Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.greenbergcls.cls #WT_GAQ_versus_WT_NA.greenbergcls.cls #WT_GAQ_versus_WT_NA_repos |
| Phenotype | greenbergcls.cls#WT_GAQ_versus_WT_NA_repos |
| Upregulated in class | WT_NA |
| GeneSet | GOBP_CELL_CYCLE_DNA_REPLICATION |
| Enrichment Score (ES) | -0.7874614 |
| Normalized Enrichment Score (NES) | -1.5892134 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0861278 |
| FWER p-Value | 0.815 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | POLE4 | DNA polymerase epsilon 4, accessory subunit [Source:HGNC Symbol;Acc:HGNC:18755] | 507 | 2.081 | 0.0068 | No |
| 2 | BCL6 | BCL6 transcription repressor [Source:HGNC Symbol;Acc:HGNC:1001] | 1162 | 1.317 | 0.0021 | No |
| 3 | INO80 | INO80 complex ATPase subunit [Source:HGNC Symbol;Acc:HGNC:26956] | 1531 | 1.094 | 0.0030 | No |
| 4 | ZPR1 | ZPR1 zinc finger [Source:HGNC Symbol;Acc:HGNC:13051] | 1946 | 0.918 | 0.0008 | No |
| 5 | ZMPSTE24 | zinc metallopeptidase STE24 [Source:HGNC Symbol;Acc:HGNC:12877] | 2493 | 0.726 | -0.0068 | No |
| 6 | ZNF830 | zinc finger protein 830 [Source:HGNC Symbol;Acc:HGNC:28291] | 2524 | 0.717 | -0.0005 | No |
| 7 | SENP2 | SUMO specific peptidase 2 [Source:HGNC Symbol;Acc:HGNC:23116] | 2773 | 0.645 | -0.0008 | No |
| 8 | WIZ | WIZ zinc finger [Source:HGNC Symbol;Acc:HGNC:30917] | 2898 | 0.614 | 0.0018 | No |
| 9 | RTF2 | replication termination factor 2 [Source:HGNC Symbol;Acc:HGNC:15890] | 3295 | 0.524 | -0.0037 | No |
| 10 | MCMDC2 | minichromosome maintenance domain containing 2 [Source:HGNC Symbol;Acc:HGNC:26368] | 3491 | 0.483 | -0.0042 | No |
| 11 | UPF1 | UPF1 RNA helicase and ATPase [Source:HGNC Symbol;Acc:HGNC:9962] | 3860 | 0.414 | -0.0101 | No |
| 12 | POLD4 | DNA polymerase delta 4, accessory subunit [Source:HGNC Symbol;Acc:HGNC:14106] | 4652 | 0.288 | -0.0286 | No |
| 13 | DONSON | DNA replication fork stabilization factor DONSON [Source:HGNC Symbol;Acc:HGNC:2993] | 6492 | 0.030 | -0.0780 | No |
| 14 | DBF4B | DBF4 zinc finger B [Source:HGNC Symbol;Acc:HGNC:17883] | 13714 | 0.000 | -0.2730 | No |
| 15 | NUGGC | nuclear GTPase, germinal center associated [Source:HGNC Symbol;Acc:HGNC:33550] | 25379 | 0.000 | -0.5880 | No |
| 16 | ORC3 | origin recognition complex subunit 3 [Source:HGNC Symbol;Acc:HGNC:8489] | 28869 | -0.174 | -0.6805 | No |
| 17 | AICDA | activation induced cytidine deaminase [Source:HGNC Symbol;Acc:HGNC:13203] | 29973 | -0.309 | -0.7072 | No |
| 18 | POLE3 | DNA polymerase epsilon 3, accessory subunit [Source:HGNC Symbol;Acc:HGNC:13546] | 30647 | -0.399 | -0.7215 | No |
| 19 | POLA2 | DNA polymerase alpha 2, accessory subunit [Source:HGNC Symbol;Acc:HGNC:30073] | 31413 | -0.515 | -0.7371 | No |
| 20 | TERF2 | telomeric repeat binding factor 2 [Source:HGNC Symbol;Acc:HGNC:11729] | 32041 | -0.623 | -0.7479 | No |
| 21 | FEN1 | flap structure-specific endonuclease 1 [Source:HGNC Symbol;Acc:HGNC:3650] | 32680 | -0.764 | -0.7576 | No |
| 22 | CDC7 | cell division cycle 7 [Source:HGNC Symbol;Acc:HGNC:1745] | 33160 | -0.882 | -0.7618 | No |
| 23 | PCNA | proliferating cell nuclear antigen [Source:HGNC Symbol;Acc:HGNC:8729] | 34110 | -1.145 | -0.7762 | Yes |
| 24 | CDT1 | chromatin licensing and DNA replication factor 1 [Source:HGNC Symbol;Acc:HGNC:24576] | 34120 | -1.149 | -0.7651 | Yes |
| 25 | RTEL1 | regulator of telomere elongation helicase 1 [Source:HGNC Symbol;Acc:HGNC:15888] | 34126 | -1.153 | -0.7539 | Yes |
| 26 | TIPIN | TIMELESS interacting protein [Source:HGNC Symbol;Acc:HGNC:30750] | 34183 | -1.174 | -0.7438 | Yes |
| 27 | CDC45 | cell division cycle 45 [Source:HGNC Symbol;Acc:HGNC:1739] | 34224 | -1.190 | -0.7332 | Yes |
| 28 | TERF1 | telomeric repeat binding factor 1 [Source:HGNC Symbol;Acc:HGNC:11728] | 34628 | -1.341 | -0.7308 | Yes |
| 29 | MCM3 | minichromosome maintenance complex component 3 [Source:HGNC Symbol;Acc:HGNC:6945] | 34716 | -1.383 | -0.7196 | Yes |
| 30 | POLD3 | DNA polymerase delta 3, accessory subunit [Source:HGNC Symbol;Acc:HGNC:20932] | 34734 | -1.392 | -0.7063 | Yes |
| 31 | POLD2 | DNA polymerase delta 2, accessory subunit [Source:HGNC Symbol;Acc:HGNC:9176] | 34769 | -1.405 | -0.6934 | Yes |
| 32 | RFC3 | replication factor C subunit 3 [Source:HGNC Symbol;Acc:HGNC:9971] | 34852 | -1.446 | -0.6813 | Yes |
| 33 | DACH1 | dachshund family transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:2663] | 35109 | -1.574 | -0.6727 | Yes |
| 34 | DBF4 | DBF4 zinc finger [Source:HGNC Symbol;Acc:HGNC:17364] | 35128 | -1.584 | -0.6576 | Yes |
| 35 | BRCA2 | BRCA2 DNA repair associated [Source:HGNC Symbol;Acc:HGNC:1101] | 35234 | -1.641 | -0.6443 | Yes |
| 36 | RPA3 | replication protein A3 [Source:HGNC Symbol;Acc:HGNC:10291] | 35321 | -1.686 | -0.6300 | Yes |
| 37 | RAD51 | RAD51 recombinase [Source:HGNC Symbol;Acc:HGNC:9817] | 35435 | -1.752 | -0.6158 | Yes |
| 38 | ATRX | ATRX chromatin remodeler [Source:HGNC Symbol;Acc:HGNC:886] | 35516 | -1.800 | -0.6002 | Yes |
| 39 | RFC5 | replication factor C subunit 5 [Source:HGNC Symbol;Acc:HGNC:9973] | 35533 | -1.810 | -0.5828 | Yes |
| 40 | RPA2 | replication protein A2 [Source:HGNC Symbol;Acc:HGNC:10290] | 35535 | -1.811 | -0.5650 | Yes |
| 41 | GINS1 | GINS complex subunit 1 [Source:HGNC Symbol;Acc:HGNC:28980] | 35614 | -1.860 | -0.5487 | Yes |
| 42 | MCM4 | minichromosome maintenance complex component 4 [Source:HGNC Symbol;Acc:HGNC:6947] | 35681 | -1.914 | -0.5317 | Yes |
| 43 | PRIM2 | DNA primase subunit 2 [Source:HGNC Symbol;Acc:HGNC:9370] | 35686 | -1.917 | -0.5129 | Yes |
| 44 | MCM5 | minichromosome maintenance complex component 5 [Source:HGNC Symbol;Acc:HGNC:6948] | 35722 | -1.939 | -0.4947 | Yes |
| 45 | RFC1 | replication factor C subunit 1 [Source:HGNC Symbol;Acc:HGNC:9969] | 35764 | -1.973 | -0.4764 | Yes |
| 46 | RFC4 | replication factor C subunit 4 [Source:HGNC Symbol;Acc:HGNC:9972] | 35922 | -2.100 | -0.4599 | Yes |
| 47 | DNA2 | DNA replication helicase/nuclease 2 [Source:HGNC Symbol;Acc:HGNC:2939] | 35993 | -2.147 | -0.4407 | Yes |
| 48 | PRIM1 | DNA primase subunit 1 [Source:HGNC Symbol;Acc:HGNC:9369] | 35994 | -2.147 | -0.4195 | Yes |
| 49 | POLE2 | DNA polymerase epsilon 2, accessory subunit [Source:HGNC Symbol;Acc:HGNC:9178] | 35999 | -2.149 | -0.3984 | Yes |
| 50 | FBXO5 | F-box protein 5 [Source:HGNC Symbol;Acc:HGNC:13584] | 36028 | -2.174 | -0.3778 | Yes |
| 51 | MCM2 | minichromosome maintenance complex component 2 [Source:HGNC Symbol;Acc:HGNC:6944] | 36041 | -2.186 | -0.3565 | Yes |
| 52 | POLA1 | DNA polymerase alpha 1, catalytic subunit [Source:HGNC Symbol;Acc:HGNC:9173] | 36270 | -2.402 | -0.3390 | Yes |
| 53 | POLE | DNA polymerase epsilon, catalytic subunit [Source:HGNC Symbol;Acc:HGNC:9177] | 36417 | -2.569 | -0.3177 | Yes |
| 54 | POLD1 | DNA polymerase delta 1, catalytic subunit [Source:HGNC Symbol;Acc:HGNC:9175] | 36434 | -2.597 | -0.2925 | Yes |
| 55 | RFC2 | replication factor C subunit 2 [Source:HGNC Symbol;Acc:HGNC:9970] | 36539 | -2.738 | -0.2683 | Yes |
| 56 | RPA1 | replication protein A1 [Source:HGNC Symbol;Acc:HGNC:10289] | 36551 | -2.763 | -0.2414 | Yes |
| 57 | MCM7 | minichromosome maintenance complex component 7 [Source:HGNC Symbol;Acc:HGNC:6950] | 36636 | -2.885 | -0.2152 | Yes |
| 58 | CHEK2 | checkpoint kinase 2 [Source:HGNC Symbol;Acc:HGNC:16627] | 36675 | -2.952 | -0.1872 | Yes |
| 59 | E2F7 | E2F transcription factor 7 [Source:HGNC Symbol;Acc:HGNC:23820] | 36800 | -3.180 | -0.1592 | Yes |
| 60 | E2F8 | E2F transcription factor 8 [Source:HGNC Symbol;Acc:HGNC:24727] | 36808 | -3.196 | -0.1279 | Yes |
| 61 | LIG1 | DNA ligase 1 [Source:HGNC Symbol;Acc:HGNC:6598] | 36816 | -3.214 | -0.0964 | Yes |
| 62 | MCM6 | minichromosome maintenance complex component 6 [Source:HGNC Symbol;Acc:HGNC:6949] | 36860 | -3.318 | -0.0649 | Yes |
| 63 | GINS3 | GINS complex subunit 3 [Source:HGNC Symbol;Acc:HGNC:25851] | 36906 | -3.514 | -0.0314 | Yes |
| 64 | GMNN | geminin DNA replication inhibitor [Source:HGNC Symbol;Acc:HGNC:17493] | 36962 | -3.693 | 0.0035 | Yes |
