Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.greenbergcls.cls #WT_GAQ_versus_WT_NA.greenbergcls.cls #WT_GAQ_versus_WT_NA_repos |
| Phenotype | greenbergcls.cls#WT_GAQ_versus_WT_NA_repos |
| Upregulated in class | WT_GAQ |
| GeneSet | HALLMARK_COAGULATION |
| Enrichment Score (ES) | 0.4288562 |
| Normalized Enrichment Score (NES) | 1.1326003 |
| Nominal p-value | 0.10714286 |
| FDR q-value | 0.1769323 |
| FWER p-Value | 0.586 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | PDGFB | platelet derived growth factor subunit B [Source:HGNC Symbol;Acc:HGNC:8800] | 34 | 4.388 | 0.0468 | Yes |
| 2 | FURIN | furin, paired basic amino acid cleaving enzyme [Source:HGNC Symbol;Acc:HGNC:8568] | 109 | 3.552 | 0.0834 | Yes |
| 3 | SERPINE1 | serpin family E member 1 [Source:HGNC Symbol;Acc:HGNC:8583] | 149 | 3.274 | 0.1179 | Yes |
| 4 | TIMP1 | TIMP metallopeptidase inhibitor 1 [Source:HGNC Symbol;Acc:HGNC:11820] | 172 | 3.156 | 0.1516 | Yes |
| 5 | PLEK | pleckstrin [Source:HGNC Symbol;Acc:HGNC:9070] | 278 | 2.662 | 0.1777 | Yes |
| 6 | FBN1 | fibrillin 1 [Source:HGNC Symbol;Acc:HGNC:3603] | 422 | 2.289 | 0.1987 | Yes |
| 7 | CFB | complement factor B [Source:HGNC Symbol;Acc:HGNC:1037] | 455 | 2.211 | 0.2219 | Yes |
| 8 | WDR1 | WD repeat domain 1 [Source:HGNC Symbol;Acc:HGNC:12754] | 531 | 2.034 | 0.2420 | Yes |
| 9 | MMP2 | matrix metallopeptidase 2 [Source:HGNC Symbol;Acc:HGNC:7166] | 546 | 2.017 | 0.2635 | Yes |
| 10 | SERPINB2 | serpin family B member 2 [Source:HGNC Symbol;Acc:HGNC:8584] | 580 | 1.960 | 0.2840 | Yes |
| 11 | MMP9 | matrix metallopeptidase 9 [Source:HGNC Symbol;Acc:HGNC:7176] | 657 | 1.811 | 0.3016 | Yes |
| 12 | SERPINC1 | serpin family C member 1 [Source:HGNC Symbol;Acc:HGNC:775] | 689 | 1.775 | 0.3200 | Yes |
| 13 | CD9 | CD9 molecule [Source:HGNC Symbol;Acc:HGNC:1709] | 709 | 1.741 | 0.3384 | Yes |
| 14 | F9 | coagulation factor IX [Source:HGNC Symbol;Acc:HGNC:3551] | 754 | 1.680 | 0.3555 | Yes |
| 15 | MMP14 | matrix metallopeptidase 14 [Source:HGNC Symbol;Acc:HGNC:7160] | 811 | 1.614 | 0.3715 | Yes |
| 16 | CLU | clusterin [Source:HGNC Symbol;Acc:HGNC:2095] | 981 | 1.443 | 0.3827 | Yes |
| 17 | ANXA1 | annexin A1 [Source:HGNC Symbol;Acc:HGNC:533] | 1055 | 1.393 | 0.3958 | Yes |
| 18 | MAFF | MAF bZIP transcription factor F [Source:HGNC Symbol;Acc:HGNC:6780] | 1287 | 1.223 | 0.4029 | Yes |
| 19 | CTSV | cathepsin V [Source:HGNC Symbol;Acc:HGNC:2538] | 1655 | 1.046 | 0.4043 | Yes |
| 20 | FYN | FYN proto-oncogene, Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:4037] | 2147 | 0.836 | 0.4001 | Yes |
| 21 | THBS1 | thrombospondin 1 [Source:HGNC Symbol;Acc:HGNC:11785] | 2607 | 0.693 | 0.3952 | Yes |
| 22 | F10 | coagulation factor X [Source:HGNC Symbol;Acc:HGNC:3528] | 2726 | 0.656 | 0.3992 | Yes |
| 23 | GNG12 | G protein subunit gamma 12 [Source:HGNC Symbol;Acc:HGNC:19663] | 2741 | 0.652 | 0.4059 | Yes |
| 24 | ADAM9 | ADAM metallopeptidase domain 9 [Source:HGNC Symbol;Acc:HGNC:216] | 2971 | 0.596 | 0.4062 | Yes |
| 25 | PREP | prolyl endopeptidase [Source:HGNC Symbol;Acc:HGNC:9358] | 3035 | 0.581 | 0.4108 | Yes |
| 26 | BMP1 | bone morphogenetic protein 1 [Source:HGNC Symbol;Acc:HGNC:1067] | 3126 | 0.563 | 0.4145 | Yes |
| 27 | KLF7 | Kruppel like factor 7 [Source:HGNC Symbol;Acc:HGNC:6350] | 3165 | 0.552 | 0.4194 | Yes |
| 28 | CTSH | cathepsin H [Source:HGNC Symbol;Acc:HGNC:2535] | 3210 | 0.542 | 0.4241 | Yes |
| 29 | KLK8 | kallikrein related peptidase 8 [Source:HGNC Symbol;Acc:HGNC:6369] | 3481 | 0.484 | 0.4221 | Yes |
| 30 | GDA | guanine deaminase [Source:HGNC Symbol;Acc:HGNC:4212] | 3499 | 0.480 | 0.4269 | Yes |
| 31 | RABIF | RAB interacting factor [Source:HGNC Symbol;Acc:HGNC:9797] | 3653 | 0.450 | 0.4276 | Yes |
| 32 | CPN1 | carboxypeptidase N subunit 1 [Source:HGNC Symbol;Acc:HGNC:2312] | 3929 | 0.401 | 0.4245 | Yes |
| 33 | C3 | complement C3 [Source:HGNC Symbol;Acc:HGNC:1318] | 3931 | 0.401 | 0.4289 | Yes |
| 34 | ITIH1 | inter-alpha-trypsin inhibitor heavy chain 1 [Source:HGNC Symbol;Acc:HGNC:6166] | 4269 | 0.344 | 0.4235 | No |
| 35 | GNB2 | G protein subunit beta 2 [Source:HGNC Symbol;Acc:HGNC:4398] | 4399 | 0.323 | 0.4235 | No |
| 36 | FN1 | fibronectin 1 [Source:HGNC Symbol;Acc:HGNC:3778] | 4499 | 0.309 | 0.4242 | No |
| 37 | A2M | alpha-2-macroglobulin [Source:HGNC Symbol;Acc:HGNC:7] | 4651 | 0.288 | 0.4232 | No |
| 38 | F3 | coagulation factor III, tissue factor [Source:HGNC Symbol;Acc:HGNC:3541] | 4844 | 0.255 | 0.4208 | No |
| 39 | FGA | fibrinogen alpha chain [Source:HGNC Symbol;Acc:HGNC:3661] | 4877 | 0.251 | 0.4227 | No |
| 40 | MASP2 | mannan binding lectin serine peptidase 2 [Source:HGNC Symbol;Acc:HGNC:6902] | 4897 | 0.247 | 0.4248 | No |
| 41 | ARF4 | ADP ribosylation factor 4 [Source:HGNC Symbol;Acc:HGNC:655] | 5213 | 0.199 | 0.4185 | No |
| 42 | APOA1 | apolipoprotein A1 [Source:HGNC Symbol;Acc:HGNC:600] | 5269 | 0.190 | 0.4190 | No |
| 43 | ITGB3 | integrin subunit beta 3 [Source:HGNC Symbol;Acc:HGNC:6156] | 5409 | 0.168 | 0.4171 | No |
| 44 | SH2B2 | SH2B adaptor protein 2 [Source:HGNC Symbol;Acc:HGNC:17381] | 5476 | 0.158 | 0.4170 | No |
| 45 | RAC1 | Rac family small GTPase 1 [Source:HGNC Symbol;Acc:HGNC:9801] | 5525 | 0.150 | 0.4174 | No |
| 46 | CPB2 | carboxypeptidase B2 [Source:HGNC Symbol;Acc:HGNC:2300] | 5801 | 0.114 | 0.4112 | No |
| 47 | MMP10 | matrix metallopeptidase 10 [Source:HGNC Symbol;Acc:HGNC:7156] | 5838 | 0.108 | 0.4114 | No |
| 48 | S100A13 | S100 calcium binding protein A13 [Source:HGNC Symbol;Acc:HGNC:10490] | 6441 | 0.034 | 0.3954 | No |
| 49 | RAPGEF3 | Rap guanine nucleotide exchange factor 3 [Source:HGNC Symbol;Acc:HGNC:16629] | 7039 | 0.000 | 0.3793 | No |
| 50 | PLAT | plasminogen activator, tissue type [Source:HGNC Symbol;Acc:HGNC:9051] | 10223 | 0.000 | 0.2932 | No |
| 51 | APOC3 | apolipoprotein C3 [Source:HGNC Symbol;Acc:HGNC:610] | 10444 | 0.000 | 0.2872 | No |
| 52 | APOC2 | apolipoprotein C2 [Source:HGNC Symbol;Acc:HGNC:609] | 10446 | 0.000 | 0.2872 | No |
| 53 | APOC1 | apolipoprotein C1 [Source:HGNC Symbol;Acc:HGNC:607] | 10447 | 0.000 | 0.2872 | No |
| 54 | F13B | coagulation factor XIII B chain [Source:HGNC Symbol;Acc:HGNC:3534] | 11147 | 0.000 | 0.2683 | No |
| 55 | KLKB1 | kallikrein B1 [Source:HGNC Symbol;Acc:HGNC:6371] | 11410 | 0.000 | 0.2612 | No |
| 56 | TMPRSS6 | transmembrane serine protease 6 [Source:HGNC Symbol;Acc:HGNC:16517] | 11798 | 0.000 | 0.2507 | No |
| 57 | PROZ | protein Z, vitamin K dependent plasma glycoprotein [Source:HGNC Symbol;Acc:HGNC:9460] | 11843 | 0.000 | 0.2495 | No |
| 58 | PROC | protein C, inactivator of coagulation factors Va and VIIIa [Source:HGNC Symbol;Acc:HGNC:9451] | 11861 | 0.000 | 0.2491 | No |
| 59 | ACOX2 | acyl-CoA oxidase 2 [Source:HGNC Symbol;Acc:HGNC:120] | 12549 | 0.000 | 0.2305 | No |
| 60 | P2RY1 | purinergic receptor P2Y1 [Source:HGNC Symbol;Acc:HGNC:8539] | 14306 | 0.000 | 0.1829 | No |
| 61 | MBL2 | mannose binding lectin 2 [Source:HGNC Symbol;Acc:HGNC:6922] | 15729 | 0.000 | 0.1445 | No |
| 62 | C8B | complement C8 beta chain [Source:HGNC Symbol;Acc:HGNC:1353] | 15797 | 0.000 | 0.1426 | No |
| 63 | C8A | complement C8 alpha chain [Source:HGNC Symbol;Acc:HGNC:1352] | 15798 | 0.000 | 0.1426 | No |
| 64 | C8G | complement C8 gamma chain [Source:HGNC Symbol;Acc:HGNC:1354] | 15800 | 0.000 | 0.1426 | No |
| 65 | HTRA1 | HtrA serine peptidase 1 [Source:HGNC Symbol;Acc:HGNC:9476] | 15822 | 0.000 | 0.1421 | No |
| 66 | CFD | complement factor D [Source:HGNC Symbol;Acc:HGNC:2771] | 15892 | 0.000 | 0.1402 | No |
| 67 | CFI | complement factor I [Source:HGNC Symbol;Acc:HGNC:5394] | 15893 | 0.000 | 0.1402 | No |
| 68 | DCT | dopachrome tautomerase [Source:HGNC Symbol;Acc:HGNC:2709] | 16132 | 0.000 | 0.1337 | No |
| 69 | C2 | complement C2 [Source:HGNC Symbol;Acc:HGNC:1248] | 16205 | 0.000 | 0.1318 | No |
| 70 | C9 | complement C9 [Source:HGNC Symbol;Acc:HGNC:1358] | 16209 | 0.000 | 0.1317 | No |
| 71 | F2 | coagulation factor II, thrombin [Source:HGNC Symbol;Acc:HGNC:3535] | 16252 | 0.000 | 0.1306 | No |
| 72 | F12 | coagulation factor XII [Source:HGNC Symbol;Acc:HGNC:3530] | 16537 | 0.000 | 0.1229 | No |
| 73 | F11 | coagulation factor XI [Source:HGNC Symbol;Acc:HGNC:3529] | 16538 | 0.000 | 0.1229 | No |
| 74 | FGG | fibrinogen gamma chain [Source:HGNC Symbol;Acc:HGNC:3694] | 16761 | 0.000 | 0.1169 | No |
| 75 | OLR1 | oxidized low density lipoprotein receptor 1 [Source:HGNC Symbol;Acc:HGNC:8133] | 16808 | 0.000 | 0.1156 | No |
| 76 | GP9 | glycoprotein IX platelet [Source:HGNC Symbol;Acc:HGNC:4444] | 17183 | 0.000 | 0.1055 | No |
| 77 | TIMP3 | TIMP metallopeptidase inhibitor 3 [Source:HGNC Symbol;Acc:HGNC:11822] | 17190 | 0.000 | 0.1054 | No |
| 78 | HRG | histidine rich glycoprotein [Source:HGNC Symbol;Acc:HGNC:5181] | 17516 | 0.000 | 0.0966 | No |
| 79 | HNF4A | hepatocyte nuclear factor 4 alpha [Source:HGNC Symbol;Acc:HGNC:5024] | 17689 | 0.000 | 0.0919 | No |
| 80 | SERPING1 | serpin family G member 1 [Source:HGNC Symbol;Acc:HGNC:1228] | 17802 | 0.000 | 0.0889 | No |
| 81 | SERPINA1 | serpin family A member 1 [Source:HGNC Symbol;Acc:HGNC:8941] | 17812 | 0.000 | 0.0886 | No |
| 82 | DPP4 | dipeptidyl peptidase 4 [Source:HGNC Symbol;Acc:HGNC:3009] | 17955 | 0.000 | 0.0848 | No |
| 83 | MMP7 | matrix metallopeptidase 7 [Source:HGNC Symbol;Acc:HGNC:7174] | 19084 | 0.000 | 0.0543 | No |
| 84 | MMP1 | matrix metallopeptidase 1 [Source:HGNC Symbol;Acc:HGNC:7155] | 19087 | 0.000 | 0.0542 | No |
| 85 | MMP3 | matrix metallopeptidase 3 [Source:HGNC Symbol;Acc:HGNC:7173] | 19091 | 0.000 | 0.0541 | No |
| 86 | MMP8 | matrix metallopeptidase 8 [Source:HGNC Symbol;Acc:HGNC:7175] | 19097 | 0.000 | 0.0540 | No |
| 87 | PF4 | platelet factor 4 [Source:HGNC Symbol;Acc:HGNC:8861] | 19955 | 0.000 | 0.0308 | No |
| 88 | HMGCS2 | 3-hydroxy-3-methylglutaryl-CoA synthase 2 [Source:HGNC Symbol;Acc:HGNC:5008] | 19996 | 0.000 | 0.0297 | No |
| 89 | PLG | plasminogen [Source:HGNC Symbol;Acc:HGNC:9071] | 20029 | 0.000 | 0.0289 | No |
| 90 | C1QA | complement C1q A chain [Source:HGNC Symbol;Acc:HGNC:1241] | 20084 | 0.000 | 0.0274 | No |
| 91 | LEFTY2 | left-right determination factor 2 [Source:HGNC Symbol;Acc:HGNC:3122] | 20193 | 0.000 | 0.0245 | No |
| 92 | MMP11 | matrix metallopeptidase 11 [Source:HGNC Symbol;Acc:HGNC:7157] | 20853 | 0.000 | 0.0066 | No |
| 93 | MMP15 | matrix metallopeptidase 15 [Source:HGNC Symbol;Acc:HGNC:7161] | 20858 | 0.000 | 0.0065 | No |
| 94 | F2RL2 | coagulation factor II thrombin receptor like 2 [Source:HGNC Symbol;Acc:HGNC:3539] | 21179 | 0.000 | -0.0021 | No |
| 95 | MEP1A | meprin A subunit alpha [Source:HGNC Symbol;Acc:HGNC:7015] | 23272 | 0.000 | -0.0587 | No |
| 96 | GP1BA | glycoprotein Ib platelet subunit alpha [Source:HGNC Symbol;Acc:HGNC:4439] | 23333 | 0.000 | -0.0604 | No |
| 97 | TFPI2 | tissue factor pathway inhibitor 2 [Source:HGNC Symbol;Acc:HGNC:11761] | 24981 | 0.000 | -0.1049 | No |
| 98 | PRSS23 | serine protease 23 [Source:HGNC Symbol;Acc:HGNC:14370] | 25250 | 0.000 | -0.1122 | No |
| 99 | ITGA2 | integrin subunit alpha 2 [Source:HGNC Symbol;Acc:HGNC:6137] | 26436 | 0.000 | -0.1442 | No |
| 100 | SPARC | secreted protein acidic and cysteine rich [Source:HGNC Symbol;Acc:HGNC:11219] | 27336 | 0.000 | -0.1686 | No |
| 101 | THBD | thrombomodulin [Source:HGNC Symbol;Acc:HGNC:11784] | 27809 | -0.047 | -0.1808 | No |
| 102 | CTSO | cathepsin O [Source:HGNC Symbol;Acc:HGNC:2542] | 27863 | -0.054 | -0.1817 | No |
| 103 | MSRB2 | methionine sulfoxide reductase B2 [Source:HGNC Symbol;Acc:HGNC:17061] | 28516 | -0.131 | -0.1979 | No |
| 104 | RGN | regucalcin [Source:HGNC Symbol;Acc:HGNC:9989] | 28554 | -0.134 | -0.1974 | No |
| 105 | CTSK | cathepsin K [Source:HGNC Symbol;Acc:HGNC:2536] | 28699 | -0.150 | -0.1997 | No |
| 106 | CRIP2 | cysteine rich protein 2 [Source:HGNC Symbol;Acc:HGNC:2361] | 29486 | -0.249 | -0.2183 | No |
| 107 | HPN | hepsin [Source:HGNC Symbol;Acc:HGNC:5155] | 29566 | -0.261 | -0.2176 | No |
| 108 | C1S | complement C1s [Source:HGNC Symbol;Acc:HGNC:1247] | 30184 | -0.335 | -0.2306 | No |
| 109 | MST1 | macrophage stimulating 1 [Source:HGNC Symbol;Acc:HGNC:7380] | 30447 | -0.371 | -0.2337 | No |
| 110 | LAMP2 | lysosomal associated membrane protein 2 [Source:HGNC Symbol;Acc:HGNC:6501] | 30745 | -0.414 | -0.2372 | No |
| 111 | DUSP6 | dual specificity phosphatase 6 [Source:HGNC Symbol;Acc:HGNC:3072] | 31330 | -0.503 | -0.2476 | No |
| 112 | F8 | coagulation factor VIII [Source:HGNC Symbol;Acc:HGNC:3546] | 31671 | -0.559 | -0.2507 | No |
| 113 | PEF1 | penta-EF-hand domain containing 1 [Source:HGNC Symbol;Acc:HGNC:30009] | 31992 | -0.612 | -0.2527 | No |
| 114 | PROS1 | protein S [Source:HGNC Symbol;Acc:HGNC:9456] | 32089 | -0.630 | -0.2484 | No |
| 115 | CTSE | cathepsin E [Source:HGNC Symbol;Acc:HGNC:2530] | 32159 | -0.644 | -0.2433 | No |
| 116 | S100A1 | S100 calcium binding protein A1 [Source:HGNC Symbol;Acc:HGNC:10486] | 33005 | -0.843 | -0.2570 | No |
| 117 | CTSB | cathepsin B [Source:HGNC Symbol;Acc:HGNC:2527] | 33055 | -0.856 | -0.2490 | No |
| 118 | SIRT2 | sirtuin 2 [Source:HGNC Symbol;Acc:HGNC:10886] | 33140 | -0.876 | -0.2418 | No |
| 119 | COMP | cartilage oligomeric matrix protein [Source:HGNC Symbol;Acc:HGNC:2227] | 33201 | -0.894 | -0.2337 | No |
| 120 | ISCU | iron-sulfur cluster assembly enzyme [Source:HGNC Symbol;Acc:HGNC:29882] | 33214 | -0.896 | -0.2243 | No |
| 121 | CAPN2 | calpain 2 [Source:HGNC Symbol;Acc:HGNC:1479] | 33687 | -1.031 | -0.2258 | No |
| 122 | CPQ | carboxypeptidase Q [Source:HGNC Symbol;Acc:HGNC:16910] | 33715 | -1.036 | -0.2153 | No |
| 123 | USP11 | ubiquitin specific peptidase 11 [Source:HGNC Symbol;Acc:HGNC:12609] | 33766 | -1.046 | -0.2053 | No |
| 124 | CASP9 | caspase 9 [Source:HGNC Symbol;Acc:HGNC:1511] | 33850 | -1.068 | -0.1959 | No |
| 125 | C1R | complement C1r [Source:HGNC Symbol;Acc:HGNC:1246] | 34053 | -1.132 | -0.1891 | No |
| 126 | DUSP14 | dual specificity phosphatase 14 [Source:HGNC Symbol;Acc:HGNC:17007] | 34272 | -1.206 | -0.1819 | No |
| 127 | TF | transferrin [Source:HGNC Symbol;Acc:HGNC:11740] | 34324 | -1.224 | -0.1700 | No |
| 128 | LTA4H | leukotriene A4 hydrolase [Source:HGNC Symbol;Acc:HGNC:6710] | 34811 | -1.424 | -0.1676 | No |
| 129 | LRP1 | LDL receptor related protein 1 [Source:HGNC Symbol;Acc:HGNC:6692] | 35000 | -1.518 | -0.1562 | No |
| 130 | VWF | von Willebrand factor [Source:HGNC Symbol;Acc:HGNC:12726] | 35081 | -1.560 | -0.1414 | No |
| 131 | CSRP1 | cysteine and glycine rich protein 1 [Source:HGNC Symbol;Acc:HGNC:2469] | 35683 | -1.915 | -0.1369 | No |
| 132 | CAPN5 | calpain 5 [Source:HGNC Symbol;Acc:HGNC:1482] | 35903 | -2.087 | -0.1201 | No |
| 133 | LGMN | legumain [Source:HGNC Symbol;Acc:HGNC:9472] | 35984 | -2.141 | -0.0990 | No |
| 134 | PLAU | plasminogen activator, urokinase [Source:HGNC Symbol;Acc:HGNC:9052] | 36442 | -2.609 | -0.0830 | No |
| 135 | GSN | gelsolin [Source:HGNC Symbol;Acc:HGNC:4620] | 36594 | -2.820 | -0.0564 | No |
| 136 | CFH | complement factor H [Source:HGNC Symbol;Acc:HGNC:4883] | 36782 | -3.154 | -0.0272 | No |
| 137 | ANG | angiogenin [Source:HGNC Symbol;Acc:HGNC:483] | 36835 | -3.267 | 0.0069 | No |
