Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.greenbergcls.cls #WT_GAQ_versus_WT_NA.greenbergcls.cls #WT_GAQ_versus_WT_NA_repos |
| Phenotype | greenbergcls.cls#WT_GAQ_versus_WT_NA_repos |
| Upregulated in class | WT_NA |
| GeneSet | GOCC_LYSOSOMAL_LUMEN |
| Enrichment Score (ES) | -0.76773894 |
| Normalized Enrichment Score (NES) | -1.6128383 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.065301344 |
| FWER p-Value | 0.542 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | PLD3 | phospholipase D family member 3 [Source:HGNC Symbol;Acc:HGNC:17158] | 706 | 1.749 | 0.0003 | No |
| 2 | HSP90AA1 | heat shock protein 90 alpha family class A member 1 [Source:HGNC Symbol;Acc:HGNC:5253] | 1654 | 1.047 | -0.0136 | No |
| 3 | CTSV | cathepsin V [Source:HGNC Symbol;Acc:HGNC:2538] | 1655 | 1.046 | -0.0020 | No |
| 4 | AGRN | agrin [Source:HGNC Symbol;Acc:HGNC:329] | 3176 | 0.550 | -0.0370 | No |
| 5 | SDC4 | syndecan 4 [Source:HGNC Symbol;Acc:HGNC:10661] | 3692 | 0.443 | -0.0460 | No |
| 6 | SDC2 | syndecan 2 [Source:HGNC Symbol;Acc:HGNC:10659] | 4649 | 0.288 | -0.0686 | No |
| 7 | CSPG5 | chondroitin sulfate proteoglycan 5 [Source:HGNC Symbol;Acc:HGNC:2467] | 5072 | 0.220 | -0.0776 | No |
| 8 | BGN | biglycan [Source:HGNC Symbol;Acc:HGNC:1044] | 5319 | 0.183 | -0.0822 | No |
| 9 | CTSD | cathepsin D [Source:HGNC Symbol;Acc:HGNC:2529] | 5479 | 0.158 | -0.0847 | No |
| 10 | CUBN | cubilin [Source:HGNC Symbol;Acc:HGNC:2548] | 5555 | 0.147 | -0.0851 | No |
| 11 | HSPG2 | heparan sulfate proteoglycan 2 [Source:HGNC Symbol;Acc:HGNC:5273] | 5614 | 0.139 | -0.0852 | No |
| 12 | GPC1 | glypican 1 [Source:HGNC Symbol;Acc:HGNC:4449] | 5618 | 0.138 | -0.0837 | No |
| 13 | ACP2 | acid phosphatase 2, lysosomal [Source:HGNC Symbol;Acc:HGNC:123] | 6129 | 0.074 | -0.0967 | No |
| 14 | NPC2 | NPC intracellular cholesterol transporter 2 [Source:HGNC Symbol;Acc:HGNC:14537] | 6592 | 0.016 | -0.1090 | No |
| 15 | EPDR1 | ependymin related 1 [Source:HGNC Symbol;Acc:HGNC:17572] | 6911 | 0.000 | -0.1176 | No |
| 16 | RNASET2 | ribonuclease T2 [Source:HGNC Symbol;Acc:HGNC:21686] | 7127 | 0.000 | -0.1234 | No |
| 17 | APOB | apolipoprotein B [Source:HGNC Symbol;Acc:HGNC:603] | 7201 | 0.000 | -0.1254 | No |
| 18 | NEU4 | neuraminidase 4 [Source:HGNC Symbol;Acc:HGNC:21328] | 10175 | 0.000 | -0.2057 | No |
| 19 | IFI30 | IFI30 lysosomal thiol reductase [Source:HGNC Symbol;Acc:HGNC:5398] | 11754 | 0.000 | -0.2484 | No |
| 20 | CBLIF | cobalamin binding intrinsic factor [Source:HGNC Symbol;Acc:HGNC:4268] | 13621 | 0.000 | -0.2988 | No |
| 21 | BCAN | brevican [Source:HGNC Symbol;Acc:HGNC:23059] | 15884 | 0.000 | -0.3600 | No |
| 22 | DCN | decorin [Source:HGNC Symbol;Acc:HGNC:2705] | 16129 | 0.000 | -0.3666 | No |
| 23 | GC | GC vitamin D binding protein [Source:HGNC Symbol;Acc:HGNC:4187] | 16273 | 0.000 | -0.3704 | No |
| 24 | KERA | keratocan [Source:HGNC Symbol;Acc:HGNC:6309] | 18466 | 0.000 | -0.4297 | No |
| 25 | LUM | lumican [Source:HGNC Symbol;Acc:HGNC:6724] | 18761 | 0.000 | -0.4376 | No |
| 26 | OMD | osteomodulin [Source:HGNC Symbol;Acc:HGNC:8134] | 19714 | 0.000 | -0.4633 | No |
| 27 | FASLG | Fas ligand [Source:HGNC Symbol;Acc:HGNC:11936] | 20227 | 0.000 | -0.4772 | No |
| 28 | NCAN | neurocan [Source:HGNC Symbol;Acc:HGNC:2465] | 22777 | 0.000 | -0.5461 | No |
| 29 | SERPINB13 | serpin family B member 13 [Source:HGNC Symbol;Acc:HGNC:8944] | 22803 | 0.000 | -0.5468 | No |
| 30 | CD1E | CD1e molecule [Source:HGNC Symbol;Acc:HGNC:1638] | 22972 | 0.000 | -0.5513 | No |
| 31 | GPC3 | glypican 3 [Source:HGNC Symbol;Acc:HGNC:4451] | 23062 | 0.000 | -0.5537 | No |
| 32 | GPC2 | glypican 2 [Source:HGNC Symbol;Acc:HGNC:4450] | 23064 | 0.000 | -0.5537 | No |
| 33 | GPC5 | glypican 5 [Source:HGNC Symbol;Acc:HGNC:4453] | 23066 | 0.000 | -0.5538 | No |
| 34 | GPC4 | glypican 4 [Source:HGNC Symbol;Acc:HGNC:4452] | 23068 | 0.000 | -0.5538 | No |
| 35 | GPC6 | glypican 6 [Source:HGNC Symbol;Acc:HGNC:4454] | 23070 | 0.000 | -0.5538 | No |
| 36 | PRELP | proline and arginine rich end leucine rich repeat protein [Source:HGNC Symbol;Acc:HGNC:9357] | 23998 | 0.000 | -0.5789 | No |
| 37 | SPACA7 | sperm acrosome associated 7 [Source:HGNC Symbol;Acc:HGNC:29575] | 24206 | 0.000 | -0.5845 | No |
| 38 | CTSL | cathepsin L [Source:HGNC Symbol;Acc:HGNC:2537] | 25069 | 0.000 | -0.6078 | No |
| 39 | FMOD | fibromodulin [Source:HGNC Symbol;Acc:HGNC:3774] | 27150 | 0.000 | -0.6640 | No |
| 40 | ACAN | aggrecan [Source:HGNC Symbol;Acc:HGNC:319] | 27887 | -0.058 | -0.6832 | No |
| 41 | CSPG4 | chondroitin sulfate proteoglycan 4 [Source:HGNC Symbol;Acc:HGNC:2466] | 28502 | -0.130 | -0.6984 | No |
| 42 | CTSK | cathepsin K [Source:HGNC Symbol;Acc:HGNC:2536] | 28699 | -0.150 | -0.7020 | No |
| 43 | GUSB | glucuronidase beta [Source:HGNC Symbol;Acc:HGNC:4696] | 29751 | -0.282 | -0.7273 | No |
| 44 | CHID1 | chitinase domain containing 1 [Source:HGNC Symbol;Acc:HGNC:28474] | 30056 | -0.319 | -0.7320 | No |
| 45 | OGN | osteoglycin [Source:HGNC Symbol;Acc:HGNC:8126] | 30342 | -0.356 | -0.7357 | No |
| 46 | LAMP2 | lysosomal associated membrane protein 2 [Source:HGNC Symbol;Acc:HGNC:6501] | 30745 | -0.414 | -0.7420 | No |
| 47 | VCAN | versican [Source:HGNC Symbol;Acc:HGNC:2464] | 30920 | -0.440 | -0.7418 | No |
| 48 | TXNDC5 | thioredoxin domain containing 5 [Source:HGNC Symbol;Acc:HGNC:21073] | 30944 | -0.444 | -0.7375 | No |
| 49 | HSPA8 | heat shock protein family A (Hsp70) member 8 [Source:HGNC Symbol;Acc:HGNC:5241] | 31308 | -0.501 | -0.7418 | No |
| 50 | GBA | glucosylceramidase beta [Source:HGNC Symbol;Acc:HGNC:4177] | 31459 | -0.523 | -0.7400 | No |
| 51 | PLBD2 | phospholipase B domain containing 2 [Source:HGNC Symbol;Acc:HGNC:27283] | 32486 | -0.719 | -0.7598 | Yes |
| 52 | SDC1 | syndecan 1 [Source:HGNC Symbol;Acc:HGNC:10658] | 32707 | -0.771 | -0.7571 | Yes |
| 53 | HPSE | heparanase [Source:HGNC Symbol;Acc:HGNC:5164] | 32717 | -0.774 | -0.7488 | Yes |
| 54 | PPT2 | palmitoyl-protein thioesterase 2 [Source:HGNC Symbol;Acc:HGNC:9326] | 33051 | -0.855 | -0.7483 | Yes |
| 55 | CTSB | cathepsin B [Source:HGNC Symbol;Acc:HGNC:2527] | 33055 | -0.856 | -0.7389 | Yes |
| 56 | SMPD1 | sphingomyelin phosphodiesterase 1 [Source:HGNC Symbol;Acc:HGNC:11120] | 33084 | -0.862 | -0.7301 | Yes |
| 57 | CTSS | cathepsin S [Source:HGNC Symbol;Acc:HGNC:2545] | 33106 | -0.868 | -0.7210 | Yes |
| 58 | LIPA | lipase A, lysosomal acid type [Source:HGNC Symbol;Acc:HGNC:6617] | 33606 | -1.003 | -0.7233 | Yes |
| 59 | NEU1 | neuraminidase 1 [Source:HGNC Symbol;Acc:HGNC:7758] | 33668 | -1.023 | -0.7136 | Yes |
| 60 | TCN2 | transcobalamin 2 [Source:HGNC Symbol;Acc:HGNC:11653] | 33684 | -1.029 | -0.7026 | Yes |
| 61 | GNS | glucosamine (N-acetyl)-6-sulfatase [Source:HGNC Symbol;Acc:HGNC:4422] | 34346 | -1.233 | -0.7068 | Yes |
| 62 | IDS | iduronate 2-sulfatase [Source:HGNC Symbol;Acc:HGNC:5389] | 34486 | -1.288 | -0.6962 | Yes |
| 63 | ASAH1 | N-acylsphingosine amidohydrolase 1 [Source:HGNC Symbol;Acc:HGNC:735] | 34516 | -1.299 | -0.6826 | Yes |
| 64 | CD74 | CD74 molecule [Source:HGNC Symbol;Acc:HGNC:1697] | 34633 | -1.342 | -0.6708 | Yes |
| 65 | SCARB2 | scavenger receptor class B member 2 [Source:HGNC Symbol;Acc:HGNC:1665] | 34662 | -1.355 | -0.6565 | Yes |
| 66 | GLA | galactosidase alpha [Source:HGNC Symbol;Acc:HGNC:4296] | 34678 | -1.362 | -0.6418 | Yes |
| 67 | MAN2B2 | mannosidase alpha class 2B member 2 [Source:HGNC Symbol;Acc:HGNC:29623] | 34802 | -1.419 | -0.6294 | Yes |
| 68 | GALC | galactosylceramidase [Source:HGNC Symbol;Acc:HGNC:4115] | 34899 | -1.470 | -0.6157 | Yes |
| 69 | PDGFRB | platelet derived growth factor receptor beta [Source:HGNC Symbol;Acc:HGNC:8804] | 34952 | -1.492 | -0.6005 | Yes |
| 70 | GAA | glucosidase alpha, acid [Source:HGNC Symbol;Acc:HGNC:4065] | 34981 | -1.503 | -0.5846 | Yes |
| 71 | PPT1 | palmitoyl-protein thioesterase 1 [Source:HGNC Symbol;Acc:HGNC:9325] | 35004 | -1.518 | -0.5683 | Yes |
| 72 | MANBA | mannosidase beta [Source:HGNC Symbol;Acc:HGNC:6831] | 35209 | -1.631 | -0.5557 | Yes |
| 73 | ARSA | arylsulfatase A [Source:HGNC Symbol;Acc:HGNC:713] | 35413 | -1.740 | -0.5419 | Yes |
| 74 | FUCA1 | alpha-L-fucosidase 1 [Source:HGNC Symbol;Acc:HGNC:4006] | 35481 | -1.780 | -0.5239 | Yes |
| 75 | GALNS | galactosamine (N-acetyl)-6-sulfatase [Source:HGNC Symbol;Acc:HGNC:4122] | 35536 | -1.812 | -0.5053 | Yes |
| 76 | CTSA | cathepsin A [Source:HGNC Symbol;Acc:HGNC:9251] | 35590 | -1.840 | -0.4863 | Yes |
| 77 | IDUA | alpha-L-iduronidase [Source:HGNC Symbol;Acc:HGNC:5391] | 35620 | -1.863 | -0.4664 | Yes |
| 78 | GLB1 | galactosidase beta 1 [Source:HGNC Symbol;Acc:HGNC:4298] | 35873 | -2.057 | -0.4503 | Yes |
| 79 | GYG1 | glycogenin 1 [Source:HGNC Symbol;Acc:HGNC:4699] | 35935 | -2.113 | -0.4285 | Yes |
| 80 | LGMN | legumain [Source:HGNC Symbol;Acc:HGNC:9472] | 35984 | -2.141 | -0.4060 | Yes |
| 81 | TPP1 | tripeptidyl peptidase 1 [Source:HGNC Symbol;Acc:HGNC:2073] | 36053 | -2.193 | -0.3835 | Yes |
| 82 | HEXA | hexosaminidase subunit alpha [Source:HGNC Symbol;Acc:HGNC:4878] | 36142 | -2.275 | -0.3607 | Yes |
| 83 | MAN2B1 | mannosidase alpha class 2B member 1 [Source:HGNC Symbol;Acc:HGNC:6826] | 36235 | -2.354 | -0.3370 | Yes |
| 84 | ARSB | arylsulfatase B [Source:HGNC Symbol;Acc:HGNC:714] | 36268 | -2.400 | -0.3112 | Yes |
| 85 | NAGLU | N-acetyl-alpha-glucosaminidase [Source:HGNC Symbol;Acc:HGNC:7632] | 36310 | -2.433 | -0.2853 | Yes |
| 86 | SDC3 | syndecan 3 [Source:HGNC Symbol;Acc:HGNC:10660] | 36359 | -2.495 | -0.2589 | Yes |
| 87 | PSAP | prosaposin [Source:HGNC Symbol;Acc:HGNC:9498] | 36560 | -2.772 | -0.2335 | Yes |
| 88 | HEXB | hexosaminidase subunit beta [Source:HGNC Symbol;Acc:HGNC:4879] | 36563 | -2.774 | -0.2028 | Yes |
| 89 | GM2A | GM2 ganglioside activator [Source:HGNC Symbol;Acc:HGNC:4367] | 36593 | -2.819 | -0.1723 | Yes |
| 90 | CTSF | cathepsin F [Source:HGNC Symbol;Acc:HGNC:2531] | 36646 | -2.895 | -0.1415 | Yes |
| 91 | HYAL1 | hyaluronidase 1 [Source:HGNC Symbol;Acc:HGNC:5320] | 36684 | -2.964 | -0.1096 | Yes |
| 92 | ATP13A2 | ATPase cation transporting 13A2 [Source:HGNC Symbol;Acc:HGNC:30213] | 36872 | -3.361 | -0.0774 | Yes |
| 93 | NAAA | N-acylethanolamine acid amidase [Source:HGNC Symbol;Acc:HGNC:736] | 36946 | -3.635 | -0.0390 | Yes |
| 94 | SGSH | N-sulfoglucosamine sulfohydrolase [Source:HGNC Symbol;Acc:HGNC:10818] | 36997 | -3.859 | 0.0025 | Yes |
