Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.greenbergcls.cls #WT_GAQ_versus_WT_NA.greenbergcls.cls #WT_GAQ_versus_WT_NA_repos |
| Phenotype | greenbergcls.cls#WT_GAQ_versus_WT_NA_repos |
| Upregulated in class | WT_NA |
| GeneSet | RB_DN.V1_UP |
| Enrichment Score (ES) | -0.6791659 |
| Normalized Enrichment Score (NES) | -1.451028 |
| Nominal p-value | 0.0034207525 |
| FDR q-value | 0.062046602 |
| FWER p-Value | 0.265 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | ID1 | inhibitor of DNA binding 1, HLH protein [Source:HGNC Symbol;Acc:HGNC:5360] | 14 | 4.746 | 0.0313 | No |
| 2 | MYC | MYC proto-oncogene, bHLH transcription factor [Source:HGNC Symbol;Acc:HGNC:7553] | 94 | 3.654 | 0.0535 | No |
| 3 | GCLM | glutamate-cysteine ligase modifier subunit [Source:HGNC Symbol;Acc:HGNC:4312] | 577 | 1.967 | 0.0536 | No |
| 4 | IER2 | immediate early response 2 [Source:HGNC Symbol;Acc:HGNC:28871] | 587 | 1.948 | 0.0663 | No |
| 5 | ST3GAL4 | ST3 beta-galactoside alpha-2,3-sialyltransferase 4 [Source:HGNC Symbol;Acc:HGNC:10864] | 594 | 1.922 | 0.0789 | No |
| 6 | SLC7A7 | solute carrier family 7 member 7 [Source:HGNC Symbol;Acc:HGNC:11065] | 616 | 1.894 | 0.0910 | No |
| 7 | BTG2 | BTG anti-proliferation factor 2 [Source:HGNC Symbol;Acc:HGNC:1131] | 777 | 1.647 | 0.0977 | No |
| 8 | PLA2G6 | phospholipase A2 group VI [Source:HGNC Symbol;Acc:HGNC:9039] | 818 | 1.610 | 0.1073 | No |
| 9 | PRKAB1 | protein kinase AMP-activated non-catalytic subunit beta 1 [Source:HGNC Symbol;Acc:HGNC:9378] | 1285 | 1.225 | 0.1029 | No |
| 10 | MDM2 | MDM2 proto-oncogene [Source:HGNC Symbol;Acc:HGNC:6973] | 1584 | 1.075 | 0.1020 | No |
| 11 | PRKCE | protein kinase C epsilon [Source:HGNC Symbol;Acc:HGNC:9401] | 2545 | 0.711 | 0.0808 | No |
| 12 | TGM1 | transglutaminase 1 [Source:HGNC Symbol;Acc:HGNC:11777] | 2896 | 0.614 | 0.0754 | No |
| 13 | NUDT5 | nudix hydrolase 5 [Source:HGNC Symbol;Acc:HGNC:8052] | 3508 | 0.479 | 0.0621 | No |
| 14 | FBP1 | fructose-bisphosphatase 1 [Source:HGNC Symbol;Acc:HGNC:3606] | 4098 | 0.375 | 0.0486 | No |
| 15 | POLD4 | DNA polymerase delta 4, accessory subunit [Source:HGNC Symbol;Acc:HGNC:14106] | 4652 | 0.288 | 0.0356 | No |
| 16 | ZSCAN22 | zinc finger and SCAN domain containing 22 [Source:HGNC Symbol;Acc:HGNC:4929] | 5051 | 0.223 | 0.0263 | No |
| 17 | ADGRE1 | adhesion G protein-coupled receptor E1 [Source:HGNC Symbol;Acc:HGNC:3336] | 5083 | 0.219 | 0.0269 | No |
| 18 | GRM8 | glutamate metabotropic receptor 8 [Source:HGNC Symbol;Acc:HGNC:4600] | 5550 | 0.147 | 0.0153 | No |
| 19 | NXT1 | nuclear transport factor 2 like export factor 1 [Source:HGNC Symbol;Acc:HGNC:15913] | 5781 | 0.117 | 0.0099 | No |
| 20 | PALMD | palmdelphin [Source:HGNC Symbol;Acc:HGNC:15846] | 6093 | 0.077 | 0.0020 | No |
| 21 | FXYD6 | FXYD domain containing ion transport regulator 6 [Source:HGNC Symbol;Acc:HGNC:4030] | 7021 | 0.000 | -0.0231 | No |
| 22 | HES1 | hes family bHLH transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:5192] | 7559 | 0.000 | -0.0376 | No |
| 23 | ARTN | artemin [Source:HGNC Symbol;Acc:HGNC:727] | 7834 | 0.000 | -0.0450 | No |
| 24 | TNFSF9 | TNF superfamily member 9 [Source:HGNC Symbol;Acc:HGNC:11939] | 9175 | 0.000 | -0.0813 | No |
| 25 | TNFRSF18 | TNF receptor superfamily member 18 [Source:HGNC Symbol;Acc:HGNC:11914] | 9557 | 0.000 | -0.0916 | No |
| 26 | GRB7 | growth factor receptor bound protein 7 [Source:HGNC Symbol;Acc:HGNC:4567] | 10172 | 0.000 | -0.1082 | No |
| 27 | PKHD1 | PKHD1 ciliary IPT domain containing fibrocystin/polyductin [Source:HGNC Symbol;Acc:HGNC:9016] | 10174 | 0.000 | -0.1082 | No |
| 28 | OVOL2 | ovo like zinc finger 2 [Source:HGNC Symbol;Acc:HGNC:15804] | 11002 | 0.000 | -0.1306 | No |
| 29 | LYNX1 | Ly6/neurotoxin 1 [Source:HGNC Symbol;Acc:HGNC:29604] | 11789 | 0.000 | -0.1518 | No |
| 30 | IL36RN | interleukin 36 receptor antagonist [Source:HGNC Symbol;Acc:HGNC:15561] | 12769 | 0.000 | -0.1783 | No |
| 31 | DDIT4L | DNA damage inducible transcript 4 like [Source:HGNC Symbol;Acc:HGNC:30555] | 13623 | 0.000 | -0.2014 | No |
| 32 | MANSC1 | MANSC domain containing 1 [Source:HGNC Symbol;Acc:HGNC:25505] | 14093 | 0.000 | -0.2141 | No |
| 33 | PCDH10 | protocadherin 10 [Source:HGNC Symbol;Acc:HGNC:13404] | 14782 | 0.000 | -0.2327 | No |
| 34 | NOXO1 | NADPH oxidase organizer 1 [Source:HGNC Symbol;Acc:HGNC:19404] | 15543 | 0.000 | -0.2532 | No |
| 35 | DCT | dopachrome tautomerase [Source:HGNC Symbol;Acc:HGNC:2709] | 16132 | 0.000 | -0.2691 | No |
| 36 | SPOCK1 | SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1 [Source:HGNC Symbol;Acc:HGNC:11251] | 17115 | 0.000 | -0.2957 | No |
| 37 | SMARCA1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 [Source:HGNC Symbol;Acc:HGNC:11097] | 19723 | 0.000 | -0.3662 | No |
| 38 | TMEM54 | transmembrane protein 54 [Source:HGNC Symbol;Acc:HGNC:24143] | 20199 | 0.000 | -0.3791 | No |
| 39 | TYRP1 | tyrosinase related protein 1 [Source:HGNC Symbol;Acc:HGNC:12450] | 21876 | 0.000 | -0.4244 | No |
| 40 | SFRP1 | secreted frizzled related protein 1 [Source:HGNC Symbol;Acc:HGNC:10776] | 23634 | 0.000 | -0.4719 | No |
| 41 | SNAP25 | synaptosome associated protein 25 [Source:HGNC Symbol;Acc:HGNC:11132] | 24173 | 0.000 | -0.4865 | No |
| 42 | DUOXA1 | dual oxidase maturation factor 1 [Source:HGNC Symbol;Acc:HGNC:26507] | 25924 | 0.000 | -0.5338 | No |
| 43 | ALPK3 | alpha kinase 3 [Source:HGNC Symbol;Acc:HGNC:17574] | 27618 | -0.023 | -0.5794 | No |
| 44 | SLC24A1 | solute carrier family 24 member 1 [Source:HGNC Symbol;Acc:HGNC:10975] | 27950 | -0.063 | -0.5880 | No |
| 45 | HEY2 | hes related family bHLH transcription factor with YRPW motif 2 [Source:HGNC Symbol;Acc:HGNC:4881] | 28082 | -0.077 | -0.5910 | No |
| 46 | GNB1L | G protein subunit beta 1 like [Source:HGNC Symbol;Acc:HGNC:4397] | 28312 | -0.109 | -0.5965 | No |
| 47 | CRIP2 | cysteine rich protein 2 [Source:HGNC Symbol;Acc:HGNC:2361] | 29486 | -0.249 | -0.6265 | No |
| 48 | PLEKHA6 | pleckstrin homology domain containing A6 [Source:HGNC Symbol;Acc:HGNC:17053] | 30250 | -0.344 | -0.6449 | No |
| 49 | MRPL49 | mitochondrial ribosomal protein L49 [Source:HGNC Symbol;Acc:HGNC:1176] | 30263 | -0.346 | -0.6429 | No |
| 50 | SLBP | stem-loop binding protein [Source:HGNC Symbol;Acc:HGNC:10904] | 30480 | -0.375 | -0.6462 | No |
| 51 | MAN1B1 | mannosidase alpha class 1B member 1 [Source:HGNC Symbol;Acc:HGNC:6823] | 30898 | -0.436 | -0.6546 | No |
| 52 | IFT27 | intraflagellar transport 27 [Source:HGNC Symbol;Acc:HGNC:18626] | 31232 | -0.489 | -0.6603 | No |
| 53 | EI24 | EI24 autophagy associated transmembrane protein [Source:HGNC Symbol;Acc:HGNC:13276] | 31249 | -0.492 | -0.6575 | No |
| 54 | ZW10 | zw10 kinetochore protein [Source:HGNC Symbol;Acc:HGNC:13194] | 31664 | -0.558 | -0.6650 | No |
| 55 | DNAJC9 | DnaJ heat shock protein family (Hsp40) member C9 [Source:HGNC Symbol;Acc:HGNC:19123] | 31752 | -0.570 | -0.6635 | No |
| 56 | GAB3 | GRB2 associated binding protein 3 [Source:HGNC Symbol;Acc:HGNC:17515] | 31843 | -0.583 | -0.6621 | No |
| 57 | BAZ1B | bromodomain adjacent to zinc finger domain 1B [Source:HGNC Symbol;Acc:HGNC:961] | 31858 | -0.586 | -0.6585 | No |
| 58 | UCK1 | uridine-cytidine kinase 1 [Source:HGNC Symbol;Acc:HGNC:14859] | 32015 | -0.617 | -0.6586 | No |
| 59 | SULF2 | sulfatase 2 [Source:HGNC Symbol;Acc:HGNC:20392] | 32289 | -0.674 | -0.6615 | No |
| 60 | AHCY | adenosylhomocysteinase [Source:HGNC Symbol;Acc:HGNC:343] | 32318 | -0.681 | -0.6578 | No |
| 61 | SIVA1 | SIVA1 apoptosis inducing factor [Source:HGNC Symbol;Acc:HGNC:17712] | 32902 | -0.817 | -0.6681 | No |
| 62 | PCBP2 | poly(rC) binding protein 2 [Source:HGNC Symbol;Acc:HGNC:8648] | 33313 | -0.927 | -0.6730 | Yes |
| 63 | SLC2A9 | solute carrier family 2 member 9 [Source:HGNC Symbol;Acc:HGNC:13446] | 33322 | -0.930 | -0.6670 | Yes |
| 64 | ACOX3 | acyl-CoA oxidase 3, pristanoyl [Source:HGNC Symbol;Acc:HGNC:121] | 33522 | -0.979 | -0.6659 | Yes |
| 65 | NANS | N-acetylneuraminate synthase [Source:HGNC Symbol;Acc:HGNC:19237] | 33525 | -0.980 | -0.6594 | Yes |
| 66 | AAAS | aladin WD repeat nucleoporin [Source:HGNC Symbol;Acc:HGNC:13666] | 33996 | -1.115 | -0.6647 | Yes |
| 67 | CTDSP1 | CTD small phosphatase 1 [Source:HGNC Symbol;Acc:HGNC:21614] | 34043 | -1.128 | -0.6584 | Yes |
| 68 | HAT1 | histone acetyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:4821] | 34075 | -1.137 | -0.6516 | Yes |
| 69 | PCNA | proliferating cell nuclear antigen [Source:HGNC Symbol;Acc:HGNC:8729] | 34110 | -1.145 | -0.6449 | Yes |
| 70 | TIPIN | TIMELESS interacting protein [Source:HGNC Symbol;Acc:HGNC:30750] | 34183 | -1.174 | -0.6390 | Yes |
| 71 | TIMELESS | timeless circadian regulator [Source:HGNC Symbol;Acc:HGNC:11813] | 34204 | -1.180 | -0.6317 | Yes |
| 72 | ZFP30 | ZFP30 zinc finger protein [Source:HGNC Symbol;Acc:HGNC:29555] | 34342 | -1.230 | -0.6272 | Yes |
| 73 | TKFC | triokinase and FMN cyclase [Source:HGNC Symbol;Acc:HGNC:24552] | 34425 | -1.261 | -0.6210 | Yes |
| 74 | LCMT1 | leucine carboxyl methyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:17557] | 34522 | -1.302 | -0.6150 | Yes |
| 75 | STUB1 | STIP1 homology and U-box containing protein 1 [Source:HGNC Symbol;Acc:HGNC:11427] | 34603 | -1.332 | -0.6082 | Yes |
| 76 | MRPL45 | mitochondrial ribosomal protein L45 [Source:HGNC Symbol;Acc:HGNC:16651] | 34721 | -1.384 | -0.6022 | Yes |
| 77 | MMGT1 | membrane magnesium transporter 1 [Source:HGNC Symbol;Acc:HGNC:28100] | 34759 | -1.402 | -0.5938 | Yes |
| 78 | RFC3 | replication factor C subunit 3 [Source:HGNC Symbol;Acc:HGNC:9971] | 34852 | -1.446 | -0.5867 | Yes |
| 79 | CCNE1 | cyclin E1 [Source:HGNC Symbol;Acc:HGNC:1589] | 34998 | -1.516 | -0.5805 | Yes |
| 80 | PMS2 | PMS1 homolog 2, mismatch repair system component [Source:HGNC Symbol;Acc:HGNC:9122] | 35203 | -1.626 | -0.5752 | Yes |
| 81 | ADA | adenosine deaminase [Source:HGNC Symbol;Acc:HGNC:186] | 35282 | -1.667 | -0.5662 | Yes |
| 82 | MAPK13 | mitogen-activated protein kinase 13 [Source:HGNC Symbol;Acc:HGNC:6875] | 35304 | -1.677 | -0.5556 | Yes |
| 83 | PLXNB2 | plexin B2 [Source:HGNC Symbol;Acc:HGNC:9104] | 35313 | -1.681 | -0.5446 | Yes |
| 84 | TUBG1 | tubulin gamma 1 [Source:HGNC Symbol;Acc:HGNC:12417] | 35422 | -1.744 | -0.5359 | Yes |
| 85 | NUMBL | NUMB like endocytic adaptor protein [Source:HGNC Symbol;Acc:HGNC:8061] | 35479 | -1.780 | -0.5255 | Yes |
| 86 | PEX11B | peroxisomal biogenesis factor 11 beta [Source:HGNC Symbol;Acc:HGNC:8853] | 35613 | -1.860 | -0.5167 | Yes |
| 87 | MRE11 | MRE11 homolog, double strand break repair nuclease [Source:HGNC Symbol;Acc:HGNC:7230] | 35640 | -1.881 | -0.5049 | Yes |
| 88 | PPM1M | protein phosphatase, Mg2+/Mn2+ dependent 1M [Source:HGNC Symbol;Acc:HGNC:26506] | 35958 | -2.123 | -0.4993 | Yes |
| 89 | DNA2 | DNA replication helicase/nuclease 2 [Source:HGNC Symbol;Acc:HGNC:2939] | 35993 | -2.147 | -0.4859 | Yes |
| 90 | PRIM1 | DNA primase subunit 1 [Source:HGNC Symbol;Acc:HGNC:9369] | 35994 | -2.147 | -0.4716 | Yes |
| 91 | POLE2 | DNA polymerase epsilon 2, accessory subunit [Source:HGNC Symbol;Acc:HGNC:9178] | 35999 | -2.149 | -0.4574 | Yes |
| 92 | UBE2T | ubiquitin conjugating enzyme E2 T [Source:HGNC Symbol;Acc:HGNC:25009] | 36026 | -2.171 | -0.4436 | Yes |
| 93 | PDXP | pyridoxal phosphatase [Source:HGNC Symbol;Acc:HGNC:30259] | 36030 | -2.176 | -0.4292 | Yes |
| 94 | GANC | glucosidase alpha, neutral C [Source:HGNC Symbol;Acc:HGNC:4139] | 36054 | -2.194 | -0.4152 | Yes |
| 95 | RAD51C | RAD51 paralog C [Source:HGNC Symbol;Acc:HGNC:9820] | 36081 | -2.221 | -0.4011 | Yes |
| 96 | SPICE1 | spindle and centriole associated protein 1 [Source:HGNC Symbol;Acc:HGNC:25083] | 36161 | -2.294 | -0.3879 | Yes |
| 97 | TPRA1 | transmembrane protein adipocyte associated 1 [Source:HGNC Symbol;Acc:HGNC:30413] | 36185 | -2.315 | -0.3731 | Yes |
| 98 | VPS16 | VPS16 core subunit of CORVET and HOPS complexes [Source:HGNC Symbol;Acc:HGNC:14584] | 36212 | -2.335 | -0.3582 | Yes |
| 99 | SLC35B2 | solute carrier family 35 member B2 [Source:HGNC Symbol;Acc:HGNC:16872] | 36247 | -2.372 | -0.3433 | Yes |
| 100 | STMN1 | stathmin 1 [Source:HGNC Symbol;Acc:HGNC:6510] | 36274 | -2.405 | -0.3280 | Yes |
| 101 | NME4 | NME/NM23 nucleoside diphosphate kinase 4 [Source:HGNC Symbol;Acc:HGNC:7852] | 36293 | -2.422 | -0.3124 | Yes |
| 102 | DCXR | dicarbonyl and L-xylulose reductase [Source:HGNC Symbol;Acc:HGNC:18985] | 36372 | -2.507 | -0.2978 | Yes |
| 103 | DNASE1L1 | deoxyribonuclease 1 like 1 [Source:HGNC Symbol;Acc:HGNC:2957] | 36378 | -2.514 | -0.2811 | Yes |
| 104 | BBC3 | BCL2 binding component 3 [Source:HGNC Symbol;Acc:HGNC:17868] | 36385 | -2.525 | -0.2645 | Yes |
| 105 | RAD54L | RAD54 like [Source:HGNC Symbol;Acc:HGNC:9826] | 36522 | -2.718 | -0.2500 | Yes |
| 106 | RPA1 | replication protein A1 [Source:HGNC Symbol;Acc:HGNC:10289] | 36551 | -2.763 | -0.2324 | Yes |
| 107 | MCM7 | minichromosome maintenance complex component 7 [Source:HGNC Symbol;Acc:HGNC:6950] | 36636 | -2.885 | -0.2154 | Yes |
| 108 | THRA | thyroid hormone receptor alpha [Source:HGNC Symbol;Acc:HGNC:11796] | 36657 | -2.922 | -0.1965 | Yes |
| 109 | RRM2 | ribonucleotide reductase regulatory subunit M2 [Source:HGNC Symbol;Acc:HGNC:10452] | 36676 | -2.954 | -0.1773 | Yes |
| 110 | DNMT1 | DNA methyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:2976] | 36698 | -2.991 | -0.1579 | Yes |
| 111 | MSH6 | mutS homolog 6 [Source:HGNC Symbol;Acc:HGNC:7329] | 36764 | -3.125 | -0.1388 | Yes |
| 112 | MCM6 | minichromosome maintenance complex component 6 [Source:HGNC Symbol;Acc:HGNC:6949] | 36860 | -3.318 | -0.1193 | Yes |
| 113 | CLN6 | CLN6 transmembrane ER protein [Source:HGNC Symbol;Acc:HGNC:2077] | 36868 | -3.343 | -0.0972 | Yes |
| 114 | PMM1 | phosphomannomutase 1 [Source:HGNC Symbol;Acc:HGNC:9114] | 36917 | -3.549 | -0.0748 | Yes |
| 115 | EPHX1 | epoxide hydrolase 1 [Source:HGNC Symbol;Acc:HGNC:3401] | 36949 | -3.651 | -0.0513 | Yes |
| 116 | CCNE2 | cyclin E2 [Source:HGNC Symbol;Acc:HGNC:1590] | 37009 | -3.919 | -0.0268 | Yes |
| 117 | SLC2A8 | solute carrier family 2 member 8 [Source:HGNC Symbol;Acc:HGNC:13812] | 37069 | -4.345 | 0.0006 | Yes |
