Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #KO_GAQ_versus_KO_NA.Nof1.cls #KO_GAQ_versus_KO_NA_repos |
| Phenotype | Nof1.cls#KO_GAQ_versus_KO_NA_repos |
| Upregulated in class | KO_GAQ |
| GeneSet | HALLMARK_IL6_JAK_STAT3_SIGNALING |
| Enrichment Score (ES) | 0.73880804 |
| Normalized Enrichment Score (NES) | 1.8358576 |
| Nominal p-value | 0.0 |
| FDR q-value | 4.2000003E-4 |
| FWER p-Value | 0.001 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | IL1B | interleukin 1 beta [Source:HGNC Symbol;Acc:HGNC:5992] | 0 | 4.989 | 0.0594 | Yes |
| 2 | SOCS3 | suppressor of cytokine signaling 3 [Source:HGNC Symbol;Acc:HGNC:19391] | 13 | 4.740 | 0.1155 | Yes |
| 3 | TNFRSF1B | TNF receptor superfamily member 1B [Source:HGNC Symbol;Acc:HGNC:11917] | 17 | 4.615 | 0.1704 | Yes |
| 4 | TNF | tumor necrosis factor [Source:HGNC Symbol;Acc:HGNC:11892] | 41 | 4.239 | 0.2203 | Yes |
| 5 | PIK3R5 | phosphoinositide-3-kinase regulatory subunit 5 [Source:HGNC Symbol;Acc:HGNC:30035] | 175 | 3.013 | 0.2526 | Yes |
| 6 | CD44 | CD44 molecule (Indian blood group) [Source:HGNC Symbol;Acc:HGNC:1681] | 192 | 2.933 | 0.2871 | Yes |
| 7 | STAT3 | signal transducer and activator of transcription 3 [Source:HGNC Symbol;Acc:HGNC:11364] | 242 | 2.756 | 0.3186 | Yes |
| 8 | CD14 | CD14 molecule [Source:HGNC Symbol;Acc:HGNC:1628] | 263 | 2.685 | 0.3500 | Yes |
| 9 | SOCS1 | suppressor of cytokine signaling 1 [Source:HGNC Symbol;Acc:HGNC:19383] | 373 | 2.309 | 0.3746 | Yes |
| 10 | PIM1 | Pim-1 proto-oncogene, serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:8986] | 395 | 2.261 | 0.4009 | Yes |
| 11 | TGFB1 | transforming growth factor beta 1 [Source:HGNC Symbol;Acc:HGNC:11766] | 402 | 2.254 | 0.4276 | Yes |
| 12 | STAT2 | signal transducer and activator of transcription 2 [Source:HGNC Symbol;Acc:HGNC:11363] | 406 | 2.252 | 0.4543 | Yes |
| 13 | CD36 | CD36 molecule [Source:HGNC Symbol;Acc:HGNC:1663] | 431 | 2.203 | 0.4799 | Yes |
| 14 | STAT1 | signal transducer and activator of transcription 1 [Source:HGNC Symbol;Acc:HGNC:11362] | 454 | 2.149 | 0.5049 | Yes |
| 15 | MYD88 | MYD88 innate immune signal transduction adaptor [Source:HGNC Symbol;Acc:HGNC:7562] | 513 | 2.058 | 0.5279 | Yes |
| 16 | HAX1 | HCLS1 associated protein X-1 [Source:HGNC Symbol;Acc:HGNC:16915] | 523 | 2.042 | 0.5519 | Yes |
| 17 | CXCL10 | C-X-C motif chemokine ligand 10 [Source:HGNC Symbol;Acc:HGNC:10637] | 625 | 1.882 | 0.5716 | Yes |
| 18 | IRF9 | interferon regulatory factor 9 [Source:HGNC Symbol;Acc:HGNC:6131] | 668 | 1.833 | 0.5923 | Yes |
| 19 | PTPN11 | protein tyrosine phosphatase non-receptor type 11 [Source:HGNC Symbol;Acc:HGNC:9644] | 962 | 1.506 | 0.6023 | Yes |
| 20 | CD9 | CD9 molecule [Source:HGNC Symbol;Acc:HGNC:1709] | 995 | 1.474 | 0.6190 | Yes |
| 21 | TNFRSF1A | TNF receptor superfamily member 1A [Source:HGNC Symbol;Acc:HGNC:11916] | 1012 | 1.464 | 0.6360 | Yes |
| 22 | BAK1 | BCL2 antagonist/killer 1 [Source:HGNC Symbol;Acc:HGNC:949] | 1023 | 1.456 | 0.6531 | Yes |
| 23 | TLR2 | toll like receptor 2 [Source:HGNC Symbol;Acc:HGNC:11848] | 1097 | 1.398 | 0.6678 | Yes |
| 24 | IL2RG | interleukin 2 receptor subunit gamma [Source:HGNC Symbol;Acc:HGNC:6010] | 1310 | 1.267 | 0.6771 | Yes |
| 25 | MAP3K8 | mitogen-activated protein kinase kinase kinase 8 [Source:HGNC Symbol;Acc:HGNC:6860] | 1585 | 1.127 | 0.6832 | Yes |
| 26 | STAM2 | signal transducing adaptor molecule 2 [Source:HGNC Symbol;Acc:HGNC:11358] | 1713 | 1.055 | 0.6923 | Yes |
| 27 | PTPN1 | protein tyrosine phosphatase non-receptor type 1 [Source:HGNC Symbol;Acc:HGNC:9642] | 1923 | 0.966 | 0.6981 | Yes |
| 28 | IL17RA | interleukin 17 receptor A [Source:HGNC Symbol;Acc:HGNC:5985] | 2107 | 0.893 | 0.7038 | Yes |
| 29 | CCR1 | C-C motif chemokine receptor 1 [Source:HGNC Symbol;Acc:HGNC:1602] | 2132 | 0.886 | 0.7137 | Yes |
| 30 | ACVR1B | activin A receptor type 1B [Source:HGNC Symbol;Acc:HGNC:172] | 2321 | 0.819 | 0.7184 | Yes |
| 31 | TNFRSF12A | TNF receptor superfamily member 12A [Source:HGNC Symbol;Acc:HGNC:18152] | 2458 | 0.778 | 0.7240 | Yes |
| 32 | GRB2 | growth factor receptor bound protein 2 [Source:HGNC Symbol;Acc:HGNC:4566] | 2674 | 0.709 | 0.7266 | Yes |
| 33 | HMOX1 | heme oxygenase 1 [Source:HGNC Symbol;Acc:HGNC:5013] | 2789 | 0.684 | 0.7317 | Yes |
| 34 | IL13RA1 | interleukin 13 receptor subunit alpha 1 [Source:HGNC Symbol;Acc:HGNC:5974] | 3103 | 0.607 | 0.7305 | Yes |
| 35 | JUN | Jun proto-oncogene, AP-1 transcription factor subunit [Source:HGNC Symbol;Acc:HGNC:6204] | 3144 | 0.596 | 0.7365 | Yes |
| 36 | LTBR | lymphotoxin beta receptor [Source:HGNC Symbol;Acc:HGNC:6718] | 3306 | 0.560 | 0.7388 | Yes |
| 37 | IL6 | interleukin 6 [Source:HGNC Symbol;Acc:HGNC:6018] | 3563 | 0.500 | 0.7378 | No |
| 38 | CXCL3 | C-X-C motif chemokine ligand 3 [Source:HGNC Symbol;Acc:HGNC:4604] | 3910 | 0.434 | 0.7337 | No |
| 39 | ITGB3 | integrin subunit beta 3 [Source:HGNC Symbol;Acc:HGNC:6156] | 3998 | 0.415 | 0.7363 | No |
| 40 | FAS | Fas cell surface death receptor [Source:HGNC Symbol;Acc:HGNC:11920] | 4145 | 0.393 | 0.7370 | No |
| 41 | IL7 | interleukin 7 [Source:HGNC Symbol;Acc:HGNC:6023] | 4387 | 0.346 | 0.7346 | No |
| 42 | LTB | lymphotoxin beta [Source:HGNC Symbol;Acc:HGNC:6711] | 5250 | 0.201 | 0.7137 | No |
| 43 | LEPR | leptin receptor [Source:HGNC Symbol;Acc:HGNC:6554] | 5866 | 0.111 | 0.6984 | No |
| 44 | CBL | Cbl proto-oncogene [Source:HGNC Symbol;Acc:HGNC:1541] | 6122 | 0.075 | 0.6924 | No |
| 45 | CNTFR | ciliary neurotrophic factor receptor [Source:HGNC Symbol;Acc:HGNC:2170] | 8988 | 0.000 | 0.6150 | No |
| 46 | TNFRSF21 | TNF receptor superfamily member 21 [Source:HGNC Symbol;Acc:HGNC:13469] | 9451 | 0.000 | 0.6025 | No |
| 47 | CRLF2 | cytokine receptor like factor 2 [Source:HGNC Symbol;Acc:HGNC:14281] | 11071 | 0.000 | 0.5587 | No |
| 48 | PLA2G2A | phospholipase A2 group IIA [Source:HGNC Symbol;Acc:HGNC:9031] | 11805 | 0.000 | 0.5389 | No |
| 49 | CSF2RA | colony stimulating factor 2 receptor subunit alpha [Source:HGNC Symbol;Acc:HGNC:2435] | 12094 | 0.000 | 0.5311 | No |
| 50 | PDGFC | platelet derived growth factor C [Source:HGNC Symbol;Acc:HGNC:8801] | 13682 | 0.000 | 0.4883 | No |
| 51 | IL4R | interleukin 4 receptor [Source:HGNC Symbol;Acc:HGNC:6015] | 13998 | 0.000 | 0.4797 | No |
| 52 | IL9R | interleukin 9 receptor [Source:HGNC Symbol;Acc:HGNC:6030] | 14067 | 0.000 | 0.4779 | No |
| 53 | IL15RA | interleukin 15 receptor subunit alpha [Source:HGNC Symbol;Acc:HGNC:5978] | 14300 | 0.000 | 0.4716 | No |
| 54 | EBI3 | Epstein-Barr virus induced 3 [Source:HGNC Symbol;Acc:HGNC:3129] | 15156 | 0.000 | 0.4485 | No |
| 55 | IL17RB | interleukin 17 receptor B [Source:HGNC Symbol;Acc:HGNC:18015] | 15207 | 0.000 | 0.4472 | No |
| 56 | IL18R1 | interleukin 18 receptor 1 [Source:HGNC Symbol;Acc:HGNC:5988] | 15551 | 0.000 | 0.4379 | No |
| 57 | IL2RA | interleukin 2 receptor subunit alpha [Source:HGNC Symbol;Acc:HGNC:6008] | 15702 | 0.000 | 0.4339 | No |
| 58 | IL1R1 | interleukin 1 receptor type 1 [Source:HGNC Symbol;Acc:HGNC:5993] | 15970 | 0.000 | 0.4266 | No |
| 59 | IL1R2 | interleukin 1 receptor type 2 [Source:HGNC Symbol;Acc:HGNC:5994] | 15971 | 0.000 | 0.4266 | No |
| 60 | IL3RA | interleukin 3 receptor subunit alpha [Source:HGNC Symbol;Acc:HGNC:6012] | 16582 | 0.000 | 0.4102 | No |
| 61 | IFNAR1 | interferon alpha and beta receptor subunit 1 [Source:HGNC Symbol;Acc:HGNC:5432] | 18505 | 0.000 | 0.3582 | No |
| 62 | CXCL13 | C-X-C motif chemokine ligand 13 [Source:HGNC Symbol;Acc:HGNC:10639] | 18908 | 0.000 | 0.3474 | No |
| 63 | CXCL11 | C-X-C motif chemokine ligand 11 [Source:HGNC Symbol;Acc:HGNC:10638] | 18946 | 0.000 | 0.3464 | No |
| 64 | OSMR | oncostatin M receptor [Source:HGNC Symbol;Acc:HGNC:8507] | 19026 | 0.000 | 0.3442 | No |
| 65 | CXCL9 | C-X-C motif chemokine ligand 9 [Source:HGNC Symbol;Acc:HGNC:7098] | 19468 | 0.000 | 0.3323 | No |
| 66 | CXCL1 | C-X-C motif chemokine ligand 1 [Source:HGNC Symbol;Acc:HGNC:4602] | 19480 | 0.000 | 0.3320 | No |
| 67 | IL12RB1 | interleukin 12 receptor subunit beta 1 [Source:HGNC Symbol;Acc:HGNC:5971] | 19643 | 0.000 | 0.3276 | No |
| 68 | PF4 | platelet factor 4 [Source:HGNC Symbol;Acc:HGNC:8861] | 20014 | 0.000 | 0.3176 | No |
| 69 | IFNGR1 | interferon gamma receptor 1 [Source:HGNC Symbol;Acc:HGNC:5439] | 20532 | 0.000 | 0.3037 | No |
| 70 | IFNGR2 | interferon gamma receptor 2 [Source:HGNC Symbol;Acc:HGNC:5440] | 20534 | 0.000 | 0.3036 | No |
| 71 | CCL7 | C-C motif chemokine ligand 7 [Source:HGNC Symbol;Acc:HGNC:10634] | 23064 | 0.000 | 0.2353 | No |
| 72 | CD38 | CD38 molecule [Source:HGNC Symbol;Acc:HGNC:1667] | 23160 | 0.000 | 0.2327 | No |
| 73 | CSF2 | colony stimulating factor 2 [Source:HGNC Symbol;Acc:HGNC:2434] | 24724 | 0.000 | 0.1905 | No |
| 74 | REG1A | regenerating family member 1 alpha [Source:HGNC Symbol;Acc:HGNC:9951] | 26659 | 0.000 | 0.1382 | No |
| 75 | A2M | alpha-2-macroglobulin [Source:HGNC Symbol;Acc:HGNC:7] | 27266 | 0.000 | 0.1218 | No |
| 76 | PTPN2 | protein tyrosine phosphatase non-receptor type 2 [Source:HGNC Symbol;Acc:HGNC:9650] | 27932 | -0.025 | 0.1042 | No |
| 77 | CSF1 | colony stimulating factor 1 [Source:HGNC Symbol;Acc:HGNC:2432] | 28392 | -0.088 | 0.0928 | No |
| 78 | ACVRL1 | activin A receptor like type 1 [Source:HGNC Symbol;Acc:HGNC:175] | 28745 | -0.137 | 0.0849 | No |
| 79 | DNTT | DNA nucleotidylexotransferase [Source:HGNC Symbol;Acc:HGNC:2983] | 29469 | -0.240 | 0.0683 | No |
| 80 | IRF1 | interferon regulatory factor 1 [Source:HGNC Symbol;Acc:HGNC:6116] | 29766 | -0.285 | 0.0636 | No |
| 81 | IL10RB | interleukin 10 receptor subunit beta [Source:HGNC Symbol;Acc:HGNC:5965] | 32260 | -0.695 | 0.0046 | No |
| 82 | TYK2 | tyrosine kinase 2 [Source:HGNC Symbol;Acc:HGNC:12440] | 32274 | -0.698 | 0.0125 | No |
| 83 | INHBE | inhibin subunit beta E [Source:HGNC Symbol;Acc:HGNC:24029] | 32435 | -0.728 | 0.0169 | No |
| 84 | CSF2RB | colony stimulating factor 2 receptor subunit beta [Source:HGNC Symbol;Acc:HGNC:2436] | 32767 | -0.816 | 0.0176 | No |
| 85 | CSF3R | colony stimulating factor 3 receptor [Source:HGNC Symbol;Acc:HGNC:2439] | 35573 | -1.883 | -0.0357 | No |
| 86 | IL6ST | interleukin 6 signal transducer [Source:HGNC Symbol;Acc:HGNC:6021] | 36212 | -2.376 | -0.0247 | No |
| 87 | ITGA4 | integrin subunit alpha 4 [Source:HGNC Symbol;Acc:HGNC:6140] | 37018 | -4.063 | 0.0019 | No |
