Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.greenbergcls.cls #WT_LPS_versus_WT_NA.greenbergcls.cls #WT_LPS_versus_WT_NA_repos |
| Phenotype | greenbergcls.cls#WT_LPS_versus_WT_NA_repos |
| Upregulated in class | WT_LPS |
| GeneSet | HALLMARK_PI3K_AKT_MTOR_SIGNALING |
| Enrichment Score (ES) | 0.3815663 |
| Normalized Enrichment Score (NES) | 0.9605607 |
| Nominal p-value | 0.58474576 |
| FDR q-value | 0.58713436 |
| FWER p-Value | 0.917 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | STAT2 | signal transducer and activator of transcription 2 [Source:HGNC Symbol;Acc:HGNC:11363] | 132 | 3.896 | 0.0349 | Yes |
| 2 | NFKBIB | NFKB inhibitor beta [Source:HGNC Symbol;Acc:HGNC:7798] | 228 | 3.315 | 0.0650 | Yes |
| 3 | SQSTM1 | sequestosome 1 [Source:HGNC Symbol;Acc:HGNC:11280] | 239 | 3.274 | 0.0970 | Yes |
| 4 | MYD88 | MYD88 innate immune signal transduction adaptor [Source:HGNC Symbol;Acc:HGNC:7562] | 322 | 2.909 | 0.1235 | Yes |
| 5 | MAP2K3 | mitogen-activated protein kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6843] | 376 | 2.682 | 0.1485 | Yes |
| 6 | LCK | LCK proto-oncogene, Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:6524] | 475 | 2.404 | 0.1696 | Yes |
| 7 | IL2RG | interleukin 2 receptor subunit gamma [Source:HGNC Symbol;Acc:HGNC:6010] | 510 | 2.318 | 0.1916 | Yes |
| 8 | TNFRSF1A | TNF receptor superfamily member 1A [Source:HGNC Symbol;Acc:HGNC:11916] | 575 | 2.183 | 0.2114 | Yes |
| 9 | ACTR3 | actin related protein 3 [Source:HGNC Symbol;Acc:HGNC:170] | 974 | 1.583 | 0.2162 | Yes |
| 10 | UBE2D3 | ubiquitin conjugating enzyme E2 D3 [Source:HGNC Symbol;Acc:HGNC:12476] | 1034 | 1.518 | 0.2296 | Yes |
| 11 | PFN1 | profilin 1 [Source:HGNC Symbol;Acc:HGNC:8881] | 1071 | 1.494 | 0.2434 | Yes |
| 12 | ACTR2 | actin related protein 2 [Source:HGNC Symbol;Acc:HGNC:169] | 1079 | 1.489 | 0.2579 | Yes |
| 13 | PIN1 | peptidylprolyl cis/trans isomerase, NIMA-interacting 1 [Source:HGNC Symbol;Acc:HGNC:8988] | 1300 | 1.313 | 0.2649 | Yes |
| 14 | SLC2A1 | solute carrier family 2 member 1 [Source:HGNC Symbol;Acc:HGNC:11005] | 1317 | 1.301 | 0.2773 | Yes |
| 15 | CFL1 | cofilin 1 [Source:HGNC Symbol;Acc:HGNC:1874] | 1337 | 1.290 | 0.2895 | Yes |
| 16 | DDIT3 | DNA damage inducible transcript 3 [Source:HGNC Symbol;Acc:HGNC:2726] | 1487 | 1.182 | 0.2971 | Yes |
| 17 | TBK1 | TANK binding kinase 1 [Source:HGNC Symbol;Acc:HGNC:11584] | 1725 | 1.043 | 0.3010 | Yes |
| 18 | TRIB3 | tribbles pseudokinase 3 [Source:HGNC Symbol;Acc:HGNC:16228] | 1771 | 1.022 | 0.3099 | Yes |
| 19 | PAK4 | p21 (RAC1) activated kinase 4 [Source:HGNC Symbol;Acc:HGNC:16059] | 1779 | 1.018 | 0.3197 | Yes |
| 20 | CALR | calreticulin [Source:HGNC Symbol;Acc:HGNC:1455] | 1859 | 0.983 | 0.3273 | Yes |
| 21 | RIT1 | Ras like without CAAX 1 [Source:HGNC Symbol;Acc:HGNC:10023] | 2024 | 0.909 | 0.3318 | Yes |
| 22 | PPP2R1B | protein phosphatase 2 scaffold subunit Abeta [Source:HGNC Symbol;Acc:HGNC:9303] | 2257 | 0.815 | 0.3336 | Yes |
| 23 | UBE2N | ubiquitin conjugating enzyme E2 N [Source:HGNC Symbol;Acc:HGNC:12492] | 2322 | 0.792 | 0.3397 | Yes |
| 24 | ADCY2 | adenylate cyclase 2 [Source:HGNC Symbol;Acc:HGNC:233] | 2339 | 0.789 | 0.3470 | Yes |
| 25 | YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta [Source:HGNC Symbol;Acc:HGNC:12849] | 2346 | 0.785 | 0.3546 | Yes |
| 26 | NOD1 | nucleotide binding oligomerization domain containing 1 [Source:HGNC Symbol;Acc:HGNC:16390] | 2349 | 0.785 | 0.3623 | Yes |
| 27 | AP2M1 | adaptor related protein complex 2 subunit mu 1 [Source:HGNC Symbol;Acc:HGNC:564] | 2395 | 0.767 | 0.3687 | Yes |
| 28 | TRAF2 | TNF receptor associated factor 2 [Source:HGNC Symbol;Acc:HGNC:12032] | 2449 | 0.750 | 0.3746 | Yes |
| 29 | AKT1S1 | AKT1 substrate 1 [Source:HGNC Symbol;Acc:HGNC:28426] | 2666 | 0.678 | 0.3755 | Yes |
| 30 | CDKN1A | cyclin dependent kinase inhibitor 1A [Source:HGNC Symbol;Acc:HGNC:1784] | 2687 | 0.672 | 0.3816 | Yes |
| 31 | PTPN11 | protein tyrosine phosphatase non-receptor type 11 [Source:HGNC Symbol;Acc:HGNC:9644] | 3076 | 0.563 | 0.3766 | No |
| 32 | ARF1 | ADP ribosylation factor 1 [Source:HGNC Symbol;Acc:HGNC:652] | 3264 | 0.515 | 0.3767 | No |
| 33 | IRAK4 | interleukin 1 receptor associated kinase 4 [Source:HGNC Symbol;Acc:HGNC:17967] | 3550 | 0.450 | 0.3734 | No |
| 34 | CAB39 | calcium binding protein 39 [Source:HGNC Symbol;Acc:HGNC:20292] | 4059 | 0.349 | 0.3631 | No |
| 35 | CSNK2B | casein kinase 2 beta [Source:HGNC Symbol;Acc:HGNC:2460] | 4126 | 0.337 | 0.3646 | No |
| 36 | ARPC3 | actin related protein 2/3 complex subunit 3 [Source:HGNC Symbol;Acc:HGNC:706] | 4162 | 0.330 | 0.3669 | No |
| 37 | ATF1 | activating transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:783] | 4178 | 0.327 | 0.3698 | No |
| 38 | ARHGDIA | Rho GDP dissociation inhibitor alpha [Source:HGNC Symbol;Acc:HGNC:678] | 4263 | 0.309 | 0.3705 | No |
| 39 | THEM4 | thioesterase superfamily member 4 [Source:HGNC Symbol;Acc:HGNC:17947] | 4615 | 0.249 | 0.3635 | No |
| 40 | PPP1CA | protein phosphatase 1 catalytic subunit alpha [Source:HGNC Symbol;Acc:HGNC:9281] | 4756 | 0.226 | 0.3619 | No |
| 41 | NCK1 | NCK adaptor protein 1 [Source:HGNC Symbol;Acc:HGNC:7664] | 4865 | 0.212 | 0.3611 | No |
| 42 | CLTC | clathrin heavy chain [Source:HGNC Symbol;Acc:HGNC:2092] | 4929 | 0.203 | 0.3614 | No |
| 43 | GSK3B | glycogen synthase kinase 3 beta [Source:HGNC Symbol;Acc:HGNC:4617] | 5098 | 0.178 | 0.3586 | No |
| 44 | RALB | RAS like proto-oncogene B [Source:HGNC Symbol;Acc:HGNC:9840] | 5107 | 0.177 | 0.3602 | No |
| 45 | GRB2 | growth factor receptor bound protein 2 [Source:HGNC Symbol;Acc:HGNC:4566] | 5270 | 0.153 | 0.3573 | No |
| 46 | FGF17 | fibroblast growth factor 17 [Source:HGNC Symbol;Acc:HGNC:3673] | 5293 | 0.150 | 0.3582 | No |
| 47 | CAB39L | calcium binding protein 39 like [Source:HGNC Symbol;Acc:HGNC:20290] | 5526 | 0.118 | 0.3531 | No |
| 48 | RIPK1 | receptor interacting serine/threonine kinase 1 [Source:HGNC Symbol;Acc:HGNC:10019] | 5564 | 0.113 | 0.3532 | No |
| 49 | SMAD2 | SMAD family member 2 [Source:HGNC Symbol;Acc:HGNC:6768] | 5636 | 0.105 | 0.3523 | No |
| 50 | EIF4E | eukaryotic translation initiation factor 4E [Source:HGNC Symbol;Acc:HGNC:3287] | 6009 | 0.053 | 0.3428 | No |
| 51 | PRKAA2 | protein kinase AMP-activated catalytic subunit alpha 2 [Source:HGNC Symbol;Acc:HGNC:9377] | 6806 | 0.000 | 0.3212 | No |
| 52 | FGF22 | fibroblast growth factor 22 [Source:HGNC Symbol;Acc:HGNC:3679] | 6918 | 0.000 | 0.3182 | No |
| 53 | PITX2 | paired like homeodomain 2 [Source:HGNC Symbol;Acc:HGNC:9005] | 7348 | 0.000 | 0.3066 | No |
| 54 | CAMK4 | calcium/calmodulin dependent protein kinase IV [Source:HGNC Symbol;Acc:HGNC:1464] | 9026 | 0.000 | 0.2613 | No |
| 55 | GNGT1 | G protein subunit gamma transducin 1 [Source:HGNC Symbol;Acc:HGNC:4411] | 16226 | 0.000 | 0.0666 | No |
| 56 | IL4 | interleukin 4 [Source:HGNC Symbol;Acc:HGNC:6014] | 17624 | 0.000 | 0.0289 | No |
| 57 | NGF | nerve growth factor [Source:HGNC Symbol;Acc:HGNC:7808] | 19140 | 0.000 | -0.0121 | No |
| 58 | FASLG | Fas ligand [Source:HGNC Symbol;Acc:HGNC:11936] | 20110 | 0.000 | -0.0383 | No |
| 59 | EGFR | epidermal growth factor receptor [Source:HGNC Symbol;Acc:HGNC:3236] | 21916 | 0.000 | -0.0871 | No |
| 60 | FGF6 | fibroblast growth factor 6 [Source:HGNC Symbol;Acc:HGNC:3684] | 25056 | 0.000 | -0.1720 | No |
| 61 | RAC1 | Rac family small GTPase 1 [Source:HGNC Symbol;Acc:HGNC:9801] | 27366 | -0.044 | -0.2340 | No |
| 62 | PLCB1 | phospholipase C beta 1 [Source:HGNC Symbol;Acc:HGNC:15917] | 27783 | -0.093 | -0.2443 | No |
| 63 | TIAM1 | TIAM Rac1 associated GEF 1 [Source:HGNC Symbol;Acc:HGNC:11805] | 27855 | -0.103 | -0.2452 | No |
| 64 | RPTOR | regulatory associated protein of MTOR complex 1 [Source:HGNC Symbol;Acc:HGNC:30287] | 28002 | -0.123 | -0.2479 | No |
| 65 | MAP3K7 | mitogen-activated protein kinase kinase kinase 7 [Source:HGNC Symbol;Acc:HGNC:6859] | 28525 | -0.189 | -0.2602 | No |
| 66 | GNA14 | G protein subunit alpha 14 [Source:HGNC Symbol;Acc:HGNC:4382] | 28903 | -0.241 | -0.2680 | No |
| 67 | RPS6KA3 | ribosomal protein S6 kinase A3 [Source:HGNC Symbol;Acc:HGNC:10432] | 29220 | -0.284 | -0.2737 | No |
| 68 | HRAS | HRas proto-oncogene, GTPase [Source:HGNC Symbol;Acc:HGNC:5173] | 29250 | -0.288 | -0.2717 | No |
| 69 | PIKFYVE | phosphoinositide kinase, FYVE-type zinc finger containing [Source:HGNC Symbol;Acc:HGNC:23785] | 29397 | -0.312 | -0.2725 | No |
| 70 | MAPK8 | mitogen-activated protein kinase 8 [Source:HGNC Symbol;Acc:HGNC:6881] | 29409 | -0.314 | -0.2697 | No |
| 71 | ECSIT | ECSIT signaling integrator [Source:HGNC Symbol;Acc:HGNC:29548] | 29514 | -0.326 | -0.2693 | No |
| 72 | PTEN | phosphatase and tensin homolog [Source:HGNC Symbol;Acc:HGNC:9588] | 29610 | -0.341 | -0.2685 | No |
| 73 | PRKAG1 | protein kinase AMP-activated non-catalytic subunit gamma 1 [Source:HGNC Symbol;Acc:HGNC:9385] | 29709 | -0.355 | -0.2677 | No |
| 74 | HSP90B1 | heat shock protein 90 beta family member 1 [Source:HGNC Symbol;Acc:HGNC:12028] | 29936 | -0.388 | -0.2700 | No |
| 75 | AKT1 | AKT serine/threonine kinase 1 [Source:HGNC Symbol;Acc:HGNC:391] | 30051 | -0.405 | -0.2691 | No |
| 76 | TSC2 | TSC complex subunit 2 [Source:HGNC Symbol;Acc:HGNC:12363] | 30236 | -0.434 | -0.2697 | No |
| 77 | RAF1 | Raf-1 proto-oncogene, serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:9829] | 30865 | -0.535 | -0.2814 | No |
| 78 | PLA2G12A | phospholipase A2 group XIIA [Source:HGNC Symbol;Acc:HGNC:18554] | 31210 | -0.591 | -0.2849 | No |
| 79 | MKNK1 | MAPK interacting serine/threonine kinase 1 [Source:HGNC Symbol;Acc:HGNC:7110] | 31339 | -0.614 | -0.2823 | No |
| 80 | MAPK10 | mitogen-activated protein kinase 10 [Source:HGNC Symbol;Acc:HGNC:6872] | 31560 | -0.661 | -0.2818 | No |
| 81 | MAPK9 | mitogen-activated protein kinase 9 [Source:HGNC Symbol;Acc:HGNC:6886] | 31612 | -0.673 | -0.2765 | No |
| 82 | MAPK1 | mitogen-activated protein kinase 1 [Source:HGNC Symbol;Acc:HGNC:6871] | 31992 | -0.762 | -0.2792 | No |
| 83 | SFN | stratifin [Source:HGNC Symbol;Acc:HGNC:10773] | 32221 | -0.813 | -0.2774 | No |
| 84 | MAPKAP1 | MAPK associated protein 1 [Source:HGNC Symbol;Acc:HGNC:18752] | 32316 | -0.836 | -0.2717 | No |
| 85 | PRKCB | protein kinase C beta [Source:HGNC Symbol;Acc:HGNC:9395] | 32505 | -0.880 | -0.2681 | No |
| 86 | PIK3R3 | phosphoinositide-3-kinase regulatory subunit 3 [Source:HGNC Symbol;Acc:HGNC:8981] | 33170 | -1.067 | -0.2755 | No |
| 87 | SLA | Src like adaptor [Source:HGNC Symbol;Acc:HGNC:10902] | 33174 | -1.067 | -0.2650 | No |
| 88 | RPS6KA1 | ribosomal protein S6 kinase A1 [Source:HGNC Symbol;Acc:HGNC:10430] | 33181 | -1.068 | -0.2547 | No |
| 89 | GRK2 | G protein-coupled receptor kinase 2 [Source:HGNC Symbol;Acc:HGNC:289] | 33864 | -1.290 | -0.2604 | No |
| 90 | CDK1 | cyclin dependent kinase 1 [Source:HGNC Symbol;Acc:HGNC:1722] | 33887 | -1.300 | -0.2481 | No |
| 91 | ITPR2 | inositol 1,4,5-trisphosphate receptor type 2 [Source:HGNC Symbol;Acc:HGNC:6181] | 33931 | -1.316 | -0.2363 | No |
| 92 | CXCR4 | C-X-C motif chemokine receptor 4 [Source:HGNC Symbol;Acc:HGNC:2561] | 34217 | -1.417 | -0.2301 | No |
| 93 | ACACA | acetyl-CoA carboxylase alpha [Source:HGNC Symbol;Acc:HGNC:84] | 34549 | -1.561 | -0.2236 | No |
| 94 | DAPP1 | dual adaptor of phosphotyrosine and 3-phosphoinositides 1 [Source:HGNC Symbol;Acc:HGNC:16500] | 34586 | -1.576 | -0.2090 | No |
| 95 | MKNK2 | MAPK interacting serine/threonine kinase 2 [Source:HGNC Symbol;Acc:HGNC:7111] | 35024 | -1.780 | -0.2033 | No |
| 96 | PRKAR2A | protein kinase cAMP-dependent type II regulatory subunit alpha [Source:HGNC Symbol;Acc:HGNC:9391] | 35069 | -1.808 | -0.1866 | No |
| 97 | DUSP3 | dual specificity phosphatase 3 [Source:HGNC Symbol;Acc:HGNC:3069] | 35158 | -1.855 | -0.1707 | No |
| 98 | VAV3 | vav guanine nucleotide exchange factor 3 [Source:HGNC Symbol;Acc:HGNC:12659] | 35481 | -2.071 | -0.1590 | No |
| 99 | CDK4 | cyclin dependent kinase 4 [Source:HGNC Symbol;Acc:HGNC:1773] | 35505 | -2.086 | -0.1390 | No |
| 100 | CDKN1B | cyclin dependent kinase inhibitor 1B [Source:HGNC Symbol;Acc:HGNC:1785] | 35569 | -2.133 | -0.1197 | No |
| 101 | MAP2K6 | mitogen-activated protein kinase kinase 6 [Source:HGNC Symbol;Acc:HGNC:6846] | 35828 | -2.343 | -0.1035 | No |
| 102 | CDK2 | cyclin dependent kinase 2 [Source:HGNC Symbol;Acc:HGNC:1771] | 35868 | -2.378 | -0.0811 | No |
| 103 | E2F1 | E2F transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:3113] | 36737 | -3.406 | -0.0710 | No |
| 104 | PLCG1 | phospholipase C gamma 1 [Source:HGNC Symbol;Acc:HGNC:9065] | 36883 | -3.717 | -0.0383 | No |
| 105 | PDK1 | pyruvate dehydrogenase kinase 1 [Source:HGNC Symbol;Acc:HGNC:8809] | 37050 | -4.442 | 0.0011 | No |
