Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.greenbergcls.cls #WT_GAQ_versus_WT_NA.greenbergcls.cls #WT_GAQ_versus_WT_NA_repos |
| Phenotype | greenbergcls.cls#WT_GAQ_versus_WT_NA_repos |
| Upregulated in class | WT_GAQ |
| GeneSet | HALLMARK_IL6_JAK_STAT3_SIGNALING |
| Enrichment Score (ES) | 0.75519735 |
| Normalized Enrichment Score (NES) | 1.8954338 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0 |
| FWER p-Value | 0.0 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | IL1B | interleukin 1 beta [Source:HGNC Symbol;Acc:HGNC:5992] | 0 | 4.925 | 0.0566 | Yes |
| 2 | SOCS3 | suppressor of cytokine signaling 3 [Source:HGNC Symbol;Acc:HGNC:19391] | 19 | 4.687 | 0.1100 | Yes |
| 3 | TNFRSF1B | TNF receptor superfamily member 1B [Source:HGNC Symbol;Acc:HGNC:11917] | 24 | 4.568 | 0.1624 | Yes |
| 4 | TNF | tumor necrosis factor [Source:HGNC Symbol;Acc:HGNC:11892] | 40 | 4.264 | 0.2110 | Yes |
| 5 | PIM1 | Pim-1 proto-oncogene, serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:8986] | 144 | 3.297 | 0.2461 | Yes |
| 6 | CD44 | CD44 molecule (Indian blood group) [Source:HGNC Symbol;Acc:HGNC:1681] | 183 | 3.113 | 0.2809 | Yes |
| 7 | STAT1 | signal transducer and activator of transcription 1 [Source:HGNC Symbol;Acc:HGNC:11362] | 206 | 3.020 | 0.3150 | Yes |
| 8 | PIK3R5 | phosphoinositide-3-kinase regulatory subunit 5 [Source:HGNC Symbol;Acc:HGNC:30035] | 209 | 2.985 | 0.3492 | Yes |
| 9 | CD14 | CD14 molecule [Source:HGNC Symbol;Acc:HGNC:1628] | 296 | 2.608 | 0.3769 | Yes |
| 10 | TGFB1 | transforming growth factor beta 1 [Source:HGNC Symbol;Acc:HGNC:11766] | 349 | 2.475 | 0.4039 | Yes |
| 11 | STAT2 | signal transducer and activator of transcription 2 [Source:HGNC Symbol;Acc:HGNC:11363] | 358 | 2.459 | 0.4320 | Yes |
| 12 | CD36 | CD36 molecule [Source:HGNC Symbol;Acc:HGNC:1663] | 374 | 2.425 | 0.4595 | Yes |
| 13 | STAT3 | signal transducer and activator of transcription 3 [Source:HGNC Symbol;Acc:HGNC:11364] | 378 | 2.414 | 0.4871 | Yes |
| 14 | MYD88 | MYD88 innate immune signal transduction adaptor [Source:HGNC Symbol;Acc:HGNC:7562] | 435 | 2.263 | 0.5116 | Yes |
| 15 | HAX1 | HCLS1 associated protein X-1 [Source:HGNC Symbol;Acc:HGNC:16915] | 508 | 2.081 | 0.5336 | Yes |
| 16 | SOCS1 | suppressor of cytokine signaling 1 [Source:HGNC Symbol;Acc:HGNC:19383] | 532 | 2.033 | 0.5563 | Yes |
| 17 | IRF9 | interferon regulatory factor 9 [Source:HGNC Symbol;Acc:HGNC:6131] | 553 | 1.992 | 0.5787 | Yes |
| 18 | TNFRSF1A | TNF receptor superfamily member 1A [Source:HGNC Symbol;Acc:HGNC:11916] | 591 | 1.934 | 0.5999 | Yes |
| 19 | MAP3K8 | mitogen-activated protein kinase kinase kinase 8 [Source:HGNC Symbol;Acc:HGNC:6860] | 688 | 1.777 | 0.6178 | Yes |
| 20 | CD9 | CD9 molecule [Source:HGNC Symbol;Acc:HGNC:1709] | 709 | 1.741 | 0.6372 | Yes |
| 21 | TNFRSF12A | TNF receptor superfamily member 12A [Source:HGNC Symbol;Acc:HGNC:18152] | 757 | 1.678 | 0.6553 | Yes |
| 22 | TLR2 | toll like receptor 2 [Source:HGNC Symbol;Acc:HGNC:11848] | 776 | 1.649 | 0.6737 | Yes |
| 23 | FAS | Fas cell surface death receptor [Source:HGNC Symbol;Acc:HGNC:11920] | 785 | 1.642 | 0.6924 | Yes |
| 24 | IL2RG | interleukin 2 receptor subunit gamma [Source:HGNC Symbol;Acc:HGNC:6010] | 1138 | 1.335 | 0.6982 | Yes |
| 25 | IL17RA | interleukin 17 receptor A [Source:HGNC Symbol;Acc:HGNC:5985] | 1377 | 1.164 | 0.7052 | Yes |
| 26 | CSF1 | colony stimulating factor 1 [Source:HGNC Symbol;Acc:HGNC:2432] | 1404 | 1.146 | 0.7176 | Yes |
| 27 | CXCL10 | C-X-C motif chemokine ligand 10 [Source:HGNC Symbol;Acc:HGNC:10637] | 1571 | 1.078 | 0.7255 | Yes |
| 28 | HMOX1 | heme oxygenase 1 [Source:HGNC Symbol;Acc:HGNC:5013] | 1572 | 1.078 | 0.7379 | Yes |
| 29 | PTPN1 | protein tyrosine phosphatase non-receptor type 1 [Source:HGNC Symbol;Acc:HGNC:9642] | 1676 | 1.037 | 0.7471 | Yes |
| 30 | PTPN11 | protein tyrosine phosphatase non-receptor type 11 [Source:HGNC Symbol;Acc:HGNC:9644] | 1801 | 0.985 | 0.7550 | Yes |
| 31 | GRB2 | growth factor receptor bound protein 2 [Source:HGNC Symbol;Acc:HGNC:4566] | 2378 | 0.761 | 0.7482 | Yes |
| 32 | STAM2 | signal transducing adaptor molecule 2 [Source:HGNC Symbol;Acc:HGNC:11358] | 2436 | 0.741 | 0.7552 | Yes |
| 33 | LTBR | lymphotoxin beta receptor [Source:HGNC Symbol;Acc:HGNC:6718] | 2721 | 0.657 | 0.7551 | No |
| 34 | JUN | Jun proto-oncogene, AP-1 transcription factor subunit [Source:HGNC Symbol;Acc:HGNC:6204] | 3490 | 0.483 | 0.7399 | No |
| 35 | CCR1 | C-C motif chemokine receptor 1 [Source:HGNC Symbol;Acc:HGNC:1602] | 3981 | 0.393 | 0.7311 | No |
| 36 | BAK1 | BCL2 antagonist/killer 1 [Source:HGNC Symbol;Acc:HGNC:949] | 4409 | 0.322 | 0.7233 | No |
| 37 | ACVR1B | activin A receptor type 1B [Source:HGNC Symbol;Acc:HGNC:172] | 4475 | 0.313 | 0.7251 | No |
| 38 | CXCL3 | C-X-C motif chemokine ligand 3 [Source:HGNC Symbol;Acc:HGNC:4604] | 4525 | 0.304 | 0.7273 | No |
| 39 | A2M | alpha-2-macroglobulin [Source:HGNC Symbol;Acc:HGNC:7] | 4651 | 0.288 | 0.7273 | No |
| 40 | IL6 | interleukin 6 [Source:HGNC Symbol;Acc:HGNC:6018] | 4960 | 0.237 | 0.7217 | No |
| 41 | LTB | lymphotoxin beta [Source:HGNC Symbol;Acc:HGNC:6711] | 5062 | 0.221 | 0.7215 | No |
| 42 | ITGB3 | integrin subunit beta 3 [Source:HGNC Symbol;Acc:HGNC:6156] | 5409 | 0.168 | 0.7141 | No |
| 43 | PTPN2 | protein tyrosine phosphatase non-receptor type 2 [Source:HGNC Symbol;Acc:HGNC:9650] | 5424 | 0.166 | 0.7156 | No |
| 44 | IL13RA1 | interleukin 13 receptor subunit alpha 1 [Source:HGNC Symbol;Acc:HGNC:5974] | 5435 | 0.164 | 0.7172 | No |
| 45 | CBL | Cbl proto-oncogene [Source:HGNC Symbol;Acc:HGNC:1541] | 5684 | 0.130 | 0.7120 | No |
| 46 | LEPR | leptin receptor [Source:HGNC Symbol;Acc:HGNC:6554] | 5913 | 0.098 | 0.7069 | No |
| 47 | CNTFR | ciliary neurotrophic factor receptor [Source:HGNC Symbol;Acc:HGNC:2170] | 9113 | 0.000 | 0.6205 | No |
| 48 | TNFRSF21 | TNF receptor superfamily member 21 [Source:HGNC Symbol;Acc:HGNC:13469] | 9565 | 0.000 | 0.6083 | No |
| 49 | CRLF2 | cytokine receptor like factor 2 [Source:HGNC Symbol;Acc:HGNC:14281] | 11184 | 0.000 | 0.5646 | No |
| 50 | PLA2G2A | phospholipase A2 group IIA [Source:HGNC Symbol;Acc:HGNC:9031] | 11907 | 0.000 | 0.5451 | No |
| 51 | CSF2RA | colony stimulating factor 2 receptor subunit alpha [Source:HGNC Symbol;Acc:HGNC:2435] | 12191 | 0.000 | 0.5374 | No |
| 52 | PDGFC | platelet derived growth factor C [Source:HGNC Symbol;Acc:HGNC:8801] | 13740 | 0.000 | 0.4956 | No |
| 53 | IL4R | interleukin 4 receptor [Source:HGNC Symbol;Acc:HGNC:6015] | 14056 | 0.000 | 0.4871 | No |
| 54 | IL9R | interleukin 9 receptor [Source:HGNC Symbol;Acc:HGNC:6030] | 14120 | 0.000 | 0.4854 | No |
| 55 | IL15RA | interleukin 15 receptor subunit alpha [Source:HGNC Symbol;Acc:HGNC:5978] | 14345 | 0.000 | 0.4793 | No |
| 56 | EBI3 | Epstein-Barr virus induced 3 [Source:HGNC Symbol;Acc:HGNC:3129] | 15180 | 0.000 | 0.4568 | No |
| 57 | IL17RB | interleukin 17 receptor B [Source:HGNC Symbol;Acc:HGNC:18015] | 15229 | 0.000 | 0.4555 | No |
| 58 | IL18R1 | interleukin 18 receptor 1 [Source:HGNC Symbol;Acc:HGNC:5988] | 15571 | 0.000 | 0.4463 | No |
| 59 | IL2RA | interleukin 2 receptor subunit alpha [Source:HGNC Symbol;Acc:HGNC:6008] | 15747 | 0.000 | 0.4415 | No |
| 60 | IL1R1 | interleukin 1 receptor type 1 [Source:HGNC Symbol;Acc:HGNC:5993] | 16004 | 0.000 | 0.4346 | No |
| 61 | IL1R2 | interleukin 1 receptor type 2 [Source:HGNC Symbol;Acc:HGNC:5994] | 16005 | 0.000 | 0.4346 | No |
| 62 | IL3RA | interleukin 3 receptor subunit alpha [Source:HGNC Symbol;Acc:HGNC:6012] | 16605 | 0.000 | 0.4184 | No |
| 63 | IL7 | interleukin 7 [Source:HGNC Symbol;Acc:HGNC:6023] | 17753 | 0.000 | 0.3874 | No |
| 64 | IFNAR1 | interferon alpha and beta receptor subunit 1 [Source:HGNC Symbol;Acc:HGNC:5432] | 18473 | 0.000 | 0.3680 | No |
| 65 | CXCL13 | C-X-C motif chemokine ligand 13 [Source:HGNC Symbol;Acc:HGNC:10639] | 18871 | 0.000 | 0.3573 | No |
| 66 | CXCL11 | C-X-C motif chemokine ligand 11 [Source:HGNC Symbol;Acc:HGNC:10638] | 18909 | 0.000 | 0.3563 | No |
| 67 | OSMR | oncostatin M receptor [Source:HGNC Symbol;Acc:HGNC:8507] | 18989 | 0.000 | 0.3541 | No |
| 68 | CXCL9 | C-X-C motif chemokine ligand 9 [Source:HGNC Symbol;Acc:HGNC:7098] | 19427 | 0.000 | 0.3423 | No |
| 69 | CXCL1 | C-X-C motif chemokine ligand 1 [Source:HGNC Symbol;Acc:HGNC:4602] | 19438 | 0.000 | 0.3421 | No |
| 70 | IL12RB1 | interleukin 12 receptor subunit beta 1 [Source:HGNC Symbol;Acc:HGNC:5971] | 19599 | 0.000 | 0.3377 | No |
| 71 | PF4 | platelet factor 4 [Source:HGNC Symbol;Acc:HGNC:8861] | 19955 | 0.000 | 0.3282 | No |
| 72 | IFNGR2 | interferon gamma receptor 2 [Source:HGNC Symbol;Acc:HGNC:5440] | 20468 | 0.000 | 0.3143 | No |
| 73 | CCL7 | C-C motif chemokine ligand 7 [Source:HGNC Symbol;Acc:HGNC:10634] | 22920 | 0.000 | 0.2481 | No |
| 74 | CD38 | CD38 molecule [Source:HGNC Symbol;Acc:HGNC:1667] | 23012 | 0.000 | 0.2456 | No |
| 75 | CSF2 | colony stimulating factor 2 [Source:HGNC Symbol;Acc:HGNC:2434] | 24528 | 0.000 | 0.2047 | No |
| 76 | REG1A | regenerating family member 1 alpha [Source:HGNC Symbol;Acc:HGNC:9951] | 26390 | 0.000 | 0.1544 | No |
| 77 | IFNGR1 | interferon gamma receptor 1 [Source:HGNC Symbol;Acc:HGNC:5439] | 29317 | -0.226 | 0.0779 | No |
| 78 | TYK2 | tyrosine kinase 2 [Source:HGNC Symbol;Acc:HGNC:12440] | 30959 | -0.447 | 0.0387 | No |
| 79 | INHBE | inhibin subunit beta E [Source:HGNC Symbol;Acc:HGNC:24029] | 31419 | -0.516 | 0.0322 | No |
| 80 | IRF1 | interferon regulatory factor 1 [Source:HGNC Symbol;Acc:HGNC:6116] | 31490 | -0.528 | 0.0364 | No |
| 81 | CSF2RB | colony stimulating factor 2 receptor subunit beta [Source:HGNC Symbol;Acc:HGNC:2436] | 31703 | -0.564 | 0.0372 | No |
| 82 | ACVRL1 | activin A receptor like type 1 [Source:HGNC Symbol;Acc:HGNC:175] | 32362 | -0.691 | 0.0273 | No |
| 83 | DNTT | DNA nucleotidylexotransferase [Source:HGNC Symbol;Acc:HGNC:2983] | 32447 | -0.711 | 0.0332 | No |
| 84 | CSF3R | colony stimulating factor 3 receptor [Source:HGNC Symbol;Acc:HGNC:2439] | 33855 | -1.069 | 0.0075 | No |
| 85 | IL10RB | interleukin 10 receptor subunit beta [Source:HGNC Symbol;Acc:HGNC:5965] | 34041 | -1.128 | 0.0155 | No |
| 86 | IL6ST | interleukin 6 signal transducer [Source:HGNC Symbol;Acc:HGNC:6021] | 35719 | -1.938 | -0.0076 | No |
| 87 | ITGA4 | integrin subunit alpha 4 [Source:HGNC Symbol;Acc:HGNC:6140] | 37002 | -3.881 | 0.0024 | No |
