Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #KO_GAQ_versus_KO_NA.Nof1.cls #KO_GAQ_versus_KO_NA_repos |
| Phenotype | Nof1.cls#KO_GAQ_versus_KO_NA_repos |
| Upregulated in class | KO_NA |
| GeneSet | GOCC_LYSOSOMAL_LUMEN |
| Enrichment Score (ES) | -0.7907153 |
| Normalized Enrichment Score (NES) | -1.6389239 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.031191649 |
| FWER p-Value | 0.273 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | PLD3 | phospholipase D family member 3 [Source:HGNC Symbol;Acc:HGNC:17158] | 1171 | 1.346 | -0.0173 | No |
| 2 | HSP90AA1 | heat shock protein 90 alpha family class A member 1 [Source:HGNC Symbol;Acc:HGNC:5253] | 1693 | 1.067 | -0.0201 | No |
| 3 | CTSV | cathepsin V [Source:HGNC Symbol;Acc:HGNC:2538] | 2933 | 0.646 | -0.0467 | No |
| 4 | NPC2 | NPC intracellular cholesterol transporter 2 [Source:HGNC Symbol;Acc:HGNC:14537] | 4612 | 0.310 | -0.0887 | No |
| 5 | SDC4 | syndecan 4 [Source:HGNC Symbol;Acc:HGNC:10661] | 4731 | 0.292 | -0.0888 | No |
| 6 | AGRN | agrin [Source:HGNC Symbol;Acc:HGNC:329] | 4766 | 0.285 | -0.0867 | No |
| 7 | GPC1 | glypican 1 [Source:HGNC Symbol;Acc:HGNC:4449] | 5034 | 0.236 | -0.0914 | No |
| 8 | CTSD | cathepsin D [Source:HGNC Symbol;Acc:HGNC:2529] | 5313 | 0.190 | -0.0969 | No |
| 9 | CTSK | cathepsin K [Source:HGNC Symbol;Acc:HGNC:2536] | 5584 | 0.148 | -0.1026 | No |
| 10 | CSPG4 | chondroitin sulfate proteoglycan 4 [Source:HGNC Symbol;Acc:HGNC:2466] | 6012 | 0.087 | -0.1132 | No |
| 11 | EPDR1 | ependymin related 1 [Source:HGNC Symbol;Acc:HGNC:17572] | 6766 | 0.000 | -0.1336 | No |
| 12 | RNASET2 | ribonuclease T2 [Source:HGNC Symbol;Acc:HGNC:21686] | 6976 | 0.000 | -0.1392 | No |
| 13 | SDC2 | syndecan 2 [Source:HGNC Symbol;Acc:HGNC:10659] | 7047 | 0.000 | -0.1411 | No |
| 14 | APOB | apolipoprotein B [Source:HGNC Symbol;Acc:HGNC:603] | 7052 | 0.000 | -0.1412 | No |
| 15 | NEU4 | neuraminidase 4 [Source:HGNC Symbol;Acc:HGNC:21328] | 10044 | 0.000 | -0.2221 | No |
| 16 | HSPG2 | heparan sulfate proteoglycan 2 [Source:HGNC Symbol;Acc:HGNC:5273] | 10492 | 0.000 | -0.2342 | No |
| 17 | ACAN | aggrecan [Source:HGNC Symbol;Acc:HGNC:319] | 10981 | 0.000 | -0.2474 | No |
| 18 | IFI30 | IFI30 lysosomal thiol reductase [Source:HGNC Symbol;Acc:HGNC:5398] | 11648 | 0.000 | -0.2654 | No |
| 19 | CBLIF | cobalamin binding intrinsic factor [Source:HGNC Symbol;Acc:HGNC:4268] | 13553 | 0.000 | -0.3168 | No |
| 20 | BCAN | brevican [Source:HGNC Symbol;Acc:HGNC:23059] | 15846 | 0.000 | -0.3788 | No |
| 21 | DCN | decorin [Source:HGNC Symbol;Acc:HGNC:2705] | 16096 | 0.000 | -0.3855 | No |
| 22 | GC | GC vitamin D binding protein [Source:HGNC Symbol;Acc:HGNC:4187] | 16239 | 0.000 | -0.3893 | No |
| 23 | KERA | keratocan [Source:HGNC Symbol;Acc:HGNC:6309] | 18498 | 0.000 | -0.4504 | No |
| 24 | LUM | lumican [Source:HGNC Symbol;Acc:HGNC:6724] | 18794 | 0.000 | -0.4583 | No |
| 25 | OGN | osteoglycin [Source:HGNC Symbol;Acc:HGNC:8126] | 19698 | 0.000 | -0.4828 | No |
| 26 | OMD | osteomodulin [Source:HGNC Symbol;Acc:HGNC:8134] | 19765 | 0.000 | -0.4845 | No |
| 27 | FASLG | Fas ligand [Source:HGNC Symbol;Acc:HGNC:11936] | 20291 | 0.000 | -0.4987 | No |
| 28 | NCAN | neurocan [Source:HGNC Symbol;Acc:HGNC:2465] | 22916 | 0.000 | -0.5697 | No |
| 29 | SERPINB13 | serpin family B member 13 [Source:HGNC Symbol;Acc:HGNC:8944] | 22945 | 0.000 | -0.5704 | No |
| 30 | CD1E | CD1e molecule [Source:HGNC Symbol;Acc:HGNC:1638] | 23120 | 0.000 | -0.5751 | No |
| 31 | GPC3 | glypican 3 [Source:HGNC Symbol;Acc:HGNC:4451] | 23208 | 0.000 | -0.5775 | No |
| 32 | GPC2 | glypican 2 [Source:HGNC Symbol;Acc:HGNC:4450] | 23210 | 0.000 | -0.5775 | No |
| 33 | GPC5 | glypican 5 [Source:HGNC Symbol;Acc:HGNC:4453] | 23212 | 0.000 | -0.5775 | No |
| 34 | GPC4 | glypican 4 [Source:HGNC Symbol;Acc:HGNC:4452] | 23214 | 0.000 | -0.5775 | No |
| 35 | GPC6 | glypican 6 [Source:HGNC Symbol;Acc:HGNC:4454] | 23216 | 0.000 | -0.5776 | No |
| 36 | PRELP | proline and arginine rich end leucine rich repeat protein [Source:HGNC Symbol;Acc:HGNC:9357] | 24182 | 0.000 | -0.6037 | No |
| 37 | SPACA7 | sperm acrosome associated 7 [Source:HGNC Symbol;Acc:HGNC:29575] | 24398 | 0.000 | -0.6095 | No |
| 38 | CTSL | cathepsin L [Source:HGNC Symbol;Acc:HGNC:2537] | 25275 | 0.000 | -0.6331 | No |
| 39 | FMOD | fibromodulin [Source:HGNC Symbol;Acc:HGNC:3774] | 27435 | 0.000 | -0.6915 | No |
| 40 | CUBN | cubilin [Source:HGNC Symbol;Acc:HGNC:2548] | 27937 | -0.026 | -0.7048 | No |
| 41 | ACP2 | acid phosphatase 2, lysosomal [Source:HGNC Symbol;Acc:HGNC:123] | 28216 | -0.066 | -0.7116 | No |
| 42 | PDGFRB | platelet derived growth factor receptor beta [Source:HGNC Symbol;Acc:HGNC:8804] | 28565 | -0.112 | -0.7198 | No |
| 43 | GUSB | glucuronidase beta [Source:HGNC Symbol;Acc:HGNC:4696] | 29125 | -0.188 | -0.7329 | No |
| 44 | VCAN | versican [Source:HGNC Symbol;Acc:HGNC:2464] | 29361 | -0.226 | -0.7368 | No |
| 45 | HSPA8 | heat shock protein family A (Hsp70) member 8 [Source:HGNC Symbol;Acc:HGNC:5241] | 29366 | -0.227 | -0.7345 | No |
| 46 | CSPG5 | chondroitin sulfate proteoglycan 5 [Source:HGNC Symbol;Acc:HGNC:2467] | 30215 | -0.343 | -0.7538 | No |
| 47 | GBA | glucosylceramidase beta [Source:HGNC Symbol;Acc:HGNC:4177] | 30448 | -0.375 | -0.7561 | No |
| 48 | LAMP2 | lysosomal associated membrane protein 2 [Source:HGNC Symbol;Acc:HGNC:6501] | 30456 | -0.376 | -0.7523 | No |
| 49 | NEU1 | neuraminidase 1 [Source:HGNC Symbol;Acc:HGNC:7758] | 30526 | -0.388 | -0.7500 | No |
| 50 | BGN | biglycan [Source:HGNC Symbol;Acc:HGNC:1044] | 31120 | -0.480 | -0.7610 | No |
| 51 | TCN2 | transcobalamin 2 [Source:HGNC Symbol;Acc:HGNC:11653] | 31125 | -0.480 | -0.7559 | No |
| 52 | TXNDC5 | thioredoxin domain containing 5 [Source:HGNC Symbol;Acc:HGNC:21073] | 32054 | -0.652 | -0.7741 | No |
| 53 | CHID1 | chitinase domain containing 1 [Source:HGNC Symbol;Acc:HGNC:28474] | 32289 | -0.702 | -0.7730 | No |
| 54 | CTSS | cathepsin S [Source:HGNC Symbol;Acc:HGNC:2545] | 32808 | -0.825 | -0.7782 | No |
| 55 | MAN2B2 | mannosidase alpha class 2B member 2 [Source:HGNC Symbol;Acc:HGNC:29623] | 33273 | -0.951 | -0.7806 | Yes |
| 56 | CTSB | cathepsin B [Source:HGNC Symbol;Acc:HGNC:2527] | 33473 | -1.011 | -0.7752 | Yes |
| 57 | PLBD2 | phospholipase B domain containing 2 [Source:HGNC Symbol;Acc:HGNC:27283] | 33635 | -1.058 | -0.7683 | Yes |
| 58 | GNS | glucosamine (N-acetyl)-6-sulfatase [Source:HGNC Symbol;Acc:HGNC:4422] | 33772 | -1.102 | -0.7603 | Yes |
| 59 | SDC1 | syndecan 1 [Source:HGNC Symbol;Acc:HGNC:10658] | 33863 | -1.134 | -0.7506 | Yes |
| 60 | LIPA | lipase A, lysosomal acid type [Source:HGNC Symbol;Acc:HGNC:6617] | 33912 | -1.154 | -0.7396 | Yes |
| 61 | GAA | glucosidase alpha, acid [Source:HGNC Symbol;Acc:HGNC:4065] | 34313 | -1.283 | -0.7368 | Yes |
| 62 | PPT1 | palmitoyl-protein thioesterase 1 [Source:HGNC Symbol;Acc:HGNC:9325] | 34438 | -1.330 | -0.7260 | Yes |
| 63 | SMPD1 | sphingomyelin phosphodiesterase 1 [Source:HGNC Symbol;Acc:HGNC:11120] | 34475 | -1.343 | -0.7127 | Yes |
| 64 | ASAH1 | N-acylsphingosine amidohydrolase 1 [Source:HGNC Symbol;Acc:HGNC:735] | 34544 | -1.366 | -0.7000 | Yes |
| 65 | GLA | galactosidase alpha [Source:HGNC Symbol;Acc:HGNC:4296] | 34554 | -1.370 | -0.6856 | Yes |
| 66 | HPSE | heparanase [Source:HGNC Symbol;Acc:HGNC:5164] | 34568 | -1.379 | -0.6713 | Yes |
| 67 | PPT2 | palmitoyl-protein thioesterase 2 [Source:HGNC Symbol;Acc:HGNC:9326] | 35071 | -1.610 | -0.6678 | Yes |
| 68 | CD74 | CD74 molecule [Source:HGNC Symbol;Acc:HGNC:1697] | 35074 | -1.612 | -0.6507 | Yes |
| 69 | MANBA | mannosidase beta [Source:HGNC Symbol;Acc:HGNC:6831] | 35433 | -1.798 | -0.6412 | Yes |
| 70 | GYG1 | glycogenin 1 [Source:HGNC Symbol;Acc:HGNC:4699] | 35439 | -1.802 | -0.6222 | Yes |
| 71 | IDS | iduronate 2-sulfatase [Source:HGNC Symbol;Acc:HGNC:5389] | 35468 | -1.816 | -0.6036 | Yes |
| 72 | GLB1 | galactosidase beta 1 [Source:HGNC Symbol;Acc:HGNC:4298] | 35563 | -1.874 | -0.5862 | Yes |
| 73 | FUCA1 | alpha-L-fucosidase 1 [Source:HGNC Symbol;Acc:HGNC:4006] | 35577 | -1.885 | -0.5665 | Yes |
| 74 | CTSA | cathepsin A [Source:HGNC Symbol;Acc:HGNC:9251] | 35641 | -1.931 | -0.5476 | Yes |
| 75 | GALNS | galactosamine (N-acetyl)-6-sulfatase [Source:HGNC Symbol;Acc:HGNC:4122] | 35690 | -1.967 | -0.5280 | Yes |
| 76 | LGMN | legumain [Source:HGNC Symbol;Acc:HGNC:9472] | 35855 | -2.097 | -0.5101 | Yes |
| 77 | IDUA | alpha-L-iduronidase [Source:HGNC Symbol;Acc:HGNC:5391] | 35939 | -2.160 | -0.4894 | Yes |
| 78 | TPP1 | tripeptidyl peptidase 1 [Source:HGNC Symbol;Acc:HGNC:2073] | 36025 | -2.225 | -0.4680 | Yes |
| 79 | SCARB2 | scavenger receptor class B member 2 [Source:HGNC Symbol;Acc:HGNC:1665] | 36097 | -2.276 | -0.4457 | Yes |
| 80 | HEXA | hexosaminidase subunit alpha [Source:HGNC Symbol;Acc:HGNC:4878] | 36142 | -2.316 | -0.4222 | Yes |
| 81 | ARSB | arylsulfatase B [Source:HGNC Symbol;Acc:HGNC:714] | 36166 | -2.344 | -0.3979 | Yes |
| 82 | GALC | galactosylceramidase [Source:HGNC Symbol;Acc:HGNC:4115] | 36201 | -2.365 | -0.3737 | Yes |
| 83 | ARSA | arylsulfatase A [Source:HGNC Symbol;Acc:HGNC:713] | 36215 | -2.380 | -0.3487 | Yes |
| 84 | NAGLU | N-acetyl-alpha-glucosaminidase [Source:HGNC Symbol;Acc:HGNC:7632] | 36276 | -2.443 | -0.3243 | Yes |
| 85 | SDC3 | syndecan 3 [Source:HGNC Symbol;Acc:HGNC:10660] | 36351 | -2.528 | -0.2994 | Yes |
| 86 | CTSF | cathepsin F [Source:HGNC Symbol;Acc:HGNC:2531] | 36374 | -2.555 | -0.2728 | Yes |
| 87 | NAAA | N-acylethanolamine acid amidase [Source:HGNC Symbol;Acc:HGNC:736] | 36588 | -2.870 | -0.2481 | Yes |
| 88 | MAN2B1 | mannosidase alpha class 2B member 1 [Source:HGNC Symbol;Acc:HGNC:6826] | 36683 | -3.011 | -0.2186 | Yes |
| 89 | PSAP | prosaposin [Source:HGNC Symbol;Acc:HGNC:9498] | 36685 | -3.014 | -0.1865 | Yes |
| 90 | HEXB | hexosaminidase subunit beta [Source:HGNC Symbol;Acc:HGNC:4879] | 36810 | -3.294 | -0.1548 | Yes |
| 91 | ATP13A2 | ATPase cation transporting 13A2 [Source:HGNC Symbol;Acc:HGNC:30213] | 36833 | -3.366 | -0.1196 | Yes |
| 92 | SGSH | N-sulfoglucosamine sulfohydrolase [Source:HGNC Symbol;Acc:HGNC:10818] | 36938 | -3.732 | -0.0827 | Yes |
| 93 | GM2A | GM2 ganglioside activator [Source:HGNC Symbol;Acc:HGNC:4367] | 36963 | -3.822 | -0.0427 | Yes |
| 94 | HYAL1 | hyaluronidase 1 [Source:HGNC Symbol;Acc:HGNC:5320] | 37056 | -4.329 | 0.0009 | Yes |
