Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.greenbergcls.cls #WT_LPS_versus_WT_NA.greenbergcls.cls #WT_LPS_versus_WT_NA_repos |
| Phenotype | greenbergcls.cls#WT_LPS_versus_WT_NA_repos |
| Upregulated in class | WT_NA |
| GeneSet | HALLMARK_PROTEIN_SECRETION |
| Enrichment Score (ES) | -0.48619786 |
| Normalized Enrichment Score (NES) | -1.0063782 |
| Nominal p-value | 0.47662485 |
| FDR q-value | 0.7726947 |
| FWER p-Value | 1.0 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | ABCA1 | ATP binding cassette subfamily A member 1 [Source:HGNC Symbol;Acc:HGNC:29] | 234 | 3.285 | 0.0367 | No |
| 2 | M6PR | mannose-6-phosphate receptor, cation dependent [Source:HGNC Symbol;Acc:HGNC:6752] | 774 | 1.857 | 0.0464 | No |
| 3 | CTSC | cathepsin C [Source:HGNC Symbol;Acc:HGNC:2528] | 872 | 1.694 | 0.0660 | No |
| 4 | DST | dystonin [Source:HGNC Symbol;Acc:HGNC:1090] | 905 | 1.655 | 0.0868 | No |
| 5 | ATP6V1H | ATPase H+ transporting V1 subunit H [Source:HGNC Symbol;Acc:HGNC:18303] | 1482 | 1.184 | 0.0867 | No |
| 6 | RAB22A | RAB22A, member RAS oncogene family [Source:HGNC Symbol;Acc:HGNC:9764] | 1501 | 1.175 | 0.1016 | No |
| 7 | STX12 | syntaxin 12 [Source:HGNC Symbol;Acc:HGNC:11430] | 1639 | 1.093 | 0.1122 | No |
| 8 | AP2B1 | adaptor related protein complex 2 subunit beta 1 [Source:HGNC Symbol;Acc:HGNC:563] | 1827 | 0.998 | 0.1202 | No |
| 9 | YKT6 | YKT6 v-SNARE homolog [Source:HGNC Symbol;Acc:HGNC:16959] | 2003 | 0.917 | 0.1275 | No |
| 10 | ATP7A | ATPase copper transporting alpha [Source:HGNC Symbol;Acc:HGNC:869] | 2117 | 0.870 | 0.1358 | No |
| 11 | AP2M1 | adaptor related protein complex 2 subunit mu 1 [Source:HGNC Symbol;Acc:HGNC:564] | 2395 | 0.767 | 0.1384 | No |
| 12 | USO1 | USO1 vesicle transport factor [Source:HGNC Symbol;Acc:HGNC:30904] | 2750 | 0.650 | 0.1373 | No |
| 13 | VPS4B | vacuolar protein sorting 4 homolog B [Source:HGNC Symbol;Acc:HGNC:10895] | 2964 | 0.587 | 0.1393 | No |
| 14 | RAB2A | RAB2A, member RAS oncogene family [Source:HGNC Symbol;Acc:HGNC:9763] | 3096 | 0.559 | 0.1430 | No |
| 15 | SEC22B | SEC22 homolog B, vesicle trafficking protein (gene/pseudogene) [Source:HGNC Symbol;Acc:HGNC:10700] | 3203 | 0.530 | 0.1471 | No |
| 16 | ARF1 | ADP ribosylation factor 1 [Source:HGNC Symbol;Acc:HGNC:652] | 3264 | 0.515 | 0.1522 | No |
| 17 | ARFGEF1 | ADP ribosylation factor guanine nucleotide exchange factor 1 [Source:HGNC Symbol;Acc:HGNC:15772] | 3512 | 0.458 | 0.1515 | No |
| 18 | RAB5A | RAB5A, member RAS oncogene family [Source:HGNC Symbol;Acc:HGNC:9783] | 3842 | 0.392 | 0.1478 | No |
| 19 | SNX2 | sorting nexin 2 [Source:HGNC Symbol;Acc:HGNC:11173] | 4456 | 0.277 | 0.1348 | No |
| 20 | ARCN1 | archain 1 [Source:HGNC Symbol;Acc:HGNC:649] | 4479 | 0.273 | 0.1378 | No |
| 21 | AP1G1 | adaptor related protein complex 1 subunit gamma 1 [Source:HGNC Symbol;Acc:HGNC:555] | 4896 | 0.208 | 0.1293 | No |
| 22 | CLTC | clathrin heavy chain [Source:HGNC Symbol;Acc:HGNC:2092] | 4929 | 0.203 | 0.1311 | No |
| 23 | LAMP2 | lysosomal associated membrane protein 2 [Source:HGNC Symbol;Acc:HGNC:6501] | 5010 | 0.190 | 0.1314 | No |
| 24 | ATP6V1B1 | ATPase H+ transporting V1 subunit B1 [Source:HGNC Symbol;Acc:HGNC:853] | 5295 | 0.149 | 0.1257 | No |
| 25 | YIPF6 | Yip1 domain family member 6 [Source:HGNC Symbol;Acc:HGNC:28304] | 5307 | 0.147 | 0.1273 | No |
| 26 | STX16 | syntaxin 16 [Source:HGNC Symbol;Acc:HGNC:11431] | 5344 | 0.141 | 0.1282 | No |
| 27 | VAMP3 | vesicle associated membrane protein 3 [Source:HGNC Symbol;Acc:HGNC:12644] | 5380 | 0.137 | 0.1290 | No |
| 28 | ARFGAP3 | ADP ribosylation factor GTPase activating protein 3 [Source:HGNC Symbol;Acc:HGNC:661] | 5435 | 0.129 | 0.1293 | No |
| 29 | TMX1 | thioredoxin related transmembrane protein 1 [Source:HGNC Symbol;Acc:HGNC:15487] | 5658 | 0.103 | 0.1246 | No |
| 30 | LMAN1 | lectin, mannose binding 1 [Source:HGNC Symbol;Acc:HGNC:6631] | 5942 | 0.062 | 0.1178 | No |
| 31 | TMED2 | transmembrane p24 trafficking protein 2 [Source:HGNC Symbol;Acc:HGNC:16996] | 6158 | 0.030 | 0.1123 | No |
| 32 | TSPAN8 | tetraspanin 8 [Source:HGNC Symbol;Acc:HGNC:11855] | 11472 | 0.000 | -0.0313 | No |
| 33 | SCRN1 | secernin 1 [Source:HGNC Symbol;Acc:HGNC:22192] | 14027 | 0.000 | -0.1003 | No |
| 34 | KRT18 | keratin 18 [Source:HGNC Symbol;Acc:HGNC:6430] | 21757 | 0.000 | -0.3092 | No |
| 35 | EGFR | epidermal growth factor receptor [Source:HGNC Symbol;Acc:HGNC:3236] | 21916 | 0.000 | -0.3135 | No |
| 36 | SSPN | sarcospan [Source:HGNC Symbol;Acc:HGNC:11322] | 26731 | 0.000 | -0.4436 | No |
| 37 | GBF1 | golgi brefeldin A resistant guanine nucleotide exchange factor 1 [Source:HGNC Symbol;Acc:HGNC:4181] | 27280 | -0.030 | -0.4580 | No |
| 38 | TSG101 | tumor susceptibility 101 [Source:HGNC Symbol;Acc:HGNC:15971] | 27377 | -0.045 | -0.4600 | No |
| 39 | RER1 | retention in endoplasmic reticulum sorting receptor 1 [Source:HGNC Symbol;Acc:HGNC:30309] | 27404 | -0.048 | -0.4601 | No |
| 40 | IGF2R | insulin like growth factor 2 receptor [Source:HGNC Symbol;Acc:HGNC:5467] | 27462 | -0.057 | -0.4609 | No |
| 41 | STAM | signal transducing adaptor molecule [Source:HGNC Symbol;Acc:HGNC:11357] | 27896 | -0.108 | -0.4712 | No |
| 42 | COG2 | component of oligomeric golgi complex 2 [Source:HGNC Symbol;Acc:HGNC:6546] | 28238 | -0.151 | -0.4785 | No |
| 43 | KIF1B | kinesin family member 1B [Source:HGNC Symbol;Acc:HGNC:16636] | 28276 | -0.155 | -0.4774 | No |
| 44 | SEC31A | SEC31 homolog A, COPII coat complex component [Source:HGNC Symbol;Acc:HGNC:17052] | 28344 | -0.163 | -0.4771 | No |
| 45 | TPD52 | tumor protein D52 [Source:HGNC Symbol;Acc:HGNC:12005] | 28565 | -0.194 | -0.4805 | No |
| 46 | GOSR2 | golgi SNAP receptor complex member 2 [Source:HGNC Symbol;Acc:HGNC:4431] | 28661 | -0.207 | -0.4804 | No |
| 47 | COPB2 | COPI coat complex subunit beta 2 [Source:HGNC Symbol;Acc:HGNC:2232] | 28878 | -0.238 | -0.4831 | Yes |
| 48 | CD63 | CD63 molecule [Source:HGNC Symbol;Acc:HGNC:1692] | 28900 | -0.241 | -0.4805 | Yes |
| 49 | AP2S1 | adaptor related protein complex 2 subunit sigma 1 [Source:HGNC Symbol;Acc:HGNC:565] | 28950 | -0.246 | -0.4786 | Yes |
| 50 | RAB14 | RAB14, member RAS oncogene family [Source:HGNC Symbol;Acc:HGNC:16524] | 29112 | -0.269 | -0.4794 | Yes |
| 51 | MON2 | MON2 homolog, regulator of endosome-to-Golgi trafficking [Source:HGNC Symbol;Acc:HGNC:29177] | 29151 | -0.276 | -0.4768 | Yes |
| 52 | RPS6KA3 | ribosomal protein S6 kinase A3 [Source:HGNC Symbol;Acc:HGNC:10432] | 29220 | -0.284 | -0.4750 | Yes |
| 53 | CLN5 | CLN5 intracellular trafficking protein [Source:HGNC Symbol;Acc:HGNC:2076] | 29420 | -0.315 | -0.4762 | Yes |
| 54 | ATP1A1 | ATPase Na+/K+ transporting subunit alpha 1 [Source:HGNC Symbol;Acc:HGNC:799] | 29510 | -0.326 | -0.4743 | Yes |
| 55 | SOD1 | superoxide dismutase 1 [Source:HGNC Symbol;Acc:HGNC:11179] | 29601 | -0.340 | -0.4723 | Yes |
| 56 | ARFIP1 | ADP ribosylation factor interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:21496] | 29627 | -0.343 | -0.4685 | Yes |
| 57 | COPB1 | COPI coat complex subunit beta 1 [Source:HGNC Symbol;Acc:HGNC:2231] | 29687 | -0.352 | -0.4655 | Yes |
| 58 | OCRL | OCRL inositol polyphosphate-5-phosphatase [Source:HGNC Symbol;Acc:HGNC:8108] | 29799 | -0.367 | -0.4637 | Yes |
| 59 | NAPA | NSF attachment protein alpha [Source:HGNC Symbol;Acc:HGNC:7641] | 30099 | -0.412 | -0.4664 | Yes |
| 60 | AP3S1 | adaptor related protein complex 3 subunit sigma 1 [Source:HGNC Symbol;Acc:HGNC:2013] | 30138 | -0.419 | -0.4619 | Yes |
| 61 | BET1 | Bet1 golgi vesicular membrane trafficking protein [Source:HGNC Symbol;Acc:HGNC:14562] | 30764 | -0.517 | -0.4720 | Yes |
| 62 | SNAP23 | synaptosome associated protein 23 [Source:HGNC Symbol;Acc:HGNC:11131] | 30766 | -0.517 | -0.4653 | Yes |
| 63 | DOP1A | DOP1 leucine zipper like protein A [Source:HGNC Symbol;Acc:HGNC:21194] | 30799 | -0.524 | -0.4593 | Yes |
| 64 | ARFGEF2 | ADP ribosylation factor guanine nucleotide exchange factor 2 [Source:HGNC Symbol;Acc:HGNC:15853] | 30860 | -0.534 | -0.4539 | Yes |
| 65 | ANP32E | acidic nuclear phosphoprotein 32 family member E [Source:HGNC Symbol;Acc:HGNC:16673] | 31243 | -0.597 | -0.4564 | Yes |
| 66 | AP3B1 | adaptor related protein complex 3 subunit beta 1 [Source:HGNC Symbol;Acc:HGNC:566] | 31275 | -0.603 | -0.4494 | Yes |
| 67 | TMED10 | transmembrane p24 trafficking protein 10 [Source:HGNC Symbol;Acc:HGNC:16998] | 31315 | -0.609 | -0.4425 | Yes |
| 68 | SCAMP3 | secretory carrier membrane protein 3 [Source:HGNC Symbol;Acc:HGNC:10565] | 31399 | -0.626 | -0.4365 | Yes |
| 69 | VAMP7 | vesicle associated membrane protein 7 [Source:HGNC Symbol;Acc:HGNC:11486] | 31741 | -0.695 | -0.4366 | Yes |
| 70 | CLTA | clathrin light chain A [Source:HGNC Symbol;Acc:HGNC:2090] | 31932 | -0.747 | -0.4320 | Yes |
| 71 | MAPK1 | mitogen-activated protein kinase 1 [Source:HGNC Symbol;Acc:HGNC:6871] | 31992 | -0.762 | -0.4236 | Yes |
| 72 | STX7 | syntaxin 7 [Source:HGNC Symbol;Acc:HGNC:11442] | 31994 | -0.762 | -0.4137 | Yes |
| 73 | NAPG | NSF attachment protein gamma [Source:HGNC Symbol;Acc:HGNC:7642] | 32070 | -0.779 | -0.4055 | Yes |
| 74 | GOLGA4 | golgin A4 [Source:HGNC Symbol;Acc:HGNC:4427] | 32202 | -0.809 | -0.3985 | Yes |
| 75 | SEC24D | SEC24 homolog D, COPII coat complex component [Source:HGNC Symbol;Acc:HGNC:10706] | 32251 | -0.820 | -0.3890 | Yes |
| 76 | DNM1L | dynamin 1 like [Source:HGNC Symbol;Acc:HGNC:2973] | 32282 | -0.827 | -0.3790 | Yes |
| 77 | ZW10 | zw10 kinetochore protein [Source:HGNC Symbol;Acc:HGNC:13194] | 32984 | -1.010 | -0.3847 | Yes |
| 78 | ERGIC3 | ERGIC and golgi 3 [Source:HGNC Symbol;Acc:HGNC:15927] | 33084 | -1.043 | -0.3737 | Yes |
| 79 | GNAS | GNAS complex locus [Source:HGNC Symbol;Acc:HGNC:4392] | 33320 | -1.115 | -0.3655 | Yes |
| 80 | COPE | COPI coat complex subunit epsilon [Source:HGNC Symbol;Acc:HGNC:2234] | 33349 | -1.123 | -0.3516 | Yes |
| 81 | RAB9A | RAB9A, member RAS oncogene family [Source:HGNC Symbol;Acc:HGNC:9792] | 34298 | -1.455 | -0.3581 | Yes |
| 82 | VPS45 | vacuolar protein sorting 45 homolog [Source:HGNC Symbol;Acc:HGNC:14579] | 34419 | -1.508 | -0.3416 | Yes |
| 83 | SH3GL2 | SH3 domain containing GRB2 like 2, endophilin A1 [Source:HGNC Symbol;Acc:HGNC:10831] | 34554 | -1.564 | -0.3248 | Yes |
| 84 | GALC | galactosylceramidase [Source:HGNC Symbol;Acc:HGNC:4115] | 34663 | -1.612 | -0.3066 | Yes |
| 85 | ADAM10 | ADAM metallopeptidase domain 10 [Source:HGNC Symbol;Acc:HGNC:188] | 34879 | -1.706 | -0.2901 | Yes |
| 86 | CLCN3 | chloride voltage-gated channel 3 [Source:HGNC Symbol;Acc:HGNC:2021] | 35000 | -1.769 | -0.2702 | Yes |
| 87 | PAM | peptidylglycine alpha-amidating monooxygenase [Source:HGNC Symbol;Acc:HGNC:8596] | 35078 | -1.813 | -0.2485 | Yes |
| 88 | GLA | galactosidase alpha [Source:HGNC Symbol;Acc:HGNC:4296] | 35157 | -1.854 | -0.2264 | Yes |
| 89 | SGMS1 | sphingomyelin synthase 1 [Source:HGNC Symbol;Acc:HGNC:29799] | 35523 | -2.096 | -0.2088 | Yes |
| 90 | PPT1 | palmitoyl-protein thioesterase 1 [Source:HGNC Symbol;Acc:HGNC:9325] | 35577 | -2.137 | -0.1822 | Yes |
| 91 | TOM1L1 | target of myb1 like 1 membrane trafficking protein [Source:HGNC Symbol;Acc:HGNC:11983] | 35697 | -2.232 | -0.1562 | Yes |
| 92 | SCAMP1 | secretory carrier membrane protein 1 [Source:HGNC Symbol;Acc:HGNC:10563] | 35817 | -2.334 | -0.1289 | Yes |
| 93 | VAMP4 | vesicle associated membrane protein 4 [Source:HGNC Symbol;Acc:HGNC:12645] | 35920 | -2.424 | -0.0999 | Yes |
| 94 | CAV2 | caveolin 2 [Source:HGNC Symbol;Acc:HGNC:1528] | 36299 | -2.818 | -0.0732 | Yes |
| 95 | ICA1 | islet cell autoantigen 1 [Source:HGNC Symbol;Acc:HGNC:5343] | 36397 | -2.922 | -0.0376 | Yes |
| 96 | BNIP3 | BCL2 interacting protein 3 [Source:HGNC Symbol;Acc:HGNC:1084] | 37030 | -4.302 | 0.0016 | Yes |
