Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #KO_GAQ_versus_KO_NA.Nof1.cls #KO_GAQ_versus_KO_NA_repos |
| Phenotype | Nof1.cls#KO_GAQ_versus_KO_NA_repos |
| Upregulated in class | KO_NA |
| GeneSet | HALLMARK_BILE_ACID_METABOLISM |
| Enrichment Score (ES) | -0.61863977 |
| Normalized Enrichment Score (NES) | -1.3240154 |
| Nominal p-value | 0.032183908 |
| FDR q-value | 0.1645037 |
| FWER p-Value | 0.645 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | AQP9 | aquaporin 9 [Source:HGNC Symbol;Acc:HGNC:643] | 71 | 3.793 | 0.0317 | No |
| 2 | ABCA1 | ATP binding cassette subfamily A member 1 [Source:HGNC Symbol;Acc:HGNC:29] | 219 | 2.843 | 0.0529 | No |
| 3 | ATXN1 | ataxin 1 [Source:HGNC Symbol;Acc:HGNC:10548] | 244 | 2.754 | 0.0766 | No |
| 4 | GCLM | glutamate-cysteine ligase modifier subunit [Source:HGNC Symbol;Acc:HGNC:4312] | 773 | 1.699 | 0.0774 | No |
| 5 | PRDX5 | peroxiredoxin 5 [Source:HGNC Symbol;Acc:HGNC:9355] | 834 | 1.624 | 0.0901 | No |
| 6 | TFCP2L1 | transcription factor CP2 like 1 [Source:HGNC Symbol;Acc:HGNC:17925] | 903 | 1.550 | 0.1020 | No |
| 7 | PEX11A | peroxisomal biogenesis factor 11 alpha [Source:HGNC Symbol;Acc:HGNC:8852] | 1408 | 1.199 | 0.0990 | No |
| 8 | LCK | LCK proto-oncogene, Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:6524] | 1493 | 1.158 | 0.1070 | No |
| 9 | PEX12 | peroxisomal biogenesis factor 12 [Source:HGNC Symbol;Acc:HGNC:8854] | 1917 | 0.969 | 0.1041 | No |
| 10 | HAO1 | hydroxyacid oxidase 1 [Source:HGNC Symbol;Acc:HGNC:4809] | 2051 | 0.918 | 0.1087 | No |
| 11 | BCAR3 | BCAR3 adaptor protein, NSP family member [Source:HGNC Symbol;Acc:HGNC:973] | 2243 | 0.847 | 0.1110 | No |
| 12 | LIPE | lipase E, hormone sensitive type [Source:HGNC Symbol;Acc:HGNC:6621] | 2381 | 0.796 | 0.1143 | No |
| 13 | IDI1 | isopentenyl-diphosphate delta isomerase 1 [Source:HGNC Symbol;Acc:HGNC:5387] | 3265 | 0.568 | 0.0955 | No |
| 14 | OPTN | optineurin [Source:HGNC Symbol;Acc:HGNC:17142] | 4290 | 0.363 | 0.0710 | No |
| 15 | AR | androgen receptor [Source:HGNC Symbol;Acc:HGNC:644] | 4425 | 0.340 | 0.0704 | No |
| 16 | CH25H | cholesterol 25-hydroxylase [Source:HGNC Symbol;Acc:HGNC:1907] | 5419 | 0.174 | 0.0451 | No |
| 17 | PEX19 | peroxisomal biogenesis factor 19 [Source:HGNC Symbol;Acc:HGNC:9713] | 5794 | 0.124 | 0.0361 | No |
| 18 | PEX13 | peroxisomal biogenesis factor 13 [Source:HGNC Symbol;Acc:HGNC:8855] | 6293 | 0.043 | 0.0230 | No |
| 19 | SOAT2 | sterol O-acyltransferase 2 [Source:HGNC Symbol;Acc:HGNC:11178] | 6321 | 0.038 | 0.0226 | No |
| 20 | EPHX2 | epoxide hydrolase 2 [Source:HGNC Symbol;Acc:HGNC:3402] | 8153 | 0.000 | -0.0269 | No |
| 21 | ALDH8A1 | aldehyde dehydrogenase 8 family member A1 [Source:HGNC Symbol;Acc:HGNC:15471] | 8826 | 0.000 | -0.0451 | No |
| 22 | GSTK1 | glutathione S-transferase kappa 1 [Source:HGNC Symbol;Acc:HGNC:16906] | 9831 | 0.000 | -0.0723 | No |
| 23 | SLC23A1 | solute carrier family 23 member 1 [Source:HGNC Symbol;Acc:HGNC:10974] | 10021 | 0.000 | -0.0774 | No |
| 24 | APOA1 | apolipoprotein A1 [Source:HGNC Symbol;Acc:HGNC:600] | 10304 | 0.000 | -0.0850 | No |
| 25 | NEDD4 | NEDD4 E3 ubiquitin protein ligase [Source:HGNC Symbol;Acc:HGNC:7727] | 10640 | 0.000 | -0.0941 | No |
| 26 | SLC27A2 | solute carrier family 27 member 2 [Source:HGNC Symbol;Acc:HGNC:10996] | 11078 | 0.000 | -0.1059 | No |
| 27 | AKR1D1 | aldo-keto reductase family 1 member D1 [Source:HGNC Symbol;Acc:HGNC:388] | 11697 | 0.000 | -0.1226 | No |
| 28 | AGXT | alanine--glyoxylate and serine--pyruvate aminotransferase [Source:HGNC Symbol;Acc:HGNC:341] | 12310 | 0.000 | -0.1391 | No |
| 29 | CYP39A1 | cytochrome P450 family 39 subfamily A member 1 [Source:HGNC Symbol;Acc:HGNC:17449] | 12586 | 0.000 | -0.1466 | No |
| 30 | HSD3B1 | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 [Source:HGNC Symbol;Acc:HGNC:5217] | 12722 | 0.000 | -0.1502 | No |
| 31 | TTR | transthyretin [Source:HGNC Symbol;Acc:HGNC:12405] | 12838 | 0.000 | -0.1533 | No |
| 32 | CYP8B1 | cytochrome P450 family 8 subfamily B member 1 [Source:HGNC Symbol;Acc:HGNC:2653] | 15540 | 0.000 | -0.2264 | No |
| 33 | DIO1 | iodothyronine deiodinase 1 [Source:HGNC Symbol;Acc:HGNC:2883] | 15904 | 0.000 | -0.2362 | No |
| 34 | GC | GC vitamin D binding protein [Source:HGNC Symbol;Acc:HGNC:4187] | 16239 | 0.000 | -0.2452 | No |
| 35 | SERPINA6 | serpin family A member 6 [Source:HGNC Symbol;Acc:HGNC:1540] | 17839 | 0.000 | -0.2885 | No |
| 36 | BMP6 | bone morphogenetic protein 6 [Source:HGNC Symbol;Acc:HGNC:1073] | 19099 | 0.000 | -0.3225 | No |
| 37 | HSD17B6 | hydroxysteroid 17-beta dehydrogenase 6 [Source:HGNC Symbol;Acc:HGNC:23316] | 19795 | 0.000 | -0.3413 | No |
| 38 | NR1I2 | nuclear receptor subfamily 1 group I member 2 [Source:HGNC Symbol;Acc:HGNC:7968] | 19977 | 0.000 | -0.3462 | No |
| 39 | NR1H4 | nuclear receptor subfamily 1 group H member 4 [Source:HGNC Symbol;Acc:HGNC:7967] | 20001 | 0.000 | -0.3468 | No |
| 40 | KLF1 | Kruppel like factor 1 [Source:HGNC Symbol;Acc:HGNC:6345] | 20673 | 0.000 | -0.3650 | No |
| 41 | BBOX1 | gamma-butyrobetaine hydroxylase 1 [Source:HGNC Symbol;Acc:HGNC:964] | 20944 | 0.000 | -0.3723 | No |
| 42 | CYP7B1 | cytochrome P450 family 7 subfamily B member 1 [Source:HGNC Symbol;Acc:HGNC:2652] | 21242 | 0.000 | -0.3803 | No |
| 43 | CYP7A1 | cytochrome P450 family 7 subfamily A member 1 [Source:HGNC Symbol;Acc:HGNC:2651] | 21264 | 0.000 | -0.3809 | No |
| 44 | SULT2B1 | sulfotransferase family 2B member 1 [Source:HGNC Symbol;Acc:HGNC:11459] | 23955 | 0.000 | -0.4536 | No |
| 45 | SULT1B1 | sulfotransferase family 1B member 1 [Source:HGNC Symbol;Acc:HGNC:17845] | 24257 | 0.000 | -0.4617 | No |
| 46 | PIPOX | pipecolic acid and sarcosine oxidase [Source:HGNC Symbol;Acc:HGNC:17804] | 25152 | 0.000 | -0.4859 | No |
| 47 | ALDH1A1 | aldehyde dehydrogenase 1 family member A1 [Source:HGNC Symbol;Acc:HGNC:402] | 25945 | 0.000 | -0.5073 | No |
| 48 | ABCA6 | ATP binding cassette subfamily A member 6 [Source:HGNC Symbol;Acc:HGNC:36] | 27106 | 0.000 | -0.5387 | No |
| 49 | ABCA4 | ATP binding cassette subfamily A member 4 [Source:HGNC Symbol;Acc:HGNC:34] | 27109 | 0.000 | -0.5388 | No |
| 50 | SLCO1A2 | solute carrier organic anion transporter family member 1A2 [Source:HGNC Symbol;Acc:HGNC:10956] | 27157 | 0.000 | -0.5400 | No |
| 51 | PECR | peroxisomal trans-2-enoyl-CoA reductase [Source:HGNC Symbol;Acc:HGNC:18281] | 27824 | -0.005 | -0.5580 | No |
| 52 | ABCA9 | ATP binding cassette subfamily A member 9 [Source:HGNC Symbol;Acc:HGNC:39] | 28099 | -0.047 | -0.5650 | No |
| 53 | ABCA8 | ATP binding cassette subfamily A member 8 [Source:HGNC Symbol;Acc:HGNC:38] | 28177 | -0.060 | -0.5665 | No |
| 54 | ABCG8 | ATP binding cassette subfamily G member 8 [Source:HGNC Symbol;Acc:HGNC:13887] | 28548 | -0.109 | -0.5756 | No |
| 55 | SOD1 | superoxide dismutase 1 [Source:HGNC Symbol;Acc:HGNC:11179] | 29328 | -0.220 | -0.5947 | No |
| 56 | GNMT | glycine N-methyltransferase [Source:HGNC Symbol;Acc:HGNC:4415] | 29499 | -0.242 | -0.5972 | No |
| 57 | HSD17B11 | hydroxysteroid 17-beta dehydrogenase 11 [Source:HGNC Symbol;Acc:HGNC:22960] | 29798 | -0.290 | -0.6027 | No |
| 58 | CYP46A1 | cytochrome P450 family 46 subfamily A member 1 [Source:HGNC Symbol;Acc:HGNC:2641] | 30390 | -0.368 | -0.6154 | Yes |
| 59 | SLC22A18 | solute carrier family 22 member 18 [Source:HGNC Symbol;Acc:HGNC:10964] | 30418 | -0.371 | -0.6128 | Yes |
| 60 | SLC23A2 | solute carrier family 23 member 2 [Source:HGNC Symbol;Acc:HGNC:10973] | 30539 | -0.390 | -0.6126 | Yes |
| 61 | GNPAT | glyceronephosphate O-acyltransferase [Source:HGNC Symbol;Acc:HGNC:4416] | 30629 | -0.407 | -0.6114 | Yes |
| 62 | SLC27A5 | solute carrier family 27 member 5 [Source:HGNC Symbol;Acc:HGNC:10999] | 30726 | -0.421 | -0.6103 | Yes |
| 63 | PEX11G | peroxisomal biogenesis factor 11 gamma [Source:HGNC Symbol;Acc:HGNC:20208] | 30820 | -0.436 | -0.6090 | Yes |
| 64 | ABCA5 | ATP binding cassette subfamily A member 5 [Source:HGNC Symbol;Acc:HGNC:35] | 31080 | -0.474 | -0.6118 | Yes |
| 65 | RBP1 | retinol binding protein 1 [Source:HGNC Symbol;Acc:HGNC:9919] | 31093 | -0.476 | -0.6079 | Yes |
| 66 | PEX6 | peroxisomal biogenesis factor 6 [Source:HGNC Symbol;Acc:HGNC:8859] | 31117 | -0.479 | -0.6042 | Yes |
| 67 | PHYH | phytanoyl-CoA 2-hydroxylase [Source:HGNC Symbol;Acc:HGNC:8940] | 31334 | -0.516 | -0.6055 | Yes |
| 68 | ACSL5 | acyl-CoA synthetase long chain family member 5 [Source:HGNC Symbol;Acc:HGNC:16526] | 31518 | -0.549 | -0.6056 | Yes |
| 69 | DIO2 | iodothyronine deiodinase 2 [Source:HGNC Symbol;Acc:HGNC:2884] | 31767 | -0.592 | -0.6071 | Yes |
| 70 | ISOC1 | isochorismatase domain containing 1 [Source:HGNC Symbol;Acc:HGNC:24254] | 31779 | -0.594 | -0.6021 | Yes |
| 71 | PEX7 | peroxisomal biogenesis factor 7 [Source:HGNC Symbol;Acc:HGNC:8860] | 31888 | -0.614 | -0.5996 | Yes |
| 72 | NR0B2 | nuclear receptor subfamily 0 group B member 2 [Source:HGNC Symbol;Acc:HGNC:7961] | 32480 | -0.740 | -0.6090 | Yes |
| 73 | NUDT12 | nudix hydrolase 12 [Source:HGNC Symbol;Acc:HGNC:18826] | 32646 | -0.783 | -0.6066 | Yes |
| 74 | NR3C2 | nuclear receptor subfamily 3 group C member 2 [Source:HGNC Symbol;Acc:HGNC:7979] | 33044 | -0.884 | -0.6095 | Yes |
| 75 | EFHC1 | EF-hand domain containing 1 [Source:HGNC Symbol;Acc:HGNC:16406] | 33204 | -0.931 | -0.6055 | Yes |
| 76 | PNPLA8 | patatin like phospholipase domain containing 8 [Source:HGNC Symbol;Acc:HGNC:28900] | 33506 | -1.022 | -0.6046 | Yes |
| 77 | NPC1 | NPC intracellular cholesterol transporter 1 [Source:HGNC Symbol;Acc:HGNC:7897] | 33526 | -1.027 | -0.5960 | Yes |
| 78 | ACSL1 | acyl-CoA synthetase long chain family member 1 [Source:HGNC Symbol;Acc:HGNC:3569] | 33710 | -1.081 | -0.5914 | Yes |
| 79 | CAT | catalase [Source:HGNC Symbol;Acc:HGNC:1516] | 34050 | -1.199 | -0.5900 | Yes |
| 80 | PXMP2 | peroxisomal membrane protein 2 [Source:HGNC Symbol;Acc:HGNC:9716] | 34121 | -1.215 | -0.5811 | Yes |
| 81 | AMACR | alpha-methylacyl-CoA racemase [Source:HGNC Symbol;Acc:HGNC:451] | 34357 | -1.301 | -0.5759 | Yes |
| 82 | HSD3B7 | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 [Source:HGNC Symbol;Acc:HGNC:18324] | 34477 | -1.343 | -0.5672 | Yes |
| 83 | LONP2 | lon peptidase 2, peroxisomal [Source:HGNC Symbol;Acc:HGNC:20598] | 34590 | -1.388 | -0.5580 | Yes |
| 84 | PEX26 | peroxisomal biogenesis factor 26 [Source:HGNC Symbol;Acc:HGNC:22965] | 34711 | -1.430 | -0.5486 | Yes |
| 85 | MLYCD | malonyl-CoA decarboxylase [Source:HGNC Symbol;Acc:HGNC:7150] | 34936 | -1.532 | -0.5411 | Yes |
| 86 | PEX16 | peroxisomal biogenesis factor 16 [Source:HGNC Symbol;Acc:HGNC:8857] | 35004 | -1.565 | -0.5290 | Yes |
| 87 | RETSAT | retinol saturase [Source:HGNC Symbol;Acc:HGNC:25991] | 35100 | -1.626 | -0.5172 | Yes |
| 88 | ABCA2 | ATP binding cassette subfamily A member 2 [Source:HGNC Symbol;Acc:HGNC:32] | 35192 | -1.668 | -0.5049 | Yes |
| 89 | FDXR | ferredoxin reductase [Source:HGNC Symbol;Acc:HGNC:3642] | 35289 | -1.725 | -0.4922 | Yes |
| 90 | SCP2 | sterol carrier protein 2 [Source:HGNC Symbol;Acc:HGNC:10606] | 35297 | -1.729 | -0.4771 | Yes |
| 91 | RXRG | retinoid X receptor gamma [Source:HGNC Symbol;Acc:HGNC:10479] | 35365 | -1.760 | -0.4633 | Yes |
| 92 | ABCD3 | ATP binding cassette subfamily D member 3 [Source:HGNC Symbol;Acc:HGNC:67] | 35419 | -1.787 | -0.4489 | Yes |
| 93 | HSD17B4 | hydroxysteroid 17-beta dehydrogenase 4 [Source:HGNC Symbol;Acc:HGNC:5213] | 35498 | -1.835 | -0.4348 | Yes |
| 94 | DHCR24 | 24-dehydrocholesterol reductase [Source:HGNC Symbol;Acc:HGNC:2859] | 35555 | -1.870 | -0.4197 | Yes |
| 95 | IDH2 | isocitrate dehydrogenase (NADP(+)) 2 [Source:HGNC Symbol;Acc:HGNC:5383] | 35984 | -2.196 | -0.4119 | Yes |
| 96 | PEX1 | peroxisomal biogenesis factor 1 [Source:HGNC Symbol;Acc:HGNC:8850] | 36004 | -2.207 | -0.3928 | Yes |
| 97 | RXRA | retinoid X receptor alpha [Source:HGNC Symbol;Acc:HGNC:10477] | 36045 | -2.238 | -0.3741 | Yes |
| 98 | FADS2 | fatty acid desaturase 2 [Source:HGNC Symbol;Acc:HGNC:3575] | 36156 | -2.332 | -0.3564 | Yes |
| 99 | SLC35B2 | solute carrier family 35 member B2 [Source:HGNC Symbol;Acc:HGNC:16872] | 36196 | -2.360 | -0.3366 | Yes |
| 100 | ABCA3 | ATP binding cassette subfamily A member 3 [Source:HGNC Symbol;Acc:HGNC:33] | 36224 | -2.389 | -0.3162 | Yes |
| 101 | CROT | carnitine O-octanoyltransferase [Source:HGNC Symbol;Acc:HGNC:2366] | 36258 | -2.425 | -0.2956 | Yes |
| 102 | ABCG4 | ATP binding cassette subfamily G member 4 [Source:HGNC Symbol;Acc:HGNC:13884] | 36262 | -2.431 | -0.2741 | Yes |
| 103 | FADS1 | fatty acid desaturase 1 [Source:HGNC Symbol;Acc:HGNC:3574] | 36282 | -2.449 | -0.2530 | Yes |
| 104 | SLC29A1 | solute carrier family 29 member 1 (Augustine blood group) [Source:HGNC Symbol;Acc:HGNC:11003] | 36380 | -2.561 | -0.2329 | Yes |
| 105 | ABCD1 | ATP binding cassette subfamily D member 1 [Source:HGNC Symbol;Acc:HGNC:61] | 36461 | -2.663 | -0.2115 | Yes |
| 106 | ALDH9A1 | aldehyde dehydrogenase 9 family member A1 [Source:HGNC Symbol;Acc:HGNC:412] | 36561 | -2.810 | -0.1893 | Yes |
| 107 | HACL1 | 2-hydroxyacyl-CoA lyase 1 [Source:HGNC Symbol;Acc:HGNC:17856] | 36603 | -2.883 | -0.1649 | Yes |
| 108 | PAOX | polyamine oxidase [Source:HGNC Symbol;Acc:HGNC:20837] | 36907 | -3.591 | -0.1413 | Yes |
| 109 | IDH1 | isocitrate dehydrogenase (NADP(+)) 1 [Source:HGNC Symbol;Acc:HGNC:5382] | 36914 | -3.618 | -0.1094 | Yes |
| 110 | CYP27A1 | cytochrome P450 family 27 subfamily A member 1 [Source:HGNC Symbol;Acc:HGNC:2605] | 37007 | -4.017 | -0.0763 | Yes |
| 111 | PFKM | phosphofructokinase, muscle [Source:HGNC Symbol;Acc:HGNC:8877] | 37015 | -4.046 | -0.0407 | Yes |
| 112 | ABCD2 | ATP binding cassette subfamily D member 2 [Source:HGNC Symbol;Acc:HGNC:66] | 37084 | -4.825 | 0.0002 | Yes |
