Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.greenbergcls.cls #WT_LPS_versus_WT_NA.greenbergcls.cls #WT_LPS_versus_WT_NA_repos |
| Phenotype | greenbergcls.cls#WT_LPS_versus_WT_NA_repos |
| Upregulated in class | WT_LPS |
| GeneSet | NEMETH_INFLAMMATORY_RESPONSE_LPS_UP |
| Enrichment Score (ES) | 0.9227609 |
| Normalized Enrichment Score (NES) | 2.3024306 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0 |
| FWER p-Value | 0.0 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | PTGS2 | prostaglandin-endoperoxide synthase 2 [Source:HGNC Symbol;Acc:HGNC:9605] | 7 | 4.952 | 0.0244 | Yes |
| 2 | IL1RN | interleukin 1 receptor antagonist [Source:HGNC Symbol;Acc:HGNC:6000] | 12 | 4.922 | 0.0487 | Yes |
| 3 | ODC1 | ornithine decarboxylase 1 [Source:HGNC Symbol;Acc:HGNC:8109] | 38 | 4.680 | 0.0712 | Yes |
| 4 | TNFRSF1B | TNF receptor superfamily member 1B [Source:HGNC Symbol;Acc:HGNC:11917] | 49 | 4.576 | 0.0936 | Yes |
| 5 | TNF | tumor necrosis factor [Source:HGNC Symbol;Acc:HGNC:11892] | 51 | 4.548 | 0.1162 | Yes |
| 6 | SLFN12 | schlafen family member 12 [Source:HGNC Symbol;Acc:HGNC:25500] | 60 | 4.454 | 0.1380 | Yes |
| 7 | BCL6B | BCL6B transcription repressor [Source:HGNC Symbol;Acc:HGNC:1002] | 62 | 4.435 | 0.1600 | Yes |
| 8 | MARCKSL1 | MARCKS like 1 [Source:HGNC Symbol;Acc:HGNC:7142] | 66 | 4.401 | 0.1817 | Yes |
| 9 | RGS16 | regulator of G protein signaling 16 [Source:HGNC Symbol;Acc:HGNC:9997] | 95 | 4.128 | 0.2015 | Yes |
| 10 | BCL2L1 | BCL2 like 1 [Source:HGNC Symbol;Acc:HGNC:992] | 96 | 4.127 | 0.2219 | Yes |
| 11 | CEBPD | CCAAT enhancer binding protein delta [Source:HGNC Symbol;Acc:HGNC:1835] | 103 | 4.085 | 0.2420 | Yes |
| 12 | IER3 | immediate early response 3 [Source:HGNC Symbol;Acc:HGNC:5392] | 106 | 4.064 | 0.2621 | Yes |
| 13 | STAT1 | signal transducer and activator of transcription 1 [Source:HGNC Symbol;Acc:HGNC:11362] | 112 | 4.003 | 0.2818 | Yes |
| 14 | PNP | purine nucleoside phosphorylase [Source:HGNC Symbol;Acc:HGNC:7892] | 117 | 3.977 | 0.3015 | Yes |
| 15 | GCH1 | GTP cyclohydrolase 1 [Source:HGNC Symbol;Acc:HGNC:4193] | 128 | 3.919 | 0.3206 | Yes |
| 16 | NFKB1 | nuclear factor kappa B subunit 1 [Source:HGNC Symbol;Acc:HGNC:7794] | 135 | 3.883 | 0.3397 | Yes |
| 17 | GLRX | glutaredoxin [Source:HGNC Symbol;Acc:HGNC:4330] | 142 | 3.835 | 0.3586 | Yes |
| 18 | NFKBIA | NFKB inhibitor alpha [Source:HGNC Symbol;Acc:HGNC:7797] | 143 | 3.828 | 0.3776 | Yes |
| 19 | CFLAR | CASP8 and FADD like apoptosis regulator [Source:HGNC Symbol;Acc:HGNC:1876] | 187 | 3.543 | 0.3940 | Yes |
| 20 | IRGM | immunity related GTPase M [Source:HGNC Symbol;Acc:HGNC:29597] | 188 | 3.539 | 0.4115 | Yes |
| 21 | FURIN | furin, paired basic amino acid cleaving enzyme [Source:HGNC Symbol;Acc:HGNC:8568] | 190 | 3.533 | 0.4290 | Yes |
| 22 | TAP1 | transporter 1, ATP binding cassette subfamily B member [Source:HGNC Symbol;Acc:HGNC:43] | 201 | 3.473 | 0.4460 | Yes |
| 23 | C3AR1 | complement C3a receptor 1 [Source:HGNC Symbol;Acc:HGNC:1319] | 213 | 3.401 | 0.4625 | Yes |
| 24 | TNIP1 | TNFAIP3 interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:16903] | 216 | 3.383 | 0.4793 | Yes |
| 25 | RHOC | ras homolog family member C [Source:HGNC Symbol;Acc:HGNC:669] | 224 | 3.324 | 0.4955 | Yes |
| 26 | HCK | HCK proto-oncogene, Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:4840] | 229 | 3.311 | 0.5119 | Yes |
| 27 | CD44 | CD44 molecule (Indian blood group) [Source:HGNC Symbol;Acc:HGNC:1681] | 232 | 3.304 | 0.5282 | Yes |
| 28 | CLEC4D | C-type lectin domain family 4 member D [Source:HGNC Symbol;Acc:HGNC:14554] | 236 | 3.282 | 0.5444 | Yes |
| 29 | ETS2 | ETS proto-oncogene 2, transcription factor [Source:HGNC Symbol;Acc:HGNC:3489] | 238 | 3.275 | 0.5606 | Yes |
| 30 | SQSTM1 | sequestosome 1 [Source:HGNC Symbol;Acc:HGNC:11280] | 239 | 3.274 | 0.5768 | Yes |
| 31 | TRIM25 | tripartite motif containing 25 [Source:HGNC Symbol;Acc:HGNC:12932] | 249 | 3.241 | 0.5927 | Yes |
| 32 | SLFN12L | schlafen family member 12 like [Source:HGNC Symbol;Acc:HGNC:33920] | 274 | 3.106 | 0.6074 | Yes |
| 33 | MSR1 | macrophage scavenger receptor 1 [Source:HGNC Symbol;Acc:HGNC:7376] | 275 | 3.103 | 0.6228 | Yes |
| 34 | TXNRD1 | thioredoxin reductase 1 [Source:HGNC Symbol;Acc:HGNC:12437] | 276 | 3.100 | 0.6382 | Yes |
| 35 | STK10 | serine/threonine kinase 10 [Source:HGNC Symbol;Acc:HGNC:11388] | 280 | 3.090 | 0.6534 | Yes |
| 36 | GK | glycerol kinase [Source:HGNC Symbol;Acc:HGNC:4289] | 312 | 2.955 | 0.6672 | Yes |
| 37 | ADAR | adenosine deaminase RNA specific [Source:HGNC Symbol;Acc:HGNC:225] | 336 | 2.835 | 0.6807 | Yes |
| 38 | SRGN | serglycin [Source:HGNC Symbol;Acc:HGNC:9361] | 372 | 2.690 | 0.6931 | Yes |
| 39 | MYO10 | myosin X [Source:HGNC Symbol;Acc:HGNC:7593] | 373 | 2.685 | 0.7064 | Yes |
| 40 | TGFB1 | transforming growth factor beta 1 [Source:HGNC Symbol;Acc:HGNC:11766] | 386 | 2.651 | 0.7192 | Yes |
| 41 | IFRD1 | interferon related developmental regulator 1 [Source:HGNC Symbol;Acc:HGNC:5456] | 388 | 2.640 | 0.7323 | Yes |
| 42 | LCP2 | lymphocyte cytosolic protein 2 [Source:HGNC Symbol;Acc:HGNC:6529] | 402 | 2.598 | 0.7448 | Yes |
| 43 | HCLS1 | hematopoietic cell-specific Lyn substrate 1 [Source:HGNC Symbol;Acc:HGNC:4844] | 404 | 2.593 | 0.7576 | Yes |
| 44 | ATF3 | activating transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:785] | 409 | 2.583 | 0.7703 | Yes |
| 45 | IER2 | immediate early response 2 [Source:HGNC Symbol;Acc:HGNC:28871] | 454 | 2.459 | 0.7814 | Yes |
| 46 | TPST1 | tyrosylprotein sulfotransferase 1 [Source:HGNC Symbol;Acc:HGNC:12020] | 517 | 2.308 | 0.7911 | Yes |
| 47 | ACSL4 | acyl-CoA synthetase long chain family member 4 [Source:HGNC Symbol;Acc:HGNC:3571] | 665 | 2.041 | 0.7973 | Yes |
| 48 | PML | promyelocytic leukemia [Source:HGNC Symbol;Acc:HGNC:9113] | 687 | 2.005 | 0.8066 | Yes |
| 49 | RNF11 | ring finger protein 11 [Source:HGNC Symbol;Acc:HGNC:10056] | 694 | 1.996 | 0.8164 | Yes |
| 50 | ETF1 | eukaryotic translation termination factor 1 [Source:HGNC Symbol;Acc:HGNC:3477] | 729 | 1.937 | 0.8251 | Yes |
| 51 | SLC11A1 | solute carrier family 11 member 1 [Source:HGNC Symbol;Acc:HGNC:10907] | 758 | 1.886 | 0.8337 | Yes |
| 52 | SLC20A1 | solute carrier family 20 member 1 [Source:HGNC Symbol;Acc:HGNC:10946] | 833 | 1.748 | 0.8403 | Yes |
| 53 | JUND | JunD proto-oncogene, AP-1 transcription factor subunit [Source:HGNC Symbol;Acc:HGNC:6206] | 865 | 1.704 | 0.8479 | Yes |
| 54 | IL1RL1 | interleukin 1 receptor like 1 [Source:HGNC Symbol;Acc:HGNC:5998] | 878 | 1.688 | 0.8560 | Yes |
| 55 | CLN3 | CLN3 lysosomal/endosomal transmembrane protein, battenin [Source:HGNC Symbol;Acc:HGNC:2074] | 885 | 1.682 | 0.8642 | Yes |
| 56 | MAP2K1 | mitogen-activated protein kinase kinase 1 [Source:HGNC Symbol;Acc:HGNC:6840] | 917 | 1.645 | 0.8715 | Yes |
| 57 | SAT1 | spermidine/spermine N1-acetyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:10540] | 949 | 1.612 | 0.8786 | Yes |
| 58 | APBB1IP | amyloid beta precursor protein binding family B member 1 interacting protein [Source:HGNC Symbol;Acc:HGNC:17379] | 1110 | 1.466 | 0.8816 | Yes |
| 59 | HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase [Source:HGNC Symbol;Acc:HGNC:5006] | 1160 | 1.428 | 0.8873 | Yes |
| 60 | EIF1 | eukaryotic translation initiation factor 1 [Source:HGNC Symbol;Acc:HGNC:3249] | 1167 | 1.423 | 0.8942 | Yes |
| 61 | DEGS1 | delta 4-desaturase, sphingolipid 1 [Source:HGNC Symbol;Acc:HGNC:13709] | 1169 | 1.422 | 0.9013 | Yes |
| 62 | SLC2A1 | solute carrier family 2 member 1 [Source:HGNC Symbol;Acc:HGNC:11005] | 1317 | 1.301 | 0.9037 | Yes |
| 63 | MYADM | myeloid associated differentiation marker [Source:HGNC Symbol;Acc:HGNC:7544] | 1384 | 1.254 | 0.9082 | Yes |
| 64 | CITED2 | Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2 [Source:HGNC Symbol;Acc:HGNC:1987] | 1516 | 1.167 | 0.9104 | Yes |
| 65 | MLLT11 | MLLT11 transcription factor 7 cofactor [Source:HGNC Symbol;Acc:HGNC:16997] | 1530 | 1.162 | 0.9158 | Yes |
| 66 | CCL3 | C-C motif chemokine ligand 3 [Source:HGNC Symbol;Acc:HGNC:10627] | 1595 | 1.124 | 0.9197 | Yes |
| 67 | PIP5K1B | phosphatidylinositol-4-phosphate 5-kinase type 1 beta [Source:HGNC Symbol;Acc:HGNC:8995] | 1678 | 1.067 | 0.9228 | Yes |
| 68 | WSB1 | WD repeat and SOCS box containing 1 [Source:HGNC Symbol;Acc:HGNC:19221] | 1881 | 0.974 | 0.9221 | No |
| 69 | TOP1 | DNA topoisomerase I [Source:HGNC Symbol;Acc:HGNC:11986] | 2347 | 0.785 | 0.9135 | No |
| 70 | KPNA3 | karyopherin subunit alpha 3 [Source:HGNC Symbol;Acc:HGNC:6396] | 2420 | 0.761 | 0.9153 | No |
| 71 | SAP30 | Sin3A associated protein 30 [Source:HGNC Symbol;Acc:HGNC:10532] | 2446 | 0.752 | 0.9183 | No |
| 72 | CDKN1A | cyclin dependent kinase inhibitor 1A [Source:HGNC Symbol;Acc:HGNC:1784] | 2687 | 0.672 | 0.9152 | No |
| 73 | DAB2 | DAB adaptor protein 2 [Source:HGNC Symbol;Acc:HGNC:2662] | 2690 | 0.671 | 0.9185 | No |
| 74 | PRKCD | protein kinase C delta [Source:HGNC Symbol;Acc:HGNC:9399] | 2936 | 0.595 | 0.9148 | No |
| 75 | RCN1 | reticulocalbin 1 [Source:HGNC Symbol;Acc:HGNC:9934] | 3365 | 0.488 | 0.9057 | No |
| 76 | FCGR2B | Fc fragment of IgG receptor IIb [Source:HGNC Symbol;Acc:HGNC:3618] | 4955 | 0.198 | 0.8637 | No |
| 77 | MT1X | metallothionein 1X [Source:HGNC Symbol;Acc:HGNC:7405] | 5342 | 0.142 | 0.8540 | No |
| 78 | CCL23 | C-C motif chemokine ligand 23 [Source:HGNC Symbol;Acc:HGNC:10622] | 6430 | 0.000 | 0.8246 | No |
| 79 | TNFSF9 | TNF superfamily member 9 [Source:HGNC Symbol;Acc:HGNC:11939] | 8812 | 0.000 | 0.7603 | No |
| 80 | SLPI | secretory leukocyte peptidase inhibitor [Source:HGNC Symbol;Acc:HGNC:11092] | 9248 | 0.000 | 0.7485 | No |
| 81 | IFI16 | interferon gamma inducible protein 16 [Source:HGNC Symbol;Acc:HGNC:5395] | 11437 | 0.000 | 0.6894 | No |
| 82 | LILRB4 | leukocyte immunoglobulin like receptor B4 [Source:HGNC Symbol;Acc:HGNC:6608] | 13395 | 0.000 | 0.6365 | No |
| 83 | CASP4 | caspase 4 [Source:HGNC Symbol;Acc:HGNC:1505] | 26426 | 0.000 | 0.2844 | No |
| 84 | LTB | lymphotoxin beta [Source:HGNC Symbol;Acc:HGNC:6711] | 29053 | -0.261 | 0.2147 | No |
| 85 | MAPKAPK2 | MAPK activated protein kinase 2 [Source:HGNC Symbol;Acc:HGNC:6887] | 30606 | -0.491 | 0.1752 | No |
