Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.greenbergcls.cls #WT_GAQ_versus_WT_NA.greenbergcls.cls #WT_GAQ_versus_WT_NA_repos |
| Phenotype | greenbergcls.cls#WT_GAQ_versus_WT_NA_repos |
| Upregulated in class | WT_GAQ |
| GeneSet | REACTOME_INTERFERON_ALPHA_BETA_SIGNALING |
| Enrichment Score (ES) | 0.8313845 |
| Normalized Enrichment Score (NES) | 2.0629337 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0 |
| FWER p-Value | 0.0 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | SOCS3 | suppressor of cytokine signaling 3 [Source:HGNC Symbol;Acc:HGNC:19391] | 19 | 4.687 | 0.0550 | Yes |
| 2 | IFIT1 | interferon induced protein with tetratricopeptide repeats 1 [Source:HGNC Symbol;Acc:HGNC:5407] | 21 | 4.639 | 0.1099 | Yes |
| 3 | USP18 | ubiquitin specific peptidase 18 [Source:HGNC Symbol;Acc:HGNC:12616] | 37 | 4.297 | 0.1604 | Yes |
| 4 | OASL | 2'-5'-oligoadenylate synthetase like [Source:HGNC Symbol;Acc:HGNC:8090] | 48 | 4.133 | 0.2091 | Yes |
| 5 | IRF7 | interferon regulatory factor 7 [Source:HGNC Symbol;Acc:HGNC:6122] | 85 | 3.724 | 0.2523 | Yes |
| 6 | IFI35 | interferon induced protein 35 [Source:HGNC Symbol;Acc:HGNC:5399] | 86 | 3.723 | 0.2964 | Yes |
| 7 | OAS1 | 2'-5'-oligoadenylate synthetase 1 [Source:HGNC Symbol;Acc:HGNC:8086] | 133 | 3.364 | 0.3350 | Yes |
| 8 | MX1 | MX dynamin like GTPase 1 [Source:HGNC Symbol;Acc:HGNC:7532] | 143 | 3.299 | 0.3738 | Yes |
| 9 | ISG20 | interferon stimulated exonuclease gene 20 [Source:HGNC Symbol;Acc:HGNC:6130] | 155 | 3.255 | 0.4121 | Yes |
| 10 | STAT1 | signal transducer and activator of transcription 1 [Source:HGNC Symbol;Acc:HGNC:11362] | 206 | 3.020 | 0.4465 | Yes |
| 11 | RSAD2 | radical S-adenosyl methionine domain containing 2 [Source:HGNC Symbol;Acc:HGNC:30908] | 220 | 2.934 | 0.4809 | Yes |
| 12 | OAS3 | 2'-5'-oligoadenylate synthetase 3 [Source:HGNC Symbol;Acc:HGNC:8088] | 236 | 2.845 | 0.5142 | Yes |
| 13 | MX2 | MX dynamin like GTPase 2 [Source:HGNC Symbol;Acc:HGNC:7533] | 288 | 2.633 | 0.5440 | Yes |
| 14 | STAT2 | signal transducer and activator of transcription 2 [Source:HGNC Symbol;Acc:HGNC:11363] | 358 | 2.459 | 0.5713 | Yes |
| 15 | IFIT2 | interferon induced protein with tetratricopeptide repeats 2 [Source:HGNC Symbol;Acc:HGNC:5409] | 397 | 2.367 | 0.5983 | Yes |
| 16 | OAS2 | 2'-5'-oligoadenylate synthetase 2 [Source:HGNC Symbol;Acc:HGNC:8087] | 414 | 2.311 | 0.6252 | Yes |
| 17 | IFITM3 | interferon induced transmembrane protein 3 [Source:HGNC Symbol;Acc:HGNC:5414] | 467 | 2.166 | 0.6495 | Yes |
| 18 | ADAR | adenosine deaminase RNA specific [Source:HGNC Symbol;Acc:HGNC:225] | 469 | 2.163 | 0.6751 | Yes |
| 19 | IFITM2 | interferon induced transmembrane protein 2 [Source:HGNC Symbol;Acc:HGNC:5413] | 510 | 2.076 | 0.6986 | Yes |
| 20 | SOCS1 | suppressor of cytokine signaling 1 [Source:HGNC Symbol;Acc:HGNC:19383] | 532 | 2.033 | 0.7221 | Yes |
| 21 | IRF9 | interferon regulatory factor 9 [Source:HGNC Symbol;Acc:HGNC:6131] | 553 | 1.992 | 0.7452 | Yes |
| 22 | IRF8 | interferon regulatory factor 8 [Source:HGNC Symbol;Acc:HGNC:5358] | 1151 | 1.327 | 0.7448 | Yes |
| 23 | IFITM1 | interferon induced transmembrane protein 1 [Source:HGNC Symbol;Acc:HGNC:5412] | 1308 | 1.207 | 0.7549 | Yes |
| 24 | IP6K2 | inositol hexakisphosphate kinase 2 [Source:HGNC Symbol;Acc:HGNC:17313] | 1532 | 1.093 | 0.7618 | Yes |
| 25 | PTPN1 | protein tyrosine phosphatase non-receptor type 1 [Source:HGNC Symbol;Acc:HGNC:9642] | 1676 | 1.037 | 0.7702 | Yes |
| 26 | EGR1 | early growth response 1 [Source:HGNC Symbol;Acc:HGNC:3238] | 1723 | 1.015 | 0.7810 | Yes |
| 27 | PTPN11 | protein tyrosine phosphatase non-receptor type 11 [Source:HGNC Symbol;Acc:HGNC:9644] | 1801 | 0.985 | 0.7906 | Yes |
| 28 | GBP2 | guanylate binding protein 2 [Source:HGNC Symbol;Acc:HGNC:4183] | 1993 | 0.902 | 0.7961 | Yes |
| 29 | IRF5 | interferon regulatory factor 5 [Source:HGNC Symbol;Acc:HGNC:6120] | 2127 | 0.846 | 0.8025 | Yes |
| 30 | IRF4 | interferon regulatory factor 4 [Source:HGNC Symbol;Acc:HGNC:6119] | 2133 | 0.841 | 0.8124 | Yes |
| 31 | HLA-F | major histocompatibility complex, class I, F [Source:HGNC Symbol;Acc:HGNC:4963] | 2362 | 0.765 | 0.8153 | Yes |
| 32 | PSMB8 | proteasome 20S subunit beta 8 [Source:HGNC Symbol;Acc:HGNC:9545] | 2453 | 0.737 | 0.8216 | Yes |
| 33 | SAMHD1 | SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 [Source:HGNC Symbol;Acc:HGNC:15925] | 2494 | 0.726 | 0.8291 | Yes |
| 34 | HLA-B | major histocompatibility complex, class I, B [Source:HGNC Symbol;Acc:HGNC:4932] | 2797 | 0.639 | 0.8285 | Yes |
| 35 | HLA-C | major histocompatibility complex, class I, C [Source:HGNC Symbol;Acc:HGNC:4933] | 2954 | 0.600 | 0.8314 | Yes |
| 36 | ISG15 | ISG15 ubiquitin like modifier [Source:HGNC Symbol;Acc:HGNC:4053] | 3306 | 0.522 | 0.8281 | No |
| 37 | KPNA1 | karyopherin subunit alpha 1 [Source:HGNC Symbol;Acc:HGNC:6394] | 3717 | 0.437 | 0.8222 | No |
| 38 | HLA-A | major histocompatibility complex, class I, A [Source:HGNC Symbol;Acc:HGNC:4931] | 3753 | 0.433 | 0.8264 | No |
| 39 | ABCE1 | ATP binding cassette subfamily E member 1 [Source:HGNC Symbol;Acc:HGNC:69] | 4248 | 0.348 | 0.8171 | No |
| 40 | IFI27 | interferon alpha inducible protein 27 [Source:HGNC Symbol;Acc:HGNC:5397] | 4423 | 0.319 | 0.8162 | No |
| 41 | IFIT3 | interferon induced protein with tetratricopeptide repeats 3 [Source:HGNC Symbol;Acc:HGNC:5411] | 4881 | 0.250 | 0.8068 | No |
| 42 | KPNB1 | karyopherin subunit beta 1 [Source:HGNC Symbol;Acc:HGNC:6400] | 5748 | 0.122 | 0.7849 | No |
| 43 | HLA-E | major histocompatibility complex, class I, E [Source:HGNC Symbol;Acc:HGNC:4962] | 5753 | 0.122 | 0.7862 | No |
| 44 | HLA-G | major histocompatibility complex, class I, G [Source:HGNC Symbol;Acc:HGNC:4964] | 6450 | 0.032 | 0.7678 | No |
| 45 | IRF6 | interferon regulatory factor 6 [Source:HGNC Symbol;Acc:HGNC:6121] | 6588 | 0.016 | 0.7643 | No |
| 46 | BST2 | bone marrow stromal cell antigen 2 [Source:HGNC Symbol;Acc:HGNC:1119] | 12704 | 0.000 | 0.5991 | No |
| 47 | IFNA13 | interferon alpha 13 [Source:HGNC Symbol;Acc:HGNC:5419] | 18195 | 0.000 | 0.4508 | No |
| 48 | IFNA14 | interferon alpha 14 [Source:HGNC Symbol;Acc:HGNC:5420] | 18196 | 0.000 | 0.4508 | No |
| 49 | IFNA16 | interferon alpha 16 [Source:HGNC Symbol;Acc:HGNC:5421] | 18198 | 0.000 | 0.4508 | No |
| 50 | IFNA17 | interferon alpha 17 [Source:HGNC Symbol;Acc:HGNC:5422] | 18200 | 0.000 | 0.4508 | No |
| 51 | IFNA10 | interferon alpha 10 [Source:HGNC Symbol;Acc:HGNC:5418] | 18207 | 0.000 | 0.4506 | No |
| 52 | IFNA21 | interferon alpha 21 [Source:HGNC Symbol;Acc:HGNC:5424] | 18213 | 0.000 | 0.4505 | No |
| 53 | IFNAR2 | interferon alpha and beta receptor subunit 2 [Source:HGNC Symbol;Acc:HGNC:5433] | 18465 | 0.000 | 0.4437 | No |
| 54 | IFNAR1 | interferon alpha and beta receptor subunit 1 [Source:HGNC Symbol;Acc:HGNC:5432] | 18473 | 0.000 | 0.4435 | No |
| 55 | IFI6 | interferon alpha inducible protein 6 [Source:HGNC Symbol;Acc:HGNC:4054] | 20659 | 0.000 | 0.3845 | No |
| 56 | IFIT5 | interferon induced protein with tetratricopeptide repeats 5 [Source:HGNC Symbol;Acc:HGNC:13328] | 23289 | 0.000 | 0.3134 | No |
| 57 | IFNA5 | interferon alpha 5 [Source:HGNC Symbol;Acc:HGNC:5426] | 24700 | 0.000 | 0.2754 | No |
| 58 | IFNA4 | interferon alpha 4 [Source:HGNC Symbol;Acc:HGNC:5425] | 24701 | 0.000 | 0.2754 | No |
| 59 | IFNA7 | interferon alpha 7 [Source:HGNC Symbol;Acc:HGNC:5428] | 24703 | 0.000 | 0.2753 | No |
| 60 | IFNA6 | interferon alpha 6 [Source:HGNC Symbol;Acc:HGNC:5427] | 24705 | 0.000 | 0.2753 | No |
| 61 | IFNA1 | interferon alpha 1 [Source:HGNC Symbol;Acc:HGNC:5417] | 24706 | 0.000 | 0.2753 | No |
| 62 | IFNA2 | interferon alpha 2 [Source:HGNC Symbol;Acc:HGNC:5423] | 24707 | 0.000 | 0.2753 | No |
| 63 | IFNA8 | interferon alpha 8 [Source:HGNC Symbol;Acc:HGNC:5429] | 24709 | 0.000 | 0.2753 | No |
| 64 | IFNB1 | interferon beta 1 [Source:HGNC Symbol;Acc:HGNC:5434] | 24739 | 0.000 | 0.2745 | No |
| 65 | XAF1 | XIAP associated factor 1 [Source:HGNC Symbol;Acc:HGNC:30932] | 27252 | 0.000 | 0.2066 | No |
| 66 | JAK1 | Janus kinase 1 [Source:HGNC Symbol;Acc:HGNC:6190] | 27544 | -0.012 | 0.1989 | No |
| 67 | HLA-H | major histocompatibility complex, class I, H (pseudogene) [Source:HGNC Symbol;Acc:HGNC:4965] | 28231 | -0.099 | 0.1816 | No |
| 68 | IRF3 | interferon regulatory factor 3 [Source:HGNC Symbol;Acc:HGNC:6118] | 30349 | -0.357 | 0.1286 | No |
| 69 | TYK2 | tyrosine kinase 2 [Source:HGNC Symbol;Acc:HGNC:12440] | 30959 | -0.447 | 0.1174 | No |
| 70 | PTPN6 | protein tyrosine phosphatase non-receptor type 6 [Source:HGNC Symbol;Acc:HGNC:9658] | 31042 | -0.459 | 0.1207 | No |
| 71 | IRF1 | interferon regulatory factor 1 [Source:HGNC Symbol;Acc:HGNC:6116] | 31490 | -0.528 | 0.1148 | No |
| 72 | IRF2 | interferon regulatory factor 2 [Source:HGNC Symbol;Acc:HGNC:6117] | 34229 | -1.191 | 0.0550 | No |
| 73 | RNASEL | ribonuclease L [Source:HGNC Symbol;Acc:HGNC:10050] | 35641 | -1.881 | 0.0391 | No |
