Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.greenbergcls.cls #WT_GAQ_versus_WT_NA.greenbergcls.cls #WT_GAQ_versus_WT_NA_repos |
| Phenotype | greenbergcls.cls#WT_GAQ_versus_WT_NA_repos |
| Upregulated in class | WT_NA |
| GeneSet | PUJANA_BRCA_CENTERED_NETWORK |
| Enrichment Score (ES) | -0.7595538 |
| Normalized Enrichment Score (NES) | -1.649664 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0061504813 |
| FWER p-Value | 0.127 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | SLC7A1 | solute carrier family 7 member 1 [Source:HGNC Symbol;Acc:HGNC:11057] | 515 | 2.055 | -0.0016 | No |
| 2 | DCP2 | decapping mRNA 2 [Source:HGNC Symbol;Acc:HGNC:24452] | 1034 | 1.410 | -0.0072 | No |
| 3 | MAT2A | methionine adenosyltransferase 2A [Source:HGNC Symbol;Acc:HGNC:6904] | 1124 | 1.344 | -0.0016 | No |
| 4 | DDX39A | DExD-box helicase 39A [Source:HGNC Symbol;Acc:HGNC:17821] | 1602 | 1.067 | -0.0081 | No |
| 5 | TOP1 | DNA topoisomerase I [Source:HGNC Symbol;Acc:HGNC:11986] | 1697 | 1.024 | -0.0045 | No |
| 6 | ZNHIT3 | zinc finger HIT-type containing 3 [Source:HGNC Symbol;Acc:HGNC:12309] | 1715 | 1.018 | 0.0011 | No |
| 7 | SNRPA1 | small nuclear ribonucleoprotein polypeptide A' [Source:HGNC Symbol;Acc:HGNC:11152] | 2230 | 0.810 | -0.0080 | No |
| 8 | SRSF11 | serine and arginine rich splicing factor 11 [Source:HGNC Symbol;Acc:HGNC:10782] | 2291 | 0.789 | -0.0049 | No |
| 9 | AATF | apoptosis antagonizing transcription factor [Source:HGNC Symbol;Acc:HGNC:19235] | 2342 | 0.772 | -0.0016 | No |
| 10 | ZNF330 | zinc finger protein 330 [Source:HGNC Symbol;Acc:HGNC:15462] | 2419 | 0.747 | 0.0008 | No |
| 11 | SNRPB | small nuclear ribonucleoprotein polypeptides B and B1 [Source:HGNC Symbol;Acc:HGNC:11153] | 2714 | 0.658 | -0.0032 | No |
| 12 | STAT5A | signal transducer and activator of transcription 5A [Source:HGNC Symbol;Acc:HGNC:11366] | 3572 | 0.466 | -0.0236 | No |
| 13 | RAD1 | RAD1 checkpoint DNA exonuclease [Source:HGNC Symbol;Acc:HGNC:9806] | 3624 | 0.455 | -0.0223 | No |
| 14 | NCK1 | NCK adaptor protein 1 [Source:HGNC Symbol;Acc:HGNC:7664] | 3727 | 0.435 | -0.0224 | No |
| 15 | MED20 | mediator complex subunit 20 [Source:HGNC Symbol;Acc:HGNC:16840] | 3836 | 0.417 | -0.0229 | No |
| 16 | SNRPA | small nuclear ribonucleoprotein polypeptide A [Source:HGNC Symbol;Acc:HGNC:11151] | 4027 | 0.385 | -0.0257 | No |
| 17 | PPP1CC | protein phosphatase 1 catalytic subunit gamma [Source:HGNC Symbol;Acc:HGNC:9283] | 4309 | 0.337 | -0.0313 | No |
| 18 | DDX39B | DExD-box helicase 39B [Source:HGNC Symbol;Acc:HGNC:13917] | 4734 | 0.275 | -0.0411 | No |
| 19 | CSNK2A1 | casein kinase 2 alpha 1 [Source:HGNC Symbol;Acc:HGNC:2457] | 4776 | 0.267 | -0.0406 | No |
| 20 | TAF11 | TATA-box binding protein associated factor 11 [Source:HGNC Symbol;Acc:HGNC:11544] | 4779 | 0.267 | -0.0391 | No |
| 21 | METAP1 | methionyl aminopeptidase 1 [Source:HGNC Symbol;Acc:HGNC:15789] | 5548 | 0.147 | -0.0590 | No |
| 22 | POLR2B | RNA polymerase II subunit B [Source:HGNC Symbol;Acc:HGNC:9188] | 5583 | 0.142 | -0.0590 | No |
| 23 | PRPF4 | pre-mRNA processing factor 4 [Source:HGNC Symbol;Acc:HGNC:17349] | 5771 | 0.119 | -0.0634 | No |
| 24 | TCERG1 | transcription elongation regulator 1 [Source:HGNC Symbol;Acc:HGNC:15630] | 6073 | 0.080 | -0.0710 | No |
| 25 | CDK1 | cyclin dependent kinase 1 [Source:HGNC Symbol;Acc:HGNC:1722] | 6135 | 0.073 | -0.0723 | No |
| 26 | RPIA | ribose 5-phosphate isomerase A [Source:HGNC Symbol;Acc:HGNC:10297] | 6341 | 0.047 | -0.0775 | No |
| 27 | PRPS1 | phosphoribosyl pyrophosphate synthetase 1 [Source:HGNC Symbol;Acc:HGNC:9462] | 6448 | 0.033 | -0.0802 | No |
| 28 | SEC31A | SEC31 homolog A, COPII coat complex component [Source:HGNC Symbol;Acc:HGNC:17052] | 6555 | 0.020 | -0.0829 | No |
| 29 | KATNA1 | katanin catalytic subunit A1 [Source:HGNC Symbol;Acc:HGNC:6216] | 6607 | 0.013 | -0.0842 | No |
| 30 | DDX46 | DEAD-box helicase 46 [Source:HGNC Symbol;Acc:HGNC:18681] | 27546 | -0.012 | -0.6505 | No |
| 31 | CNOT3 | CCR4-NOT transcription complex subunit 3 [Source:HGNC Symbol;Acc:HGNC:7879] | 27958 | -0.063 | -0.6612 | No |
| 32 | BUB3 | BUB3 mitotic checkpoint protein [Source:HGNC Symbol;Acc:HGNC:1151] | 28342 | -0.112 | -0.6709 | No |
| 33 | ASF1A | anti-silencing function 1A histone chaperone [Source:HGNC Symbol;Acc:HGNC:20995] | 28728 | -0.153 | -0.6804 | No |
| 34 | CAD | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase [Source:HGNC Symbol;Acc:HGNC:1424] | 29663 | -0.273 | -0.7040 | No |
| 35 | TBCA | tubulin folding cofactor A [Source:HGNC Symbol;Acc:HGNC:11579] | 30079 | -0.321 | -0.7133 | No |
| 36 | NAE1 | NEDD8 activating enzyme E1 subunit 1 [Source:HGNC Symbol;Acc:HGNC:621] | 30102 | -0.324 | -0.7120 | No |
| 37 | DHFR | dihydrofolate reductase [Source:HGNC Symbol;Acc:HGNC:2861] | 30127 | -0.328 | -0.7107 | No |
| 38 | CNOT9 | CCR4-NOT transcription complex subunit 9 [Source:HGNC Symbol;Acc:HGNC:10445] | 30166 | -0.333 | -0.7097 | No |
| 39 | CPSF4 | cleavage and polyadenylation specific factor 4 [Source:HGNC Symbol;Acc:HGNC:2327] | 30238 | -0.342 | -0.7096 | No |
| 40 | COPS3 | COP9 signalosome subunit 3 [Source:HGNC Symbol;Acc:HGNC:2239] | 30567 | -0.388 | -0.7161 | No |
| 41 | ABCB7 | ATP binding cassette subfamily B member 7 [Source:HGNC Symbol;Acc:HGNC:48] | 30821 | -0.426 | -0.7204 | No |
| 42 | AURKA | aurora kinase A [Source:HGNC Symbol;Acc:HGNC:11393] | 31738 | -0.568 | -0.7418 | No |
| 43 | EIF3H | eukaryotic translation initiation factor 3 subunit H [Source:HGNC Symbol;Acc:HGNC:3273] | 31932 | -0.599 | -0.7434 | No |
| 44 | HMGB2 | high mobility group box 2 [Source:HGNC Symbol;Acc:HGNC:5000] | 32479 | -0.717 | -0.7539 | No |
| 45 | IDH3B | isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta [Source:HGNC Symbol;Acc:HGNC:5385] | 32688 | -0.765 | -0.7550 | Yes |
| 46 | LMNB1 | lamin B1 [Source:HGNC Symbol;Acc:HGNC:6637] | 32757 | -0.782 | -0.7521 | Yes |
| 47 | RAD51AP1 | RAD51 associated protein 1 [Source:HGNC Symbol;Acc:HGNC:16956] | 32901 | -0.817 | -0.7511 | Yes |
| 48 | RNASEH2B | ribonuclease H2 subunit B [Source:HGNC Symbol;Acc:HGNC:25671] | 33035 | -0.851 | -0.7496 | Yes |
| 49 | CDC7 | cell division cycle 7 [Source:HGNC Symbol;Acc:HGNC:1745] | 33160 | -0.882 | -0.7477 | Yes |
| 50 | TFDP1 | transcription factor Dp-1 [Source:HGNC Symbol;Acc:HGNC:11749] | 33452 | -0.960 | -0.7499 | Yes |
| 51 | SKP2 | S-phase kinase associated protein 2 [Source:HGNC Symbol;Acc:HGNC:10901] | 33584 | -0.997 | -0.7474 | Yes |
| 52 | RBBP4 | RB binding protein 4, chromatin remodeling factor [Source:HGNC Symbol;Acc:HGNC:9887] | 33638 | -1.014 | -0.7428 | Yes |
| 53 | CDC20 | cell division cycle 20 [Source:HGNC Symbol;Acc:HGNC:1723] | 33672 | -1.025 | -0.7376 | Yes |
| 54 | NEMP1 | nuclear envelope integral membrane protein 1 [Source:HGNC Symbol;Acc:HGNC:29001] | 33825 | -1.061 | -0.7353 | Yes |
| 55 | ESPL1 | extra spindle pole bodies like 1, separase [Source:HGNC Symbol;Acc:HGNC:16856] | 33977 | -1.108 | -0.7328 | Yes |
| 56 | PCNA | proliferating cell nuclear antigen [Source:HGNC Symbol;Acc:HGNC:8729] | 34110 | -1.145 | -0.7295 | Yes |
| 57 | TIMELESS | timeless circadian regulator [Source:HGNC Symbol;Acc:HGNC:11813] | 34204 | -1.180 | -0.7250 | Yes |
| 58 | TCF3 | transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:11633] | 34470 | -1.281 | -0.7245 | Yes |
| 59 | NFYB | nuclear transcription factor Y subunit beta [Source:HGNC Symbol;Acc:HGNC:7805] | 34635 | -1.342 | -0.7209 | Yes |
| 60 | SUZ12 | SUZ12 polycomb repressive complex 2 subunit [Source:HGNC Symbol;Acc:HGNC:17101] | 34693 | -1.371 | -0.7142 | Yes |
| 61 | XPO1 | exportin 1 [Source:HGNC Symbol;Acc:HGNC:12825] | 34706 | -1.378 | -0.7063 | Yes |
| 62 | UBE2C | ubiquitin conjugating enzyme E2 C [Source:HGNC Symbol;Acc:HGNC:15937] | 34791 | -1.414 | -0.7001 | Yes |
| 63 | PPP2R5C | protein phosphatase 2 regulatory subunit B'gamma [Source:HGNC Symbol;Acc:HGNC:9311] | 34792 | -1.415 | -0.6917 | Yes |
| 64 | SMC1A | structural maintenance of chromosomes 1A [Source:HGNC Symbol;Acc:HGNC:11111] | 34805 | -1.420 | -0.6835 | Yes |
| 65 | RFC3 | replication factor C subunit 3 [Source:HGNC Symbol;Acc:HGNC:9971] | 34852 | -1.446 | -0.6761 | Yes |
| 66 | PRKDC | protein kinase, DNA-activated, catalytic subunit [Source:HGNC Symbol;Acc:HGNC:9413] | 35043 | -1.541 | -0.6720 | Yes |
| 67 | SMC2 | structural maintenance of chromosomes 2 [Source:HGNC Symbol;Acc:HGNC:14011] | 35127 | -1.583 | -0.6648 | Yes |
| 68 | RBBP8 | RB binding protein 8, endonuclease [Source:HGNC Symbol;Acc:HGNC:9891] | 35220 | -1.637 | -0.6575 | Yes |
| 69 | BRCA2 | BRCA2 DNA repair associated [Source:HGNC Symbol;Acc:HGNC:1101] | 35234 | -1.641 | -0.6481 | Yes |
| 70 | NASP | nuclear autoantigenic sperm protein [Source:HGNC Symbol;Acc:HGNC:7644] | 35268 | -1.661 | -0.6390 | Yes |
| 71 | RAD21 | RAD21 cohesin complex component [Source:HGNC Symbol;Acc:HGNC:9811] | 35280 | -1.666 | -0.6294 | Yes |
| 72 | FANCI | FA complementation group I [Source:HGNC Symbol;Acc:HGNC:25568] | 35401 | -1.734 | -0.6222 | Yes |
| 73 | SMC4 | structural maintenance of chromosomes 4 [Source:HGNC Symbol;Acc:HGNC:14013] | 35408 | -1.739 | -0.6120 | Yes |
| 74 | CHAF1A | chromatin assembly factor 1 subunit A [Source:HGNC Symbol;Acc:HGNC:1910] | 35426 | -1.748 | -0.6020 | Yes |
| 75 | DEK | DEK proto-oncogene [Source:HGNC Symbol;Acc:HGNC:2768] | 35478 | -1.780 | -0.5927 | Yes |
| 76 | MAD2L1 | mitotic arrest deficient 2 like 1 [Source:HGNC Symbol;Acc:HGNC:6763] | 35525 | -1.805 | -0.5832 | Yes |
| 77 | GINS1 | GINS complex subunit 1 [Source:HGNC Symbol;Acc:HGNC:28980] | 35614 | -1.860 | -0.5745 | Yes |
| 78 | TOP2A | DNA topoisomerase II alpha [Source:HGNC Symbol;Acc:HGNC:11989] | 35626 | -1.864 | -0.5636 | Yes |
| 79 | HMMR | hyaluronan mediated motility receptor [Source:HGNC Symbol;Acc:HGNC:5012] | 35633 | -1.871 | -0.5526 | Yes |
| 80 | MRE11 | MRE11 homolog, double strand break repair nuclease [Source:HGNC Symbol;Acc:HGNC:7230] | 35640 | -1.881 | -0.5415 | Yes |
| 81 | EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit [Source:HGNC Symbol;Acc:HGNC:3527] | 35653 | -1.889 | -0.5305 | Yes |
| 82 | LBR | lamin B receptor [Source:HGNC Symbol;Acc:HGNC:6518] | 35657 | -1.892 | -0.5193 | Yes |
| 83 | MCM4 | minichromosome maintenance complex component 4 [Source:HGNC Symbol;Acc:HGNC:6947] | 35681 | -1.914 | -0.5085 | Yes |
| 84 | SMC3 | structural maintenance of chromosomes 3 [Source:HGNC Symbol;Acc:HGNC:2468] | 35717 | -1.937 | -0.4978 | Yes |
| 85 | MCM5 | minichromosome maintenance complex component 5 [Source:HGNC Symbol;Acc:HGNC:6948] | 35722 | -1.939 | -0.4864 | Yes |
| 86 | BLM | BLM RecQ like helicase [Source:HGNC Symbol;Acc:HGNC:1058] | 35779 | -1.982 | -0.4760 | Yes |
| 87 | KIFC1 | kinesin family member C1 [Source:HGNC Symbol;Acc:HGNC:6389] | 35895 | -2.079 | -0.4667 | Yes |
| 88 | SSBP2 | single stranded DNA binding protein 2 [Source:HGNC Symbol;Acc:HGNC:15831] | 35897 | -2.080 | -0.4543 | Yes |
| 89 | RFC4 | replication factor C subunit 4 [Source:HGNC Symbol;Acc:HGNC:9972] | 35922 | -2.100 | -0.4424 | Yes |
| 90 | DNA2 | DNA replication helicase/nuclease 2 [Source:HGNC Symbol;Acc:HGNC:2939] | 35993 | -2.147 | -0.4314 | Yes |
| 91 | RRM1 | ribonucleotide reductase catalytic subunit M1 [Source:HGNC Symbol;Acc:HGNC:10451] | 35995 | -2.149 | -0.4186 | Yes |
| 92 | RECQL | RecQ like helicase [Source:HGNC Symbol;Acc:HGNC:9948] | 36010 | -2.162 | -0.4061 | Yes |
| 93 | MCM2 | minichromosome maintenance complex component 2 [Source:HGNC Symbol;Acc:HGNC:6944] | 36041 | -2.186 | -0.3938 | Yes |
| 94 | RAD51C | RAD51 paralog C [Source:HGNC Symbol;Acc:HGNC:9820] | 36081 | -2.221 | -0.3816 | Yes |
| 95 | TMPO | thymopoietin [Source:HGNC Symbol;Acc:HGNC:11875] | 36104 | -2.244 | -0.3688 | Yes |
| 96 | TTF2 | transcription termination factor 2 [Source:HGNC Symbol;Acc:HGNC:12398] | 36127 | -2.262 | -0.3558 | Yes |
| 97 | CCNA2 | cyclin A2 [Source:HGNC Symbol;Acc:HGNC:1578] | 36192 | -2.319 | -0.3437 | Yes |
| 98 | POLA1 | DNA polymerase alpha 1, catalytic subunit [Source:HGNC Symbol;Acc:HGNC:9173] | 36270 | -2.402 | -0.3314 | Yes |
| 99 | TOPBP1 | DNA topoisomerase II binding protein 1 [Source:HGNC Symbol;Acc:HGNC:17008] | 36291 | -2.418 | -0.3175 | Yes |
| 100 | PSIP1 | PC4 and SFRS1 interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:9527] | 36313 | -2.436 | -0.3035 | Yes |
| 101 | NCAPD2 | non-SMC condensin I complex subunit D2 [Source:HGNC Symbol;Acc:HGNC:24305] | 36323 | -2.449 | -0.2891 | Yes |
| 102 | ATM | ATM serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:795] | 36325 | -2.450 | -0.2745 | Yes |
| 103 | NDC80 | NDC80 kinetochore complex component [Source:HGNC Symbol;Acc:HGNC:16909] | 36364 | -2.499 | -0.2606 | Yes |
| 104 | POLE | DNA polymerase epsilon, catalytic subunit [Source:HGNC Symbol;Acc:HGNC:9177] | 36417 | -2.569 | -0.2466 | Yes |
| 105 | DUT | deoxyuridine triphosphatase [Source:HGNC Symbol;Acc:HGNC:3078] | 36479 | -2.649 | -0.2324 | Yes |
| 106 | RAD54L | RAD54 like [Source:HGNC Symbol;Acc:HGNC:9826] | 36522 | -2.718 | -0.2173 | Yes |
| 107 | RPA1 | replication protein A1 [Source:HGNC Symbol;Acc:HGNC:10289] | 36551 | -2.763 | -0.2015 | Yes |
| 108 | MYBL2 | MYB proto-oncogene like 2 [Source:HGNC Symbol;Acc:HGNC:7548] | 36648 | -2.896 | -0.1868 | Yes |
| 109 | CHEK2 | checkpoint kinase 2 [Source:HGNC Symbol;Acc:HGNC:16627] | 36675 | -2.952 | -0.1699 | Yes |
| 110 | DNMT1 | DNA methyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:2976] | 36698 | -2.991 | -0.1526 | Yes |
| 111 | PAICS | phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase [Source:HGNC Symbol;Acc:HGNC:8587] | 36722 | -3.033 | -0.1351 | Yes |
| 112 | BRCA1 | BRCA1 DNA repair associated [Source:HGNC Symbol;Acc:HGNC:1100] | 36790 | -3.161 | -0.1180 | Yes |
| 113 | UNG | uracil DNA glycosylase [Source:HGNC Symbol;Acc:HGNC:12572] | 36823 | -3.229 | -0.0995 | Yes |
| 114 | MCM6 | minichromosome maintenance complex component 6 [Source:HGNC Symbol;Acc:HGNC:6949] | 36860 | -3.318 | -0.0807 | Yes |
| 115 | TFDP2 | transcription factor Dp-2 [Source:HGNC Symbol;Acc:HGNC:11751] | 36874 | -3.364 | -0.0609 | Yes |
| 116 | H2AZ2 | H2A.Z variant histone 2 [Source:HGNC Symbol;Acc:HGNC:20664] | 36936 | -3.599 | -0.0410 | Yes |
| 117 | MSH2 | mutS homolog 2 [Source:HGNC Symbol;Acc:HGNC:7325] | 36967 | -3.703 | -0.0197 | Yes |
| 118 | RB1 | RB transcriptional corepressor 1 [Source:HGNC Symbol;Acc:HGNC:9884] | 36995 | -3.849 | 0.0026 | Yes |
