogen-activated protein kinase 6 [Source:HGNC Symbol;Acc:HGNC:6879] | 30131 | -0.399 | -0.1723 | No |
| 92 | TRPM3 | transient receptor potential cation channel subfamily M member 3 [Source:HGNC Symbol;Acc:HGNC:17992] | 30242 | -0.414 | -0.1721 | No |
| 93 | TERF2IP | TERF2 interacting protein [Source:HGNC Symbol;Acc:HGNC:19246] | 30317 | -0.426 | -0.1708 | No |
| 94 | GPR52 | G protein-coupled receptor 52 [Source:HGNC Symbol;Acc:HGNC:4508] | 30952 | -0.522 | -0.1839 | No |
| 95 | TRMT6 | tRNA methyltransferase 6 [Source:HGNC Symbol;Acc:HGNC:20900] | 31022 | -0.535 | -0.1816 | No |
| 96 | MITF | melanocyte inducing transcription factor [Source:HGNC Symbol;Acc:HGNC:7105] | 31083 | -0.545 | -0.1790 | No |
| 97 | NABP2 | nucleic acid binding protein 2 [Source:HGNC Symbol;Acc:HGNC:28412] | 31105 | -0.548 | -0.1754 | No |
| 98 | DLX1 | distal-less homeobox 1 [Source:HGNC Symbol;Acc:HGNC:2914] | 31346 | -0.586 | -0.1773 | No |
| 99 | HPCAL1 | hippocalcin like 1 [Source:HGNC Symbol;Acc:HGNC:5145] | 31399 | -0.597 | -0.1741 | No |
| 100 | OTX1 | orthodenticle homeobox 1 [Source:HGNC Symbol;Acc:HGNC:8521] | 31538 | -0.625 | -0.1730 | No |
| 101 | ABHD16A | abhydrolase domain containing 16A, phospholipase [Source:HGNC Symbol;Acc:HGNC:13921] | 31701 | -0.655 | -0.1724 | No |
| 102 | PRKD2 | protein kinase D2 [Source:HGNC Symbol;Acc:HGNC:17293] | 31819 | -0.683 | -0.1702 | No |
| 103 | RELCH | RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing [Source:HGNC Symbol;Acc:HGNC:29289] | 31822 | -0.683 | -0.1650 | No |
| 104 | YY1AP1 | YY1 associated protein 1 [Source:HGNC Symbol;Acc:HGNC:30935] | 32446 | -0.838 | -0.1754 | No |
| 105 | ESR1 | estrogen receptor 1 [Source:HGNC Symbol;Acc:HGNC:3467] | 32629 | -0.884 | -0.1735 | No |
| 106 | HDAC4 | histone deacetylase 4 [Source:HGNC Symbol;Acc:HGNC:14063] | 32664 | -0.896 | -0.1675 | No |
| 107 | TNFSF13B | TNF superfamily member 13b [Source:HGNC Symbol;Acc:HGNC:11929] | 32796 | -0.926 | -0.1639 | No |
| 108 | CCDC6 | coiled-coil domain containing 6 [Source:HGNC Symbol;Acc:HGNC:18782] | 33081 | -1.007 | -0.1638 | No |
| 109 | BBX | BBX high mobility group box domain containing [Source:HGNC Symbol;Acc:HGNC:14422] | 33155 | -1.029 | -0.1578 | No |
| 110 | USP5 | ubiquitin specific peptidase 5 [Source:HGNC Symbol;Acc:HGNC:12628] | 33203 | -1.046 | -0.1510 | No |
| 111 | TGFB3 | transforming growth factor beta 3 [Source:HGNC Symbol;Acc:HGNC:11769] | 34008 | -1.314 | -0.1626 | No |
| 112 | PLXNC1 | plexin C1 [Source:HGNC Symbol;Acc:HGNC:9106] | 34052 | -1.329 | -0.1535 | No |
| 113 | VGLL4 | vestigial like family member 4 [Source:HGNC Symbol;Acc:HGNC:28966] | 34284 | -1.427 | -0.1487 | No |
| 114 | DAP3 | death associated protein 3 [Source:HGNC Symbol;Acc:HGNC:2673] | 34325 | -1.444 | -0.1386 | No |
| 115 | USF1 | upstream transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:12593] | 34691 | -1.589 | -0.1362 | No |
| 116 | RNF220 | ring finger protein 220 [Source:HGNC Symbol;Acc:HGNC:25552] | 34693 | -1.589 | -0.1240 | No |
| 117 | SIPA1 | signal-induced proliferation-associated 1 [Source:HGNC Symbol;Acc:HGNC:10885] | 35230 | -1.878 | -0.1240 | No |
| 118 | AMER1 | APC membrane recruitment protein 1 [Source:HGNC Symbol;Acc:HGNC:26837] | 35231 | -1.878 | -0.1095 | No |
| 119 | DDX17 | DEAD-box helicase 17 [Source:HGNC Symbol;Acc:HGNC:2740] | 35242 | -1.885 | -0.0952 | No |
| 120 | NR3C2 | nuclear receptor subfamily 3 group C member 2 [Source:HGNC Symbol;Acc:HGNC:7979] | 35294 | -1.917 | -0.0817 | No |
| 121 | ARHGAP5 | Rho GTPase activating protein 5 [Source:HGNC Symbol;Acc:HGNC:675] | 35431 | -1.998 | -0.0700 | No |
| 122 | DEPDC7 | DEP domain containing 7 [Source:HGNC Symbol;Acc:HGNC:29899] | 35478 | -2.033 | -0.0555 | No |
| 123 | KDM3A | lysine demethylase 3A [Source:HGNC Symbol;Acc:HGNC:20815] | 35487 | -2.040 | -0.0400 | No |
| 124 | SORBS1 | sorbin and SH3 domain containing 1 [Source:HGNC Symbol;Acc:HGNC:14565] | 36086 | -2.533 | -0.0366 | No |
| 125 | ARHGEF6 | Rac/Cdc42 guanine nucleotide exchange factor 6 [Source:HGNC Symbol;Acc:HGNC:685] | 36205 | -2.661 | -0.0192 | No |
| 126 | MCM8 | minichromosome maintenance 8 homologous recombination repair factor [Source:HGNC Symbol;Acc:HGNC:16147] | 36266 | -2.737 | 0.0003 | No |
| 127 | FAM13C | family with sequence similarity 13 member C [Source:HGNC Symbol;Acc:HGNC:19371] | 36338 | -2.841 | 0.0203 | No |
