Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.greenbergcls.cls #WT_GAQ_versus_WT_NA.greenbergcls.cls #WT_GAQ_versus_WT_NA_repos |
| Phenotype | greenbergcls.cls#WT_GAQ_versus_WT_NA_repos |
| Upregulated in class | WT_NA |
| GeneSet | WP_RETINOBLASTOMA_GENE_IN_CANCER |
| Enrichment Score (ES) | -0.784189 |
| Normalized Enrichment Score (NES) | -1.6635373 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0049057403 |
| FWER p-Value | 0.075 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | MYC | MYC proto-oncogene, bHLH transcription factor [Source:HGNC Symbol;Acc:HGNC:7553] | 94 | 3.654 | 0.0231 | No |
| 2 | PRMT2 | protein arginine methyltransferase 2 [Source:HGNC Symbol;Acc:HGNC:5186] | 1461 | 1.121 | -0.0060 | No |
| 3 | MDM2 | MDM2 proto-oncogene [Source:HGNC Symbol;Acc:HGNC:6973] | 1584 | 1.075 | -0.0018 | No |
| 4 | CDC25A | cell division cycle 25A [Source:HGNC Symbol;Acc:HGNC:1725] | 1852 | 0.965 | -0.0022 | No |
| 5 | E2F3 | E2F transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:3115] | 1909 | 0.940 | 0.0028 | No |
| 6 | CDK6 | cyclin dependent kinase 6 [Source:HGNC Symbol;Acc:HGNC:1777] | 2157 | 0.833 | 0.0020 | No |
| 7 | HDAC1 | histone deacetylase 1 [Source:HGNC Symbol;Acc:HGNC:4852] | 2536 | 0.714 | -0.0032 | No |
| 8 | ZNF655 | zinc finger protein 655 [Source:HGNC Symbol;Acc:HGNC:30899] | 3493 | 0.482 | -0.0257 | No |
| 9 | RABIF | RAB interacting factor [Source:HGNC Symbol;Acc:HGNC:9797] | 3653 | 0.450 | -0.0268 | No |
| 10 | ORC1 | origin recognition complex subunit 1 [Source:HGNC Symbol;Acc:HGNC:8487] | 5294 | 0.186 | -0.0698 | No |
| 11 | DCK | deoxycytidine kinase [Source:HGNC Symbol;Acc:HGNC:2704] | 5414 | 0.167 | -0.0719 | No |
| 12 | CDK1 | cyclin dependent kinase 1 [Source:HGNC Symbol;Acc:HGNC:1722] | 6135 | 0.073 | -0.0908 | No |
| 13 | CDKN1A | cyclin dependent kinase inhibitor 1A [Source:HGNC Symbol;Acc:HGNC:1784] | 12854 | 0.000 | -0.2724 | No |
| 14 | MIR3917 | microRNA 3917 [Source:HGNC Symbol;Acc:HGNC:38911] | 20799 | 0.000 | -0.4871 | No |
| 15 | RBBP7 | RB binding protein 7, chromatin remodeling factor [Source:HGNC Symbol;Acc:HGNC:9890] | 28837 | -0.169 | -0.7031 | No |
| 16 | TP53 | tumor protein p53 [Source:HGNC Symbol;Acc:HGNC:11998] | 29665 | -0.274 | -0.7235 | No |
| 17 | SAP30 | Sin3A associated protein 30 [Source:HGNC Symbol;Acc:HGNC:10532] | 29770 | -0.284 | -0.7243 | No |
| 18 | RAF1 | Raf-1 proto-oncogene, serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:9829] | 29978 | -0.310 | -0.7278 | No |
| 19 | DHFR | dihydrofolate reductase [Source:HGNC Symbol;Acc:HGNC:2861] | 30127 | -0.328 | -0.7295 | No |
| 20 | PLK4 | polo like kinase 4 [Source:HGNC Symbol;Acc:HGNC:11397] | 32153 | -0.642 | -0.7797 | Yes |
| 21 | CCNB1 | cyclin B1 [Source:HGNC Symbol;Acc:HGNC:1579] | 32260 | -0.666 | -0.7779 | Yes |
| 22 | CCND1 | cyclin D1 [Source:HGNC Symbol;Acc:HGNC:1582] | 32413 | -0.702 | -0.7771 | Yes |
| 23 | HMGB2 | high mobility group box 2 [Source:HGNC Symbol;Acc:HGNC:5000] | 32479 | -0.717 | -0.7738 | Yes |
| 24 | FANCG | FA complementation group G [Source:HGNC Symbol;Acc:HGNC:3588] | 32511 | -0.724 | -0.7696 | Yes |
| 25 | RBP1 | retinol binding protein 1 [Source:HGNC Symbol;Acc:HGNC:9919] | 32852 | -0.805 | -0.7731 | Yes |
| 26 | CDC7 | cell division cycle 7 [Source:HGNC Symbol;Acc:HGNC:1745] | 33160 | -0.882 | -0.7753 | Yes |
| 27 | HMGB1 | high mobility group box 1 [Source:HGNC Symbol;Acc:HGNC:4983] | 33164 | -0.884 | -0.7691 | Yes |
| 28 | TYMS | thymidylate synthetase [Source:HGNC Symbol;Acc:HGNC:12441] | 33395 | -0.948 | -0.7687 | Yes |
| 29 | TFDP1 | transcription factor Dp-1 [Source:HGNC Symbol;Acc:HGNC:11749] | 33452 | -0.960 | -0.7635 | Yes |
| 30 | SKP2 | S-phase kinase associated protein 2 [Source:HGNC Symbol;Acc:HGNC:10901] | 33584 | -0.997 | -0.7601 | Yes |
| 31 | RBBP4 | RB binding protein 4, chromatin remodeling factor [Source:HGNC Symbol;Acc:HGNC:9887] | 33638 | -1.014 | -0.7544 | Yes |
| 32 | PCNA | proliferating cell nuclear antigen [Source:HGNC Symbol;Acc:HGNC:8729] | 34110 | -1.145 | -0.7591 | Yes |
| 33 | CDT1 | chromatin licensing and DNA replication factor 1 [Source:HGNC Symbol;Acc:HGNC:24576] | 34120 | -1.149 | -0.7513 | Yes |
| 34 | H2AZ1 | H2A.Z variant histone 1 [Source:HGNC Symbol;Acc:HGNC:4741] | 34211 | -1.183 | -0.7454 | Yes |
| 35 | CDC45 | cell division cycle 45 [Source:HGNC Symbol;Acc:HGNC:1739] | 34224 | -1.190 | -0.7374 | Yes |
| 36 | FAF1 | Fas associated factor 1 [Source:HGNC Symbol;Acc:HGNC:3578] | 34514 | -1.299 | -0.7361 | Yes |
| 37 | BARD1 | BRCA1 associated RING domain 1 [Source:HGNC Symbol;Acc:HGNC:952] | 34661 | -1.354 | -0.7306 | Yes |
| 38 | MCM3 | minichromosome maintenance complex component 3 [Source:HGNC Symbol;Acc:HGNC:6945] | 34716 | -1.383 | -0.7224 | Yes |
| 39 | POLD3 | DNA polymerase delta 3, accessory subunit [Source:HGNC Symbol;Acc:HGNC:20932] | 34734 | -1.392 | -0.7131 | Yes |
| 40 | CDK4 | cyclin dependent kinase 4 [Source:HGNC Symbol;Acc:HGNC:1773] | 34787 | -1.412 | -0.7046 | Yes |
| 41 | SMC1A | structural maintenance of chromosomes 1A [Source:HGNC Symbol;Acc:HGNC:11111] | 34805 | -1.420 | -0.6951 | Yes |
| 42 | RFC3 | replication factor C subunit 3 [Source:HGNC Symbol;Acc:HGNC:9971] | 34852 | -1.446 | -0.6862 | Yes |
| 43 | CCND3 | cyclin D3 [Source:HGNC Symbol;Acc:HGNC:1585] | 34930 | -1.484 | -0.6779 | Yes |
| 44 | CCDC6 | coiled-coil domain containing 6 [Source:HGNC Symbol;Acc:HGNC:18782] | 34957 | -1.494 | -0.6681 | Yes |
| 45 | CCNE1 | cyclin E1 [Source:HGNC Symbol;Acc:HGNC:1589] | 34998 | -1.516 | -0.6586 | Yes |
| 46 | PRKDC | protein kinase, DNA-activated, catalytic subunit [Source:HGNC Symbol;Acc:HGNC:9413] | 35043 | -1.541 | -0.6490 | Yes |
| 47 | SMC2 | structural maintenance of chromosomes 2 [Source:HGNC Symbol;Acc:HGNC:14011] | 35127 | -1.583 | -0.6401 | Yes |
| 48 | CHEK1 | checkpoint kinase 1 [Source:HGNC Symbol;Acc:HGNC:1925] | 35131 | -1.586 | -0.6291 | Yes |
| 49 | NPAT | nuclear protein, coactivator of histone transcription [Source:HGNC Symbol;Acc:HGNC:7896] | 35243 | -1.647 | -0.6206 | Yes |
| 50 | SUV39H1 | suppressor of variegation 3-9 homolog 1 [Source:HGNC Symbol;Acc:HGNC:11479] | 35288 | -1.670 | -0.6101 | Yes |
| 51 | MAPK13 | mitogen-activated protein kinase 13 [Source:HGNC Symbol;Acc:HGNC:6875] | 35304 | -1.677 | -0.5987 | Yes |
| 52 | RPA3 | replication protein A3 [Source:HGNC Symbol;Acc:HGNC:10291] | 35321 | -1.686 | -0.5874 | Yes |
| 53 | KIF4A | kinesin family member 4A [Source:HGNC Symbol;Acc:HGNC:13339] | 35419 | -1.743 | -0.5778 | Yes |
| 54 | RFC5 | replication factor C subunit 5 [Source:HGNC Symbol;Acc:HGNC:9973] | 35533 | -1.810 | -0.5681 | Yes |
| 55 | RPA2 | replication protein A2 [Source:HGNC Symbol;Acc:HGNC:10290] | 35535 | -1.811 | -0.5555 | Yes |
| 56 | TOP2A | DNA topoisomerase II alpha [Source:HGNC Symbol;Acc:HGNC:11989] | 35626 | -1.864 | -0.5449 | Yes |
| 57 | CDK2 | cyclin dependent kinase 2 [Source:HGNC Symbol;Acc:HGNC:1771] | 35643 | -1.882 | -0.5321 | Yes |
| 58 | MCM4 | minichromosome maintenance complex component 4 [Source:HGNC Symbol;Acc:HGNC:6947] | 35681 | -1.914 | -0.5197 | Yes |
| 59 | SMC3 | structural maintenance of chromosomes 3 [Source:HGNC Symbol;Acc:HGNC:2468] | 35717 | -1.937 | -0.5071 | Yes |
| 60 | SIN3A | SIN3 transcription regulator family member A [Source:HGNC Symbol;Acc:HGNC:19353] | 35744 | -1.959 | -0.4941 | Yes |
| 61 | CCNB2 | cyclin B2 [Source:HGNC Symbol;Acc:HGNC:1580] | 35787 | -1.989 | -0.4813 | Yes |
| 62 | ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:76] | 35838 | -2.027 | -0.4684 | Yes |
| 63 | RFC4 | replication factor C subunit 4 [Source:HGNC Symbol;Acc:HGNC:9972] | 35922 | -2.100 | -0.4559 | Yes |
| 64 | PRIM1 | DNA primase subunit 1 [Source:HGNC Symbol;Acc:HGNC:9369] | 35994 | -2.147 | -0.4428 | Yes |
| 65 | RRM1 | ribonucleotide reductase catalytic subunit M1 [Source:HGNC Symbol;Acc:HGNC:10451] | 35995 | -2.149 | -0.4278 | Yes |
| 66 | POLE2 | DNA polymerase epsilon 2, accessory subunit [Source:HGNC Symbol;Acc:HGNC:9178] | 35999 | -2.149 | -0.4128 | Yes |
| 67 | TTK | TTK protein kinase [Source:HGNC Symbol;Acc:HGNC:12401] | 36013 | -2.163 | -0.3980 | Yes |
| 68 | SMARCA2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 [Source:HGNC Symbol;Acc:HGNC:11098] | 36042 | -2.187 | -0.3834 | Yes |
| 69 | ANLN | anillin actin binding protein [Source:HGNC Symbol;Acc:HGNC:14082] | 36068 | -2.206 | -0.3687 | Yes |
| 70 | CCNA2 | cyclin A2 [Source:HGNC Symbol;Acc:HGNC:1578] | 36192 | -2.319 | -0.3557 | Yes |
| 71 | CDKN1B | cyclin dependent kinase inhibitor 1B [Source:HGNC Symbol;Acc:HGNC:1785] | 36244 | -2.370 | -0.3405 | Yes |
| 72 | POLA1 | DNA polymerase alpha 1, catalytic subunit [Source:HGNC Symbol;Acc:HGNC:9173] | 36270 | -2.402 | -0.3244 | Yes |
| 73 | STMN1 | stathmin 1 [Source:HGNC Symbol;Acc:HGNC:6510] | 36274 | -2.405 | -0.3076 | Yes |
| 74 | POLE | DNA polymerase epsilon, catalytic subunit [Source:HGNC Symbol;Acc:HGNC:9177] | 36417 | -2.569 | -0.2934 | Yes |
| 75 | RPA1 | replication protein A1 [Source:HGNC Symbol;Acc:HGNC:10289] | 36551 | -2.763 | -0.2777 | Yes |
| 76 | HLTF | helicase like transcription factor [Source:HGNC Symbol;Acc:HGNC:11099] | 36562 | -2.773 | -0.2585 | Yes |
| 77 | CDC25B | cell division cycle 25B [Source:HGNC Symbol;Acc:HGNC:1726] | 36589 | -2.814 | -0.2395 | Yes |
| 78 | MCM7 | minichromosome maintenance complex component 7 [Source:HGNC Symbol;Acc:HGNC:6950] | 36636 | -2.885 | -0.2206 | Yes |
| 79 | RRM2 | ribonucleotide reductase regulatory subunit M2 [Source:HGNC Symbol;Acc:HGNC:10452] | 36676 | -2.954 | -0.2009 | Yes |
| 80 | DNMT1 | DNA methyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:2976] | 36698 | -2.991 | -0.1805 | Yes |
| 81 | E2F1 | E2F transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:3113] | 36728 | -3.048 | -0.1600 | Yes |
| 82 | MSH6 | mutS homolog 6 [Source:HGNC Symbol;Acc:HGNC:7329] | 36764 | -3.125 | -0.1390 | Yes |
| 83 | WEE1 | WEE1 G2 checkpoint kinase [Source:HGNC Symbol;Acc:HGNC:12761] | 36855 | -3.309 | -0.1183 | Yes |
| 84 | MCM6 | minichromosome maintenance complex component 6 [Source:HGNC Symbol;Acc:HGNC:6949] | 36860 | -3.318 | -0.0951 | Yes |
| 85 | E2F2 | E2F transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:3114] | 36862 | -3.322 | -0.0719 | Yes |
| 86 | TFDP2 | transcription factor Dp-2 [Source:HGNC Symbol;Acc:HGNC:11751] | 36874 | -3.364 | -0.0486 | Yes |
| 87 | RB1 | RB transcriptional corepressor 1 [Source:HGNC Symbol;Acc:HGNC:9884] | 36995 | -3.849 | -0.0249 | Yes |
| 88 | CCNE2 | cyclin E2 [Source:HGNC Symbol;Acc:HGNC:1590] | 37009 | -3.919 | 0.0022 | Yes |
