Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #KO_GAQ_versus_KO_NA.Nof1.cls #KO_GAQ_versus_KO_NA_repos |
| Phenotype | Nof1.cls#KO_GAQ_versus_KO_NA_repos |
| Upregulated in class | KO_GAQ |
| GeneSet | REACTOME_FCGR_ACTIVATION |
| Enrichment Score (ES) | 0.9028415 |
| Normalized Enrichment Score (NES) | 2.1650655 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0 |
| FWER p-Value | 0.0 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | HCK | HCK proto-oncogene, Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:4840] | 123 | 3.321 | 0.1987 | Yes |
| 2 | FGR | FGR proto-oncogene, Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:3697] | 178 | 3.001 | 0.3798 | Yes |
| 3 | LYN | LYN proto-oncogene, Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:6735] | 230 | 2.796 | 0.5484 | Yes |
| 4 | FCGR2A | Fc fragment of IgG receptor IIa [Source:HGNC Symbol;Acc:HGNC:3616] | 345 | 2.383 | 0.6903 | Yes |
| 5 | SRC | SRC proto-oncogene, non-receptor tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:11283] | 591 | 1.934 | 0.8013 | Yes |
| 6 | SYK | spleen associated tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:11491] | 1194 | 1.334 | 0.8662 | Yes |
| 7 | YES1 | YES proto-oncogene 1, Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:12841] | 2948 | 0.643 | 0.8579 | Yes |
| 8 | FYN | FYN proto-oncogene, Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:4037] | 3395 | 0.538 | 0.8786 | Yes |
| 9 | FCGR1A | Fc fragment of IgG receptor Ia [Source:HGNC Symbol;Acc:HGNC:3613] | 3605 | 0.492 | 0.9028 | Yes |
| 10 | IGHV2-70 | immunoglobulin heavy variable 2-70 [Source:HGNC Symbol;Acc:HGNC:5577] | 6708 | 0.000 | 0.8191 | No |
| 11 | IGHV1-69 | immunoglobulin heavy variable 1-69 [Source:HGNC Symbol;Acc:HGNC:5558] | 7482 | 0.000 | 0.7982 | No |
| 12 | IGHV1-46 | immunoglobulin heavy variable 1-46 [Source:HGNC Symbol;Acc:HGNC:5554] | 7512 | 0.000 | 0.7974 | No |
| 13 | IGLV7-43 | immunoglobulin lambda variable 7-43 [Source:HGNC Symbol;Acc:HGNC:5929] | 8155 | 0.000 | 0.7800 | No |
| 14 | IGKV2-28 | immunoglobulin kappa variable 2-28 [Source:HGNC Symbol;Acc:HGNC:5783] | 8164 | 0.000 | 0.7798 | No |
| 15 | IGKV2-30 | immunoglobulin kappa variable 2-30 [Source:HGNC Symbol;Acc:HGNC:5785] | 8173 | 0.000 | 0.7796 | No |
| 16 | CD247 | CD247 molecule [Source:HGNC Symbol;Acc:HGNC:1677] | 8328 | 0.000 | 0.7755 | No |
| 17 | IGHV3-7 | immunoglobulin heavy variable 3-7 [Source:HGNC Symbol;Acc:HGNC:5620] | 9354 | 0.000 | 0.7478 | No |
| 18 | IGHV4-59 | immunoglobulin heavy variable 4-59 [Source:HGNC Symbol;Acc:HGNC:5654] | 11315 | 0.000 | 0.6948 | No |
| 19 | IGHV4-34 | immunoglobulin heavy variable 4-34 [Source:HGNC Symbol;Acc:HGNC:5650] | 11328 | 0.000 | 0.6945 | No |
| 20 | IGHV4-39 | immunoglobulin heavy variable 4-39 [Source:HGNC Symbol;Acc:HGNC:5651] | 11329 | 0.000 | 0.6945 | No |
| 21 | FCGR3A | Fc fragment of IgG receptor IIIa [Source:HGNC Symbol;Acc:HGNC:3619] | 11604 | 0.000 | 0.6871 | No |
| 22 | IGLV3-19 | immunoglobulin lambda variable 3-19 [Source:HGNC Symbol;Acc:HGNC:5903] | 11881 | 0.000 | 0.6796 | No |
| 23 | IGLV3-25 | immunoglobulin lambda variable 3-25 [Source:HGNC Symbol;Acc:HGNC:5908] | 11885 | 0.000 | 0.6796 | No |
| 24 | IGLV3-27 | immunoglobulin lambda variable 3-27 [Source:HGNC Symbol;Acc:HGNC:5910] | 11887 | 0.000 | 0.6795 | No |
| 25 | IGLV3-21 | immunoglobulin lambda variable 3-21 [Source:HGNC Symbol;Acc:HGNC:5905] | 11888 | 0.000 | 0.6795 | No |
| 26 | IGLV3-1 | immunoglobulin lambda variable 3-1 [Source:HGNC Symbol;Acc:HGNC:5896] | 12700 | 0.000 | 0.6576 | No |
| 27 | IGKV1-39 | immunoglobulin kappa variable 1-39 (gene/pseudogene) [Source:HGNC Symbol;Acc:HGNC:5740] | 12706 | 0.000 | 0.6575 | No |
| 28 | IGKV1-33 | immunoglobulin kappa variable 1-33 [Source:HGNC Symbol;Acc:HGNC:5737] | 12716 | 0.000 | 0.6573 | No |
| 29 | IGKV1-16 | immunoglobulin kappa variable 1-16 [Source:HGNC Symbol;Acc:HGNC:5732] | 12734 | 0.000 | 0.6568 | No |
| 30 | IGKV1-17 | immunoglobulin kappa variable 1-17 [Source:HGNC Symbol;Acc:HGNC:5733] | 12735 | 0.000 | 0.6568 | No |
| 31 | IGKV1-12 | immunoglobulin kappa variable 1-12 [Source:HGNC Symbol;Acc:HGNC:5730] | 12736 | 0.000 | 0.6568 | No |
| 32 | IGKV2D-28 | immunoglobulin kappa variable 2D-28 [Source:HGNC Symbol;Acc:HGNC:5799] | 12864 | 0.000 | 0.6534 | No |
| 33 | IGKV2D-30 | immunoglobulin kappa variable 2D-30 [Source:HGNC Symbol;Acc:HGNC:5801] | 12873 | 0.000 | 0.6532 | No |
| 34 | IGKV2D-40 | immunoglobulin kappa variable 2D-40 [Source:HGNC Symbol;Acc:HGNC:5804] | 12877 | 0.000 | 0.6531 | No |
| 35 | IGKV5-2 | immunoglobulin kappa variable 5-2 [Source:HGNC Symbol;Acc:HGNC:5835] | 14081 | 0.000 | 0.6206 | No |
| 36 | IGLV2-8 | immunoglobulin lambda variable 2-8 [Source:HGNC Symbol;Acc:HGNC:5895] | 15122 | 0.000 | 0.5925 | No |
| 37 | IGLV2-11 | immunoglobulin lambda variable 2-11 [Source:HGNC Symbol;Acc:HGNC:5887] | 16269 | 0.000 | 0.5615 | No |
| 38 | IGLV2-14 | immunoglobulin lambda variable 2-14 [Source:HGNC Symbol;Acc:HGNC:5888] | 16270 | 0.000 | 0.5615 | No |
| 39 | IGLV2-23 | immunoglobulin lambda variable 2-23 [Source:HGNC Symbol;Acc:HGNC:5890] | 16277 | 0.000 | 0.5614 | No |
| 40 | IGHG4 | immunoglobulin heavy constant gamma 4 (G4m marker) [Source:HGNC Symbol;Acc:HGNC:5528] | 17220 | 0.000 | 0.5359 | No |
| 41 | IGHG1 | immunoglobulin heavy constant gamma 1 (G1m marker) [Source:HGNC Symbol;Acc:HGNC:5525] | 17223 | 0.000 | 0.5359 | No |
| 42 | IGHG2 | immunoglobulin heavy constant gamma 2 (G2m marker) [Source:HGNC Symbol;Acc:HGNC:5526] | 17225 | 0.000 | 0.5358 | No |
| 43 | IGLC3 | immunoglobulin lambda constant 3 (Kern-Oz+ marker) [Source:HGNC Symbol;Acc:HGNC:5857] | 17780 | 0.000 | 0.5209 | No |
| 44 | IGLC2 | immunoglobulin lambda constant 2 [Source:HGNC Symbol;Acc:HGNC:5856] | 17784 | 0.000 | 0.5208 | No |
| 45 | IGHV3-23 | immunoglobulin heavy variable 3-23 [Source:HGNC Symbol;Acc:HGNC:5588] | 18038 | 0.000 | 0.5140 | No |
| 46 | IGHV3-30 | immunoglobulin heavy variable 3-30 [Source:HGNC Symbol;Acc:HGNC:5591] | 18055 | 0.000 | 0.5135 | No |
| 47 | IGHV3-33 | immunoglobulin heavy variable 3-33 [Source:HGNC Symbol;Acc:HGNC:5596] | 18058 | 0.000 | 0.5135 | No |
| 48 | IGHV3-11 | immunoglobulin heavy variable 3-11 (gene/pseudogene) [Source:HGNC Symbol;Acc:HGNC:5580] | 18096 | 0.000 | 0.5125 | No |
| 49 | IGHV3-13 | immunoglobulin heavy variable 3-13 [Source:HGNC Symbol;Acc:HGNC:5581] | 18099 | 0.000 | 0.5124 | No |
| 50 | IGHV3-48 | immunoglobulin heavy variable 3-48 [Source:HGNC Symbol;Acc:HGNC:5606] | 18272 | 0.000 | 0.5078 | No |
| 51 | IGHV3-53 | immunoglobulin heavy variable 3-53 [Source:HGNC Symbol;Acc:HGNC:5610] | 18281 | 0.000 | 0.5076 | No |
| 52 | IGKV1-5 | immunoglobulin kappa variable 1-5 [Source:HGNC Symbol;Acc:HGNC:5741] | 18335 | 0.000 | 0.5061 | No |
| 53 | IGKV4-1 | immunoglobulin kappa variable 4-1 [Source:HGNC Symbol;Acc:HGNC:5834] | 19328 | 0.000 | 0.4793 | No |
| 54 | IGKV1D-39 | immunoglobulin kappa variable 1D-39 [Source:HGNC Symbol;Acc:HGNC:5756] | 22982 | 0.000 | 0.3807 | No |
| 55 | IGKV1D-33 | immunoglobulin kappa variable 1D-33 [Source:HGNC Symbol;Acc:HGNC:5753] | 22984 | 0.000 | 0.3806 | No |
| 56 | IGKV1D-16 | immunoglobulin kappa variable 1D-16 [Source:HGNC Symbol;Acc:HGNC:5748] | 23017 | 0.000 | 0.3798 | No |
| 57 | IGKV1D-12 | immunoglobulin kappa variable 1D-12 [Source:HGNC Symbol;Acc:HGNC:5746] | 23024 | 0.000 | 0.3796 | No |
| 58 | CD3G | CD3g molecule [Source:HGNC Symbol;Acc:HGNC:1675] | 23152 | 0.000 | 0.3762 | No |
| 59 | IGLV6-57 | immunoglobulin lambda variable 6-57 [Source:HGNC Symbol;Acc:HGNC:5927] | 23258 | 0.000 | 0.3733 | No |
| 60 | IGKV3D-20 | immunoglobulin kappa variable 3D-20 [Source:HGNC Symbol;Acc:HGNC:5825] | 24059 | 0.000 | 0.3517 | No |
| 61 | IGLV1-40 | immunoglobulin lambda variable 1-40 [Source:HGNC Symbol;Acc:HGNC:5877] | 24781 | 0.000 | 0.3323 | No |
| 62 | IGLV1-47 | immunoglobulin lambda variable 1-47 [Source:HGNC Symbol;Acc:HGNC:5880] | 24782 | 0.000 | 0.3323 | No |
| 63 | IGLV1-44 | immunoglobulin lambda variable 1-44 [Source:HGNC Symbol;Acc:HGNC:5879] | 24783 | 0.000 | 0.3323 | No |
| 64 | IGLV1-51 | immunoglobulin lambda variable 1-51 [Source:HGNC Symbol;Acc:HGNC:5882] | 24797 | 0.000 | 0.3319 | No |
| 65 | IGKV3-15 | immunoglobulin kappa variable 3-15 [Source:HGNC Symbol;Acc:HGNC:5816] | 25324 | 0.000 | 0.3177 | No |
| 66 | IGKV3-11 | immunoglobulin kappa variable 3-11 [Source:HGNC Symbol;Acc:HGNC:5815] | 25331 | 0.000 | 0.3175 | No |
| 67 | IGKV3-20 | immunoglobulin kappa variable 3-20 [Source:HGNC Symbol;Acc:HGNC:5817] | 25357 | 0.000 | 0.3169 | No |
| 68 | IGHV1-2 | immunoglobulin heavy variable 1-2 [Source:HGNC Symbol;Acc:HGNC:5550] | 27166 | 0.000 | 0.2680 | No |
| 69 | IGHV2-5 | immunoglobulin heavy variable 2-5 [Source:HGNC Symbol;Acc:HGNC:5576] | 27580 | 0.000 | 0.2569 | No |
