Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.greenbergcls.cls #WT_LPS_versus_WT_NA.greenbergcls.cls #WT_LPS_versus_WT_NA_repos |
| Phenotype | greenbergcls.cls#WT_LPS_versus_WT_NA_repos |
| Upregulated in class | WT_NA |
| GeneSet | HALLMARK_BILE_ACID_METABOLISM |
| Enrichment Score (ES) | -0.6063869 |
| Normalized Enrichment Score (NES) | -1.2697234 |
| Nominal p-value | 0.05543237 |
| FDR q-value | 0.19707729 |
| FWER p-Value | 0.878 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | ATXN1 | ataxin 1 [Source:HGNC Symbol;Acc:HGNC:10548] | 210 | 3.412 | 0.0212 | No |
| 2 | AQP9 | aquaporin 9 [Source:HGNC Symbol;Acc:HGNC:643] | 217 | 3.381 | 0.0477 | No |
| 3 | ABCA1 | ATP binding cassette subfamily A member 1 [Source:HGNC Symbol;Acc:HGNC:29] | 234 | 3.285 | 0.0731 | No |
| 4 | HAO1 | hydroxyacid oxidase 1 [Source:HGNC Symbol;Acc:HGNC:4809] | 305 | 2.978 | 0.0947 | No |
| 5 | PRDX5 | peroxiredoxin 5 [Source:HGNC Symbol;Acc:HGNC:9355] | 414 | 2.564 | 0.1119 | No |
| 6 | LCK | LCK proto-oncogene, Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:6524] | 475 | 2.404 | 0.1292 | No |
| 7 | GCLM | glutamate-cysteine ligase modifier subunit [Source:HGNC Symbol;Acc:HGNC:4312] | 671 | 2.029 | 0.1399 | No |
| 8 | BCAR3 | BCAR3 adaptor protein, NSP family member [Source:HGNC Symbol;Acc:HGNC:973] | 1036 | 1.515 | 0.1420 | No |
| 9 | CH25H | cholesterol 25-hydroxylase [Source:HGNC Symbol;Acc:HGNC:1907] | 1287 | 1.321 | 0.1457 | No |
| 10 | LIPE | lipase E, hormone sensitive type [Source:HGNC Symbol;Acc:HGNC:6621] | 1888 | 0.968 | 0.1371 | No |
| 11 | TFCP2L1 | transcription factor CP2 like 1 [Source:HGNC Symbol;Acc:HGNC:17925] | 2334 | 0.789 | 0.1313 | No |
| 12 | PEX11A | peroxisomal biogenesis factor 11 alpha [Source:HGNC Symbol;Acc:HGNC:8852] | 2618 | 0.694 | 0.1291 | No |
| 13 | PEX12 | peroxisomal biogenesis factor 12 [Source:HGNC Symbol;Acc:HGNC:8854] | 3080 | 0.562 | 0.1210 | No |
| 14 | ABCA4 | ATP binding cassette subfamily A member 4 [Source:HGNC Symbol;Acc:HGNC:34] | 3630 | 0.432 | 0.1096 | No |
| 15 | SLC27A2 | solute carrier family 27 member 2 [Source:HGNC Symbol;Acc:HGNC:10996] | 4964 | 0.197 | 0.0751 | No |
| 16 | DIO2 | iodothyronine deiodinase 2 [Source:HGNC Symbol;Acc:HGNC:2884] | 5162 | 0.167 | 0.0711 | No |
| 17 | GC | GC vitamin D binding protein [Source:HGNC Symbol;Acc:HGNC:4187] | 5472 | 0.124 | 0.0637 | No |
| 18 | EPHX2 | epoxide hydrolase 2 [Source:HGNC Symbol;Acc:HGNC:3402] | 7927 | 0.000 | -0.0027 | No |
| 19 | ALDH8A1 | aldehyde dehydrogenase 8 family member A1 [Source:HGNC Symbol;Acc:HGNC:15471] | 8595 | 0.000 | -0.0207 | No |
| 20 | GSTK1 | glutathione S-transferase kappa 1 [Source:HGNC Symbol;Acc:HGNC:16906] | 9658 | 0.000 | -0.0494 | No |
| 21 | SLC23A1 | solute carrier family 23 member 1 [Source:HGNC Symbol;Acc:HGNC:10974] | 9847 | 0.000 | -0.0545 | No |
| 22 | APOA1 | apolipoprotein A1 [Source:HGNC Symbol;Acc:HGNC:600] | 10124 | 0.000 | -0.0620 | No |
| 23 | NEDD4 | NEDD4 E3 ubiquitin protein ligase [Source:HGNC Symbol;Acc:HGNC:7727] | 10461 | 0.000 | -0.0710 | No |
| 24 | AKR1D1 | aldo-keto reductase family 1 member D1 [Source:HGNC Symbol;Acc:HGNC:388] | 11503 | 0.000 | -0.0992 | No |
| 25 | AGXT | alanine--glyoxylate and serine--pyruvate aminotransferase [Source:HGNC Symbol;Acc:HGNC:341] | 12108 | 0.000 | -0.1155 | No |
| 26 | CYP39A1 | cytochrome P450 family 39 subfamily A member 1 [Source:HGNC Symbol;Acc:HGNC:17449] | 12437 | 0.000 | -0.1244 | No |
| 27 | HSD3B1 | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 [Source:HGNC Symbol;Acc:HGNC:5217] | 12569 | 0.000 | -0.1279 | No |
| 28 | TTR | transthyretin [Source:HGNC Symbol;Acc:HGNC:12405] | 12680 | 0.000 | -0.1309 | No |
| 29 | CYP8B1 | cytochrome P450 family 8 subfamily B member 1 [Source:HGNC Symbol;Acc:HGNC:2653] | 15313 | 0.000 | -0.2021 | No |
| 30 | DIO1 | iodothyronine deiodinase 1 [Source:HGNC Symbol;Acc:HGNC:2883] | 15803 | 0.000 | -0.2153 | No |
| 31 | SERPINA6 | serpin family A member 6 [Source:HGNC Symbol;Acc:HGNC:1540] | 17691 | 0.000 | -0.2663 | No |
| 32 | OPTN | optineurin [Source:HGNC Symbol;Acc:HGNC:17142] | 17928 | 0.000 | -0.2727 | No |
| 33 | BMP6 | bone morphogenetic protein 6 [Source:HGNC Symbol;Acc:HGNC:1073] | 18935 | 0.000 | -0.2999 | No |
| 34 | HSD17B6 | hydroxysteroid 17-beta dehydrogenase 6 [Source:HGNC Symbol;Acc:HGNC:23316] | 19627 | 0.000 | -0.3186 | No |
| 35 | NR1H4 | nuclear receptor subfamily 1 group H member 4 [Source:HGNC Symbol;Acc:HGNC:7967] | 19826 | 0.000 | -0.3240 | No |
| 36 | BBOX1 | gamma-butyrobetaine hydroxylase 1 [Source:HGNC Symbol;Acc:HGNC:964] | 20751 | 0.000 | -0.3490 | No |
| 37 | CYP7B1 | cytochrome P450 family 7 subfamily B member 1 [Source:HGNC Symbol;Acc:HGNC:2652] | 20900 | 0.000 | -0.3530 | No |
| 38 | CYP7A1 | cytochrome P450 family 7 subfamily A member 1 [Source:HGNC Symbol;Acc:HGNC:2651] | 20923 | 0.000 | -0.3536 | No |
| 39 | SULT2B1 | sulfotransferase family 2B member 1 [Source:HGNC Symbol;Acc:HGNC:11459] | 23477 | 0.000 | -0.4226 | No |
| 40 | SULT1B1 | sulfotransferase family 1B member 1 [Source:HGNC Symbol;Acc:HGNC:17845] | 23770 | 0.000 | -0.4305 | No |
| 41 | PIPOX | pipecolic acid and sarcosine oxidase [Source:HGNC Symbol;Acc:HGNC:17804] | 24640 | 0.000 | -0.4540 | No |
| 42 | ALDH1A1 | aldehyde dehydrogenase 1 family member A1 [Source:HGNC Symbol;Acc:HGNC:402] | 25326 | 0.000 | -0.4725 | No |
| 43 | CYP46A1 | cytochrome P450 family 46 subfamily A member 1 [Source:HGNC Symbol;Acc:HGNC:2641] | 25560 | 0.000 | -0.4788 | No |
| 44 | ABCA6 | ATP binding cassette subfamily A member 6 [Source:HGNC Symbol;Acc:HGNC:36] | 26467 | 0.000 | -0.5033 | No |
| 45 | ABCA9 | ATP binding cassette subfamily A member 9 [Source:HGNC Symbol;Acc:HGNC:39] | 26470 | 0.000 | -0.5034 | No |
| 46 | SLCO1A2 | solute carrier organic anion transporter family member 1A2 [Source:HGNC Symbol;Acc:HGNC:10956] | 26514 | 0.000 | -0.5045 | No |
| 47 | ABCG8 | ATP binding cassette subfamily G member 8 [Source:HGNC Symbol;Acc:HGNC:13887] | 27064 | 0.000 | -0.5194 | No |
| 48 | ABCA8 | ATP binding cassette subfamily A member 8 [Source:HGNC Symbol;Acc:HGNC:38] | 27402 | -0.048 | -0.5281 | No |
| 49 | SLC22A18 | solute carrier family 22 member 18 [Source:HGNC Symbol;Acc:HGNC:10964] | 27622 | -0.073 | -0.5335 | No |
| 50 | HSD17B11 | hydroxysteroid 17-beta dehydrogenase 11 [Source:HGNC Symbol;Acc:HGNC:22960] | 27683 | -0.079 | -0.5345 | No |
| 51 | PEX13 | peroxisomal biogenesis factor 13 [Source:HGNC Symbol;Acc:HGNC:8855] | 27712 | -0.084 | -0.5346 | No |
| 52 | ISOC1 | isochorismatase domain containing 1 [Source:HGNC Symbol;Acc:HGNC:24254] | 27762 | -0.091 | -0.5352 | No |
| 53 | SOAT2 | sterol O-acyltransferase 2 [Source:HGNC Symbol;Acc:HGNC:11178] | 28014 | -0.124 | -0.5410 | No |
| 54 | PECR | peroxisomal trans-2-enoyl-CoA reductase [Source:HGNC Symbol;Acc:HGNC:18281] | 28033 | -0.126 | -0.5405 | No |
| 55 | AR | androgen receptor [Source:HGNC Symbol;Acc:HGNC:644] | 28141 | -0.138 | -0.5423 | No |
| 56 | PEX19 | peroxisomal biogenesis factor 19 [Source:HGNC Symbol;Acc:HGNC:9713] | 28442 | -0.177 | -0.5490 | No |
| 57 | NR1I2 | nuclear receptor subfamily 1 group I member 2 [Source:HGNC Symbol;Acc:HGNC:7968] | 28453 | -0.179 | -0.5479 | No |
| 58 | IDI1 | isopentenyl-diphosphate delta isomerase 1 [Source:HGNC Symbol;Acc:HGNC:5387] | 28721 | -0.216 | -0.5534 | No |
| 59 | KLF1 | Kruppel like factor 1 [Source:HGNC Symbol;Acc:HGNC:6345] | 28785 | -0.225 | -0.5533 | No |
| 60 | GNMT | glycine N-methyltransferase [Source:HGNC Symbol;Acc:HGNC:4415] | 28911 | -0.242 | -0.5548 | No |
| 61 | SLC27A5 | solute carrier family 27 member 5 [Source:HGNC Symbol;Acc:HGNC:10999] | 29453 | -0.320 | -0.5669 | No |
| 62 | SLC23A2 | solute carrier family 23 member 2 [Source:HGNC Symbol;Acc:HGNC:10973] | 29497 | -0.324 | -0.5655 | No |
| 63 | SOD1 | superoxide dismutase 1 [Source:HGNC Symbol;Acc:HGNC:11179] | 29601 | -0.340 | -0.5656 | No |
| 64 | RXRA | retinoid X receptor alpha [Source:HGNC Symbol;Acc:HGNC:10477] | 30357 | -0.450 | -0.5825 | No |
| 65 | MLYCD | malonyl-CoA decarboxylase [Source:HGNC Symbol;Acc:HGNC:7150] | 30903 | -0.540 | -0.5930 | No |
| 66 | EFHC1 | EF-hand domain containing 1 [Source:HGNC Symbol;Acc:HGNC:16406] | 30984 | -0.553 | -0.5908 | No |
| 67 | PEX16 | peroxisomal biogenesis factor 16 [Source:HGNC Symbol;Acc:HGNC:8857] | 31144 | -0.581 | -0.5905 | No |
| 68 | ACSL1 | acyl-CoA synthetase long chain family member 1 [Source:HGNC Symbol;Acc:HGNC:3569] | 31206 | -0.590 | -0.5875 | No |
| 69 | ACSL5 | acyl-CoA synthetase long chain family member 5 [Source:HGNC Symbol;Acc:HGNC:16526] | 31905 | -0.739 | -0.6006 | Yes |
| 70 | PEX7 | peroxisomal biogenesis factor 7 [Source:HGNC Symbol;Acc:HGNC:8860] | 31910 | -0.741 | -0.5948 | Yes |
| 71 | RBP1 | retinol binding protein 1 [Source:HGNC Symbol;Acc:HGNC:9919] | 32179 | -0.805 | -0.5958 | Yes |
| 72 | PEX26 | peroxisomal biogenesis factor 26 [Source:HGNC Symbol;Acc:HGNC:22965] | 32243 | -0.818 | -0.5910 | Yes |
| 73 | PEX6 | peroxisomal biogenesis factor 6 [Source:HGNC Symbol;Acc:HGNC:8859] | 32260 | -0.821 | -0.5850 | Yes |
| 74 | PHYH | phytanoyl-CoA 2-hydroxylase [Source:HGNC Symbol;Acc:HGNC:8940] | 32550 | -0.891 | -0.5858 | Yes |
| 75 | PNPLA8 | patatin like phospholipase domain containing 8 [Source:HGNC Symbol;Acc:HGNC:28900] | 32606 | -0.905 | -0.5801 | Yes |
| 76 | PEX11G | peroxisomal biogenesis factor 11 gamma [Source:HGNC Symbol;Acc:HGNC:20208] | 33075 | -1.040 | -0.5846 | Yes |
| 77 | NUDT12 | nudix hydrolase 12 [Source:HGNC Symbol;Acc:HGNC:18826] | 33188 | -1.071 | -0.5792 | Yes |
| 78 | NR0B2 | nuclear receptor subfamily 0 group B member 2 [Source:HGNC Symbol;Acc:HGNC:7961] | 33234 | -1.084 | -0.5719 | Yes |
| 79 | NR3C2 | nuclear receptor subfamily 3 group C member 2 [Source:HGNC Symbol;Acc:HGNC:7979] | 33298 | -1.108 | -0.5649 | Yes |
| 80 | AMACR | alpha-methylacyl-CoA racemase [Source:HGNC Symbol;Acc:HGNC:451] | 33568 | -1.192 | -0.5627 | Yes |
| 81 | RXRG | retinoid X receptor gamma [Source:HGNC Symbol;Acc:HGNC:10479] | 33719 | -1.240 | -0.5570 | Yes |
| 82 | LONP2 | lon peptidase 2, peroxisomal [Source:HGNC Symbol;Acc:HGNC:20598] | 33859 | -1.289 | -0.5506 | Yes |
| 83 | GNPAT | glyceronephosphate O-acyltransferase [Source:HGNC Symbol;Acc:HGNC:4416] | 33892 | -1.302 | -0.5413 | Yes |
| 84 | PEX1 | peroxisomal biogenesis factor 1 [Source:HGNC Symbol;Acc:HGNC:8850] | 34200 | -1.409 | -0.5385 | Yes |
| 85 | NPC1 | NPC intracellular cholesterol transporter 1 [Source:HGNC Symbol;Acc:HGNC:7897] | 34383 | -1.493 | -0.5316 | Yes |
| 86 | ABCD3 | ATP binding cassette subfamily D member 3 [Source:HGNC Symbol;Acc:HGNC:67] | 34703 | -1.629 | -0.5274 | Yes |
| 87 | PXMP2 | peroxisomal membrane protein 2 [Source:HGNC Symbol;Acc:HGNC:9716] | 34960 | -1.751 | -0.5206 | Yes |
| 88 | ABCG4 | ATP binding cassette subfamily G member 4 [Source:HGNC Symbol;Acc:HGNC:13884] | 35406 | -2.016 | -0.5167 | Yes |
| 89 | SCP2 | sterol carrier protein 2 [Source:HGNC Symbol;Acc:HGNC:10606] | 35417 | -2.022 | -0.5011 | Yes |
| 90 | ABCD1 | ATP binding cassette subfamily D member 1 [Source:HGNC Symbol;Acc:HGNC:61] | 35552 | -2.116 | -0.4880 | Yes |
| 91 | CROT | carnitine O-octanoyltransferase [Source:HGNC Symbol;Acc:HGNC:2366] | 35628 | -2.180 | -0.4729 | Yes |
| 92 | CAT | catalase [Source:HGNC Symbol;Acc:HGNC:1516] | 35726 | -2.257 | -0.4577 | Yes |
| 93 | RETSAT | retinol saturase [Source:HGNC Symbol;Acc:HGNC:25991] | 35792 | -2.309 | -0.4413 | Yes |
| 94 | FDXR | ferredoxin reductase [Source:HGNC Symbol;Acc:HGNC:3642] | 35798 | -2.313 | -0.4232 | Yes |
| 95 | IDH2 | isocitrate dehydrogenase (NADP(+)) 2 [Source:HGNC Symbol;Acc:HGNC:5383] | 35823 | -2.340 | -0.4054 | Yes |
| 96 | ABCA3 | ATP binding cassette subfamily A member 3 [Source:HGNC Symbol;Acc:HGNC:33] | 35910 | -2.418 | -0.3887 | Yes |
| 97 | ABCA2 | ATP binding cassette subfamily A member 2 [Source:HGNC Symbol;Acc:HGNC:32] | 36018 | -2.513 | -0.3718 | Yes |
| 98 | HSD17B4 | hydroxysteroid 17-beta dehydrogenase 4 [Source:HGNC Symbol;Acc:HGNC:5213] | 36219 | -2.736 | -0.3557 | Yes |
| 99 | ABCA5 | ATP binding cassette subfamily A member 5 [Source:HGNC Symbol;Acc:HGNC:35] | 36305 | -2.822 | -0.3357 | Yes |
| 100 | SLC35B2 | solute carrier family 35 member B2 [Source:HGNC Symbol;Acc:HGNC:16872] | 36365 | -2.887 | -0.3146 | Yes |
| 101 | PAOX | polyamine oxidase [Source:HGNC Symbol;Acc:HGNC:20837] | 36387 | -2.912 | -0.2922 | Yes |
| 102 | FADS1 | fatty acid desaturase 1 [Source:HGNC Symbol;Acc:HGNC:3574] | 36426 | -2.958 | -0.2700 | Yes |
| 103 | ALDH9A1 | aldehyde dehydrogenase 9 family member A1 [Source:HGNC Symbol;Acc:HGNC:412] | 36441 | -2.969 | -0.2470 | Yes |
| 104 | HSD3B7 | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 [Source:HGNC Symbol;Acc:HGNC:18324] | 36463 | -2.987 | -0.2240 | Yes |
| 105 | FADS2 | fatty acid desaturase 2 [Source:HGNC Symbol;Acc:HGNC:3575] | 36575 | -3.127 | -0.2024 | Yes |
| 106 | DHCR24 | 24-dehydrocholesterol reductase [Source:HGNC Symbol;Acc:HGNC:2859] | 36670 | -3.276 | -0.1791 | Yes |
| 107 | SLC29A1 | solute carrier family 29 member 1 (Augustine blood group) [Source:HGNC Symbol;Acc:HGNC:11003] | 36790 | -3.513 | -0.1547 | Yes |
| 108 | CYP27A1 | cytochrome P450 family 27 subfamily A member 1 [Source:HGNC Symbol;Acc:HGNC:2605] | 36901 | -3.771 | -0.1279 | Yes |
| 109 | IDH1 | isocitrate dehydrogenase (NADP(+)) 1 [Source:HGNC Symbol;Acc:HGNC:5382] | 36928 | -3.878 | -0.0981 | Yes |
| 110 | PFKM | phosphofructokinase, muscle [Source:HGNC Symbol;Acc:HGNC:8877] | 36937 | -3.899 | -0.0676 | Yes |
| 111 | HACL1 | 2-hydroxyacyl-CoA lyase 1 [Source:HGNC Symbol;Acc:HGNC:17856] | 37032 | -4.335 | -0.0360 | Yes |
| 112 | ABCD2 | ATP binding cassette subfamily D member 2 [Source:HGNC Symbol;Acc:HGNC:66] | 37080 | -4.769 | 0.0003 | Yes |
