Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #KO_GAQ_versus_KO_NA.Nof1.cls #KO_GAQ_versus_KO_NA_repos |
| Phenotype | Nof1.cls#KO_GAQ_versus_KO_NA_repos |
| Upregulated in class | KO_GAQ |
| GeneSet | REACTOME_INTERFERON_ALPHA_BETA_SIGNALING |
| Enrichment Score (ES) | 0.7943799 |
| Normalized Enrichment Score (NES) | 1.9436823 |
| Nominal p-value | 0.0 |
| FDR q-value | 9.275816E-4 |
| FWER p-Value | 0.006 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | SOCS3 | suppressor of cytokine signaling 3 [Source:HGNC Symbol;Acc:HGNC:19391] | 13 | 4.740 | 0.0707 | Yes |
| 2 | USP18 | ubiquitin specific peptidase 18 [Source:HGNC Symbol;Acc:HGNC:12616] | 68 | 3.816 | 0.1264 | Yes |
| 3 | IFI35 | interferon induced protein 35 [Source:HGNC Symbol;Acc:HGNC:5399] | 114 | 3.371 | 0.1757 | Yes |
| 4 | OAS1 | 2'-5'-oligoadenylate synthetase 1 [Source:HGNC Symbol;Acc:HGNC:8086] | 134 | 3.225 | 0.2235 | Yes |
| 5 | IRF7 | interferon regulatory factor 7 [Source:HGNC Symbol;Acc:HGNC:6122] | 262 | 2.688 | 0.2604 | Yes |
| 6 | OAS2 | 2'-5'-oligoadenylate synthetase 2 [Source:HGNC Symbol;Acc:HGNC:8087] | 330 | 2.446 | 0.2952 | Yes |
| 7 | IFITM3 | interferon induced transmembrane protein 3 [Source:HGNC Symbol;Acc:HGNC:5414] | 349 | 2.375 | 0.3303 | Yes |
| 8 | OAS3 | 2'-5'-oligoadenylate synthetase 3 [Source:HGNC Symbol;Acc:HGNC:8088] | 372 | 2.318 | 0.3645 | Yes |
| 9 | SOCS1 | suppressor of cytokine signaling 1 [Source:HGNC Symbol;Acc:HGNC:19383] | 373 | 2.309 | 0.3991 | Yes |
| 10 | OASL | 2'-5'-oligoadenylate synthetase like [Source:HGNC Symbol;Acc:HGNC:8090] | 374 | 2.308 | 0.4336 | Yes |
| 11 | STAT2 | signal transducer and activator of transcription 2 [Source:HGNC Symbol;Acc:HGNC:11363] | 406 | 2.252 | 0.4666 | Yes |
| 12 | STAT1 | signal transducer and activator of transcription 1 [Source:HGNC Symbol;Acc:HGNC:11362] | 454 | 2.149 | 0.4975 | Yes |
| 13 | ADAR | adenosine deaminase RNA specific [Source:HGNC Symbol;Acc:HGNC:225] | 458 | 2.142 | 0.5295 | Yes |
| 14 | RSAD2 | radical S-adenosyl methionine domain containing 2 [Source:HGNC Symbol;Acc:HGNC:30908] | 498 | 2.081 | 0.5596 | Yes |
| 15 | IFITM2 | interferon induced transmembrane protein 2 [Source:HGNC Symbol;Acc:HGNC:5413] | 606 | 1.909 | 0.5853 | Yes |
| 16 | MX1 | MX dynamin like GTPase 1 [Source:HGNC Symbol;Acc:HGNC:7532] | 635 | 1.863 | 0.6125 | Yes |
| 17 | ISG20 | interferon stimulated exonuclease gene 20 [Source:HGNC Symbol;Acc:HGNC:6130] | 641 | 1.857 | 0.6402 | Yes |
| 18 | MX2 | MX dynamin like GTPase 2 [Source:HGNC Symbol;Acc:HGNC:7533] | 647 | 1.846 | 0.6677 | Yes |
| 19 | IRF9 | interferon regulatory factor 9 [Source:HGNC Symbol;Acc:HGNC:6131] | 668 | 1.833 | 0.6947 | Yes |
| 20 | IRF8 | interferon regulatory factor 8 [Source:HGNC Symbol;Acc:HGNC:5358] | 946 | 1.520 | 0.7100 | Yes |
| 21 | PTPN11 | protein tyrosine phosphatase non-receptor type 11 [Source:HGNC Symbol;Acc:HGNC:9644] | 962 | 1.506 | 0.7321 | Yes |
| 22 | IP6K2 | inositol hexakisphosphate kinase 2 [Source:HGNC Symbol;Acc:HGNC:17313] | 1110 | 1.390 | 0.7490 | Yes |
| 23 | IFIT1 | interferon induced protein with tetratricopeptide repeats 1 [Source:HGNC Symbol;Acc:HGNC:5407] | 1396 | 1.208 | 0.7594 | Yes |
| 24 | GBP2 | guanylate binding protein 2 [Source:HGNC Symbol;Acc:HGNC:4183] | 1437 | 1.186 | 0.7761 | Yes |
| 25 | IFIT2 | interferon induced protein with tetratricopeptide repeats 2 [Source:HGNC Symbol;Acc:HGNC:5409] | 1633 | 1.095 | 0.7872 | Yes |
| 26 | PTPN1 | protein tyrosine phosphatase non-receptor type 1 [Source:HGNC Symbol;Acc:HGNC:9642] | 1923 | 0.966 | 0.7939 | Yes |
| 27 | HLA-B | major histocompatibility complex, class I, B [Source:HGNC Symbol;Acc:HGNC:4932] | 2531 | 0.752 | 0.7888 | Yes |
| 28 | EGR1 | early growth response 1 [Source:HGNC Symbol;Acc:HGNC:3238] | 3036 | 0.622 | 0.7845 | Yes |
| 29 | IRF6 | interferon regulatory factor 6 [Source:HGNC Symbol;Acc:HGNC:6121] | 3038 | 0.622 | 0.7938 | Yes |
| 30 | PSMB8 | proteasome 20S subunit beta 8 [Source:HGNC Symbol;Acc:HGNC:9545] | 3688 | 0.474 | 0.7833 | Yes |
| 31 | IRF5 | interferon regulatory factor 5 [Source:HGNC Symbol;Acc:HGNC:6120] | 3909 | 0.434 | 0.7839 | Yes |
| 32 | ABCE1 | ATP binding cassette subfamily E member 1 [Source:HGNC Symbol;Acc:HGNC:69] | 3959 | 0.425 | 0.7889 | Yes |
| 33 | IRF4 | interferon regulatory factor 4 [Source:HGNC Symbol;Acc:HGNC:6119] | 4048 | 0.407 | 0.7927 | Yes |
| 34 | KPNA1 | karyopherin subunit alpha 1 [Source:HGNC Symbol;Acc:HGNC:6394] | 4225 | 0.375 | 0.7935 | Yes |
| 35 | HLA-F | major histocompatibility complex, class I, F [Source:HGNC Symbol;Acc:HGNC:4963] | 4386 | 0.346 | 0.7944 | Yes |
| 36 | HLA-E | major histocompatibility complex, class I, E [Source:HGNC Symbol;Acc:HGNC:4962] | 4694 | 0.298 | 0.7906 | No |
| 37 | JAK1 | Janus kinase 1 [Source:HGNC Symbol;Acc:HGNC:6190] | 4784 | 0.281 | 0.7924 | No |
| 38 | IFIT3 | interferon induced protein with tetratricopeptide repeats 3 [Source:HGNC Symbol;Acc:HGNC:5411] | 5157 | 0.212 | 0.7855 | No |
| 39 | KPNB1 | karyopherin subunit beta 1 [Source:HGNC Symbol;Acc:HGNC:6400] | 5410 | 0.176 | 0.7813 | No |
| 40 | HLA-A | major histocompatibility complex, class I, A [Source:HGNC Symbol;Acc:HGNC:4931] | 5903 | 0.106 | 0.7696 | No |
| 41 | HLA-C | major histocompatibility complex, class I, C [Source:HGNC Symbol;Acc:HGNC:4933] | 6146 | 0.071 | 0.7641 | No |
| 42 | BST2 | bone marrow stromal cell antigen 2 [Source:HGNC Symbol;Acc:HGNC:1119] | 12608 | 0.000 | 0.5896 | No |
| 43 | IFNA13 | interferon alpha 13 [Source:HGNC Symbol;Acc:HGNC:5419] | 18216 | 0.000 | 0.4381 | No |
| 44 | IFNA14 | interferon alpha 14 [Source:HGNC Symbol;Acc:HGNC:5420] | 18217 | 0.000 | 0.4381 | No |
| 45 | IFNA16 | interferon alpha 16 [Source:HGNC Symbol;Acc:HGNC:5421] | 18219 | 0.000 | 0.4381 | No |
| 46 | IFNA17 | interferon alpha 17 [Source:HGNC Symbol;Acc:HGNC:5422] | 18221 | 0.000 | 0.4381 | No |
| 47 | IFNA10 | interferon alpha 10 [Source:HGNC Symbol;Acc:HGNC:5418] | 18228 | 0.000 | 0.4379 | No |
| 48 | IFNA21 | interferon alpha 21 [Source:HGNC Symbol;Acc:HGNC:5424] | 18235 | 0.000 | 0.4378 | No |
| 49 | IFNAR2 | interferon alpha and beta receptor subunit 2 [Source:HGNC Symbol;Acc:HGNC:5433] | 18497 | 0.000 | 0.4307 | No |
| 50 | IFNAR1 | interferon alpha and beta receptor subunit 1 [Source:HGNC Symbol;Acc:HGNC:5432] | 18505 | 0.000 | 0.4305 | No |
| 51 | IFI6 | interferon alpha inducible protein 6 [Source:HGNC Symbol;Acc:HGNC:4054] | 20730 | 0.000 | 0.3704 | No |
| 52 | ISG15 | ISG15 ubiquitin like modifier [Source:HGNC Symbol;Acc:HGNC:4053] | 23262 | 0.000 | 0.3021 | No |
| 53 | IFIT5 | interferon induced protein with tetratricopeptide repeats 5 [Source:HGNC Symbol;Acc:HGNC:13328] | 23455 | 0.000 | 0.2969 | No |
| 54 | IFNA5 | interferon alpha 5 [Source:HGNC Symbol;Acc:HGNC:5426] | 24897 | 0.000 | 0.2580 | No |
| 55 | IFNA4 | interferon alpha 4 [Source:HGNC Symbol;Acc:HGNC:5425] | 24898 | 0.000 | 0.2580 | No |
| 56 | IFNA7 | interferon alpha 7 [Source:HGNC Symbol;Acc:HGNC:5428] | 24900 | 0.000 | 0.2579 | No |
| 57 | IFNA6 | interferon alpha 6 [Source:HGNC Symbol;Acc:HGNC:5427] | 24901 | 0.000 | 0.2579 | No |
| 58 | IFNA1 | interferon alpha 1 [Source:HGNC Symbol;Acc:HGNC:5417] | 24902 | 0.000 | 0.2579 | No |
| 59 | IFNA2 | interferon alpha 2 [Source:HGNC Symbol;Acc:HGNC:5423] | 24903 | 0.000 | 0.2579 | No |
| 60 | IFNA8 | interferon alpha 8 [Source:HGNC Symbol;Acc:HGNC:5429] | 24906 | 0.000 | 0.2579 | No |
| 61 | IFNB1 | interferon beta 1 [Source:HGNC Symbol;Acc:HGNC:5434] | 24936 | 0.000 | 0.2571 | No |
| 62 | XAF1 | XIAP associated factor 1 [Source:HGNC Symbol;Acc:HGNC:30932] | 27539 | 0.000 | 0.1868 | No |
| 63 | IRF3 | interferon regulatory factor 3 [Source:HGNC Symbol;Acc:HGNC:6118] | 28146 | -0.055 | 0.1713 | No |
| 64 | SAMHD1 | SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 [Source:HGNC Symbol;Acc:HGNC:15925] | 28821 | -0.146 | 0.1552 | No |
| 65 | IFITM1 | interferon induced transmembrane protein 1 [Source:HGNC Symbol;Acc:HGNC:5412] | 29283 | -0.213 | 0.1460 | No |
| 66 | IRF1 | interferon regulatory factor 1 [Source:HGNC Symbol;Acc:HGNC:6116] | 29766 | -0.285 | 0.1372 | No |
| 67 | HLA-H | major histocompatibility complex, class I, H (pseudogene) [Source:HGNC Symbol;Acc:HGNC:4965] | 30341 | -0.361 | 0.1271 | No |
| 68 | IFI27 | interferon alpha inducible protein 27 [Source:HGNC Symbol;Acc:HGNC:5397] | 30371 | -0.365 | 0.1318 | No |
| 69 | HLA-G | major histocompatibility complex, class I, G [Source:HGNC Symbol;Acc:HGNC:4964] | 30483 | -0.379 | 0.1345 | No |
| 70 | PTPN6 | protein tyrosine phosphatase non-receptor type 6 [Source:HGNC Symbol;Acc:HGNC:9658] | 31450 | -0.535 | 0.1164 | No |
| 71 | TYK2 | tyrosine kinase 2 [Source:HGNC Symbol;Acc:HGNC:12440] | 32274 | -0.698 | 0.1047 | No |
| 72 | IRF2 | interferon regulatory factor 2 [Source:HGNC Symbol;Acc:HGNC:6117] | 32740 | -0.809 | 0.1042 | No |
| 73 | RNASEL | ribonuclease L [Source:HGNC Symbol;Acc:HGNC:10050] | 33050 | -0.885 | 0.1091 | No |
