Datasetgreenberg_collapsed_to_symbols.Nof1.cls
#KO_GAQ_versus_KO_NA.Nof1.cls
#KO_GAQ_versus_KO_NA_repos
PhenotypeNof1.cls#KO_GAQ_versus_KO_NA_repos
Upregulated in classKO_GAQ
GeneSetHALLMARK_PI3K_AKT_MTOR_SIGNALING
Enrichment Score (ES)0.36647642
Normalized Enrichment Score (NES)0.9360809
Nominal p-value0.672
FDR q-value0.68199635
FWER p-Value0.98
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_PI3K_AKT_MTOR_SIGNALING   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

SYMBOLTITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1MAP2K3mitogen-activated protein kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6843]2562.7070.0258Yes
2STAT2signal transducer and activator of transcription 2 [Source:HGNC Symbol;Acc:HGNC:11363]4062.2520.0490Yes
3MYD88MYD88 innate immune signal transduction adaptor [Source:HGNC Symbol;Acc:HGNC:7562]5132.0580.0710Yes
4NFKBIBNFKB inhibitor beta [Source:HGNC Symbol;Acc:HGNC:7798]5841.9420.0925Yes
5SQSTM1sequestosome 1 [Source:HGNC Symbol;Acc:HGNC:11280]6391.8590.1135Yes
6PFN1profilin 1 [Source:HGNC Symbol;Acc:HGNC:8881]7811.6860.1301Yes
7CFL1cofilin 1 [Source:HGNC Symbol;Acc:HGNC:1874]8911.5640.1460Yes
8ADCY2adenylate cyclase 2 [Source:HGNC Symbol;Acc:HGNC:233]9571.5100.1625Yes
9PTPN11protein tyrosine phosphatase non-receptor type 11 [Source:HGNC Symbol;Acc:HGNC:9644]9621.5060.1806Yes
10PIN1peptidylprolyl cis/trans isomerase, NIMA-interacting 1 [Source:HGNC Symbol;Acc:HGNC:8988]9671.5030.1987Yes
11ACTR3actin related protein 3 [Source:HGNC Symbol;Acc:HGNC:170]9781.4900.2164Yes
12TNFRSF1ATNF receptor superfamily member 1A [Source:HGNC Symbol;Acc:HGNC:11916]10121.4640.2332Yes
13ACTR2actin related protein 2 [Source:HGNC Symbol;Acc:HGNC:169]11751.3430.2450Yes
14TRAF2TNF receptor associated factor 2 [Source:HGNC Symbol;Acc:HGNC:12032]12831.2830.2576Yes
15UBE2D3ubiquitin conjugating enzyme E2 D3 [Source:HGNC Symbol;Acc:HGNC:12476]12921.2780.2729Yes
16IL2RGinterleukin 2 receptor subunit gamma [Source:HGNC Symbol;Acc:HGNC:6010]13101.2670.2877Yes
17LCKLCK proto-oncogene, Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:6524]14931.1580.2968Yes
18SLC2A1solute carrier family 2 member 1 [Source:HGNC Symbol;Acc:HGNC:11005]15101.1510.3103Yes
19UBE2Nubiquitin conjugating enzyme E2 N [Source:HGNC Symbol;Acc:HGNC:12492]16831.0730.3186Yes
20PPP2R1Bprotein phosphatase 2 scaffold subunit Abeta [Source:HGNC Symbol;Acc:HGNC:9303]22070.8610.3148Yes
21CALRcalreticulin [Source:HGNC Symbol;Acc:HGNC:1455]22500.8440.3239Yes
22AP2M1adaptor related protein complex 2 subunit mu 1 [Source:HGNC Symbol;Acc:HGNC:564]25620.7440.3245Yes
23GRB2growth factor receptor bound protein 2 [Source:HGNC Symbol;Acc:HGNC:4566]26740.7090.3300Yes
24ARF1ADP ribosylation factor 1 [Source:HGNC Symbol;Acc:HGNC:652]27150.7020.3374Yes
25AKT1S1AKT1 substrate 1 [Source:HGNC Symbol;Acc:HGNC:28426]32660.5680.3294Yes
26CAB39calcium binding protein 39 [Source:HGNC Symbol;Acc:HGNC:20292]32940.5620.3355Yes
27NCK1NCK adaptor protein 1 [Source:HGNC Symbol;Acc:HGNC:7664]34180.5320.3386Yes
28YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta [Source:HGNC Symbol;Acc:HGNC:12849]36070.4920.3395Yes
29EIF4Eeukaryotic translation initiation factor 4E [Source:HGNC Symbol;Acc:HGNC:3287]36370.4860.3445Yes
30CDKN1Acyclin dependent kinase inhibitor 1A [Source:HGNC Symbol;Acc:HGNC:1784]37220.4670.3479Yes
31RIT1Ras like without CAAX 1 [Source:HGNC Symbol;Acc:HGNC:10023]41240.3950.3418Yes
32RPTORregulatory associated protein of MTOR complex 1 [Source:HGNC Symbol;Acc:HGNC:30287]41850.3830.3448Yes
33ARPC3actin related protein 2/3 complex subunit 3 [Source:HGNC Symbol;Acc:HGNC:706]41910.3820.3493Yes
34PPP1CAprotein phosphatase 1 catalytic subunit alpha [Source:HGNC Symbol;Acc:HGNC:9281]43220.3570.3501Yes
35ATF1activating transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:783]43290.3560.3543Yes
36CAB39Lcalcium binding protein 39 like [Source:HGNC Symbol;Acc:HGNC:20290]43880.3460.3569Yes
37MAPK10mitogen-activated protein kinase 10 [Source:HGNC Symbol;Acc:HGNC:6872]43950.3450.3609Yes
38SMAD2SMAD family member 2 [Source:HGNC Symbol;Acc:HGNC:6768]44320.3390.3640Yes
39ARHGDIARho GDP dissociation inhibitor alpha [Source:HGNC Symbol;Acc:HGNC:678]45460.3190.3648Yes
40HRASHRas proto-oncogene, GTPase [Source:HGNC Symbol;Acc:HGNC:5173]46230.3090.3665Yes
41PAK4p21 (RAC1) activated kinase 4 [Source:HGNC Symbol;Acc:HGNC:16059]48300.2720.3642No
42CSNK2Bcasein kinase 2 beta [Source:HGNC Symbol;Acc:HGNC:2460]49790.2480.3632No
43TBK1TANK binding kinase 1 [Source:HGNC Symbol;Acc:HGNC:11584]51320.2170.3617No
44AKT1AKT serine/threonine kinase 1 [Source:HGNC Symbol;Acc:HGNC:391]53790.1790.3572No
45PIKFYVEphosphoinositide kinase, FYVE-type zinc finger containing [Source:HGNC Symbol;Acc:HGNC:23785]54970.1620.3560No
46CLTCclathrin heavy chain [Source:HGNC Symbol;Acc:HGNC:2092]58720.1110.3472No
47SLASrc like adaptor [Source:HGNC Symbol;Acc:HGNC:10902]65350.0050.3294No
48FGF22fibroblast growth factor 22 [Source:HGNC Symbol;Acc:HGNC:3679]71200.0000.3136No
49FGF17fibroblast growth factor 17 [Source:HGNC Symbol;Acc:HGNC:3673]71230.0000.3136No
50PITX2paired like homeodomain 2 [Source:HGNC Symbol;Acc:HGNC:9005]75650.0000.3016No
51CAMK4calcium/calmodulin dependent protein kinase IV [Source:HGNC Symbol;Acc:HGNC:1464]92700.0000.2556No
52GNGT1G protein subunit gamma transducin 1 [Source:HGNC Symbol;Acc:HGNC:4411]163360.0000.0645No
53IL4interleukin 4 [Source:HGNC Symbol;Acc:HGNC:6014]177690.0000.0258No
54NGFnerve growth factor [Source:HGNC Symbol;Acc:HGNC:7808]193030.000-0.0156No
55FASLGFas ligand [Source:HGNC Symbol;Acc:HGNC:11936]202910.000-0.0423No
56EGFRepidermal growth factor receptor [Source:HGNC Symbol;Acc:HGNC:3236]222800.000-0.0961No
57THEM4thioesterase superfamily member 4 [Source:HGNC Symbol;Acc:HGNC:17947]230040.000-0.1156No
58FGF6fibroblast growth factor 6 [Source:HGNC Symbol;Acc:HGNC:3684]256690.000-0.1876No
59GNA14G protein subunit alpha 14 [Source:HGNC Symbol;Acc:HGNC:4382]270710.000-0.2255No
60PRKAG1protein kinase AMP-activated non-catalytic subunit gamma 1 [Source:HGNC Symbol;Acc:HGNC:9385]27857-0.010-0.2466No
61CDK1cyclin dependent kinase 1 [Source:HGNC Symbol;Acc:HGNC:1722]27912-0.021-0.2478No
62PRKAA2protein kinase AMP-activated catalytic subunit alpha 2 [Source:HGNC Symbol;Acc:HGNC:9377]28045-0.038-0.2509No
63RALBRAS like proto-oncogene B [Source:HGNC Symbol;Acc:HGNC:9840]28081-0.044-0.2513No
64PLCB1phospholipase C beta 1 [Source:HGNC Symbol;Acc:HGNC:15917]28481-0.102-0.2609No
65GSK3Bglycogen synthase kinase 3 beta [Source:HGNC Symbol;Acc:HGNC:4617]28536-0.107-0.2611No
66RPS6KA1ribosomal protein S6 kinase A1 [Source:HGNC Symbol;Acc:HGNC:10430]28657-0.125-0.2628No
67TRIB3tribbles pseudokinase 3 [Source:HGNC Symbol;Acc:HGNC:16228]28809-0.145-0.2651No
68NOD1nucleotide binding oligomerization domain containing 1 [Source:HGNC Symbol;Acc:HGNC:16390]28898-0.155-0.2656No
69PLA2G12Aphospholipase A2 group XIIA [Source:HGNC Symbol;Acc:HGNC:18554]28924-0.161-0.2644No
70DDIT3DNA damage inducible transcript 3 [Source:HGNC Symbol;Acc:HGNC:2726]28969-0.166-0.2635No
71MAP3K7mitogen-activated protein kinase kinase kinase 7 [Source:HGNC Symbol;Acc:HGNC:6859]29055-0.180-0.2637No
72HSP90B1heat shock protein 90 beta family member 1 [Source:HGNC Symbol;Acc:HGNC:12028]29143-0.190-0.2637No
73MKNK1MAPK interacting serine/threonine kinase 1 [Source:HGNC Symbol;Acc:HGNC:7110]29224-0.203-0.2634No
74TSC2TSC complex subunit 2 [Source:HGNC Symbol;Acc:HGNC:12363]29255-0.211-0.2617No
75RPS6KA3ribosomal protein S6 kinase A3 [Source:HGNC Symbol;Acc:HGNC:10432]29613-0.260-0.2682No
76MAPK1mitogen-activated protein kinase 1 [Source:HGNC Symbol;Acc:HGNC:6871]30062-0.325-0.2764No
77RIPK1receptor interacting serine/threonine kinase 1 [Source:HGNC Symbol;Acc:HGNC:10019]30064-0.325-0.2725No
78TIAM1TIAM Rac1 associated GEF 1 [Source:HGNC Symbol;Acc:HGNC:11805]30076-0.327-0.2688No
79RAC1Rac family small GTPase 1 [Source:HGNC Symbol;Acc:HGNC:9801]30128-0.333-0.2662No
80RAF1Raf-1 proto-oncogene, serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:9829]30739-0.423-0.2776No
81MAPK9mitogen-activated protein kinase 9 [Source:HGNC Symbol;Acc:HGNC:6886]30999-0.462-0.2790No
82MAPK8mitogen-activated protein kinase 8 [Source:HGNC Symbol;Acc:HGNC:6881]31043-0.468-0.2745No
83PIK3R3phosphoinositide-3-kinase regulatory subunit 3 [Source:HGNC Symbol;Acc:HGNC:8981]31617-0.564-0.2832No
84PRKAR2Aprotein kinase cAMP-dependent type II regulatory subunit alpha [Source:HGNC Symbol;Acc:HGNC:9391]31685-0.575-0.2781No
85MAPKAP1MAPK associated protein 1 [Source:HGNC Symbol;Acc:HGNC:18752]31791-0.596-0.2737No
86GRK2G protein-coupled receptor kinase 2 [Source:HGNC Symbol;Acc:HGNC:289]32597-0.774-0.2861No
87PTENphosphatase and tensin homolog [Source:HGNC Symbol;Acc:HGNC:9588]33000-0.873-0.2864No
88ACACAacetyl-CoA carboxylase alpha [Source:HGNC Symbol;Acc:HGNC:84]33045-0.884-0.2770No
89MAP2K6mitogen-activated protein kinase kinase 6 [Source:HGNC Symbol;Acc:HGNC:6846]33235-0.943-0.2707No
90IRAK4interleukin 1 receptor associated kinase 4 [Source:HGNC Symbol;Acc:HGNC:17967]33525-1.027-0.2661No
91ITPR2inositol 1,4,5-trisphosphate receptor type 2 [Source:HGNC Symbol;Acc:HGNC:6181]33780-1.105-0.2596No
92CXCR4C-X-C motif chemokine receptor 4 [Source:HGNC Symbol;Acc:HGNC:2561]33862-1.133-0.2481No
93DUSP3dual specificity phosphatase 3 [Source:HGNC Symbol;Acc:HGNC:3069]34098-1.209-0.2398No
94CDK4cyclin dependent kinase 4 [Source:HGNC Symbol;Acc:HGNC:1773]34451-1.336-0.2332No
95SFNstratifin [Source:HGNC Symbol;Acc:HGNC:10773]34597-1.390-0.2203No
96DAPP1dual adaptor of phosphotyrosine and 3-phosphoinositides 1 [Source:HGNC Symbol;Acc:HGNC:16500]34980-1.556-0.2119No
97MKNK2MAPK interacting serine/threonine kinase 2 [Source:HGNC Symbol;Acc:HGNC:7111]35109-1.631-0.1956No
98CDK2cyclin dependent kinase 2 [Source:HGNC Symbol;Acc:HGNC:1771]35270-1.715-0.1792No
99VAV3vav guanine nucleotide exchange factor 3 [Source:HGNC Symbol;Acc:HGNC:12659]35379-1.764-0.1608No
100CDKN1Bcyclin dependent kinase inhibitor 1B [Source:HGNC Symbol;Acc:HGNC:1785]35764-2.028-0.1467No
101PLCG1phospholipase C gamma 1 [Source:HGNC Symbol;Acc:HGNC:9065]35960-2.181-0.1256No
102ECSITECSIT signaling integrator [Source:HGNC Symbol;Acc:HGNC:29548]36365-2.547-0.1058No
103E2F1E2F transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:3113]36787-3.234-0.0781No
104PRKCBprotein kinase C beta [Source:HGNC Symbol;Acc:HGNC:9395]36797-3.265-0.0389No
105PDK1pyruvate dehydrogenase kinase 1 [Source:HGNC Symbol;Acc:HGNC:8809]36981-3.8700.0029No
Table: GSEA details [plain text format]



Fig 2: HALLMARK_PI3K_AKT_MTOR_SIGNALING   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_PI3K_AKT_MTOR_SIGNALING: Random ES distribution   
Gene set null distribution of ES for HALLMARK_PI3K_AKT_MTOR_SIGNALING