Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.greenbergcls.cls #WT_GAQ_versus_WT_NA.greenbergcls.cls #WT_GAQ_versus_WT_NA_repos |
| Phenotype | greenbergcls.cls#WT_GAQ_versus_WT_NA_repos |
| Upregulated in class | WT_GAQ |
| GeneSet | HALLMARK_UNFOLDED_PROTEIN_RESPONSE |
| Enrichment Score (ES) | 0.5621847 |
| Normalized Enrichment Score (NES) | 1.4546539 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.023892213 |
| FWER p-Value | 0.057 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | IFIT1 | interferon induced protein with tetratricopeptide repeats 1 [Source:HGNC Symbol;Acc:HGNC:5407] | 21 | 4.639 | 0.0479 | Yes |
| 2 | NABP1 | nucleic acid binding protein 1 [Source:HGNC Symbol;Acc:HGNC:26232] | 299 | 2.604 | 0.0676 | Yes |
| 3 | DNAJB9 | DnaJ heat shock protein family (Hsp40) member B9 [Source:HGNC Symbol;Acc:HGNC:6968] | 304 | 2.588 | 0.0946 | Yes |
| 4 | RRP9 | ribosomal RNA processing 9, U3 small nucleolar RNA binding protein [Source:HGNC Symbol;Acc:HGNC:16829] | 401 | 2.357 | 0.1166 | Yes |
| 5 | CHAC1 | ChaC glutathione specific gamma-glutamylcyclotransferase 1 [Source:HGNC Symbol;Acc:HGNC:28680] | 475 | 2.152 | 0.1371 | Yes |
| 6 | HERPUD1 | homocysteine inducible ER protein with ubiquitin like domain 1 [Source:HGNC Symbol;Acc:HGNC:13744] | 479 | 2.146 | 0.1595 | Yes |
| 7 | ATF3 | activating transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:785] | 496 | 2.102 | 0.1810 | Yes |
| 8 | SRPRA | SRP receptor subunit alpha [Source:HGNC Symbol;Acc:HGNC:11307] | 524 | 2.039 | 0.2016 | Yes |
| 9 | HSPA5 | heat shock protein family A (Hsp70) member 5 [Source:HGNC Symbol;Acc:HGNC:5238] | 541 | 2.024 | 0.2223 | Yes |
| 10 | FUS | FUS RNA binding protein [Source:HGNC Symbol;Acc:HGNC:4010] | 660 | 1.810 | 0.2380 | Yes |
| 11 | ASNS | asparagine synthetase (glutamine-hydrolyzing) [Source:HGNC Symbol;Acc:HGNC:753] | 791 | 1.639 | 0.2516 | Yes |
| 12 | WFS1 | wolframin ER transmembrane glycoprotein [Source:HGNC Symbol;Acc:HGNC:12762] | 894 | 1.530 | 0.2649 | Yes |
| 13 | SLC7A5 | solute carrier family 7 member 5 [Source:HGNC Symbol;Acc:HGNC:11063] | 913 | 1.510 | 0.2801 | Yes |
| 14 | YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta [Source:HGNC Symbol;Acc:HGNC:12855] | 921 | 1.501 | 0.2956 | Yes |
| 15 | SDAD1 | SDA1 domain containing 1 [Source:HGNC Symbol;Acc:HGNC:25537] | 1004 | 1.428 | 0.3083 | Yes |
| 16 | DCP2 | decapping mRNA 2 [Source:HGNC Symbol;Acc:HGNC:24452] | 1034 | 1.410 | 0.3223 | Yes |
| 17 | ATF4 | activating transcription factor 4 [Source:HGNC Symbol;Acc:HGNC:786] | 1065 | 1.388 | 0.3360 | Yes |
| 18 | CEBPB | CCAAT enhancer binding protein beta [Source:HGNC Symbol;Acc:HGNC:1834] | 1150 | 1.327 | 0.3476 | Yes |
| 19 | DKC1 | dyskerin pseudouridine synthase 1 [Source:HGNC Symbol;Acc:HGNC:2890] | 1192 | 1.297 | 0.3600 | Yes |
| 20 | LSM1 | LSM1 homolog, mRNA degradation associated [Source:HGNC Symbol;Acc:HGNC:20472] | 1254 | 1.252 | 0.3715 | Yes |
| 21 | TATDN2 | TatD DNase domain containing 2 [Source:HGNC Symbol;Acc:HGNC:28988] | 1304 | 1.211 | 0.3828 | Yes |
| 22 | EXOSC1 | exosome component 1 [Source:HGNC Symbol;Acc:HGNC:17286] | 1324 | 1.197 | 0.3948 | Yes |
| 23 | EIF2S1 | eukaryotic translation initiation factor 2 subunit alpha [Source:HGNC Symbol;Acc:HGNC:3265] | 1628 | 1.055 | 0.3976 | Yes |
| 24 | SERP1 | stress associated endoplasmic reticulum protein 1 [Source:HGNC Symbol;Acc:HGNC:10759] | 1714 | 1.019 | 0.4060 | Yes |
| 25 | NOP56 | NOP56 ribonucleoprotein [Source:HGNC Symbol;Acc:HGNC:15911] | 1736 | 1.010 | 0.4160 | Yes |
| 26 | SLC1A4 | solute carrier family 1 member 4 [Source:HGNC Symbol;Acc:HGNC:10942] | 1768 | 0.998 | 0.4255 | Yes |
| 27 | DCP1A | decapping mRNA 1A [Source:HGNC Symbol;Acc:HGNC:18714] | 1770 | 0.998 | 0.4359 | Yes |
| 28 | CALR | calreticulin [Source:HGNC Symbol;Acc:HGNC:1455] | 1858 | 0.963 | 0.4437 | Yes |
| 29 | SRPRB | SRP receptor subunit beta [Source:HGNC Symbol;Acc:HGNC:24085] | 1904 | 0.943 | 0.4523 | Yes |
| 30 | HYOU1 | hypoxia up-regulated 1 [Source:HGNC Symbol;Acc:HGNC:16931] | 2003 | 0.898 | 0.4590 | Yes |
| 31 | NOP14 | NOP14 nucleolar protein [Source:HGNC Symbol;Acc:HGNC:16821] | 2036 | 0.886 | 0.4674 | Yes |
| 32 | EXOSC2 | exosome component 2 [Source:HGNC Symbol;Acc:HGNC:17097] | 2101 | 0.857 | 0.4746 | Yes |
| 33 | BAG3 | BAG cochaperone 3 [Source:HGNC Symbol;Acc:HGNC:939] | 2252 | 0.800 | 0.4790 | Yes |
| 34 | IARS1 | isoleucyl-tRNA synthetase 1 [Source:HGNC Symbol;Acc:HGNC:5330] | 2309 | 0.784 | 0.4856 | Yes |
| 35 | MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase [Source:HGNC Symbol;Acc:HGNC:7434] | 2504 | 0.722 | 0.4879 | Yes |
| 36 | TARS1 | threonyl-tRNA synthetase 1 [Source:HGNC Symbol;Acc:HGNC:11572] | 2519 | 0.718 | 0.4951 | Yes |
| 37 | KIF5B | kinesin family member 5B [Source:HGNC Symbol;Acc:HGNC:6324] | 2585 | 0.698 | 0.5006 | Yes |
| 38 | CXXC1 | CXXC finger protein 1 [Source:HGNC Symbol;Acc:HGNC:24343] | 2727 | 0.656 | 0.5036 | Yes |
| 39 | ZBTB17 | zinc finger and BTB domain containing 17 [Source:HGNC Symbol;Acc:HGNC:12936] | 2735 | 0.654 | 0.5103 | Yes |
| 40 | EIF4EBP1 | eukaryotic translation initiation factor 4E binding protein 1 [Source:HGNC Symbol;Acc:HGNC:3288] | 2740 | 0.653 | 0.5170 | Yes |
| 41 | CNOT4 | CCR4-NOT transcription complex subunit 4 [Source:HGNC Symbol;Acc:HGNC:7880] | 2829 | 0.629 | 0.5212 | Yes |
| 42 | LSM4 | LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated [Source:HGNC Symbol;Acc:HGNC:17259] | 2978 | 0.595 | 0.5234 | Yes |
| 43 | YIF1A | Yip1 interacting factor homolog A, membrane trafficking protein [Source:HGNC Symbol;Acc:HGNC:16688] | 2983 | 0.594 | 0.5295 | Yes |
| 44 | DDIT4 | DNA damage inducible transcript 4 [Source:HGNC Symbol;Acc:HGNC:24944] | 3288 | 0.525 | 0.5268 | Yes |
| 45 | TTC37 | tetratricopeptide repeat domain 37 [Source:HGNC Symbol;Acc:HGNC:23639] | 3317 | 0.520 | 0.5314 | Yes |
| 46 | PDIA5 | protein disulfide isomerase family A member 5 [Source:HGNC Symbol;Acc:HGNC:24811] | 3335 | 0.515 | 0.5364 | Yes |
| 47 | EDC4 | enhancer of mRNA decapping 4 [Source:HGNC Symbol;Acc:HGNC:17157] | 3385 | 0.503 | 0.5403 | Yes |
| 48 | EXOSC10 | exosome component 10 [Source:HGNC Symbol;Acc:HGNC:9138] | 3406 | 0.497 | 0.5450 | Yes |
| 49 | SPCS1 | signal peptidase complex subunit 1 [Source:HGNC Symbol;Acc:HGNC:23401] | 3587 | 0.464 | 0.5449 | Yes |
| 50 | EIF4G1 | eukaryotic translation initiation factor 4 gamma 1 [Source:HGNC Symbol;Acc:HGNC:3296] | 3640 | 0.452 | 0.5483 | Yes |
| 51 | EIF4A1 | eukaryotic translation initiation factor 4A1 [Source:HGNC Symbol;Acc:HGNC:3282] | 3651 | 0.450 | 0.5527 | Yes |
| 52 | HSPA9 | heat shock protein family A (Hsp70) member 9 [Source:HGNC Symbol;Acc:HGNC:5244] | 3760 | 0.432 | 0.5543 | Yes |
| 53 | ARFGAP1 | ADP ribosylation factor GTPase activating protein 1 [Source:HGNC Symbol;Acc:HGNC:15852] | 3773 | 0.430 | 0.5585 | Yes |
| 54 | CNOT6 | CCR4-NOT transcription complex subunit 6 [Source:HGNC Symbol;Acc:HGNC:14099] | 3810 | 0.422 | 0.5619 | Yes |
| 55 | BANF1 | BAF nuclear assembly factor 1 [Source:HGNC Symbol;Acc:HGNC:17397] | 4028 | 0.385 | 0.5601 | Yes |
| 56 | GEMIN4 | gem nuclear organelle associated protein 4 [Source:HGNC Symbol;Acc:HGNC:15717] | 4095 | 0.375 | 0.5622 | Yes |
| 57 | NOLC1 | nucleolar and coiled-body phosphoprotein 1 [Source:HGNC Symbol;Acc:HGNC:15608] | 4474 | 0.314 | 0.5552 | No |
| 58 | SSR1 | signal sequence receptor subunit 1 [Source:HGNC Symbol;Acc:HGNC:11323] | 4478 | 0.312 | 0.5584 | No |
| 59 | SEC11A | SEC11 homolog A, signal peptidase complex subunit [Source:HGNC Symbol;Acc:HGNC:17718] | 4619 | 0.292 | 0.5577 | No |
| 60 | NPM1 | nucleophosmin 1 [Source:HGNC Symbol;Acc:HGNC:7910] | 5153 | 0.209 | 0.5455 | No |
| 61 | XPOT | exportin for tRNA [Source:HGNC Symbol;Acc:HGNC:12826] | 5155 | 0.208 | 0.5476 | No |
| 62 | SPCS3 | signal peptidase complex subunit 3 [Source:HGNC Symbol;Acc:HGNC:26212] | 5175 | 0.205 | 0.5492 | No |
| 63 | EXOSC4 | exosome component 4 [Source:HGNC Symbol;Acc:HGNC:18189] | 5210 | 0.200 | 0.5504 | No |
| 64 | DNAJC3 | DnaJ heat shock protein family (Hsp40) member C3 [Source:HGNC Symbol;Acc:HGNC:9439] | 5485 | 0.157 | 0.5446 | No |
| 65 | CNOT2 | CCR4-NOT transcription complex subunit 2 [Source:HGNC Symbol;Acc:HGNC:7878] | 5528 | 0.150 | 0.5451 | No |
| 66 | NHP2 | NHP2 ribonucleoprotein [Source:HGNC Symbol;Acc:HGNC:14377] | 5566 | 0.144 | 0.5456 | No |
| 67 | EIF4A2 | eukaryotic translation initiation factor 4A2 [Source:HGNC Symbol;Acc:HGNC:3284] | 5699 | 0.128 | 0.5433 | No |
| 68 | DDX10 | DEAD-box helicase 10 [Source:HGNC Symbol;Acc:HGNC:2735] | 5740 | 0.123 | 0.5435 | No |
| 69 | NFYA | nuclear transcription factor Y subunit alpha [Source:HGNC Symbol;Acc:HGNC:7804] | 5995 | 0.088 | 0.5376 | No |
| 70 | EIF4E | eukaryotic translation initiation factor 4E [Source:HGNC Symbol;Acc:HGNC:3287] | 6158 | 0.071 | 0.5339 | No |
| 71 | ATF6 | activating transcription factor 6 [Source:HGNC Symbol;Acc:HGNC:791] | 6226 | 0.061 | 0.5328 | No |
| 72 | TSPYL2 | TSPY like 2 [Source:HGNC Symbol;Acc:HGNC:24358] | 6381 | 0.041 | 0.5290 | No |
| 73 | SHC1 | SHC adaptor protein 1 [Source:HGNC Symbol;Acc:HGNC:10840] | 6408 | 0.038 | 0.5287 | No |
| 74 | POP4 | POP4 homolog, ribonuclease P/MRP subunit [Source:HGNC Symbol;Acc:HGNC:30081] | 6445 | 0.034 | 0.5281 | No |
| 75 | SEC31A | SEC31 homolog A, COPII coat complex component [Source:HGNC Symbol;Acc:HGNC:17052] | 6555 | 0.020 | 0.5254 | No |
| 76 | PDIA6 | protein disulfide isomerase family A member 6 [Source:HGNC Symbol;Acc:HGNC:30168] | 6688 | 0.005 | 0.5218 | No |
| 77 | IGFBP1 | insulin like growth factor binding protein 1 [Source:HGNC Symbol;Acc:HGNC:5469] | 12026 | 0.000 | 0.3775 | No |
| 78 | CCL2 | C-C motif chemokine ligand 2 [Source:HGNC Symbol;Acc:HGNC:10618] | 22927 | 0.000 | 0.0827 | No |
| 79 | PREB | prolactin regulatory element binding [Source:HGNC Symbol;Acc:HGNC:9356] | 27589 | -0.019 | -0.0431 | No |
| 80 | EIF4A3 | eukaryotic translation initiation factor 4A3 [Source:HGNC Symbol;Acc:HGNC:18683] | 27679 | -0.031 | -0.0452 | No |
| 81 | RPS14 | ribosomal protein S14 [Source:HGNC Symbol;Acc:HGNC:10387] | 28204 | -0.094 | -0.0584 | No |
| 82 | STC2 | stanniocalcin 2 [Source:HGNC Symbol;Acc:HGNC:11374] | 28211 | -0.096 | -0.0575 | No |
| 83 | VEGFA | vascular endothelial growth factor A [Source:HGNC Symbol;Acc:HGNC:12680] | 28797 | -0.162 | -0.0717 | No |
| 84 | DNAJA4 | DnaJ heat shock protein family (Hsp40) member A4 [Source:HGNC Symbol;Acc:HGNC:14885] | 29091 | -0.200 | -0.0775 | No |
| 85 | HSP90B1 | heat shock protein 90 beta family member 1 [Source:HGNC Symbol;Acc:HGNC:12028] | 29162 | -0.208 | -0.0772 | No |
| 86 | MTREX | Mtr4 exosome RNA helicase [Source:HGNC Symbol;Acc:HGNC:18734] | 29240 | -0.217 | -0.0770 | No |
| 87 | GOSR2 | golgi SNAP receptor complex member 2 [Source:HGNC Symbol;Acc:HGNC:4431] | 29385 | -0.235 | -0.0785 | No |
| 88 | XBP1 | X-box binding protein 1 [Source:HGNC Symbol;Acc:HGNC:12801] | 29415 | -0.240 | -0.0767 | No |
| 89 | EXOSC9 | exosome component 9 [Source:HGNC Symbol;Acc:HGNC:9137] | 29767 | -0.284 | -0.0833 | No |
| 90 | PSAT1 | phosphoserine aminotransferase 1 [Source:HGNC Symbol;Acc:HGNC:19129] | 30434 | -0.369 | -0.0974 | No |
| 91 | FKBP14 | FKBP prolyl isomerase 14 [Source:HGNC Symbol;Acc:HGNC:18625] | 30595 | -0.392 | -0.0976 | No |
| 92 | EIF2AK3 | eukaryotic translation initiation factor 2 alpha kinase 3 [Source:HGNC Symbol;Acc:HGNC:3255] | 30742 | -0.414 | -0.0973 | No |
| 93 | ALDH18A1 | aldehyde dehydrogenase 18 family member A1 [Source:HGNC Symbol;Acc:HGNC:9722] | 30845 | -0.429 | -0.0955 | No |
| 94 | CEBPG | CCAAT enhancer binding protein gamma [Source:HGNC Symbol;Acc:HGNC:1837] | 30947 | -0.445 | -0.0936 | No |
| 95 | ATP6V0D1 | ATPase H+ transporting V0 subunit d1 [Source:HGNC Symbol;Acc:HGNC:13724] | 31130 | -0.470 | -0.0936 | No |
| 96 | PAIP1 | poly(A) binding protein interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:16945] | 31269 | -0.495 | -0.0922 | No |
| 97 | KDELR3 | KDEL endoplasmic reticulum protein retention receptor 3 [Source:HGNC Symbol;Acc:HGNC:6306] | 31503 | -0.531 | -0.0929 | No |
| 98 | SLC30A5 | solute carrier family 30 member 5 [Source:HGNC Symbol;Acc:HGNC:19089] | 31538 | -0.537 | -0.0883 | No |
| 99 | EXOC2 | exocyst complex component 2 [Source:HGNC Symbol;Acc:HGNC:24968] | 32403 | -0.699 | -0.1043 | No |
| 100 | KHSRP | KH-type splicing regulatory protein [Source:HGNC Symbol;Acc:HGNC:6316] | 32961 | -0.832 | -0.1107 | No |
| 101 | EEF2 | eukaryotic translation elongation factor 2 [Source:HGNC Symbol;Acc:HGNC:3214] | 32970 | -0.834 | -0.1022 | No |
| 102 | IMP3 | IMP U3 small nucleolar ribonucleoprotein 3 [Source:HGNC Symbol;Acc:HGNC:14497] | 33328 | -0.931 | -0.1021 | No |
| 103 | TUBB2A | tubulin beta 2A class IIa [Source:HGNC Symbol;Acc:HGNC:12412] | 33388 | -0.947 | -0.0938 | No |
| 104 | CKS1B | CDC28 protein kinase regulatory subunit 1B [Source:HGNC Symbol;Acc:HGNC:19083] | 33639 | -1.014 | -0.0900 | No |
| 105 | DCTN1 | dynactin subunit 1 [Source:HGNC Symbol;Acc:HGNC:2711] | 33712 | -1.036 | -0.0811 | No |
| 106 | PARN | poly(A)-specific ribonuclease [Source:HGNC Symbol;Acc:HGNC:8609] | 34572 | -1.320 | -0.0905 | No |
| 107 | NFYB | nuclear transcription factor Y subunit beta [Source:HGNC Symbol;Acc:HGNC:7805] | 34635 | -1.342 | -0.0782 | No |
| 108 | ERN1 | endoplasmic reticulum to nucleus signaling 1 [Source:HGNC Symbol;Acc:HGNC:3449] | 35015 | -1.526 | -0.0725 | No |
| 109 | EXOSC5 | exosome component 5 [Source:HGNC Symbol;Acc:HGNC:24662] | 35126 | -1.583 | -0.0589 | No |
| 110 | H2AX | H2A.X variant histone [Source:HGNC Symbol;Acc:HGNC:4739] | 35698 | -1.925 | -0.0543 | No |
| 111 | EDEM1 | ER degradation enhancing alpha-mannosidase like protein 1 [Source:HGNC Symbol;Acc:HGNC:18967] | 36129 | -2.262 | -0.0422 | No |
| 112 | ERO1A | endoplasmic reticulum oxidoreductase 1 alpha [Source:HGNC Symbol;Acc:HGNC:13280] | 36297 | -2.424 | -0.0214 | No |
| 113 | WIPI1 | WD repeat domain, phosphoinositide interacting 1 [Source:HGNC Symbol;Acc:HGNC:25471] | 37039 | -4.100 | 0.0014 | No |
