Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.greenbergcls.cls #WT_LPS_versus_WT_NA.greenbergcls.cls #WT_LPS_versus_WT_NA_repos |
| Phenotype | greenbergcls.cls#WT_LPS_versus_WT_NA_repos |
| Upregulated in class | WT_NA |
| GeneSet | GOBP_MEIOTIC_CHROMOSOME_SEGREGATION |
| Enrichment Score (ES) | -0.7600712 |
| Normalized Enrichment Score (NES) | -1.5761418 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.07403123 |
| FWER p-Value | 0.678 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | EME2 | essential meiotic structure-specific endonuclease subunit 2 [Source:HGNC Symbol;Acc:HGNC:27289] | 676 | 2.025 | 0.0054 | No |
| 2 | ACTR3 | actin related protein 3 [Source:HGNC Symbol;Acc:HGNC:170] | 974 | 1.583 | 0.0159 | No |
| 3 | ACTR2 | actin related protein 2 [Source:HGNC Symbol;Acc:HGNC:169] | 1079 | 1.489 | 0.0306 | No |
| 4 | PTTG3P | pituitary tumor-transforming 3, pseudogene [Source:HGNC Symbol;Acc:HGNC:13422] | 4519 | 0.265 | -0.0593 | No |
| 5 | MAJIN | membrane anchored junction protein [Source:HGNC Symbol;Acc:HGNC:27441] | 4935 | 0.202 | -0.0681 | No |
| 6 | MSH4 | mutS homolog 4 [Source:HGNC Symbol;Acc:HGNC:7327] | 5509 | 0.119 | -0.0822 | No |
| 7 | RNF212 | ring finger protein 212 [Source:HGNC Symbol;Acc:HGNC:27729] | 5747 | 0.089 | -0.0876 | No |
| 8 | UBE2B | ubiquitin conjugating enzyme E2 B [Source:HGNC Symbol;Acc:HGNC:12473] | 6332 | 0.005 | -0.1033 | No |
| 9 | HFM1 | helicase for meiosis 1 [Source:HGNC Symbol;Acc:HGNC:20193] | 7522 | 0.000 | -0.1354 | No |
| 10 | ANKRD31 | ankyrin repeat domain 31 [Source:HGNC Symbol;Acc:HGNC:26853] | 7677 | 0.000 | -0.1396 | No |
| 11 | STAG3 | stromal antigen 3 [Source:HGNC Symbol;Acc:HGNC:11356] | 7829 | 0.000 | -0.1437 | No |
| 12 | PTTG2 | pituitary tumor-transforming 2 [Source:HGNC Symbol;Acc:HGNC:9691] | 7897 | 0.000 | -0.1455 | No |
| 13 | RAD21L1 | RAD21 cohesin complex component like 1 [Source:HGNC Symbol;Acc:HGNC:16271] | 8048 | 0.000 | -0.1495 | No |
| 14 | C1orf146 | chromosome 1 open reading frame 146 [Source:HGNC Symbol;Acc:HGNC:24032] | 10120 | 0.000 | -0.2055 | No |
| 15 | SHOC1 | shortage in chiasmata 1 [Source:HGNC Symbol;Acc:HGNC:26535] | 10741 | 0.000 | -0.2222 | No |
| 16 | MEIOC | meiosis specific with coiled-coil domain [Source:HGNC Symbol;Acc:HGNC:26670] | 10760 | 0.000 | -0.2227 | No |
| 17 | RNF212B | ring finger protein 212B [Source:HGNC Symbol;Acc:HGNC:20438] | 11579 | 0.000 | -0.2448 | No |
| 18 | IHO1 | interactor of HORMAD1 1 [Source:HGNC Symbol;Acc:HGNC:27945] | 12755 | 0.000 | -0.2766 | No |
| 19 | MEIKIN | meiotic kinetochore factor [Source:HGNC Symbol;Acc:HGNC:51253] | 12813 | 0.000 | -0.2781 | No |
| 20 | TERB1 | telomere repeat binding bouquet formation protein 1 [Source:HGNC Symbol;Acc:HGNC:26675] | 13096 | 0.000 | -0.2858 | No |
| 21 | TERB2 | telomere repeat binding bouquet formation protein 2 [Source:HGNC Symbol;Acc:HGNC:28520] | 13097 | 0.000 | -0.2858 | No |
| 22 | REC8 | REC8 meiotic recombination protein [Source:HGNC Symbol;Acc:HGNC:16879] | 13643 | 0.000 | -0.3005 | No |
| 23 | TEX11 | testis expressed 11 [Source:HGNC Symbol;Acc:HGNC:11733] | 15151 | 0.000 | -0.3412 | No |
| 24 | TEX12 | testis expressed 12 [Source:HGNC Symbol;Acc:HGNC:11734] | 15152 | 0.000 | -0.3412 | No |
| 25 | TEX15 | testis expressed 15, meiosis and synapsis associated [Source:HGNC Symbol;Acc:HGNC:11738] | 15153 | 0.000 | -0.3412 | No |
| 26 | MEI4 | meiotic double-stranded break formation protein 4 [Source:HGNC Symbol;Acc:HGNC:43638] | 16349 | 0.000 | -0.3735 | No |
| 27 | DMC1 | DNA meiotic recombinase 1 [Source:HGNC Symbol;Acc:HGNC:2927] | 16834 | 0.000 | -0.3866 | No |
| 28 | SYCE3 | synaptonemal complex central element protein 3 [Source:HGNC Symbol;Acc:HGNC:35245] | 16918 | 0.000 | -0.3888 | No |
| 29 | SYCE1 | synaptonemal complex central element protein 1 [Source:HGNC Symbol;Acc:HGNC:28852] | 16919 | 0.000 | -0.3888 | No |
| 30 | MAPK15 | mitogen-activated protein kinase 15 [Source:HGNC Symbol;Acc:HGNC:24667] | 17663 | 0.000 | -0.4089 | No |
| 31 | SYCP2 | synaptonemal complex protein 2 [Source:HGNC Symbol;Acc:HGNC:11490] | 17750 | 0.000 | -0.4112 | No |
| 32 | SYCP1 | synaptonemal complex protein 1 [Source:HGNC Symbol;Acc:HGNC:11487] | 17751 | 0.000 | -0.4112 | No |
| 33 | CCNB1IP1 | cyclin B1 interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:19437] | 18196 | 0.000 | -0.4232 | No |
| 34 | P3H4 | prolyl 3-hydroxylase family member 4 (inactive) [Source:HGNC Symbol;Acc:HGNC:16946] | 18444 | 0.000 | -0.4299 | No |
| 35 | MOS | MOS proto-oncogene, serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:7199] | 18874 | 0.000 | -0.4415 | No |
| 36 | SPO11 | SPO11 initiator of meiotic double stranded breaks [Source:HGNC Symbol;Acc:HGNC:11250] | 19312 | 0.000 | -0.4533 | No |
| 37 | C14orf39 | chromosome 14 open reading frame 39 [Source:HGNC Symbol;Acc:HGNC:19849] | 19546 | 0.000 | -0.4596 | No |
| 38 | HORMAD2 | HORMA domain containing 2 [Source:HGNC Symbol;Acc:HGNC:28383] | 21425 | 0.000 | -0.5104 | No |
| 39 | SYCE1L | synaptonemal complex central element protein 1 like [Source:HGNC Symbol;Acc:HGNC:37236] | 22452 | 0.000 | -0.5381 | No |
| 40 | CORT | cortistatin [Source:HGNC Symbol;Acc:HGNC:2257] | 23100 | 0.000 | -0.5556 | No |
| 41 | CENPX | centromere protein X [Source:HGNC Symbol;Acc:HGNC:11422] | 23831 | 0.000 | -0.5753 | No |
| 42 | SPATA22 | spermatogenesis associated 22 [Source:HGNC Symbol;Acc:HGNC:30705] | 24731 | 0.000 | -0.5996 | No |
| 43 | FMN2 | formin 2 [Source:HGNC Symbol;Acc:HGNC:14074] | 26734 | 0.000 | -0.6537 | No |
| 44 | MAEL | maelstrom spermatogenic transposon silencer [Source:HGNC Symbol;Acc:HGNC:25929] | 26802 | 0.000 | -0.6555 | No |
| 45 | CENPS | centromere protein S [Source:HGNC Symbol;Acc:HGNC:23163] | 27105 | -0.000 | -0.6637 | No |
| 46 | BAG6 | BAG cochaperone 6 [Source:HGNC Symbol;Acc:HGNC:13919] | 27312 | -0.037 | -0.6688 | No |
| 47 | HORMAD1 | HORMA domain containing 1 [Source:HGNC Symbol;Acc:HGNC:25245] | 28939 | -0.245 | -0.7099 | No |
| 48 | SLX4 | SLX4 structure-specific endonuclease subunit [Source:HGNC Symbol;Acc:HGNC:23845] | 29547 | -0.331 | -0.7224 | No |
| 49 | KASH5 | KASH domain containing 5 [Source:HGNC Symbol;Acc:HGNC:26520] | 30214 | -0.430 | -0.7354 | No |
| 50 | MEIOB | meiosis specific with OB-fold [Source:HGNC Symbol;Acc:HGNC:28569] | 30271 | -0.438 | -0.7318 | No |
| 51 | SYCE2 | synaptonemal complex central element protein 2 [Source:HGNC Symbol;Acc:HGNC:27411] | 30731 | -0.511 | -0.7382 | No |
| 52 | ERCC4 | ERCC excision repair 4, endonuclease catalytic subunit [Source:HGNC Symbol;Acc:HGNC:3436] | 31178 | -0.585 | -0.7434 | No |
| 53 | PTTG1 | PTTG1 regulator of sister chromatid separation, securin [Source:HGNC Symbol;Acc:HGNC:9690] | 31585 | -0.666 | -0.7466 | No |
| 54 | CHFR | checkpoint with forkhead and ring finger domains [Source:HGNC Symbol;Acc:HGNC:20455] | 32086 | -0.782 | -0.7509 | Yes |
| 55 | ZCWPW1 | zinc finger CW-type and PWWP domain containing 1 [Source:HGNC Symbol;Acc:HGNC:23486] | 32185 | -0.805 | -0.7441 | Yes |
| 56 | CENPC | centromere protein C [Source:HGNC Symbol;Acc:HGNC:1854] | 32733 | -0.943 | -0.7479 | Yes |
| 57 | MUS81 | MUS81 structure-specific endonuclease subunit [Source:HGNC Symbol;Acc:HGNC:29814] | 32764 | -0.951 | -0.7376 | Yes |
| 58 | NDC1 | NDC1 transmembrane nucleoporin [Source:HGNC Symbol;Acc:HGNC:25525] | 33125 | -1.054 | -0.7350 | Yes |
| 59 | SIRT7 | sirtuin 7 [Source:HGNC Symbol;Acc:HGNC:14935] | 33286 | -1.104 | -0.7264 | Yes |
| 60 | RMI1 | RecQ mediated genome instability 1 [Source:HGNC Symbol;Acc:HGNC:25764] | 33323 | -1.116 | -0.7143 | Yes |
| 61 | BRIP1 | BRCA1 interacting protein C-terminal helicase 1 [Source:HGNC Symbol;Acc:HGNC:20473] | 33729 | -1.244 | -0.7106 | Yes |
| 62 | ATM | ATM serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:795] | 34125 | -1.385 | -0.7051 | Yes |
| 63 | CCNE1 | cyclin E1 [Source:HGNC Symbol;Acc:HGNC:1589] | 34333 | -1.473 | -0.6934 | Yes |
| 64 | FANCM | FA complementation group M [Source:HGNC Symbol;Acc:HGNC:23168] | 34535 | -1.555 | -0.6807 | Yes |
| 65 | MLH1 | mutL homolog 1 [Source:HGNC Symbol;Acc:HGNC:7127] | 34741 | -1.644 | -0.6670 | Yes |
| 66 | MRE11 | MRE11 homolog, double strand break repair nuclease [Source:HGNC Symbol;Acc:HGNC:7230] | 34836 | -1.689 | -0.6497 | Yes |
| 67 | M1AP | meiosis 1 associated protein [Source:HGNC Symbol;Acc:HGNC:25183] | 35247 | -1.917 | -0.6384 | Yes |
| 68 | PRDM9 | PR/SET domain 9 [Source:HGNC Symbol;Acc:HGNC:13994] | 35397 | -2.010 | -0.6189 | Yes |
| 69 | RAD51C | RAD51 paralog C [Source:HGNC Symbol;Acc:HGNC:9820] | 35456 | -2.055 | -0.5964 | Yes |
| 70 | BUB1B | BUB1 mitotic checkpoint serine/threonine kinase B [Source:HGNC Symbol;Acc:HGNC:1149] | 35573 | -2.135 | -0.5745 | Yes |
| 71 | FANCD2 | FA complementation group D2 [Source:HGNC Symbol;Acc:HGNC:3585] | 35587 | -2.146 | -0.5498 | Yes |
| 72 | RAD21 | RAD21 cohesin complex component [Source:HGNC Symbol;Acc:HGNC:9811] | 35640 | -2.191 | -0.5255 | Yes |
| 73 | EME1 | essential meiotic structure-specific endonuclease 1 [Source:HGNC Symbol;Acc:HGNC:24965] | 35666 | -2.209 | -0.5003 | Yes |
| 74 | MLH3 | mutL homolog 3 [Source:HGNC Symbol;Acc:HGNC:7128] | 35679 | -2.218 | -0.4747 | Yes |
| 75 | TOP2B | DNA topoisomerase II beta [Source:HGNC Symbol;Acc:HGNC:11990] | 35733 | -2.262 | -0.4496 | Yes |
| 76 | AGO4 | argonaute RISC component 4 [Source:HGNC Symbol;Acc:HGNC:18424] | 35838 | -2.349 | -0.4249 | Yes |
| 77 | SMC4 | structural maintenance of chromosomes 4 [Source:HGNC Symbol;Acc:HGNC:14013] | 35874 | -2.384 | -0.3980 | Yes |
| 78 | SMC2 | structural maintenance of chromosomes 2 [Source:HGNC Symbol;Acc:HGNC:14011] | 35901 | -2.411 | -0.3704 | Yes |
| 79 | SGO1 | shugoshin 1 [Source:HGNC Symbol;Acc:HGNC:25088] | 36030 | -2.528 | -0.3443 | Yes |
| 80 | NCAPH2 | non-SMC condensin II complex subunit H2 [Source:HGNC Symbol;Acc:HGNC:25071] | 36226 | -2.741 | -0.3175 | Yes |
| 81 | TRIP13 | thyroid hormone receptor interactor 13 [Source:HGNC Symbol;Acc:HGNC:12307] | 36261 | -2.777 | -0.2859 | Yes |
| 82 | TOP2A | DNA topoisomerase II alpha [Source:HGNC Symbol;Acc:HGNC:11989] | 36339 | -2.870 | -0.2544 | Yes |
| 83 | ESPL1 | extra spindle pole bodies like 1, separase [Source:HGNC Symbol;Acc:HGNC:16856] | 36344 | -2.872 | -0.2209 | Yes |
| 84 | NUF2 | NUF2 component of NDC80 kinetochore complex [Source:HGNC Symbol;Acc:HGNC:14621] | 36418 | -2.951 | -0.1883 | Yes |
| 85 | SGO2 | shugoshin 2 [Source:HGNC Symbol;Acc:HGNC:30812] | 36478 | -3.003 | -0.1547 | Yes |
| 86 | PLK1 | polo like kinase 1 [Source:HGNC Symbol;Acc:HGNC:9077] | 36483 | -3.006 | -0.1196 | Yes |
| 87 | BUB1 | BUB1 mitotic checkpoint serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:1148] | 36724 | -3.390 | -0.0864 | Yes |
| 88 | TTK | TTK protein kinase [Source:HGNC Symbol;Acc:HGNC:12401] | 36894 | -3.758 | -0.0470 | Yes |
| 89 | CCNE2 | cyclin E2 [Source:HGNC Symbol;Acc:HGNC:1590] | 37055 | -4.466 | 0.0009 | Yes |
