Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #KO_GAQ_versus_KO_NA.Nof1.cls #KO_GAQ_versus_KO_NA_repos |
| Phenotype | Nof1.cls#KO_GAQ_versus_KO_NA_repos |
| Upregulated in class | KO_GAQ |
| GeneSet | HALLMARK_COAGULATION |
| Enrichment Score (ES) | 0.3671765 |
| Normalized Enrichment Score (NES) | 0.9793175 |
| Nominal p-value | 0.46721312 |
| FDR q-value | 0.53649986 |
| FWER p-Value | 0.941 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | FURIN | furin, paired basic amino acid cleaving enzyme [Source:HGNC Symbol;Acc:HGNC:8568] | 35 | 4.335 | 0.0439 | Yes |
| 2 | PDGFB | platelet derived growth factor subunit B [Source:HGNC Symbol;Acc:HGNC:8800] | 47 | 4.131 | 0.0863 | Yes |
| 3 | F9 | coagulation factor IX [Source:HGNC Symbol;Acc:HGNC:3551] | 144 | 3.182 | 0.1166 | Yes |
| 4 | PLEK | pleckstrin [Source:HGNC Symbol;Acc:HGNC:9070] | 218 | 2.844 | 0.1440 | Yes |
| 5 | MMP14 | matrix metallopeptidase 14 [Source:HGNC Symbol;Acc:HGNC:7160] | 233 | 2.792 | 0.1725 | Yes |
| 6 | GNG12 | G protein subunit gamma 12 [Source:HGNC Symbol;Acc:HGNC:19663] | 343 | 2.395 | 0.1943 | Yes |
| 7 | WDR1 | WD repeat domain 1 [Source:HGNC Symbol;Acc:HGNC:12754] | 416 | 2.241 | 0.2155 | Yes |
| 8 | GDA | guanine deaminase [Source:HGNC Symbol;Acc:HGNC:4212] | 420 | 2.226 | 0.2384 | Yes |
| 9 | SERPINE1 | serpin family E member 1 [Source:HGNC Symbol;Acc:HGNC:8583] | 492 | 2.096 | 0.2582 | Yes |
| 10 | TIMP1 | TIMP metallopeptidase inhibitor 1 [Source:HGNC Symbol;Acc:HGNC:11820] | 717 | 1.768 | 0.2704 | Yes |
| 11 | MMP9 | matrix metallopeptidase 9 [Source:HGNC Symbol;Acc:HGNC:7176] | 825 | 1.630 | 0.2844 | Yes |
| 12 | ANXA1 | annexin A1 [Source:HGNC Symbol;Acc:HGNC:533] | 871 | 1.587 | 0.2996 | Yes |
| 13 | MAFF | MAF bZIP transcription factor F [Source:HGNC Symbol;Acc:HGNC:6780] | 928 | 1.535 | 0.3139 | Yes |
| 14 | CD9 | CD9 molecule [Source:HGNC Symbol;Acc:HGNC:1709] | 995 | 1.474 | 0.3274 | Yes |
| 15 | MMP2 | matrix metallopeptidase 2 [Source:HGNC Symbol;Acc:HGNC:7166] | 996 | 1.474 | 0.3426 | Yes |
| 16 | SERPINB2 | serpin family B member 2 [Source:HGNC Symbol;Acc:HGNC:8584] | 1091 | 1.400 | 0.3545 | Yes |
| 17 | CFB | complement factor B [Source:HGNC Symbol;Acc:HGNC:1037] | 1195 | 1.334 | 0.3655 | Yes |
| 18 | SERPINC1 | serpin family C member 1 [Source:HGNC Symbol;Acc:HGNC:775] | 2023 | 0.925 | 0.3527 | Yes |
| 19 | KLF7 | Kruppel like factor 7 [Source:HGNC Symbol;Acc:HGNC:6350] | 2679 | 0.707 | 0.3423 | Yes |
| 20 | CTSV | cathepsin V [Source:HGNC Symbol;Acc:HGNC:2538] | 2933 | 0.646 | 0.3421 | Yes |
| 21 | FBN1 | fibrillin 1 [Source:HGNC Symbol;Acc:HGNC:3603] | 3286 | 0.563 | 0.3384 | Yes |
| 22 | FYN | FYN proto-oncogene, Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:4037] | 3395 | 0.538 | 0.3411 | Yes |
| 23 | THBS1 | thrombospondin 1 [Source:HGNC Symbol;Acc:HGNC:11785] | 3513 | 0.510 | 0.3432 | Yes |
| 24 | PREP | prolyl endopeptidase [Source:HGNC Symbol;Acc:HGNC:9358] | 3583 | 0.496 | 0.3464 | Yes |
| 25 | BMP1 | bone morphogenetic protein 1 [Source:HGNC Symbol;Acc:HGNC:1067] | 3601 | 0.493 | 0.3511 | Yes |
| 26 | CPN1 | carboxypeptidase N subunit 1 [Source:HGNC Symbol;Acc:HGNC:2312] | 3668 | 0.478 | 0.3542 | Yes |
| 27 | C2 | complement C2 [Source:HGNC Symbol;Acc:HGNC:1248] | 3705 | 0.470 | 0.3581 | Yes |
| 28 | ITIH1 | inter-alpha-trypsin inhibitor heavy chain 1 [Source:HGNC Symbol;Acc:HGNC:6166] | 3712 | 0.469 | 0.3628 | Yes |
| 29 | CLU | clusterin [Source:HGNC Symbol;Acc:HGNC:2095] | 3759 | 0.460 | 0.3663 | Yes |
| 30 | ITGB3 | integrin subunit beta 3 [Source:HGNC Symbol;Acc:HGNC:6156] | 3998 | 0.415 | 0.3642 | Yes |
| 31 | ADAM9 | ADAM metallopeptidase domain 9 [Source:HGNC Symbol;Acc:HGNC:216] | 4076 | 0.404 | 0.3663 | Yes |
| 32 | MASP2 | mannan binding lectin serine peptidase 2 [Source:HGNC Symbol;Acc:HGNC:6902] | 4269 | 0.367 | 0.3649 | Yes |
| 33 | ARF4 | ADP ribosylation factor 4 [Source:HGNC Symbol;Acc:HGNC:655] | 4321 | 0.357 | 0.3672 | Yes |
| 34 | RABIF | RAB interacting factor [Source:HGNC Symbol;Acc:HGNC:9797] | 4512 | 0.324 | 0.3654 | No |
| 35 | F10 | coagulation factor X [Source:HGNC Symbol;Acc:HGNC:3528] | 4678 | 0.300 | 0.3640 | No |
| 36 | S100A13 | S100 calcium binding protein A13 [Source:HGNC Symbol;Acc:HGNC:10490] | 4927 | 0.256 | 0.3600 | No |
| 37 | MMP8 | matrix metallopeptidase 8 [Source:HGNC Symbol;Acc:HGNC:7175] | 4929 | 0.255 | 0.3626 | No |
| 38 | GNB2 | G protein subunit beta 2 [Source:HGNC Symbol;Acc:HGNC:4398] | 5231 | 0.203 | 0.3565 | No |
| 39 | RGN | regucalcin [Source:HGNC Symbol;Acc:HGNC:9989] | 5301 | 0.191 | 0.3566 | No |
| 40 | MMP3 | matrix metallopeptidase 3 [Source:HGNC Symbol;Acc:HGNC:7173] | 5579 | 0.149 | 0.3507 | No |
| 41 | CTSK | cathepsin K [Source:HGNC Symbol;Acc:HGNC:2536] | 5584 | 0.148 | 0.3521 | No |
| 42 | SH2B2 | SH2B adaptor protein 2 [Source:HGNC Symbol;Acc:HGNC:17381] | 6319 | 0.039 | 0.3326 | No |
| 43 | C3 | complement C3 [Source:HGNC Symbol;Acc:HGNC:1318] | 6488 | 0.014 | 0.3282 | No |
| 44 | PLAT | plasminogen activator, tissue type [Source:HGNC Symbol;Acc:HGNC:9051] | 10092 | 0.000 | 0.2307 | No |
| 45 | APOA1 | apolipoprotein A1 [Source:HGNC Symbol;Acc:HGNC:600] | 10304 | 0.000 | 0.2250 | No |
| 46 | APOC3 | apolipoprotein C3 [Source:HGNC Symbol;Acc:HGNC:610] | 10319 | 0.000 | 0.2246 | No |
| 47 | APOC2 | apolipoprotein C2 [Source:HGNC Symbol;Acc:HGNC:609] | 10321 | 0.000 | 0.2246 | No |
| 48 | APOC1 | apolipoprotein C1 [Source:HGNC Symbol;Acc:HGNC:607] | 10322 | 0.000 | 0.2246 | No |
| 49 | F13B | coagulation factor XIII B chain [Source:HGNC Symbol;Acc:HGNC:3534] | 11031 | 0.000 | 0.2055 | No |
| 50 | KLKB1 | kallikrein B1 [Source:HGNC Symbol;Acc:HGNC:6371] | 11295 | 0.000 | 0.1983 | No |
| 51 | TMPRSS6 | transmembrane serine protease 6 [Source:HGNC Symbol;Acc:HGNC:16517] | 11694 | 0.000 | 0.1876 | No |
| 52 | PROZ | protein Z, vitamin K dependent plasma glycoprotein [Source:HGNC Symbol;Acc:HGNC:9460] | 11741 | 0.000 | 0.1863 | No |
| 53 | PROC | protein C, inactivator of coagulation factors Va and VIIIa [Source:HGNC Symbol;Acc:HGNC:9451] | 11759 | 0.000 | 0.1859 | No |
| 54 | ACOX2 | acyl-CoA oxidase 2 [Source:HGNC Symbol;Acc:HGNC:120] | 12462 | 0.000 | 0.1669 | No |
| 55 | THBD | thrombomodulin [Source:HGNC Symbol;Acc:HGNC:11784] | 12826 | 0.000 | 0.1571 | No |
| 56 | P2RY1 | purinergic receptor P2Y1 [Source:HGNC Symbol;Acc:HGNC:8539] | 14260 | 0.000 | 0.1183 | No |
| 57 | MBL2 | mannose binding lectin 2 [Source:HGNC Symbol;Acc:HGNC:6922] | 15684 | 0.000 | 0.0798 | No |
| 58 | C8B | complement C8 beta chain [Source:HGNC Symbol;Acc:HGNC:1353] | 15752 | 0.000 | 0.0780 | No |
| 59 | C8A | complement C8 alpha chain [Source:HGNC Symbol;Acc:HGNC:1352] | 15753 | 0.000 | 0.0780 | No |
| 60 | C8G | complement C8 gamma chain [Source:HGNC Symbol;Acc:HGNC:1354] | 15755 | 0.000 | 0.0779 | No |
| 61 | HTRA1 | HtrA serine peptidase 1 [Source:HGNC Symbol;Acc:HGNC:9476] | 15778 | 0.000 | 0.0773 | No |
| 62 | CFD | complement factor D [Source:HGNC Symbol;Acc:HGNC:2771] | 15854 | 0.000 | 0.0753 | No |
| 63 | CFI | complement factor I [Source:HGNC Symbol;Acc:HGNC:5394] | 15855 | 0.000 | 0.0753 | No |
| 64 | DCT | dopachrome tautomerase [Source:HGNC Symbol;Acc:HGNC:2709] | 16100 | 0.000 | 0.0687 | No |
| 65 | C9 | complement C9 [Source:HGNC Symbol;Acc:HGNC:1358] | 16173 | 0.000 | 0.0668 | No |
| 66 | F2 | coagulation factor II, thrombin [Source:HGNC Symbol;Acc:HGNC:3535] | 16215 | 0.000 | 0.0656 | No |
| 67 | F3 | coagulation factor III, tissue factor [Source:HGNC Symbol;Acc:HGNC:3541] | 16216 | 0.000 | 0.0656 | No |
| 68 | F12 | coagulation factor XII [Source:HGNC Symbol;Acc:HGNC:3530] | 16513 | 0.000 | 0.0576 | No |
| 69 | F11 | coagulation factor XI [Source:HGNC Symbol;Acc:HGNC:3529] | 16514 | 0.000 | 0.0576 | No |
| 70 | FGA | fibrinogen alpha chain [Source:HGNC Symbol;Acc:HGNC:3661] | 16741 | 0.000 | 0.0515 | No |
| 71 | FGG | fibrinogen gamma chain [Source:HGNC Symbol;Acc:HGNC:3694] | 16742 | 0.000 | 0.0515 | No |
| 72 | FN1 | fibronectin 1 [Source:HGNC Symbol;Acc:HGNC:3778] | 16781 | 0.000 | 0.0505 | No |
| 73 | OLR1 | oxidized low density lipoprotein receptor 1 [Source:HGNC Symbol;Acc:HGNC:8133] | 16791 | 0.000 | 0.0502 | No |
| 74 | GP9 | glycoprotein IX platelet [Source:HGNC Symbol;Acc:HGNC:4444] | 17188 | 0.000 | 0.0395 | No |
| 75 | TIMP3 | TIMP metallopeptidase inhibitor 3 [Source:HGNC Symbol;Acc:HGNC:11822] | 17196 | 0.000 | 0.0393 | No |
| 76 | HRG | histidine rich glycoprotein [Source:HGNC Symbol;Acc:HGNC:5181] | 17534 | 0.000 | 0.0302 | No |
| 77 | HNF4A | hepatocyte nuclear factor 4 alpha [Source:HGNC Symbol;Acc:HGNC:5024] | 17709 | 0.000 | 0.0255 | No |
| 78 | SERPING1 | serpin family G member 1 [Source:HGNC Symbol;Acc:HGNC:1228] | 17823 | 0.000 | 0.0225 | No |
| 79 | SERPINA1 | serpin family A member 1 [Source:HGNC Symbol;Acc:HGNC:8941] | 17834 | 0.000 | 0.0222 | No |
| 80 | DPP4 | dipeptidyl peptidase 4 [Source:HGNC Symbol;Acc:HGNC:3009] | 17983 | 0.000 | 0.0182 | No |
| 81 | MMP7 | matrix metallopeptidase 7 [Source:HGNC Symbol;Acc:HGNC:7174] | 19126 | 0.000 | -0.0127 | No |
| 82 | MMP1 | matrix metallopeptidase 1 [Source:HGNC Symbol;Acc:HGNC:7155] | 19129 | 0.000 | -0.0128 | No |
| 83 | PF4 | platelet factor 4 [Source:HGNC Symbol;Acc:HGNC:8861] | 20014 | 0.000 | -0.0367 | No |
| 84 | HMGCS2 | 3-hydroxy-3-methylglutaryl-CoA synthase 2 [Source:HGNC Symbol;Acc:HGNC:5008] | 20055 | 0.000 | -0.0378 | No |
| 85 | PLG | plasminogen [Source:HGNC Symbol;Acc:HGNC:9071] | 20088 | 0.000 | -0.0387 | No |
| 86 | C1QA | complement C1q A chain [Source:HGNC Symbol;Acc:HGNC:1241] | 20144 | 0.000 | -0.0401 | No |
| 87 | LEFTY2 | left-right determination factor 2 [Source:HGNC Symbol;Acc:HGNC:3122] | 20259 | 0.000 | -0.0432 | No |
| 88 | KLK8 | kallikrein related peptidase 8 [Source:HGNC Symbol;Acc:HGNC:6369] | 20698 | 0.000 | -0.0551 | No |
| 89 | MMP10 | matrix metallopeptidase 10 [Source:HGNC Symbol;Acc:HGNC:7156] | 20924 | 0.000 | -0.0612 | No |
| 90 | MMP15 | matrix metallopeptidase 15 [Source:HGNC Symbol;Acc:HGNC:7161] | 20932 | 0.000 | -0.0614 | No |
| 91 | F2RL2 | coagulation factor II thrombin receptor like 2 [Source:HGNC Symbol;Acc:HGNC:3539] | 21293 | 0.000 | -0.0711 | No |
| 92 | MEP1A | meprin A subunit alpha [Source:HGNC Symbol;Acc:HGNC:7015] | 23438 | 0.000 | -0.1291 | No |
| 93 | GP1BA | glycoprotein Ib platelet subunit alpha [Source:HGNC Symbol;Acc:HGNC:4439] | 23499 | 0.000 | -0.1307 | No |
| 94 | TFPI2 | tissue factor pathway inhibitor 2 [Source:HGNC Symbol;Acc:HGNC:11761] | 25185 | 0.000 | -0.1763 | No |
| 95 | PRSS23 | serine protease 23 [Source:HGNC Symbol;Acc:HGNC:14370] | 25460 | 0.000 | -0.1838 | No |
| 96 | ITGA2 | integrin subunit alpha 2 [Source:HGNC Symbol;Acc:HGNC:6137] | 26704 | 0.000 | -0.2174 | No |
| 97 | A2M | alpha-2-macroglobulin [Source:HGNC Symbol;Acc:HGNC:7] | 27266 | 0.000 | -0.2326 | No |
| 98 | SPARC | secreted protein acidic and cysteine rich [Source:HGNC Symbol;Acc:HGNC:11219] | 27623 | 0.000 | -0.2422 | No |
| 99 | CTSH | cathepsin H [Source:HGNC Symbol;Acc:HGNC:2535] | 27914 | -0.022 | -0.2498 | No |
| 100 | CPB2 | carboxypeptidase B2 [Source:HGNC Symbol;Acc:HGNC:2300] | 28973 | -0.167 | -0.2767 | No |
| 101 | HPN | hepsin [Source:HGNC Symbol;Acc:HGNC:5155] | 29028 | -0.176 | -0.2764 | No |
| 102 | RAPGEF3 | Rap guanine nucleotide exchange factor 3 [Source:HGNC Symbol;Acc:HGNC:16629] | 29950 | -0.310 | -0.2981 | No |
| 103 | RAC1 | Rac family small GTPase 1 [Source:HGNC Symbol;Acc:HGNC:9801] | 30128 | -0.333 | -0.2994 | No |
| 104 | LAMP2 | lysosomal associated membrane protein 2 [Source:HGNC Symbol;Acc:HGNC:6501] | 30456 | -0.376 | -0.3044 | No |
| 105 | PEF1 | penta-EF-hand domain containing 1 [Source:HGNC Symbol;Acc:HGNC:30009] | 30461 | -0.376 | -0.3006 | No |
| 106 | CRIP2 | cysteine rich protein 2 [Source:HGNC Symbol;Acc:HGNC:2361] | 30551 | -0.393 | -0.2990 | No |
| 107 | TF | transferrin [Source:HGNC Symbol;Acc:HGNC:11740] | 30588 | -0.399 | -0.2958 | No |
| 108 | ISCU | iron-sulfur cluster assembly enzyme [Source:HGNC Symbol;Acc:HGNC:29882] | 30995 | -0.462 | -0.3020 | No |
| 109 | MMP11 | matrix metallopeptidase 11 [Source:HGNC Symbol;Acc:HGNC:7157] | 31245 | -0.502 | -0.3036 | No |
| 110 | C1S | complement C1s [Source:HGNC Symbol;Acc:HGNC:1247] | 31480 | -0.541 | -0.3043 | No |
| 111 | USP11 | ubiquitin specific peptidase 11 [Source:HGNC Symbol;Acc:HGNC:12609] | 32091 | -0.660 | -0.3140 | No |
| 112 | VWF | von Willebrand factor [Source:HGNC Symbol;Acc:HGNC:12726] | 32275 | -0.699 | -0.3117 | No |
| 113 | COMP | cartilage oligomeric matrix protein [Source:HGNC Symbol;Acc:HGNC:2227] | 32333 | -0.709 | -0.3059 | No |
| 114 | SIRT2 | sirtuin 2 [Source:HGNC Symbol;Acc:HGNC:10886] | 32651 | -0.784 | -0.3064 | No |
| 115 | CASP9 | caspase 9 [Source:HGNC Symbol;Acc:HGNC:1511] | 33278 | -0.952 | -0.3135 | No |
| 116 | S100A1 | S100 calcium binding protein A1 [Source:HGNC Symbol;Acc:HGNC:10486] | 33328 | -0.965 | -0.3049 | No |
| 117 | CTSE | cathepsin E [Source:HGNC Symbol;Acc:HGNC:2530] | 33466 | -1.010 | -0.2981 | No |
| 118 | CTSB | cathepsin B [Source:HGNC Symbol;Acc:HGNC:2527] | 33473 | -1.011 | -0.2878 | No |
| 119 | PROS1 | protein S [Source:HGNC Symbol;Acc:HGNC:9456] | 33512 | -1.023 | -0.2783 | No |
| 120 | DUSP6 | dual specificity phosphatase 6 [Source:HGNC Symbol;Acc:HGNC:3072] | 33684 | -1.074 | -0.2718 | No |
| 121 | CAPN2 | calpain 2 [Source:HGNC Symbol;Acc:HGNC:1479] | 33762 | -1.098 | -0.2626 | No |
| 122 | MST1 | macrophage stimulating 1 [Source:HGNC Symbol;Acc:HGNC:7380] | 34256 | -1.266 | -0.2628 | No |
| 123 | LTA4H | leukotriene A4 hydrolase [Source:HGNC Symbol;Acc:HGNC:6710] | 34326 | -1.288 | -0.2514 | No |
| 124 | MSRB2 | methionine sulfoxide reductase B2 [Source:HGNC Symbol;Acc:HGNC:17061] | 34577 | -1.382 | -0.2438 | No |
| 125 | C1R | complement C1r [Source:HGNC Symbol;Acc:HGNC:1246] | 34754 | -1.444 | -0.2337 | No |
| 126 | LRP1 | LDL receptor related protein 1 [Source:HGNC Symbol;Acc:HGNC:6692] | 34819 | -1.471 | -0.2202 | No |
| 127 | CAPN5 | calpain 5 [Source:HGNC Symbol;Acc:HGNC:1482] | 35088 | -1.619 | -0.2107 | No |
| 128 | DUSP14 | dual specificity phosphatase 14 [Source:HGNC Symbol;Acc:HGNC:17007] | 35138 | -1.646 | -0.1950 | No |
| 129 | CTSO | cathepsin O [Source:HGNC Symbol;Acc:HGNC:2542] | 35359 | -1.757 | -0.1828 | No |
| 130 | CSRP1 | cysteine and glycine rich protein 1 [Source:HGNC Symbol;Acc:HGNC:2469] | 35414 | -1.785 | -0.1658 | No |
| 131 | LGMN | legumain [Source:HGNC Symbol;Acc:HGNC:9472] | 35855 | -2.097 | -0.1560 | No |
| 132 | CPQ | carboxypeptidase Q [Source:HGNC Symbol;Acc:HGNC:16910] | 36063 | -2.250 | -0.1384 | No |
| 133 | F8 | coagulation factor VIII [Source:HGNC Symbol;Acc:HGNC:3546] | 36539 | -2.778 | -0.1225 | No |
| 134 | GSN | gelsolin [Source:HGNC Symbol;Acc:HGNC:4620] | 36609 | -2.892 | -0.0945 | No |
| 135 | ANG | angiogenin [Source:HGNC Symbol;Acc:HGNC:483] | 36634 | -2.921 | -0.0649 | No |
| 136 | CFH | complement factor H [Source:HGNC Symbol;Acc:HGNC:4883] | 36840 | -3.388 | -0.0354 | No |
| 137 | PLAU | plasminogen activator, urokinase [Source:HGNC Symbol;Acc:HGNC:9052] | 37020 | -4.081 | 0.0019 | No |
