Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #KO_GAQ_versus_KO_NA.Nof1.cls #KO_GAQ_versus_KO_NA_repos |
| Phenotype | Nof1.cls#KO_GAQ_versus_KO_NA_repos |
| Upregulated in class | KO_NA |
| GeneSet | REACTOME_AMINE_LIGAND_BINDING_RECEPTORS |
| Enrichment Score (ES) | -0.9086453 |
| Normalized Enrichment Score (NES) | -1.7409393 |
| Nominal p-value | 0.0 |
| FDR q-value | 4.1350946E-4 |
| FWER p-Value | 0.003 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | CHRM1 | cholinergic receptor muscarinic 1 [Source:HGNC Symbol;Acc:HGNC:1950] | 5347 | 0.183 | -0.1234 | No |
| 2 | HRH1 | histamine receptor H1 [Source:HGNC Symbol;Acc:HGNC:5182] | 5607 | 0.145 | -0.1139 | No |
| 3 | HTR7 | 5-hydroxytryptamine receptor 7 [Source:HGNC Symbol;Acc:HGNC:5302] | 5920 | 0.103 | -0.1106 | No |
| 4 | TAAR8 | trace amine associated receptor 8 [Source:HGNC Symbol;Acc:HGNC:14964] | 12738 | 0.000 | -0.2946 | No |
| 5 | TAAR9 | trace amine associated receptor 9 (gene/pseudogene) [Source:HGNC Symbol;Acc:HGNC:20977] | 12739 | 0.000 | -0.2946 | No |
| 6 | TAAR6 | trace amine associated receptor 6 [Source:HGNC Symbol;Acc:HGNC:20978] | 12740 | 0.000 | -0.2946 | No |
| 7 | TAAR5 | trace amine associated receptor 5 [Source:HGNC Symbol;Acc:HGNC:30236] | 12742 | 0.000 | -0.2946 | No |
| 8 | TAAR2 | trace amine associated receptor 2 (gene/pseudogene) [Source:HGNC Symbol;Acc:HGNC:4514] | 12744 | 0.000 | -0.2947 | No |
| 9 | TAAR1 | trace amine associated receptor 1 [Source:HGNC Symbol;Acc:HGNC:17734] | 12746 | 0.000 | -0.2947 | No |
| 10 | HTR4 | 5-hydroxytryptamine receptor 4 [Source:HGNC Symbol;Acc:HGNC:5299] | 15608 | 0.000 | -0.3719 | No |
| 11 | HTR6 | 5-hydroxytryptamine receptor 6 [Source:HGNC Symbol;Acc:HGNC:5301] | 15610 | 0.000 | -0.3719 | No |
| 12 | HTR1E | 5-hydroxytryptamine receptor 1E [Source:HGNC Symbol;Acc:HGNC:5291] | 15668 | 0.000 | -0.3735 | No |
| 13 | HTR1F | 5-hydroxytryptamine receptor 1F [Source:HGNC Symbol;Acc:HGNC:5292] | 15670 | 0.000 | -0.3735 | No |
| 14 | HTR1D | 5-hydroxytryptamine receptor 1D [Source:HGNC Symbol;Acc:HGNC:5289] | 15671 | 0.000 | -0.3735 | No |
| 15 | HTR1A | 5-hydroxytryptamine receptor 1A [Source:HGNC Symbol;Acc:HGNC:5286] | 15672 | 0.000 | -0.3735 | No |
| 16 | HTR2B | 5-hydroxytryptamine receptor 2B [Source:HGNC Symbol;Acc:HGNC:5294] | 15679 | 0.000 | -0.3737 | No |
| 17 | HTR2C | 5-hydroxytryptamine receptor 2C [Source:HGNC Symbol;Acc:HGNC:5295] | 15680 | 0.000 | -0.3737 | No |
| 18 | HTR2A | 5-hydroxytryptamine receptor 2A [Source:HGNC Symbol;Acc:HGNC:5293] | 15681 | 0.000 | -0.3737 | No |
| 19 | HTR5A | 5-hydroxytryptamine receptor 5A [Source:HGNC Symbol;Acc:HGNC:5300] | 15701 | 0.000 | -0.3742 | No |
| 20 | GPR143 | G protein-coupled receptor 143 [Source:HGNC Symbol;Acc:HGNC:20145] | 16518 | 0.000 | -0.3962 | No |
| 21 | ADRA1D | adrenoceptor alpha 1D [Source:HGNC Symbol;Acc:HGNC:280] | 16570 | 0.000 | -0.3976 | No |
| 22 | ADRA1B | adrenoceptor alpha 1B [Source:HGNC Symbol;Acc:HGNC:278] | 16571 | 0.000 | -0.3976 | No |
| 23 | ADRA1A | adrenoceptor alpha 1A [Source:HGNC Symbol;Acc:HGNC:277] | 16573 | 0.000 | -0.3976 | No |
| 24 | ADRA2C | adrenoceptor alpha 2C [Source:HGNC Symbol;Acc:HGNC:283] | 16579 | 0.000 | -0.3977 | No |
| 25 | ADRA2B | adrenoceptor alpha 2B [Source:HGNC Symbol;Acc:HGNC:282] | 16580 | 0.000 | -0.3977 | No |
| 26 | CHRM2 | cholinergic receptor muscarinic 2 [Source:HGNC Symbol;Acc:HGNC:1951] | 17872 | 0.000 | -0.4326 | No |
| 27 | CHRM3 | cholinergic receptor muscarinic 3 [Source:HGNC Symbol;Acc:HGNC:1952] | 17874 | 0.000 | -0.4326 | No |
| 28 | CHRM5 | cholinergic receptor muscarinic 5 [Source:HGNC Symbol;Acc:HGNC:1954] | 17875 | 0.000 | -0.4326 | No |
| 29 | ADRB3 | adrenoceptor beta 3 [Source:HGNC Symbol;Acc:HGNC:288] | 17937 | 0.000 | -0.4343 | No |
| 30 | ADRB1 | adrenoceptor beta 1 [Source:HGNC Symbol;Acc:HGNC:285] | 17981 | 0.000 | -0.4354 | No |
| 31 | DRD1 | dopamine receptor D1 [Source:HGNC Symbol;Acc:HGNC:3020] | 18513 | 0.000 | -0.4498 | No |
| 32 | DRD2 | dopamine receptor D2 [Source:HGNC Symbol;Acc:HGNC:3023] | 18514 | 0.000 | -0.4498 | No |
| 33 | DRD3 | dopamine receptor D3 [Source:HGNC Symbol;Acc:HGNC:3024] | 18516 | 0.000 | -0.4498 | No |
| 34 | DRD4 | dopamine receptor D4 [Source:HGNC Symbol;Acc:HGNC:3025] | 18517 | 0.000 | -0.4498 | No |
| 35 | DRD5 | dopamine receptor D5 [Source:HGNC Symbol;Acc:HGNC:3026] | 18518 | 0.000 | -0.4498 | No |
| 36 | HRH3 | histamine receptor H3 [Source:HGNC Symbol;Acc:HGNC:5184] | 27051 | 0.000 | -0.6801 | No |
| 37 | HRH2 | histamine receptor H2 [Source:HGNC Symbol;Acc:HGNC:5183] | 27053 | 0.000 | -0.6801 | No |
| 38 | HRH4 | histamine receptor H4 [Source:HGNC Symbol;Acc:HGNC:17383] | 27056 | 0.000 | -0.6802 | No |
| 39 | ADRA2A | adrenoceptor alpha 2A [Source:HGNC Symbol;Acc:HGNC:281] | 27953 | -0.029 | -0.7011 | No |
| 40 | CHRM4 | cholinergic receptor muscarinic 4 [Source:HGNC Symbol;Acc:HGNC:1953] | 29951 | -0.310 | -0.7197 | Yes |
| 41 | HTR1B | 5-hydroxytryptamine receptor 1B [Source:HGNC Symbol;Acc:HGNC:5287] | 36953 | -3.790 | -0.4773 | Yes |
| 42 | ADRB2 | adrenoceptor beta 2 [Source:HGNC Symbol;Acc:HGNC:286] | 37036 | -4.226 | 0.0015 | Yes |
