Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.greenbergcls.cls #WT_GAQ_versus_WT_NA.greenbergcls.cls #WT_GAQ_versus_WT_NA_repos |
| Phenotype | greenbergcls.cls#WT_GAQ_versus_WT_NA_repos |
| Upregulated in class | WT_NA |
| GeneSet | REACTOME_AMINE_LIGAND_BINDING_RECEPTORS |
| Enrichment Score (ES) | -0.90267503 |
| Normalized Enrichment Score (NES) | -1.7258855 |
| Nominal p-value | 0.0 |
| FDR q-value | 9.673811E-4 |
| FWER p-Value | 0.006 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | CHRM1 | cholinergic receptor muscarinic 1 [Source:HGNC Symbol;Acc:HGNC:1950] | 5974 | 0.090 | -0.1512 | No |
| 2 | TAAR8 | trace amine associated receptor 8 [Source:HGNC Symbol;Acc:HGNC:14964] | 12832 | 0.000 | -0.3363 | No |
| 3 | TAAR6 | trace amine associated receptor 6 [Source:HGNC Symbol;Acc:HGNC:20978] | 12833 | 0.000 | -0.3363 | No |
| 4 | TAAR5 | trace amine associated receptor 5 [Source:HGNC Symbol;Acc:HGNC:30236] | 12835 | 0.000 | -0.3364 | No |
| 5 | TAAR2 | trace amine associated receptor 2 (gene/pseudogene) [Source:HGNC Symbol;Acc:HGNC:4514] | 12837 | 0.000 | -0.3364 | No |
| 6 | TAAR1 | trace amine associated receptor 1 [Source:HGNC Symbol;Acc:HGNC:17734] | 12840 | 0.000 | -0.3364 | No |
| 7 | HTR4 | 5-hydroxytryptamine receptor 4 [Source:HGNC Symbol;Acc:HGNC:5299] | 15652 | 0.000 | -0.4123 | No |
| 8 | HTR6 | 5-hydroxytryptamine receptor 6 [Source:HGNC Symbol;Acc:HGNC:5301] | 15654 | 0.000 | -0.4123 | No |
| 9 | HTR7 | 5-hydroxytryptamine receptor 7 [Source:HGNC Symbol;Acc:HGNC:5302] | 15655 | 0.000 | -0.4123 | No |
| 10 | HTR1E | 5-hydroxytryptamine receptor 1E [Source:HGNC Symbol;Acc:HGNC:5291] | 15716 | 0.000 | -0.4140 | No |
| 11 | HTR1F | 5-hydroxytryptamine receptor 1F [Source:HGNC Symbol;Acc:HGNC:5292] | 15718 | 0.000 | -0.4140 | No |
| 12 | HTR1D | 5-hydroxytryptamine receptor 1D [Source:HGNC Symbol;Acc:HGNC:5289] | 15719 | 0.000 | -0.4140 | No |
| 13 | HTR1A | 5-hydroxytryptamine receptor 1A [Source:HGNC Symbol;Acc:HGNC:5286] | 15720 | 0.000 | -0.4140 | No |
| 14 | HTR2B | 5-hydroxytryptamine receptor 2B [Source:HGNC Symbol;Acc:HGNC:5294] | 15726 | 0.000 | -0.4141 | No |
| 15 | HTR2C | 5-hydroxytryptamine receptor 2C [Source:HGNC Symbol;Acc:HGNC:5295] | 15727 | 0.000 | -0.4141 | No |
| 16 | HTR5A | 5-hydroxytryptamine receptor 5A [Source:HGNC Symbol;Acc:HGNC:5300] | 15746 | 0.000 | -0.4146 | No |
| 17 | GPR143 | G protein-coupled receptor 143 [Source:HGNC Symbol;Acc:HGNC:20145] | 16542 | 0.000 | -0.4361 | No |
| 18 | ADRA1D | adrenoceptor alpha 1D [Source:HGNC Symbol;Acc:HGNC:280] | 16592 | 0.000 | -0.4374 | No |
| 19 | ADRA1B | adrenoceptor alpha 1B [Source:HGNC Symbol;Acc:HGNC:278] | 16593 | 0.000 | -0.4374 | No |
| 20 | ADRA1A | adrenoceptor alpha 1A [Source:HGNC Symbol;Acc:HGNC:277] | 16595 | 0.000 | -0.4374 | No |
| 21 | ADRA2C | adrenoceptor alpha 2C [Source:HGNC Symbol;Acc:HGNC:283] | 16601 | 0.000 | -0.4375 | No |
| 22 | ADRA2B | adrenoceptor alpha 2B [Source:HGNC Symbol;Acc:HGNC:282] | 16602 | 0.000 | -0.4375 | No |
| 23 | ADRA2A | adrenoceptor alpha 2A [Source:HGNC Symbol;Acc:HGNC:281] | 16603 | 0.000 | -0.4375 | No |
| 24 | CHRM2 | cholinergic receptor muscarinic 2 [Source:HGNC Symbol;Acc:HGNC:1951] | 17848 | 0.000 | -0.4711 | No |
| 25 | CHRM5 | cholinergic receptor muscarinic 5 [Source:HGNC Symbol;Acc:HGNC:1954] | 17850 | 0.000 | -0.4711 | No |
| 26 | ADRB3 | adrenoceptor beta 3 [Source:HGNC Symbol;Acc:HGNC:288] | 17908 | 0.000 | -0.4727 | No |
| 27 | ADRB1 | adrenoceptor beta 1 [Source:HGNC Symbol;Acc:HGNC:285] | 17951 | 0.000 | -0.4738 | No |
| 28 | DRD1 | dopamine receptor D1 [Source:HGNC Symbol;Acc:HGNC:3020] | 18482 | 0.000 | -0.4881 | No |
| 29 | DRD2 | dopamine receptor D2 [Source:HGNC Symbol;Acc:HGNC:3023] | 18483 | 0.000 | -0.4881 | No |
| 30 | DRD3 | dopamine receptor D3 [Source:HGNC Symbol;Acc:HGNC:3024] | 18485 | 0.000 | -0.4882 | No |
| 31 | DRD4 | dopamine receptor D4 [Source:HGNC Symbol;Acc:HGNC:3025] | 18486 | 0.000 | -0.4882 | No |
| 32 | DRD5 | dopamine receptor D5 [Source:HGNC Symbol;Acc:HGNC:3026] | 18487 | 0.000 | -0.4882 | No |
| 33 | HRH1 | histamine receptor H1 [Source:HGNC Symbol;Acc:HGNC:5182] | 26776 | 0.000 | -0.7119 | No |
| 34 | HRH3 | histamine receptor H3 [Source:HGNC Symbol;Acc:HGNC:5184] | 26779 | 0.000 | -0.7119 | No |
| 35 | HRH2 | histamine receptor H2 [Source:HGNC Symbol;Acc:HGNC:5183] | 26781 | 0.000 | -0.7119 | No |
| 36 | HRH4 | histamine receptor H4 [Source:HGNC Symbol;Acc:HGNC:17383] | 26784 | 0.000 | -0.7120 | No |
| 37 | HTR2A | 5-hydroxytryptamine receptor 2A [Source:HGNC Symbol;Acc:HGNC:5293] | 27999 | -0.068 | -0.7373 | Yes |
| 38 | CHRM3 | cholinergic receptor muscarinic 3 [Source:HGNC Symbol;Acc:HGNC:1952] | 28245 | -0.101 | -0.7327 | Yes |
| 39 | TAAR9 | trace amine associated receptor 9 (gene/pseudogene) [Source:HGNC Symbol;Acc:HGNC:20977] | 29086 | -0.199 | -0.7333 | Yes |
| 40 | CHRM4 | cholinergic receptor muscarinic 4 [Source:HGNC Symbol;Acc:HGNC:1953] | 30682 | -0.404 | -0.7316 | Yes |
| 41 | HTR1B | 5-hydroxytryptamine receptor 1B [Source:HGNC Symbol;Acc:HGNC:5287] | 37020 | -3.981 | -0.4619 | Yes |
| 42 | ADRB2 | adrenoceptor beta 2 [Source:HGNC Symbol;Acc:HGNC:286] | 37048 | -4.188 | 0.0011 | Yes |
