Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.greenbergcls.cls #WT_GAQ_versus_WT_NA.greenbergcls.cls #WT_GAQ_versus_WT_NA_repos |
| Phenotype | greenbergcls.cls#WT_GAQ_versus_WT_NA_repos |
| Upregulated in class | WT_NA |
| GeneSet | HALLMARK_BILE_ACID_METABOLISM |
| Enrichment Score (ES) | -0.6333769 |
| Normalized Enrichment Score (NES) | -1.3697743 |
| Nominal p-value | 0.0194508 |
| FDR q-value | 0.1187458 |
| FWER p-Value | 0.409 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | ATXN1 | ataxin 1 [Source:HGNC Symbol;Acc:HGNC:10548] | 121 | 3.447 | 0.0255 | No |
| 2 | TFCP2L1 | transcription factor CP2 like 1 [Source:HGNC Symbol;Acc:HGNC:17925] | 123 | 3.431 | 0.0542 | No |
| 3 | ABCA1 | ATP binding cassette subfamily A member 1 [Source:HGNC Symbol;Acc:HGNC:29] | 179 | 3.138 | 0.0789 | No |
| 4 | HAO1 | hydroxyacid oxidase 1 [Source:HGNC Symbol;Acc:HGNC:4809] | 362 | 2.443 | 0.0944 | No |
| 5 | AQP9 | aquaporin 9 [Source:HGNC Symbol;Acc:HGNC:643] | 438 | 2.255 | 0.1113 | No |
| 6 | GCLM | glutamate-cysteine ligase modifier subunit [Source:HGNC Symbol;Acc:HGNC:4312] | 577 | 1.967 | 0.1240 | No |
| 7 | LCK | LCK proto-oncogene, Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:6524] | 778 | 1.647 | 0.1323 | No |
| 8 | PRDX5 | peroxiredoxin 5 [Source:HGNC Symbol;Acc:HGNC:9355] | 829 | 1.590 | 0.1443 | No |
| 9 | BCAR3 | BCAR3 adaptor protein, NSP family member [Source:HGNC Symbol;Acc:HGNC:973] | 1355 | 1.176 | 0.1399 | No |
| 10 | PEX12 | peroxisomal biogenesis factor 12 [Source:HGNC Symbol;Acc:HGNC:8854] | 1603 | 1.067 | 0.1422 | No |
| 11 | CH25H | cholesterol 25-hydroxylase [Source:HGNC Symbol;Acc:HGNC:1907] | 2778 | 0.644 | 0.1158 | No |
| 12 | LIPE | lipase E, hormone sensitive type [Source:HGNC Symbol;Acc:HGNC:6621] | 3213 | 0.541 | 0.1086 | No |
| 13 | PEX19 | peroxisomal biogenesis factor 19 [Source:HGNC Symbol;Acc:HGNC:9713] | 4804 | 0.263 | 0.0678 | No |
| 14 | SOAT2 | sterol O-acyltransferase 2 [Source:HGNC Symbol;Acc:HGNC:11178] | 4925 | 0.243 | 0.0666 | No |
| 15 | ALDH1A1 | aldehyde dehydrogenase 1 family member A1 [Source:HGNC Symbol;Acc:HGNC:402] | 5113 | 0.214 | 0.0633 | No |
| 16 | PEX11A | peroxisomal biogenesis factor 11 alpha [Source:HGNC Symbol;Acc:HGNC:8852] | 5214 | 0.199 | 0.0623 | No |
| 17 | APOA1 | apolipoprotein A1 [Source:HGNC Symbol;Acc:HGNC:600] | 5269 | 0.190 | 0.0624 | No |
| 18 | ALDH8A1 | aldehyde dehydrogenase 8 family member A1 [Source:HGNC Symbol;Acc:HGNC:15471] | 5731 | 0.124 | 0.0510 | No |
| 19 | PIPOX | pipecolic acid and sarcosine oxidase [Source:HGNC Symbol;Acc:HGNC:17804] | 6006 | 0.087 | 0.0443 | No |
| 20 | IDI1 | isopentenyl-diphosphate delta isomerase 1 [Source:HGNC Symbol;Acc:HGNC:5387] | 6112 | 0.076 | 0.0421 | No |
| 21 | EPHX2 | epoxide hydrolase 2 [Source:HGNC Symbol;Acc:HGNC:3402] | 8285 | 0.000 | -0.0167 | No |
| 22 | GSTK1 | glutathione S-transferase kappa 1 [Source:HGNC Symbol;Acc:HGNC:16906] | 9966 | 0.000 | -0.0621 | No |
| 23 | SLC23A1 | solute carrier family 23 member 1 [Source:HGNC Symbol;Acc:HGNC:10974] | 10152 | 0.000 | -0.0671 | No |
| 24 | NEDD4 | NEDD4 E3 ubiquitin protein ligase [Source:HGNC Symbol;Acc:HGNC:7727] | 10759 | 0.000 | -0.0835 | No |
| 25 | SLC27A2 | solute carrier family 27 member 2 [Source:HGNC Symbol;Acc:HGNC:10996] | 11191 | 0.000 | -0.0951 | No |
| 26 | AKR1D1 | aldo-keto reductase family 1 member D1 [Source:HGNC Symbol;Acc:HGNC:388] | 11801 | 0.000 | -0.1116 | No |
| 27 | AGXT | alanine--glyoxylate and serine--pyruvate aminotransferase [Source:HGNC Symbol;Acc:HGNC:341] | 12402 | 0.000 | -0.1278 | No |
| 28 | CYP39A1 | cytochrome P450 family 39 subfamily A member 1 [Source:HGNC Symbol;Acc:HGNC:17449] | 12682 | 0.000 | -0.1354 | No |
| 29 | HSD3B1 | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 [Source:HGNC Symbol;Acc:HGNC:5217] | 12816 | 0.000 | -0.1390 | No |
| 30 | TTR | transthyretin [Source:HGNC Symbol;Acc:HGNC:12405] | 12933 | 0.000 | -0.1421 | No |
| 31 | CYP8B1 | cytochrome P450 family 8 subfamily B member 1 [Source:HGNC Symbol;Acc:HGNC:2653] | 15559 | 0.000 | -0.2131 | No |
| 32 | DIO1 | iodothyronine deiodinase 1 [Source:HGNC Symbol;Acc:HGNC:2883] | 15942 | 0.000 | -0.2234 | No |
| 33 | DIO2 | iodothyronine deiodinase 2 [Source:HGNC Symbol;Acc:HGNC:2884] | 15943 | 0.000 | -0.2234 | No |
| 34 | GC | GC vitamin D binding protein [Source:HGNC Symbol;Acc:HGNC:4187] | 16273 | 0.000 | -0.2323 | No |
| 35 | SERPINA6 | serpin family A member 6 [Source:HGNC Symbol;Acc:HGNC:1540] | 17816 | 0.000 | -0.2740 | No |
| 36 | OPTN | optineurin [Source:HGNC Symbol;Acc:HGNC:17142] | 18055 | 0.000 | -0.2805 | No |
| 37 | BMP6 | bone morphogenetic protein 6 [Source:HGNC Symbol;Acc:HGNC:1073] | 19058 | 0.000 | -0.3076 | No |
| 38 | HSD17B6 | hydroxysteroid 17-beta dehydrogenase 6 [Source:HGNC Symbol;Acc:HGNC:23316] | 19742 | 0.000 | -0.3260 | No |
| 39 | NR1H4 | nuclear receptor subfamily 1 group H member 4 [Source:HGNC Symbol;Acc:HGNC:7967] | 19941 | 0.000 | -0.3314 | No |
| 40 | BBOX1 | gamma-butyrobetaine hydroxylase 1 [Source:HGNC Symbol;Acc:HGNC:964] | 20869 | 0.000 | -0.3565 | No |
| 41 | CYP7B1 | cytochrome P450 family 7 subfamily B member 1 [Source:HGNC Symbol;Acc:HGNC:2652] | 21127 | 0.000 | -0.3634 | No |
| 42 | CYP7A1 | cytochrome P450 family 7 subfamily A member 1 [Source:HGNC Symbol;Acc:HGNC:2651] | 21150 | 0.000 | -0.3640 | No |
| 43 | SULT2B1 | sulfotransferase family 2B member 1 [Source:HGNC Symbol;Acc:HGNC:11459] | 23773 | 0.000 | -0.4349 | No |
| 44 | SULT1B1 | sulfotransferase family 1B member 1 [Source:HGNC Symbol;Acc:HGNC:17845] | 24069 | 0.000 | -0.4429 | No |
| 45 | CYP46A1 | cytochrome P450 family 46 subfamily A member 1 [Source:HGNC Symbol;Acc:HGNC:2641] | 25920 | 0.000 | -0.4929 | No |
| 46 | ABCA6 | ATP binding cassette subfamily A member 6 [Source:HGNC Symbol;Acc:HGNC:36] | 26829 | 0.000 | -0.5175 | No |
| 47 | ABCA4 | ATP binding cassette subfamily A member 4 [Source:HGNC Symbol;Acc:HGNC:34] | 26832 | 0.000 | -0.5175 | No |
| 48 | ABCA9 | ATP binding cassette subfamily A member 9 [Source:HGNC Symbol;Acc:HGNC:39] | 26833 | 0.000 | -0.5175 | No |
| 49 | SLCO1A2 | solute carrier organic anion transporter family member 1A2 [Source:HGNC Symbol;Acc:HGNC:10956] | 26881 | 0.000 | -0.5188 | No |
| 50 | ABCG8 | ATP binding cassette subfamily G member 8 [Source:HGNC Symbol;Acc:HGNC:13887] | 27435 | 0.000 | -0.5337 | No |
| 51 | ABCA8 | ATP binding cassette subfamily A member 8 [Source:HGNC Symbol;Acc:HGNC:38] | 27936 | -0.063 | -0.5467 | No |
| 52 | SLC22A18 | solute carrier family 22 member 18 [Source:HGNC Symbol;Acc:HGNC:10964] | 28049 | -0.073 | -0.5492 | No |
| 53 | AR | androgen receptor [Source:HGNC Symbol;Acc:HGNC:644] | 28642 | -0.145 | -0.5640 | No |
| 54 | PEX13 | peroxisomal biogenesis factor 13 [Source:HGNC Symbol;Acc:HGNC:8855] | 28788 | -0.161 | -0.5665 | No |
| 55 | NR1I2 | nuclear receptor subfamily 1 group I member 2 [Source:HGNC Symbol;Acc:HGNC:7968] | 28908 | -0.179 | -0.5683 | No |
| 56 | SOD1 | superoxide dismutase 1 [Source:HGNC Symbol;Acc:HGNC:11179] | 29098 | -0.201 | -0.5717 | No |
| 57 | KLF1 | Kruppel like factor 1 [Source:HGNC Symbol;Acc:HGNC:6345] | 29305 | -0.225 | -0.5754 | No |
| 58 | GNMT | glycine N-methyltransferase [Source:HGNC Symbol;Acc:HGNC:4415] | 29466 | -0.247 | -0.5776 | No |
| 59 | ACSL1 | acyl-CoA synthetase long chain family member 1 [Source:HGNC Symbol;Acc:HGNC:3569] | 29772 | -0.285 | -0.5835 | No |
| 60 | PECR | peroxisomal trans-2-enoyl-CoA reductase [Source:HGNC Symbol;Acc:HGNC:18281] | 29800 | -0.288 | -0.5818 | No |
| 61 | EFHC1 | EF-hand domain containing 1 [Source:HGNC Symbol;Acc:HGNC:16406] | 29936 | -0.304 | -0.5829 | No |
| 62 | SLC27A5 | solute carrier family 27 member 5 [Source:HGNC Symbol;Acc:HGNC:10999] | 30068 | -0.320 | -0.5838 | No |
| 63 | PEX26 | peroxisomal biogenesis factor 26 [Source:HGNC Symbol;Acc:HGNC:22965] | 30609 | -0.393 | -0.5951 | No |
| 64 | PEX6 | peroxisomal biogenesis factor 6 [Source:HGNC Symbol;Acc:HGNC:8859] | 30816 | -0.425 | -0.5971 | No |
| 65 | AMACR | alpha-methylacyl-CoA racemase [Source:HGNC Symbol;Acc:HGNC:451] | 30839 | -0.429 | -0.5942 | No |
| 66 | ISOC1 | isochorismatase domain containing 1 [Source:HGNC Symbol;Acc:HGNC:24254] | 31027 | -0.458 | -0.5954 | No |
| 67 | ACSL5 | acyl-CoA synthetase long chain family member 5 [Source:HGNC Symbol;Acc:HGNC:16526] | 32053 | -0.625 | -0.6179 | No |
| 68 | HSD17B11 | hydroxysteroid 17-beta dehydrogenase 11 [Source:HGNC Symbol;Acc:HGNC:22960] | 32512 | -0.724 | -0.6242 | No |
| 69 | RBP1 | retinol binding protein 1 [Source:HGNC Symbol;Acc:HGNC:9919] | 32852 | -0.805 | -0.6267 | Yes |
| 70 | PEX7 | peroxisomal biogenesis factor 7 [Source:HGNC Symbol;Acc:HGNC:8860] | 32882 | -0.811 | -0.6207 | Yes |
| 71 | RXRA | retinoid X receptor alpha [Source:HGNC Symbol;Acc:HGNC:10477] | 33000 | -0.842 | -0.6168 | Yes |
| 72 | GNPAT | glyceronephosphate O-acyltransferase [Source:HGNC Symbol;Acc:HGNC:4416] | 33016 | -0.845 | -0.6101 | Yes |
| 73 | SLC23A2 | solute carrier family 23 member 2 [Source:HGNC Symbol;Acc:HGNC:10973] | 33089 | -0.864 | -0.6048 | Yes |
| 74 | ABCD3 | ATP binding cassette subfamily D member 3 [Source:HGNC Symbol;Acc:HGNC:67] | 33393 | -0.948 | -0.6051 | Yes |
| 75 | NR0B2 | nuclear receptor subfamily 0 group B member 2 [Source:HGNC Symbol;Acc:HGNC:7961] | 33566 | -0.991 | -0.6015 | Yes |
| 76 | PNPLA8 | patatin like phospholipase domain containing 8 [Source:HGNC Symbol;Acc:HGNC:28900] | 33824 | -1.061 | -0.5996 | Yes |
| 77 | PEX16 | peroxisomal biogenesis factor 16 [Source:HGNC Symbol;Acc:HGNC:8857] | 33991 | -1.113 | -0.5947 | Yes |
| 78 | PHYH | phytanoyl-CoA 2-hydroxylase [Source:HGNC Symbol;Acc:HGNC:8940] | 34062 | -1.133 | -0.5872 | Yes |
| 79 | LONP2 | lon peptidase 2, peroxisomal [Source:HGNC Symbol;Acc:HGNC:20598] | 34093 | -1.143 | -0.5784 | Yes |
| 80 | RXRG | retinoid X receptor gamma [Source:HGNC Symbol;Acc:HGNC:10479] | 34207 | -1.182 | -0.5716 | Yes |
| 81 | PEX11G | peroxisomal biogenesis factor 11 gamma [Source:HGNC Symbol;Acc:HGNC:20208] | 34262 | -1.203 | -0.5630 | Yes |
| 82 | MLYCD | malonyl-CoA decarboxylase [Source:HGNC Symbol;Acc:HGNC:7150] | 34395 | -1.250 | -0.5561 | Yes |
| 83 | NUDT12 | nudix hydrolase 12 [Source:HGNC Symbol;Acc:HGNC:18826] | 34453 | -1.273 | -0.5470 | Yes |
| 84 | NPC1 | NPC intracellular cholesterol transporter 1 [Source:HGNC Symbol;Acc:HGNC:7897] | 34798 | -1.417 | -0.5445 | Yes |
| 85 | HSD17B4 | hydroxysteroid 17-beta dehydrogenase 4 [Source:HGNC Symbol;Acc:HGNC:5213] | 35205 | -1.627 | -0.5419 | Yes |
| 86 | SCP2 | sterol carrier protein 2 [Source:HGNC Symbol;Acc:HGNC:10606] | 35242 | -1.647 | -0.5291 | Yes |
| 87 | CAT | catalase [Source:HGNC Symbol;Acc:HGNC:1516] | 35287 | -1.669 | -0.5163 | Yes |
| 88 | RETSAT | retinol saturase [Source:HGNC Symbol;Acc:HGNC:25991] | 35330 | -1.689 | -0.5033 | Yes |
| 89 | PXMP2 | peroxisomal membrane protein 2 [Source:HGNC Symbol;Acc:HGNC:9716] | 35433 | -1.751 | -0.4914 | Yes |
| 90 | ABCD1 | ATP binding cassette subfamily D member 1 [Source:HGNC Symbol;Acc:HGNC:61] | 35837 | -2.026 | -0.4854 | Yes |
| 91 | NR3C2 | nuclear receptor subfamily 3 group C member 2 [Source:HGNC Symbol;Acc:HGNC:7979] | 35855 | -2.046 | -0.4688 | Yes |
| 92 | ABCA2 | ATP binding cassette subfamily A member 2 [Source:HGNC Symbol;Acc:HGNC:32] | 35882 | -2.064 | -0.4522 | Yes |
| 93 | FDXR | ferredoxin reductase [Source:HGNC Symbol;Acc:HGNC:3642] | 35927 | -2.106 | -0.4358 | Yes |
| 94 | IDH2 | isocitrate dehydrogenase (NADP(+)) 2 [Source:HGNC Symbol;Acc:HGNC:5383] | 35965 | -2.127 | -0.4190 | Yes |
| 95 | ALDH9A1 | aldehyde dehydrogenase 9 family member A1 [Source:HGNC Symbol;Acc:HGNC:412] | 35971 | -2.128 | -0.4014 | Yes |
| 96 | FADS1 | fatty acid desaturase 1 [Source:HGNC Symbol;Acc:HGNC:3574] | 36138 | -2.271 | -0.3869 | Yes |
| 97 | ABCA3 | ATP binding cassette subfamily A member 3 [Source:HGNC Symbol;Acc:HGNC:33] | 36191 | -2.319 | -0.3689 | Yes |
| 98 | SLC35B2 | solute carrier family 35 member B2 [Source:HGNC Symbol;Acc:HGNC:16872] | 36247 | -2.372 | -0.3505 | Yes |
| 99 | ABCG4 | ATP binding cassette subfamily G member 4 [Source:HGNC Symbol;Acc:HGNC:13884] | 36286 | -2.417 | -0.3314 | Yes |
| 100 | ABCA5 | ATP binding cassette subfamily A member 5 [Source:HGNC Symbol;Acc:HGNC:35] | 36289 | -2.418 | -0.3112 | Yes |
| 101 | FADS2 | fatty acid desaturase 2 [Source:HGNC Symbol;Acc:HGNC:3575] | 36326 | -2.453 | -0.2917 | Yes |
| 102 | DHCR24 | 24-dehydrocholesterol reductase [Source:HGNC Symbol;Acc:HGNC:2859] | 36334 | -2.463 | -0.2713 | Yes |
| 103 | PEX1 | peroxisomal biogenesis factor 1 [Source:HGNC Symbol;Acc:HGNC:8850] | 36404 | -2.551 | -0.2518 | Yes |
| 104 | SLC29A1 | solute carrier family 29 member 1 (Augustine blood group) [Source:HGNC Symbol;Acc:HGNC:11003] | 36645 | -2.892 | -0.2341 | Yes |
| 105 | PAOX | polyamine oxidase [Source:HGNC Symbol;Acc:HGNC:20837] | 36704 | -2.999 | -0.2106 | Yes |
| 106 | HSD3B7 | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 [Source:HGNC Symbol;Acc:HGNC:18324] | 36746 | -3.084 | -0.1860 | Yes |
| 107 | CROT | carnitine O-octanoyltransferase [Source:HGNC Symbol;Acc:HGNC:2366] | 36775 | -3.146 | -0.1604 | Yes |
| 108 | CYP27A1 | cytochrome P450 family 27 subfamily A member 1 [Source:HGNC Symbol;Acc:HGNC:2605] | 36916 | -3.545 | -0.1346 | Yes |
| 109 | IDH1 | isocitrate dehydrogenase (NADP(+)) 1 [Source:HGNC Symbol;Acc:HGNC:5382] | 36979 | -3.774 | -0.1047 | Yes |
| 110 | HACL1 | 2-hydroxyacyl-CoA lyase 1 [Source:HGNC Symbol;Acc:HGNC:17856] | 37021 | -3.983 | -0.0725 | Yes |
| 111 | PFKM | phosphofructokinase, muscle [Source:HGNC Symbol;Acc:HGNC:8877] | 37035 | -4.078 | -0.0388 | Yes |
| 112 | ABCD2 | ATP binding cassette subfamily D member 2 [Source:HGNC Symbol;Acc:HGNC:66] | 37086 | -4.814 | 0.0001 | Yes |
