Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.greenbergcls.cls #WT_LPS_versus_WT_NA.greenbergcls.cls #WT_LPS_versus_WT_NA_repos |
| Phenotype | greenbergcls.cls#WT_LPS_versus_WT_NA_repos |
| Upregulated in class | WT_LPS |
| GeneSet | REACTOME_INTERFERON_ALPHA_BETA_SIGNALING |
| Enrichment Score (ES) | 0.8871062 |
| Normalized Enrichment Score (NES) | 2.142334 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0 |
| FWER p-Value | 0.0 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | RSAD2 | radical S-adenosyl methionine domain containing 2 [Source:HGNC Symbol;Acc:HGNC:30908] | 6 | 4.960 | 0.0411 | Yes |
| 2 | IFIT1 | interferon induced protein with tetratricopeptide repeats 1 [Source:HGNC Symbol;Acc:HGNC:5407] | 8 | 4.948 | 0.0823 | Yes |
| 3 | IFIT2 | interferon induced protein with tetratricopeptide repeats 2 [Source:HGNC Symbol;Acc:HGNC:5409] | 23 | 4.827 | 0.1221 | Yes |
| 4 | MX1 | MX dynamin like GTPase 1 [Source:HGNC Symbol;Acc:HGNC:7532] | 31 | 4.755 | 0.1614 | Yes |
| 5 | OASL | 2'-5'-oligoadenylate synthetase like [Source:HGNC Symbol;Acc:HGNC:8090] | 33 | 4.742 | 0.2009 | Yes |
| 6 | MX2 | MX dynamin like GTPase 2 [Source:HGNC Symbol;Acc:HGNC:7533] | 35 | 4.721 | 0.2401 | Yes |
| 7 | USP18 | ubiquitin specific peptidase 18 [Source:HGNC Symbol;Acc:HGNC:12616] | 46 | 4.625 | 0.2783 | Yes |
| 8 | SOCS3 | suppressor of cytokine signaling 3 [Source:HGNC Symbol;Acc:HGNC:19391] | 52 | 4.541 | 0.3160 | Yes |
| 9 | IRF7 | interferon regulatory factor 7 [Source:HGNC Symbol;Acc:HGNC:6122] | 56 | 4.507 | 0.3534 | Yes |
| 10 | ISG20 | interferon stimulated exonuclease gene 20 [Source:HGNC Symbol;Acc:HGNC:6130] | 65 | 4.413 | 0.3899 | Yes |
| 11 | IFI35 | interferon induced protein 35 [Source:HGNC Symbol;Acc:HGNC:5399] | 82 | 4.215 | 0.4246 | Yes |
| 12 | GBP2 | guanylate binding protein 2 [Source:HGNC Symbol;Acc:HGNC:4183] | 92 | 4.151 | 0.4589 | Yes |
| 13 | STAT1 | signal transducer and activator of transcription 1 [Source:HGNC Symbol;Acc:HGNC:11362] | 112 | 4.003 | 0.4917 | Yes |
| 14 | STAT2 | signal transducer and activator of transcription 2 [Source:HGNC Symbol;Acc:HGNC:11363] | 132 | 3.896 | 0.5236 | Yes |
| 15 | OAS1 | 2'-5'-oligoadenylate synthetase 1 [Source:HGNC Symbol;Acc:HGNC:8086] | 134 | 3.887 | 0.5559 | Yes |
| 16 | OAS2 | 2'-5'-oligoadenylate synthetase 2 [Source:HGNC Symbol;Acc:HGNC:8087] | 160 | 3.711 | 0.5861 | Yes |
| 17 | OAS3 | 2'-5'-oligoadenylate synthetase 3 [Source:HGNC Symbol;Acc:HGNC:8088] | 254 | 3.217 | 0.6104 | Yes |
| 18 | ISG15 | ISG15 ubiquitin like modifier [Source:HGNC Symbol;Acc:HGNC:4053] | 285 | 3.080 | 0.6352 | Yes |
| 19 | SAMHD1 | SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 [Source:HGNC Symbol;Acc:HGNC:15925] | 318 | 2.927 | 0.6587 | Yes |
| 20 | ADAR | adenosine deaminase RNA specific [Source:HGNC Symbol;Acc:HGNC:225] | 336 | 2.835 | 0.6818 | Yes |
| 21 | IFITM3 | interferon induced transmembrane protein 3 [Source:HGNC Symbol;Acc:HGNC:5414] | 457 | 2.456 | 0.6990 | Yes |
| 22 | IFITM2 | interferon induced transmembrane protein 2 [Source:HGNC Symbol;Acc:HGNC:5413] | 468 | 2.433 | 0.7190 | Yes |
| 23 | IRF9 | interferon regulatory factor 9 [Source:HGNC Symbol;Acc:HGNC:6131] | 524 | 2.304 | 0.7367 | Yes |
| 24 | PSMB8 | proteasome 20S subunit beta 8 [Source:HGNC Symbol;Acc:HGNC:9545] | 582 | 2.169 | 0.7532 | Yes |
| 25 | IFIT3 | interferon induced protein with tetratricopeptide repeats 3 [Source:HGNC Symbol;Acc:HGNC:5411] | 606 | 2.135 | 0.7703 | Yes |
| 26 | HLA-F | major histocompatibility complex, class I, F [Source:HGNC Symbol;Acc:HGNC:4963] | 643 | 2.075 | 0.7866 | Yes |
| 27 | IRF1 | interferon regulatory factor 1 [Source:HGNC Symbol;Acc:HGNC:6116] | 704 | 1.969 | 0.8014 | Yes |
| 28 | IRF5 | interferon regulatory factor 5 [Source:HGNC Symbol;Acc:HGNC:6120] | 821 | 1.763 | 0.8129 | Yes |
| 29 | IP6K2 | inositol hexakisphosphate kinase 2 [Source:HGNC Symbol;Acc:HGNC:17313] | 834 | 1.745 | 0.8271 | Yes |
| 30 | HLA-C | major histocompatibility complex, class I, C [Source:HGNC Symbol;Acc:HGNC:4933] | 850 | 1.724 | 0.8410 | Yes |
| 31 | SOCS1 | suppressor of cytokine signaling 1 [Source:HGNC Symbol;Acc:HGNC:19383] | 911 | 1.649 | 0.8531 | Yes |
| 32 | HLA-E | major histocompatibility complex, class I, E [Source:HGNC Symbol;Acc:HGNC:4962] | 999 | 1.553 | 0.8637 | Yes |
| 33 | HLA-A | major histocompatibility complex, class I, A [Source:HGNC Symbol;Acc:HGNC:4931] | 1007 | 1.543 | 0.8764 | Yes |
| 34 | HLA-B | major histocompatibility complex, class I, B [Source:HGNC Symbol;Acc:HGNC:4932] | 1230 | 1.368 | 0.8818 | Yes |
| 35 | IRF8 | interferon regulatory factor 8 [Source:HGNC Symbol;Acc:HGNC:5358] | 1414 | 1.237 | 0.8871 | Yes |
| 36 | HLA-G | major histocompatibility complex, class I, G [Source:HGNC Symbol;Acc:HGNC:4964] | 1781 | 1.017 | 0.8857 | No |
| 37 | IRF4 | interferon regulatory factor 4 [Source:HGNC Symbol;Acc:HGNC:6119] | 2156 | 0.855 | 0.8827 | No |
| 38 | PTPN1 | protein tyrosine phosphatase non-receptor type 1 [Source:HGNC Symbol;Acc:HGNC:9642] | 2412 | 0.763 | 0.8822 | No |
| 39 | IFITM1 | interferon induced transmembrane protein 1 [Source:HGNC Symbol;Acc:HGNC:5412] | 2780 | 0.644 | 0.8776 | No |
| 40 | HLA-H | major histocompatibility complex, class I, H (pseudogene) [Source:HGNC Symbol;Acc:HGNC:4965] | 2898 | 0.608 | 0.8795 | No |
| 41 | PTPN11 | protein tyrosine phosphatase non-receptor type 11 [Source:HGNC Symbol;Acc:HGNC:9644] | 3076 | 0.563 | 0.8794 | No |
| 42 | EGR1 | early growth response 1 [Source:HGNC Symbol;Acc:HGNC:3238] | 3097 | 0.559 | 0.8835 | No |
| 43 | TYK2 | tyrosine kinase 2 [Source:HGNC Symbol;Acc:HGNC:12440] | 3146 | 0.548 | 0.8868 | No |
| 44 | IFI27 | interferon alpha inducible protein 27 [Source:HGNC Symbol;Acc:HGNC:5397] | 3904 | 0.378 | 0.8695 | No |
| 45 | IFNA21 | interferon alpha 21 [Source:HGNC Symbol;Acc:HGNC:5424] | 5101 | 0.178 | 0.8386 | No |
| 46 | KPNA1 | karyopherin subunit alpha 1 [Source:HGNC Symbol;Acc:HGNC:6394] | 5170 | 0.166 | 0.8382 | No |
| 47 | JAK1 | Janus kinase 1 [Source:HGNC Symbol;Acc:HGNC:6190] | 6189 | 0.025 | 0.8109 | No |
| 48 | BST2 | bone marrow stromal cell antigen 2 [Source:HGNC Symbol;Acc:HGNC:1119] | 12458 | 0.000 | 0.6416 | No |
| 49 | IFNA13 | interferon alpha 13 [Source:HGNC Symbol;Acc:HGNC:5419] | 18067 | 0.000 | 0.4901 | No |
| 50 | IFNA14 | interferon alpha 14 [Source:HGNC Symbol;Acc:HGNC:5420] | 18068 | 0.000 | 0.4901 | No |
| 51 | IFNA16 | interferon alpha 16 [Source:HGNC Symbol;Acc:HGNC:5421] | 18070 | 0.000 | 0.4900 | No |
| 52 | IFNA17 | interferon alpha 17 [Source:HGNC Symbol;Acc:HGNC:5422] | 18072 | 0.000 | 0.4900 | No |
| 53 | IFNA10 | interferon alpha 10 [Source:HGNC Symbol;Acc:HGNC:5418] | 18079 | 0.000 | 0.4899 | No |
| 54 | IFNAR2 | interferon alpha and beta receptor subunit 2 [Source:HGNC Symbol;Acc:HGNC:5433] | 18340 | 0.000 | 0.4828 | No |
| 55 | IFNAR1 | interferon alpha and beta receptor subunit 1 [Source:HGNC Symbol;Acc:HGNC:5432] | 18348 | 0.000 | 0.4826 | No |
| 56 | IFI6 | interferon alpha inducible protein 6 [Source:HGNC Symbol;Acc:HGNC:4054] | 20543 | 0.000 | 0.4234 | No |
| 57 | IFIT5 | interferon induced protein with tetratricopeptide repeats 5 [Source:HGNC Symbol;Acc:HGNC:13328] | 22992 | 0.000 | 0.3572 | No |
| 58 | IFNA5 | interferon alpha 5 [Source:HGNC Symbol;Acc:HGNC:5426] | 24393 | 0.000 | 0.3194 | No |
| 59 | IFNA4 | interferon alpha 4 [Source:HGNC Symbol;Acc:HGNC:5425] | 24394 | 0.000 | 0.3194 | No |
| 60 | IFNA7 | interferon alpha 7 [Source:HGNC Symbol;Acc:HGNC:5428] | 24396 | 0.000 | 0.3194 | No |
| 61 | IFNA6 | interferon alpha 6 [Source:HGNC Symbol;Acc:HGNC:5427] | 24398 | 0.000 | 0.3194 | No |
| 62 | IFNA1 | interferon alpha 1 [Source:HGNC Symbol;Acc:HGNC:5417] | 24399 | 0.000 | 0.3194 | No |
| 63 | IFNA2 | interferon alpha 2 [Source:HGNC Symbol;Acc:HGNC:5423] | 24400 | 0.000 | 0.3194 | No |
| 64 | IFNA8 | interferon alpha 8 [Source:HGNC Symbol;Acc:HGNC:5429] | 24402 | 0.000 | 0.3193 | No |
| 65 | IFNB1 | interferon beta 1 [Source:HGNC Symbol;Acc:HGNC:5434] | 24430 | 0.000 | 0.3186 | No |
| 66 | XAF1 | XIAP associated factor 1 [Source:HGNC Symbol;Acc:HGNC:30932] | 26886 | 0.000 | 0.2523 | No |
| 67 | IRF6 | interferon regulatory factor 6 [Source:HGNC Symbol;Acc:HGNC:6121] | 27463 | -0.057 | 0.2372 | No |
| 68 | ABCE1 | ATP binding cassette subfamily E member 1 [Source:HGNC Symbol;Acc:HGNC:69] | 27594 | -0.069 | 0.2343 | No |
| 69 | IRF2 | interferon regulatory factor 2 [Source:HGNC Symbol;Acc:HGNC:6117] | 29040 | -0.259 | 0.1974 | No |
| 70 | KPNB1 | karyopherin subunit beta 1 [Source:HGNC Symbol;Acc:HGNC:6400] | 29542 | -0.331 | 0.1866 | No |
| 71 | IRF3 | interferon regulatory factor 3 [Source:HGNC Symbol;Acc:HGNC:6118] | 29777 | -0.364 | 0.1833 | No |
| 72 | RNASEL | ribonuclease L [Source:HGNC Symbol;Acc:HGNC:10050] | 30713 | -0.508 | 0.1623 | No |
| 73 | PTPN6 | protein tyrosine phosphatase non-receptor type 6 [Source:HGNC Symbol;Acc:HGNC:9658] | 33583 | -1.196 | 0.0947 | No |
