Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.greenbergcls.cls #WT_LPS_versus_WT_NA.greenbergcls.cls #WT_LPS_versus_WT_NA_repos |
| Phenotype | greenbergcls.cls#WT_LPS_versus_WT_NA_repos |
| Upregulated in class | WT_LPS |
| GeneSet | IRF2_01 |
| Enrichment Score (ES) | 0.5359979 |
| Normalized Enrichment Score (NES) | 1.4112759 |
| Nominal p-value | 0.011904762 |
| FDR q-value | 1.0 |
| FWER p-Value | 0.998 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | LIF | LIF interleukin 6 family cytokine [Source:HGNC Symbol;Acc:HGNC:6596] | 1 | 4.975 | 0.0368 | Yes |
| 2 | IL27 | interleukin 27 [Source:HGNC Symbol;Acc:HGNC:19157] | 5 | 4.960 | 0.0735 | Yes |
| 3 | USP18 | ubiquitin specific peptidase 18 [Source:HGNC Symbol;Acc:HGNC:12616] | 46 | 4.625 | 0.1067 | Yes |
| 4 | CXCL10 | C-X-C motif chemokine ligand 10 [Source:HGNC Symbol;Acc:HGNC:10637] | 48 | 4.592 | 0.1407 | Yes |
| 5 | DDX58 | DExD/H-box helicase 58 [Source:HGNC Symbol;Acc:HGNC:19102] | 100 | 4.102 | 0.1697 | Yes |
| 6 | OSM | oncostatin M [Source:HGNC Symbol;Acc:HGNC:8506] | 138 | 3.873 | 0.1974 | Yes |
| 7 | REL | REL proto-oncogene, NF-kB subunit [Source:HGNC Symbol;Acc:HGNC:9954] | 170 | 3.641 | 0.2236 | Yes |
| 8 | TAP1 | transporter 1, ATP binding cassette subfamily B member [Source:HGNC Symbol;Acc:HGNC:43] | 201 | 3.473 | 0.2485 | Yes |
| 9 | NT5C3A | 5'-nucleotidase, cytosolic IIIA [Source:HGNC Symbol;Acc:HGNC:17820] | 246 | 3.255 | 0.2714 | Yes |
| 10 | TAPBP | TAP binding protein [Source:HGNC Symbol;Acc:HGNC:11566] | 250 | 3.232 | 0.2953 | Yes |
| 11 | PARP9 | poly(ADP-ribose) polymerase family member 9 [Source:HGNC Symbol;Acc:HGNC:24118] | 309 | 2.964 | 0.3157 | Yes |
| 12 | ATF3 | activating transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:785] | 409 | 2.583 | 0.3321 | Yes |
| 13 | PRDX5 | peroxiredoxin 5 [Source:HGNC Symbol;Acc:HGNC:9355] | 414 | 2.564 | 0.3510 | Yes |
| 14 | PGM5 | phosphoglucomutase 5 [Source:HGNC Symbol;Acc:HGNC:8908] | 519 | 2.307 | 0.3653 | Yes |
| 15 | PSMB9 | proteasome 20S subunit beta 9 [Source:HGNC Symbol;Acc:HGNC:9546] | 527 | 2.297 | 0.3821 | Yes |
| 16 | PIGV | phosphatidylinositol glycan anchor biosynthesis class V [Source:HGNC Symbol;Acc:HGNC:26031] | 570 | 2.193 | 0.3972 | Yes |
| 17 | PSMB8 | proteasome 20S subunit beta 8 [Source:HGNC Symbol;Acc:HGNC:9545] | 582 | 2.169 | 0.4130 | Yes |
| 18 | PSME1 | proteasome activator subunit 1 [Source:HGNC Symbol;Acc:HGNC:9568] | 585 | 2.161 | 0.4290 | Yes |
| 19 | DTX3L | deltex E3 ubiquitin ligase 3L [Source:HGNC Symbol;Acc:HGNC:30323] | 681 | 2.018 | 0.4414 | Yes |
| 20 | LRATD2 | LRAT domain containing 2 [Source:HGNC Symbol;Acc:HGNC:24166] | 753 | 1.892 | 0.4535 | Yes |
| 21 | IL11 | interleukin 11 [Source:HGNC Symbol;Acc:HGNC:5966] | 958 | 1.596 | 0.4598 | Yes |
| 22 | TCIRG1 | T cell immune regulator 1, ATPase H+ transporting V0 subunit a3 [Source:HGNC Symbol;Acc:HGNC:11647] | 1029 | 1.520 | 0.4691 | Yes |
| 23 | MED13 | mediator complex subunit 13 [Source:HGNC Symbol;Acc:HGNC:22474] | 1062 | 1.500 | 0.4794 | Yes |
| 24 | MAP3K11 | mitogen-activated protein kinase kinase kinase 11 [Source:HGNC Symbol;Acc:HGNC:6850] | 1157 | 1.432 | 0.4874 | Yes |
| 25 | SYNE2 | spectrin repeat containing nuclear envelope protein 2 [Source:HGNC Symbol;Acc:HGNC:17084] | 1216 | 1.378 | 0.4961 | Yes |
| 26 | PCGF5 | polycomb group ring finger 5 [Source:HGNC Symbol;Acc:HGNC:28264] | 1275 | 1.331 | 0.5044 | Yes |
| 27 | PSMA3 | proteasome 20S subunit alpha 3 [Source:HGNC Symbol;Acc:HGNC:9532] | 1397 | 1.247 | 0.5104 | Yes |
| 28 | SLC38A2 | solute carrier family 38 member 2 [Source:HGNC Symbol;Acc:HGNC:13448] | 1906 | 0.958 | 0.5037 | Yes |
| 29 | E2F3 | E2F transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:3115] | 1924 | 0.946 | 0.5103 | Yes |
| 30 | ROCK1 | Rho associated coiled-coil containing protein kinase 1 [Source:HGNC Symbol;Acc:HGNC:10251] | 1941 | 0.939 | 0.5168 | Yes |
| 31 | LSM6 | LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated [Source:HGNC Symbol;Acc:HGNC:17017] | 1985 | 0.923 | 0.5225 | Yes |
| 32 | PRKD3 | protein kinase D3 [Source:HGNC Symbol;Acc:HGNC:9408] | 2005 | 0.916 | 0.5287 | Yes |
| 33 | CDK6 | cyclin dependent kinase 6 [Source:HGNC Symbol;Acc:HGNC:1777] | 2167 | 0.850 | 0.5307 | Yes |
| 34 | DNASE1L3 | deoxyribonuclease 1 like 3 [Source:HGNC Symbol;Acc:HGNC:2959] | 2201 | 0.838 | 0.5360 | Yes |
| 35 | DUSP10 | dual specificity phosphatase 10 [Source:HGNC Symbol;Acc:HGNC:3065] | 2986 | 0.582 | 0.5191 | No |
| 36 | B2M | beta-2-microglobulin [Source:HGNC Symbol;Acc:HGNC:914] | 3047 | 0.572 | 0.5217 | No |
| 37 | UPF2 | UPF2 regulator of nonsense mediated mRNA decay [Source:HGNC Symbol;Acc:HGNC:17854] | 3862 | 0.389 | 0.5026 | No |
| 38 | YY1AP1 | YY1 associated protein 1 [Source:HGNC Symbol;Acc:HGNC:30935] | 4198 | 0.324 | 0.4959 | No |
| 39 | BLK | BLK proto-oncogene, Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:1057] | 4697 | 0.237 | 0.4842 | No |
| 40 | UBD | ubiquitin D [Source:HGNC Symbol;Acc:HGNC:18795] | 5152 | 0.168 | 0.4732 | No |
| 41 | PRKD2 | protein kinase D2 [Source:HGNC Symbol;Acc:HGNC:17293] | 5436 | 0.129 | 0.4665 | No |
| 42 | TMEM229B | transmembrane protein 229B [Source:HGNC Symbol;Acc:HGNC:20130] | 5656 | 0.103 | 0.4613 | No |
| 43 | CASZ1 | castor zinc finger 1 [Source:HGNC Symbol;Acc:HGNC:26002] | 5719 | 0.093 | 0.4603 | No |
| 44 | KCNE4 | potassium voltage-gated channel subfamily E regulatory subunit 4 [Source:HGNC Symbol;Acc:HGNC:6244] | 5970 | 0.058 | 0.4540 | No |
| 45 | PRDM16 | PR/SET domain 16 [Source:HGNC Symbol;Acc:HGNC:14000] | 6966 | 0.000 | 0.4271 | No |
| 46 | ASPA | aspartoacylase [Source:HGNC Symbol;Acc:HGNC:756] | 7776 | 0.000 | 0.4052 | No |
| 47 | BHLHE22 | basic helix-loop-helix family member e22 [Source:HGNC Symbol;Acc:HGNC:11963] | 8183 | 0.000 | 0.3942 | No |
| 48 | PROX1 | prospero homeobox 1 [Source:HGNC Symbol;Acc:HGNC:9459] | 8367 | 0.000 | 0.3892 | No |
| 49 | HOXA6 | homeobox A6 [Source:HGNC Symbol;Acc:HGNC:5107] | 8756 | 0.000 | 0.3787 | No |
| 50 | H4C7 | H4 clustered histone 7 [Source:HGNC Symbol;Acc:HGNC:4792] | 10184 | 0.000 | 0.3401 | No |
| 51 | RTL9 | retrotransposon Gag like 9 [Source:HGNC Symbol;Acc:HGNC:29245] | 10465 | 0.000 | 0.3326 | No |
| 52 | LDB2 | LIM domain binding 2 [Source:HGNC Symbol;Acc:HGNC:6533] | 11037 | 0.000 | 0.3171 | No |
| 53 | TMPRSS5 | transmembrane serine protease 5 [Source:HGNC Symbol;Acc:HGNC:14908] | 11499 | 0.000 | 0.3046 | No |
| 54 | BST2 | bone marrow stromal cell antigen 2 [Source:HGNC Symbol;Acc:HGNC:1119] | 12458 | 0.000 | 0.2787 | No |
| 55 | MSX1 | msh homeobox 1 [Source:HGNC Symbol;Acc:HGNC:7391] | 12493 | 0.000 | 0.2778 | No |
| 56 | GLRA1 | glycine receptor alpha 1 [Source:HGNC Symbol;Acc:HGNC:4326] | 12902 | 0.000 | 0.2668 | No |
| 57 | TMEM108 | transmembrane protein 108 [Source:HGNC Symbol;Acc:HGNC:28451] | 13450 | 0.000 | 0.2520 | No |
| 58 | PDGFC | platelet derived growth factor C [Source:HGNC Symbol;Acc:HGNC:8801] | 13485 | 0.000 | 0.2511 | No |
| 59 | IL15RA | interleukin 15 receptor subunit alpha [Source:HGNC Symbol;Acc:HGNC:5978] | 14095 | 0.000 | 0.2346 | No |
| 60 | FLT3LG | fms related receptor tyrosine kinase 3 ligand [Source:HGNC Symbol;Acc:HGNC:3766] | 14109 | 0.000 | 0.2342 | No |
| 61 | RFX4 | regulatory factor X4 [Source:HGNC Symbol;Acc:HGNC:9985] | 14321 | 0.000 | 0.2285 | No |
| 62 | DLX4 | distal-less homeobox 4 [Source:HGNC Symbol;Acc:HGNC:2917] | 16717 | 0.000 | 0.1637 | No |
| 63 | NDN | necdin, MAGE family member [Source:HGNC Symbol;Acc:HGNC:7675] | 19124 | 0.000 | 0.0986 | No |
| 64 | BNC2 | basonuclin 2 [Source:HGNC Symbol;Acc:HGNC:30988] | 19130 | 0.000 | 0.0985 | No |
| 65 | OTX1 | orthodenticle homeobox 1 [Source:HGNC Symbol;Acc:HGNC:8521] | 19287 | 0.000 | 0.0943 | No |
| 66 | TBX1 | T-box transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:11592] | 19574 | 0.000 | 0.0865 | No |
| 67 | AGBL2 | ATP/GTP binding protein like 2 [Source:HGNC Symbol;Acc:HGNC:26296] | 20411 | 0.000 | 0.0639 | No |
| 68 | BCL11A | BAF chromatin remodeling complex subunit BCL11A [Source:HGNC Symbol;Acc:HGNC:13221] | 20515 | 0.000 | 0.0611 | No |
| 69 | PIGR | polymeric immunoglobulin receptor [Source:HGNC Symbol;Acc:HGNC:8968] | 22535 | 0.000 | 0.0065 | No |
| 70 | NPR3 | natriuretic peptide receptor 3 [Source:HGNC Symbol;Acc:HGNC:7945] | 23419 | 0.000 | -0.0174 | No |
| 71 | EGFL6 | EGF like domain multiple 6 [Source:HGNC Symbol;Acc:HGNC:3235] | 23682 | 0.000 | -0.0245 | No |
| 72 | CCDC68 | coiled-coil domain containing 68 [Source:HGNC Symbol;Acc:HGNC:24350] | 24332 | 0.000 | -0.0420 | No |
| 73 | IFNB1 | interferon beta 1 [Source:HGNC Symbol;Acc:HGNC:5434] | 24430 | 0.000 | -0.0446 | No |
| 74 | IFNL2 | interferon lambda 2 [Source:HGNC Symbol;Acc:HGNC:18364] | 24528 | 0.000 | -0.0473 | No |
| 75 | IFNL3 | interferon lambda 3 [Source:HGNC Symbol;Acc:HGNC:18365] | 24539 | 0.000 | -0.0475 | No |
| 76 | KCNMB3 | potassium calcium-activated channel subfamily M regulatory beta subunit 3 [Source:HGNC Symbol;Acc:HGNC:6287] | 24583 | 0.000 | -0.0487 | No |
| 77 | XAF1 | XIAP associated factor 1 [Source:HGNC Symbol;Acc:HGNC:30932] | 26886 | 0.000 | -0.1110 | No |
| 78 | GSDMD | gasdermin D [Source:HGNC Symbol;Acc:HGNC:25697] | 27157 | -0.007 | -0.1182 | No |
| 79 | ASH1L | ASH1 like histone lysine methyltransferase [Source:HGNC Symbol;Acc:HGNC:19088] | 27216 | -0.017 | -0.1197 | No |
| 80 | TGFB3 | transforming growth factor beta 3 [Source:HGNC Symbol;Acc:HGNC:11769] | 27602 | -0.070 | -0.1296 | No |
| 81 | TERF2IP | TERF2 interacting protein [Source:HGNC Symbol;Acc:HGNC:19246] | 27815 | -0.098 | -0.1346 | No |
| 82 | EIF4A2 | eukaryotic translation initiation factor 4A2 [Source:HGNC Symbol;Acc:HGNC:3284] | 28388 | -0.170 | -0.1488 | No |
| 83 | CUL2 | cullin 2 [Source:HGNC Symbol;Acc:HGNC:2552] | 28417 | -0.173 | -0.1483 | No |
| 84 | HPCAL1 | hippocalcin like 1 [Source:HGNC Symbol;Acc:HGNC:5145] | 28467 | -0.181 | -0.1482 | No |
| 85 | KARS1 | lysyl-tRNA synthetase 1 [Source:HGNC Symbol;Acc:HGNC:6215] | 28656 | -0.207 | -0.1518 | No |
| 86 | RAPGEF6 | Rap guanine nucleotide exchange factor 6 [Source:HGNC Symbol;Acc:HGNC:20655] | 28932 | -0.244 | -0.1574 | No |
| 87 | TMBIM4 | transmembrane BAX inhibitor motif containing 4 [Source:HGNC Symbol;Acc:HGNC:24257] | 29071 | -0.265 | -0.1592 | No |
| 88 | CAPRIN1 | cell cycle associated protein 1 [Source:HGNC Symbol;Acc:HGNC:6743] | 29284 | -0.292 | -0.1628 | No |
| 89 | TRMT112 | tRNA methyltransferase subunit 11-2 [Source:HGNC Symbol;Acc:HGNC:26940] | 29464 | -0.321 | -0.1652 | No |
| 90 | TRPM3 | transient receptor potential cation channel subfamily M member 3 [Source:HGNC Symbol;Acc:HGNC:17992] | 29543 | -0.331 | -0.1649 | No |
| 91 | BBX | BBX high mobility group box domain containing [Source:HGNC Symbol;Acc:HGNC:14422] | 29711 | -0.355 | -0.1668 | No |
| 92 | MAPK6 | mitogen-activated protein kinase 6 [Source:HGNC Symbol;Acc:HGNC:6879] | 29836 | -0.374 | -0.1674 | No |
| 93 | SREK1 | splicing regulatory glutamic acid and lysine rich protein 1 [Source:HGNC Symbol;Acc:HGNC:17882] | 29994 | -0.395 | -0.1687 | No |
| 94 | IKZF2 | IKAROS family zinc finger 2 [Source:HGNC Symbol;Acc:HGNC:13177] | 29996 | -0.395 | -0.1658 | No |
| 95 | TNFSF13B | TNF superfamily member 13b [Source:HGNC Symbol;Acc:HGNC:11929] | 30038 | -0.403 | -0.1639 | No |
| 96 | NABP2 | nucleic acid binding protein 2 [Source:HGNC Symbol;Acc:HGNC:28412] | 30075 | -0.408 | -0.1619 | No |
| 97 | ME3 | malic enzyme 3 [Source:HGNC Symbol;Acc:HGNC:6985] | 30656 | -0.499 | -0.1739 | No |
| 98 | DLG1 | discs large MAGUK scaffold protein 1 [Source:HGNC Symbol;Acc:HGNC:2900] | 31042 | -0.565 | -0.1801 | No |
| 99 | MITF | melanocyte inducing transcription factor [Source:HGNC Symbol;Acc:HGNC:7105] | 31270 | -0.602 | -0.1818 | No |
| 100 | RIMS2 | regulating synaptic membrane exocytosis 2 [Source:HGNC Symbol;Acc:HGNC:17283] | 31474 | -0.641 | -0.1825 | No |
| 101 | DLX1 | distal-less homeobox 1 [Source:HGNC Symbol;Acc:HGNC:2914] | 31588 | -0.666 | -0.1806 | No |
| 102 | ESR1 | estrogen receptor 1 [Source:HGNC Symbol;Acc:HGNC:3467] | 31611 | -0.673 | -0.1762 | No |
| 103 | TRMT6 | tRNA methyltransferase 6 [Source:HGNC Symbol;Acc:HGNC:20900] | 31786 | -0.712 | -0.1757 | No |
| 104 | RELCH | RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing [Source:HGNC Symbol;Acc:HGNC:29289] | 31827 | -0.720 | -0.1714 | No |
| 105 | USP5 | ubiquitin specific peptidase 5 [Source:HGNC Symbol;Acc:HGNC:12628] | 31938 | -0.749 | -0.1688 | No |
| 106 | GPR52 | G protein-coupled receptor 52 [Source:HGNC Symbol;Acc:HGNC:4508] | 32624 | -0.909 | -0.1806 | No |
| 107 | CSAD | cysteine sulfinic acid decarboxylase [Source:HGNC Symbol;Acc:HGNC:18966] | 33093 | -1.046 | -0.1855 | No |
| 108 | NR3C2 | nuclear receptor subfamily 3 group C member 2 [Source:HGNC Symbol;Acc:HGNC:7979] | 33298 | -1.108 | -0.1829 | No |
| 109 | CCDC6 | coiled-coil domain containing 6 [Source:HGNC Symbol;Acc:HGNC:18782] | 33456 | -1.155 | -0.1785 | No |
| 110 | ABHD16A | abhydrolase domain containing 16A, phospholipase [Source:HGNC Symbol;Acc:HGNC:13921] | 33487 | -1.165 | -0.1707 | No |
| 111 | HDAC4 | histone deacetylase 4 [Source:HGNC Symbol;Acc:HGNC:14063] | 33527 | -1.179 | -0.1630 | No |
| 112 | VGLL4 | vestigial like family member 4 [Source:HGNC Symbol;Acc:HGNC:28966] | 33720 | -1.241 | -0.1590 | No |
| 113 | RNF220 | ring finger protein 220 [Source:HGNC Symbol;Acc:HGNC:25552] | 34134 | -1.387 | -0.1599 | No |
| 114 | FXYD5 | FXYD domain containing ion transport regulator 5 [Source:HGNC Symbol;Acc:HGNC:4029] | 34337 | -1.473 | -0.1545 | No |
| 115 | DDX17 | DEAD-box helicase 17 [Source:HGNC Symbol;Acc:HGNC:2740] | 35005 | -1.770 | -0.1594 | No |
| 116 | DAP3 | death associated protein 3 [Source:HGNC Symbol;Acc:HGNC:2673] | 35057 | -1.801 | -0.1474 | No |
| 117 | PLXNC1 | plexin C1 [Source:HGNC Symbol;Acc:HGNC:9106] | 35119 | -1.833 | -0.1355 | No |
| 118 | KDM3A | lysine demethylase 3A [Source:HGNC Symbol;Acc:HGNC:20815] | 35203 | -1.890 | -0.1237 | No |
| 119 | USF1 | upstream transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:12593] | 35451 | -2.053 | -0.1152 | No |
| 120 | ARHGAP5 | Rho GTPase activating protein 5 [Source:HGNC Symbol;Acc:HGNC:675] | 35508 | -2.087 | -0.1013 | No |
| 121 | SIPA1 | signal-induced proliferation-associated 1 [Source:HGNC Symbol;Acc:HGNC:10885] | 35596 | -2.155 | -0.0877 | No |
| 122 | AMER1 | APC membrane recruitment protein 1 [Source:HGNC Symbol;Acc:HGNC:26837] | 35605 | -2.161 | -0.0719 | No |
| 123 | MCM8 | minichromosome maintenance 8 homologous recombination repair factor [Source:HGNC Symbol;Acc:HGNC:16147] | 36080 | -2.584 | -0.0655 | No |
| 124 | ARHGEF6 | Rac/Cdc42 guanine nucleotide exchange factor 6 [Source:HGNC Symbol;Acc:HGNC:685] | 36196 | -2.718 | -0.0485 | No |
| 125 | DEPDC7 | DEP domain containing 7 [Source:HGNC Symbol;Acc:HGNC:29899] | 36328 | -2.860 | -0.0309 | No |
| 126 | FAM13C | family with sequence similarity 13 member C [Source:HGNC Symbol;Acc:HGNC:19371] | 36468 | -2.991 | -0.0125 | No |
| 127 | SORBS1 | sorbin and SH3 domain containing 1 [Source:HGNC Symbol;Acc:HGNC:14565] | 36948 | -3.948 | 0.0038 | No |
