Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.greenbergcls.cls #WT_GAQ_versus_WT_NA.greenbergcls.cls #WT_GAQ_versus_WT_NA_repos |
| Phenotype | greenbergcls.cls#WT_GAQ_versus_WT_NA_repos |
| Upregulated in class | WT_NA |
| GeneSet | HALLMARK_PANCREAS_BETA_CELLS |
| Enrichment Score (ES) | -0.6632778 |
| Normalized Enrichment Score (NES) | -1.270359 |
| Nominal p-value | 0.12136536 |
| FDR q-value | 0.18184125 |
| FWER p-Value | 0.885 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | SRPRB | SRP receptor subunit beta [Source:HGNC Symbol;Acc:HGNC:24085] | 1904 | 0.943 | 0.0125 | No |
| 2 | SRP14 | signal recognition particle 14 [Source:HGNC Symbol;Acc:HGNC:11299] | 1906 | 0.942 | 0.0762 | No |
| 3 | SPCS1 | signal peptidase complex subunit 1 [Source:HGNC Symbol;Acc:HGNC:23401] | 3587 | 0.464 | 0.0623 | No |
| 4 | SEC11A | SEC11 homolog A, signal peptidase complex subunit [Source:HGNC Symbol;Acc:HGNC:17718] | 4619 | 0.292 | 0.0542 | No |
| 5 | VDR | vitamin D receptor [Source:HGNC Symbol;Acc:HGNC:12679] | 5863 | 0.105 | 0.0278 | No |
| 6 | PAK3 | p21 (RAC1) activated kinase 3 [Source:HGNC Symbol;Acc:HGNC:8592] | 6380 | 0.041 | 0.0167 | No |
| 7 | SCGN | secretagogin, EF-hand calcium binding protein [Source:HGNC Symbol;Acc:HGNC:16941] | 6908 | 0.000 | 0.0024 | No |
| 8 | CHGA | chromogranin A [Source:HGNC Symbol;Acc:HGNC:1929] | 10832 | 0.000 | -0.1035 | No |
| 9 | G6PC2 | glucose-6-phosphatase catalytic subunit 2 [Source:HGNC Symbol;Acc:HGNC:28906] | 12620 | 0.000 | -0.1517 | No |
| 10 | SST | somatostatin [Source:HGNC Symbol;Acc:HGNC:11329] | 12666 | 0.000 | -0.1529 | No |
| 11 | SYT13 | synaptotagmin 13 [Source:HGNC Symbol;Acc:HGNC:14962] | 13895 | 0.000 | -0.1860 | No |
| 12 | PAX4 | paired box 4 [Source:HGNC Symbol;Acc:HGNC:8618] | 14990 | 0.000 | -0.2156 | No |
| 13 | DCX | doublecortin [Source:HGNC Symbol;Acc:HGNC:2714] | 16134 | 0.000 | -0.2464 | No |
| 14 | PCSK2 | proprotein convertase subtilisin/kexin type 2 [Source:HGNC Symbol;Acc:HGNC:8744] | 16357 | 0.000 | -0.2524 | No |
| 15 | PCSK1 | proprotein convertase subtilisin/kexin type 1 [Source:HGNC Symbol;Acc:HGNC:8743] | 16358 | 0.000 | -0.2524 | No |
| 16 | GCG | glucagon [Source:HGNC Symbol;Acc:HGNC:4191] | 16989 | 0.000 | -0.2694 | No |
| 17 | INS | insulin [Source:HGNC Symbol;Acc:HGNC:6081] | 17779 | 0.000 | -0.2907 | No |
| 18 | DPP4 | dipeptidyl peptidase 4 [Source:HGNC Symbol;Acc:HGNC:3009] | 17955 | 0.000 | -0.2954 | No |
| 19 | NKX2-2 | NK2 homeobox 2 [Source:HGNC Symbol;Acc:HGNC:7835] | 19188 | 0.000 | -0.3287 | No |
| 20 | IAPP | islet amyloid polypeptide [Source:HGNC Symbol;Acc:HGNC:5329] | 19234 | 0.000 | -0.3299 | No |
| 21 | NEUROD1 | neuronal differentiation 1 [Source:HGNC Symbol;Acc:HGNC:7762] | 19240 | 0.000 | -0.3300 | No |
| 22 | NEUROG3 | neurogenin 3 [Source:HGNC Symbol;Acc:HGNC:13806] | 19354 | 0.000 | -0.3331 | No |
| 23 | NKX6-1 | NK6 homeobox 1 [Source:HGNC Symbol;Acc:HGNC:7839] | 20555 | 0.000 | -0.3655 | No |
| 24 | PDX1 | pancreatic and duodenal homeobox 1 [Source:HGNC Symbol;Acc:HGNC:6107] | 21273 | 0.000 | -0.3848 | No |
| 25 | INSM1 | INSM transcriptional repressor 1 [Source:HGNC Symbol;Acc:HGNC:6090] | 21891 | 0.000 | -0.4015 | No |
| 26 | ISL1 | ISL LIM homeobox 1 [Source:HGNC Symbol;Acc:HGNC:6132] | 22100 | 0.000 | -0.4071 | No |
| 27 | FOXA2 | forkhead box A2 [Source:HGNC Symbol;Acc:HGNC:5022] | 23696 | 0.000 | -0.4501 | No |
| 28 | SLC2A2 | solute carrier family 2 member 2 [Source:HGNC Symbol;Acc:HGNC:11006] | 27450 | 0.000 | -0.5514 | No |
| 29 | ABCC8 | ATP binding cassette subfamily C member 8 [Source:HGNC Symbol;Acc:HGNC:59] | 27462 | 0.000 | -0.5517 | No |
| 30 | ELP4 | elongator acetyltransferase complex subunit 4 [Source:HGNC Symbol;Acc:HGNC:1171] | 27630 | -0.024 | -0.5546 | No |
| 31 | GCK | glucokinase [Source:HGNC Symbol;Acc:HGNC:4195] | 28533 | -0.132 | -0.5700 | No |
| 32 | HNF1A | HNF1 homeobox A [Source:HGNC Symbol;Acc:HGNC:11621] | 28624 | -0.143 | -0.5627 | No |
| 33 | STXBP1 | syntaxin binding protein 1 [Source:HGNC Symbol;Acc:HGNC:11444] | 28915 | -0.180 | -0.5583 | No |
| 34 | SRP9 | signal recognition particle 9 [Source:HGNC Symbol;Acc:HGNC:11304] | 29289 | -0.223 | -0.5533 | No |
| 35 | PKLR | pyruvate kinase L/R [Source:HGNC Symbol;Acc:HGNC:9020] | 33365 | -0.938 | -0.5998 | Yes |
| 36 | FOXO1 | forkhead box O1 [Source:HGNC Symbol;Acc:HGNC:3819] | 33486 | -0.970 | -0.5373 | Yes |
| 37 | AKT3 | AKT serine/threonine kinase 3 [Source:HGNC Symbol;Acc:HGNC:393] | 34979 | -1.502 | -0.4759 | Yes |
| 38 | MAFB | MAF bZIP transcription factor B [Source:HGNC Symbol;Acc:HGNC:6408] | 35810 | -2.006 | -0.3625 | Yes |
| 39 | LMO2 | LIM domain only 2 [Source:HGNC Symbol;Acc:HGNC:6642] | 36238 | -2.357 | -0.2144 | Yes |
| 40 | PAX6 | paired box 6 [Source:HGNC Symbol;Acc:HGNC:8620] | 36903 | -3.507 | 0.0050 | Yes |
