Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #KO_GAQ_versus_KO_NA.Nof1.cls #KO_GAQ_versus_KO_NA_repos |
| Phenotype | Nof1.cls#KO_GAQ_versus_KO_NA_repos |
| Upregulated in class | KO_NA |
| GeneSet | HALLMARK_CHOLESTEROL_HOMEOSTASIS |
| Enrichment Score (ES) | -0.49901313 |
| Normalized Enrichment Score (NES) | -1.0376443 |
| Nominal p-value | 0.41007194 |
| FDR q-value | 0.6682816 |
| FWER p-Value | 1.0 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | ERRFI1 | ERBB receptor feedback inhibitor 1 [Source:HGNC Symbol;Acc:HGNC:18185] | 156 | 3.125 | 0.0332 | No |
| 2 | ACTG1 | actin gamma 1 [Source:HGNC Symbol;Acc:HGNC:144] | 185 | 2.984 | 0.0681 | No |
| 3 | S100A11 | S100 calcium binding protein A11 [Source:HGNC Symbol;Acc:HGNC:10488] | 521 | 2.043 | 0.0835 | No |
| 4 | CHKA | choline kinase alpha [Source:HGNC Symbol;Acc:HGNC:1937] | 669 | 1.831 | 0.1014 | No |
| 5 | ATF3 | activating transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:785] | 764 | 1.712 | 0.1193 | No |
| 6 | ATF5 | activating transcription factor 5 [Source:HGNC Symbol;Acc:HGNC:790] | 905 | 1.549 | 0.1341 | No |
| 7 | ALCAM | activated leukocyte cell adhesion molecule [Source:HGNC Symbol;Acc:HGNC:400] | 931 | 1.533 | 0.1517 | No |
| 8 | CD9 | CD9 molecule [Source:HGNC Symbol;Acc:HGNC:1709] | 995 | 1.474 | 0.1676 | No |
| 9 | HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase [Source:HGNC Symbol;Acc:HGNC:5006] | 1273 | 1.288 | 0.1756 | No |
| 10 | LPL | lipoprotein lipase [Source:HGNC Symbol;Acc:HGNC:6677] | 1375 | 1.224 | 0.1875 | No |
| 11 | ANTXR2 | ANTXR cell adhesion molecule 2 [Source:HGNC Symbol;Acc:HGNC:21732] | 1516 | 1.147 | 0.1974 | No |
| 12 | GNAI1 | G protein subunit alpha i1 [Source:HGNC Symbol;Acc:HGNC:4384] | 1762 | 1.031 | 0.2031 | No |
| 13 | HSD17B7 | hydroxysteroid 17-beta dehydrogenase 7 [Source:HGNC Symbol;Acc:HGNC:5215] | 1901 | 0.978 | 0.2111 | No |
| 14 | TNFRSF12A | TNF receptor superfamily member 12A [Source:HGNC Symbol;Acc:HGNC:18152] | 2458 | 0.778 | 0.2054 | No |
| 15 | ANXA5 | annexin A5 [Source:HGNC Symbol;Acc:HGNC:543] | 2491 | 0.768 | 0.2137 | No |
| 16 | NFIL3 | nuclear factor, interleukin 3 regulated [Source:HGNC Symbol;Acc:HGNC:7787] | 2755 | 0.692 | 0.2148 | No |
| 17 | LDLR | low density lipoprotein receptor [Source:HGNC Symbol;Acc:HGNC:6547] | 3116 | 0.604 | 0.2123 | No |
| 18 | FASN | fatty acid synthase [Source:HGNC Symbol;Acc:HGNC:3594] | 3219 | 0.579 | 0.2165 | No |
| 19 | IDI1 | isopentenyl-diphosphate delta isomerase 1 [Source:HGNC Symbol;Acc:HGNC:5387] | 3265 | 0.568 | 0.2221 | No |
| 20 | CTNNB1 | catenin beta 1 [Source:HGNC Symbol;Acc:HGNC:2514] | 3450 | 0.525 | 0.2234 | No |
| 21 | CLU | clusterin [Source:HGNC Symbol;Acc:HGNC:2095] | 3759 | 0.460 | 0.2206 | No |
| 22 | CYP51A1 | cytochrome P450 family 51 subfamily A member 1 [Source:HGNC Symbol;Acc:HGNC:2649] | 4596 | 0.311 | 0.2017 | No |
| 23 | GLDC | glycine decarboxylase [Source:HGNC Symbol;Acc:HGNC:4313] | 4831 | 0.272 | 0.1986 | No |
| 24 | GPX8 | glutathione peroxidase 8 (putative) [Source:HGNC Symbol;Acc:HGNC:33100] | 9667 | 0.000 | 0.0680 | No |
| 25 | GSTM2 | glutathione S-transferase mu 2 [Source:HGNC Symbol;Acc:HGNC:4634] | 9845 | 0.000 | 0.0632 | No |
| 26 | ADH4 | alcohol dehydrogenase 4 (class II), pi polypeptide [Source:HGNC Symbol;Acc:HGNC:252] | 11270 | 0.000 | 0.0248 | No |
| 27 | ANXA13 | annexin A13 [Source:HGNC Symbol;Acc:HGNC:536] | 14448 | 0.000 | -0.0611 | No |
| 28 | AVPR1A | arginine vasopressin receptor 1A [Source:HGNC Symbol;Acc:HGNC:895] | 16688 | 0.000 | -0.1216 | No |
| 29 | SEMA3B | semaphorin 3B [Source:HGNC Symbol;Acc:HGNC:10724] | 17908 | 0.000 | -0.1545 | No |
| 30 | CXCL16 | C-X-C motif chemokine ligand 16 [Source:HGNC Symbol;Acc:HGNC:16642] | 18912 | 0.000 | -0.1816 | No |
| 31 | PLAUR | plasminogen activator, urokinase receptor [Source:HGNC Symbol;Acc:HGNC:9053] | 25940 | 0.000 | -0.3714 | No |
| 32 | MAL2 | mal, T cell differentiation protein 2 (gene/pseudogene) [Source:HGNC Symbol;Acc:HGNC:13634] | 27594 | 0.000 | -0.4161 | No |
| 33 | SQLE | squalene epoxidase [Source:HGNC Symbol;Acc:HGNC:11279] | 27919 | -0.023 | -0.4245 | No |
| 34 | EBP | EBP cholestenol delta-isomerase [Source:HGNC Symbol;Acc:HGNC:3133] | 28608 | -0.119 | -0.4417 | No |
| 35 | TRIB3 | tribbles pseudokinase 3 [Source:HGNC Symbol;Acc:HGNC:16228] | 28809 | -0.145 | -0.4454 | No |
| 36 | GUSB | glucuronidase beta [Source:HGNC Symbol;Acc:HGNC:4696] | 29125 | -0.188 | -0.4516 | No |
| 37 | LSS | lanosterol synthase [Source:HGNC Symbol;Acc:HGNC:6708] | 29551 | -0.250 | -0.4601 | No |
| 38 | CPEB2 | cytoplasmic polyadenylation element binding protein 2 [Source:HGNC Symbol;Acc:HGNC:21745] | 29597 | -0.257 | -0.4583 | No |
| 39 | PLSCR1 | phospholipid scramblase 1 [Source:HGNC Symbol;Acc:HGNC:9092] | 29811 | -0.291 | -0.4606 | No |
| 40 | HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 [Source:HGNC Symbol;Acc:HGNC:5007] | 30044 | -0.322 | -0.4630 | No |
| 41 | MVK | mevalonate kinase [Source:HGNC Symbol;Acc:HGNC:7530] | 30586 | -0.399 | -0.4728 | No |
| 42 | TMEM97 | transmembrane protein 97 [Source:HGNC Symbol;Acc:HGNC:28106] | 30781 | -0.429 | -0.4729 | No |
| 43 | ATXN2 | ataxin 2 [Source:HGNC Symbol;Acc:HGNC:10555] | 31347 | -0.518 | -0.4820 | No |
| 44 | STX5 | syntaxin 5 [Source:HGNC Symbol;Acc:HGNC:11440] | 31751 | -0.588 | -0.4859 | No |
| 45 | FABP5 | fatty acid binding protein 5 [Source:HGNC Symbol;Acc:HGNC:3560] | 31973 | -0.635 | -0.4842 | No |
| 46 | JAG1 | jagged canonical Notch ligand 1 [Source:HGNC Symbol;Acc:HGNC:6188] | 32521 | -0.751 | -0.4900 | Yes |
| 47 | SREBF2 | sterol regulatory element binding transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:11290] | 32764 | -0.815 | -0.4868 | Yes |
| 48 | PMVK | phosphomevalonate kinase [Source:HGNC Symbol;Acc:HGNC:9141] | 33177 | -0.920 | -0.4869 | Yes |
| 49 | FBXO6 | F-box protein 6 [Source:HGNC Symbol;Acc:HGNC:13585] | 33551 | -1.036 | -0.4846 | Yes |
| 50 | STARD4 | StAR related lipid transfer domain containing 4 [Source:HGNC Symbol;Acc:HGNC:18058] | 33589 | -1.045 | -0.4731 | Yes |
| 51 | NSDHL | NAD(P) dependent steroid dehydrogenase-like [Source:HGNC Symbol;Acc:HGNC:13398] | 33600 | -1.049 | -0.4609 | Yes |
| 52 | FDPS | farnesyl diphosphate synthase [Source:HGNC Symbol;Acc:HGNC:3631] | 34131 | -1.218 | -0.4606 | Yes |
| 53 | SC5D | sterol-C5-desaturase [Source:HGNC Symbol;Acc:HGNC:10547] | 34161 | -1.231 | -0.4467 | Yes |
| 54 | NIBAN1 | niban apoptosis regulator 1 [Source:HGNC Symbol;Acc:HGNC:16784] | 34188 | -1.241 | -0.4325 | Yes |
| 55 | ACAT2 | acetyl-CoA acetyltransferase 2 [Source:HGNC Symbol;Acc:HGNC:94] | 34759 | -1.446 | -0.4307 | Yes |
| 56 | TP53INP1 | tumor protein p53 inducible nuclear protein 1 [Source:HGNC Symbol;Acc:HGNC:18022] | 34796 | -1.460 | -0.4142 | Yes |
| 57 | PDK3 | pyruvate dehydrogenase kinase 3 [Source:HGNC Symbol;Acc:HGNC:8811] | 34924 | -1.527 | -0.3994 | Yes |
| 58 | LGALS3 | galectin 3 [Source:HGNC Symbol;Acc:HGNC:6563] | 34949 | -1.543 | -0.3816 | Yes |
| 59 | MVD | mevalonate diphosphate decarboxylase [Source:HGNC Symbol;Acc:HGNC:7529] | 35065 | -1.604 | -0.3655 | Yes |
| 60 | PPARG | peroxisome proliferator activated receptor gamma [Source:HGNC Symbol;Acc:HGNC:9236] | 35129 | -1.641 | -0.3476 | Yes |
| 61 | ABCA2 | ATP binding cassette subfamily A member 2 [Source:HGNC Symbol;Acc:HGNC:32] | 35192 | -1.668 | -0.3293 | Yes |
| 62 | FDFT1 | farnesyl-diphosphate farnesyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:3629] | 35367 | -1.761 | -0.3129 | Yes |
| 63 | PCYT2 | phosphate cytidylyltransferase 2, ethanolamine [Source:HGNC Symbol;Acc:HGNC:8756] | 35604 | -1.911 | -0.2965 | Yes |
| 64 | ALDOC | aldolase, fructose-bisphosphate C [Source:HGNC Symbol;Acc:HGNC:418] | 35745 | -2.014 | -0.2762 | Yes |
| 65 | LGMN | legumain [Source:HGNC Symbol;Acc:HGNC:9472] | 35855 | -2.097 | -0.2540 | Yes |
| 66 | CBS | cystathionine beta-synthase [Source:HGNC Symbol;Acc:HGNC:1550] | 35957 | -2.179 | -0.2307 | Yes |
| 67 | FADS2 | fatty acid desaturase 2 [Source:HGNC Symbol;Acc:HGNC:3575] | 36156 | -2.332 | -0.2082 | Yes |
| 68 | TM7SF2 | transmembrane 7 superfamily member 2 [Source:HGNC Symbol;Acc:HGNC:11863] | 36235 | -2.398 | -0.1816 | Yes |
| 69 | PNRC1 | proline rich nuclear receptor coactivator 1 [Source:HGNC Symbol;Acc:HGNC:17278] | 36245 | -2.406 | -0.1531 | Yes |
| 70 | ACSS2 | acyl-CoA synthetase short chain family member 2 [Source:HGNC Symbol;Acc:HGNC:15814] | 36391 | -2.576 | -0.1262 | Yes |
| 71 | ETHE1 | ETHE1 persulfide dioxygenase [Source:HGNC Symbol;Acc:HGNC:23287] | 36503 | -2.718 | -0.0967 | Yes |
| 72 | DHCR7 | 7-dehydrocholesterol reductase [Source:HGNC Symbol;Acc:HGNC:2860] | 36576 | -2.839 | -0.0647 | Yes |
| 73 | ECH1 | enoyl-CoA hydratase 1 [Source:HGNC Symbol;Acc:HGNC:3149] | 36642 | -2.940 | -0.0313 | Yes |
| 74 | SCD | stearoyl-CoA desaturase [Source:HGNC Symbol;Acc:HGNC:10571] | 36918 | -3.629 | 0.0046 | Yes |
