Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #KO_GAQ_versus_KO_NA.Nof1.cls #KO_GAQ_versus_KO_NA_repos |
| Phenotype | Nof1.cls#KO_GAQ_versus_KO_NA_repos |
| Upregulated in class | KO_GAQ |
| GeneSet | HALLMARK_UNFOLDED_PROTEIN_RESPONSE |
| Enrichment Score (ES) | 0.48260027 |
| Normalized Enrichment Score (NES) | 1.2366601 |
| Nominal p-value | 0.06716418 |
| FDR q-value | 0.10531451 |
| FWER p-Value | 0.286 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | DNAJB9 | DnaJ heat shock protein family (Hsp40) member B9 [Source:HGNC Symbol;Acc:HGNC:6968] | 390 | 2.269 | 0.0147 | Yes |
| 2 | RRP9 | ribosomal RNA processing 9, U3 small nucleolar RNA binding protein [Source:HGNC Symbol;Acc:HGNC:16829] | 418 | 2.231 | 0.0388 | Yes |
| 3 | SDAD1 | SDA1 domain containing 1 [Source:HGNC Symbol;Acc:HGNC:25537] | 430 | 2.204 | 0.0630 | Yes |
| 4 | HERPUD1 | homocysteine inducible ER protein with ubiquitin like domain 1 [Source:HGNC Symbol;Acc:HGNC:13744] | 528 | 2.037 | 0.0831 | Yes |
| 5 | HSPA5 | heat shock protein family A (Hsp70) member 5 [Source:HGNC Symbol;Acc:HGNC:5238] | 551 | 1.990 | 0.1046 | Yes |
| 6 | SRPRA | SRP receptor subunit alpha [Source:HGNC Symbol;Acc:HGNC:11307] | 687 | 1.815 | 0.1211 | Yes |
| 7 | ATF3 | activating transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:785] | 764 | 1.712 | 0.1381 | Yes |
| 8 | FUS | FUS RNA binding protein [Source:HGNC Symbol;Acc:HGNC:4010] | 776 | 1.697 | 0.1567 | Yes |
| 9 | ASNS | asparagine synthetase (glutamine-hydrolyzing) [Source:HGNC Symbol;Acc:HGNC:753] | 925 | 1.537 | 0.1698 | Yes |
| 10 | CHAC1 | ChaC glutathione specific gamma-glutamylcyclotransferase 1 [Source:HGNC Symbol;Acc:HGNC:28680] | 992 | 1.477 | 0.1845 | Yes |
| 11 | DKC1 | dyskerin pseudouridine synthase 1 [Source:HGNC Symbol;Acc:HGNC:2890] | 1131 | 1.374 | 0.1960 | Yes |
| 12 | TATDN2 | TatD DNase domain containing 2 [Source:HGNC Symbol;Acc:HGNC:28988] | 1153 | 1.361 | 0.2106 | Yes |
| 13 | LSM1 | LSM1 homolog, mRNA degradation associated [Source:HGNC Symbol;Acc:HGNC:20472] | 1219 | 1.318 | 0.2235 | Yes |
| 14 | NABP1 | nucleic acid binding protein 1 [Source:HGNC Symbol;Acc:HGNC:26232] | 1275 | 1.286 | 0.2363 | Yes |
| 15 | YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta [Source:HGNC Symbol;Acc:HGNC:12855] | 1326 | 1.258 | 0.2490 | Yes |
| 16 | ATF4 | activating transcription factor 4 [Source:HGNC Symbol;Acc:HGNC:786] | 1367 | 1.229 | 0.2615 | Yes |
| 17 | IFIT1 | interferon induced protein with tetratricopeptide repeats 1 [Source:HGNC Symbol;Acc:HGNC:5407] | 1396 | 1.208 | 0.2742 | Yes |
| 18 | EIF2S1 | eukaryotic translation initiation factor 2 subunit alpha [Source:HGNC Symbol;Acc:HGNC:3265] | 1473 | 1.164 | 0.2851 | Yes |
| 19 | NOP14 | NOP14 nucleolar protein [Source:HGNC Symbol;Acc:HGNC:16821] | 1566 | 1.130 | 0.2952 | Yes |
| 20 | CEBPB | CCAAT enhancer binding protein beta [Source:HGNC Symbol;Acc:HGNC:1834] | 1575 | 1.130 | 0.3076 | Yes |
| 21 | EXOSC1 | exosome component 1 [Source:HGNC Symbol;Acc:HGNC:17286] | 1803 | 1.014 | 0.3127 | Yes |
| 22 | NOP56 | NOP56 ribonucleoprotein [Source:HGNC Symbol;Acc:HGNC:15911] | 1806 | 1.013 | 0.3239 | Yes |
| 23 | BAG3 | BAG cochaperone 3 [Source:HGNC Symbol;Acc:HGNC:939] | 1852 | 0.997 | 0.3338 | Yes |
| 24 | DCP1A | decapping mRNA 1A [Source:HGNC Symbol;Acc:HGNC:18714] | 1878 | 0.988 | 0.3441 | Yes |
| 25 | SLC7A5 | solute carrier family 7 member 5 [Source:HGNC Symbol;Acc:HGNC:11063] | 1914 | 0.970 | 0.3540 | Yes |
| 26 | DCP2 | decapping mRNA 2 [Source:HGNC Symbol;Acc:HGNC:24452] | 1915 | 0.970 | 0.3648 | Yes |
| 27 | TSPYL2 | TSPY like 2 [Source:HGNC Symbol;Acc:HGNC:24358] | 1978 | 0.948 | 0.3736 | Yes |
| 28 | CNOT4 | CCR4-NOT transcription complex subunit 4 [Source:HGNC Symbol;Acc:HGNC:7880] | 2001 | 0.935 | 0.3834 | Yes |
| 29 | HYOU1 | hypoxia up-regulated 1 [Source:HGNC Symbol;Acc:HGNC:16931] | 2142 | 0.882 | 0.3895 | Yes |
| 30 | SERP1 | stress associated endoplasmic reticulum protein 1 [Source:HGNC Symbol;Acc:HGNC:10759] | 2151 | 0.880 | 0.3990 | Yes |
| 31 | CALR | calreticulin [Source:HGNC Symbol;Acc:HGNC:1455] | 2250 | 0.844 | 0.4058 | Yes |
| 32 | NOLC1 | nucleolar and coiled-body phosphoprotein 1 [Source:HGNC Symbol;Acc:HGNC:15608] | 2285 | 0.832 | 0.4141 | Yes |
| 33 | SRPRB | SRP receptor subunit beta [Source:HGNC Symbol;Acc:HGNC:24085] | 2291 | 0.829 | 0.4232 | Yes |
| 34 | KIF5B | kinesin family member 5B [Source:HGNC Symbol;Acc:HGNC:6324] | 2298 | 0.828 | 0.4323 | Yes |
| 35 | EXOSC4 | exosome component 4 [Source:HGNC Symbol;Acc:HGNC:18189] | 2493 | 0.767 | 0.4355 | Yes |
| 36 | TARS1 | threonyl-tRNA synthetase 1 [Source:HGNC Symbol;Acc:HGNC:11572] | 2526 | 0.754 | 0.4431 | Yes |
| 37 | SLC1A4 | solute carrier family 1 member 4 [Source:HGNC Symbol;Acc:HGNC:10942] | 2585 | 0.737 | 0.4497 | Yes |
| 38 | TTC37 | tetratricopeptide repeat domain 37 [Source:HGNC Symbol;Acc:HGNC:23639] | 2782 | 0.686 | 0.4520 | Yes |
| 39 | LSM4 | LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated [Source:HGNC Symbol;Acc:HGNC:17259] | 2952 | 0.642 | 0.4546 | Yes |
| 40 | SEC11A | SEC11 homolog A, signal peptidase complex subunit [Source:HGNC Symbol;Acc:HGNC:17718] | 3200 | 0.584 | 0.4544 | Yes |
| 41 | ARFGAP1 | ADP ribosylation factor GTPase activating protein 1 [Source:HGNC Symbol;Acc:HGNC:15852] | 3254 | 0.569 | 0.4593 | Yes |
| 42 | BANF1 | BAF nuclear assembly factor 1 [Source:HGNC Symbol;Acc:HGNC:17397] | 3452 | 0.524 | 0.4598 | Yes |
| 43 | EIF4E | eukaryotic translation initiation factor 4E [Source:HGNC Symbol;Acc:HGNC:3287] | 3637 | 0.486 | 0.4603 | Yes |
| 44 | EIF4G1 | eukaryotic translation initiation factor 4 gamma 1 [Source:HGNC Symbol;Acc:HGNC:3296] | 3748 | 0.462 | 0.4624 | Yes |
| 45 | IARS1 | isoleucyl-tRNA synthetase 1 [Source:HGNC Symbol;Acc:HGNC:5330] | 3783 | 0.456 | 0.4666 | Yes |
| 46 | EIF4A1 | eukaryotic translation initiation factor 4A1 [Source:HGNC Symbol;Acc:HGNC:3282] | 3932 | 0.429 | 0.4673 | Yes |
| 47 | CCL2 | C-C motif chemokine ligand 2 [Source:HGNC Symbol;Acc:HGNC:10618] | 4122 | 0.395 | 0.4666 | Yes |
| 48 | SPCS1 | signal peptidase complex subunit 1 [Source:HGNC Symbol;Acc:HGNC:23401] | 4278 | 0.366 | 0.4665 | Yes |
| 49 | YIF1A | Yip1 interacting factor homolog A, membrane trafficking protein [Source:HGNC Symbol;Acc:HGNC:16688] | 4369 | 0.349 | 0.4680 | Yes |
| 50 | MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase [Source:HGNC Symbol;Acc:HGNC:7434] | 4439 | 0.337 | 0.4698 | Yes |
| 51 | EIF4EBP1 | eukaryotic translation initiation factor 4E binding protein 1 [Source:HGNC Symbol;Acc:HGNC:3288] | 4511 | 0.325 | 0.4715 | Yes |
| 52 | GEMIN4 | gem nuclear organelle associated protein 4 [Source:HGNC Symbol;Acc:HGNC:15717] | 4653 | 0.304 | 0.4711 | Yes |
| 53 | DNAJA4 | DnaJ heat shock protein family (Hsp40) member A4 [Source:HGNC Symbol;Acc:HGNC:14885] | 4685 | 0.299 | 0.4736 | Yes |
| 54 | CXXC1 | CXXC finger protein 1 [Source:HGNC Symbol;Acc:HGNC:24343] | 4733 | 0.291 | 0.4756 | Yes |
| 55 | SSR1 | signal sequence receptor subunit 1 [Source:HGNC Symbol;Acc:HGNC:11323] | 4734 | 0.291 | 0.4788 | Yes |
| 56 | DNAJC3 | DnaJ heat shock protein family (Hsp40) member C3 [Source:HGNC Symbol;Acc:HGNC:9439] | 4814 | 0.275 | 0.4797 | Yes |
| 57 | PREB | prolactin regulatory element binding [Source:HGNC Symbol;Acc:HGNC:9356] | 4890 | 0.260 | 0.4806 | Yes |
| 58 | PAIP1 | poly(A) binding protein interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:16945] | 5006 | 0.242 | 0.4802 | Yes |
| 59 | EXOSC2 | exosome component 2 [Source:HGNC Symbol;Acc:HGNC:17097] | 5089 | 0.227 | 0.4805 | Yes |
| 60 | NPM1 | nucleophosmin 1 [Source:HGNC Symbol;Acc:HGNC:7910] | 5103 | 0.222 | 0.4826 | Yes |
| 61 | EXOSC10 | exosome component 10 [Source:HGNC Symbol;Acc:HGNC:9138] | 5247 | 0.201 | 0.4810 | No |
| 62 | CNOT6 | CCR4-NOT transcription complex subunit 6 [Source:HGNC Symbol;Acc:HGNC:14099] | 5483 | 0.165 | 0.4764 | No |
| 63 | SPCS3 | signal peptidase complex subunit 3 [Source:HGNC Symbol;Acc:HGNC:26212] | 5488 | 0.164 | 0.4782 | No |
| 64 | NFYA | nuclear transcription factor Y subunit alpha [Source:HGNC Symbol;Acc:HGNC:7804] | 5578 | 0.149 | 0.4774 | No |
| 65 | DDX10 | DEAD-box helicase 10 [Source:HGNC Symbol;Acc:HGNC:2735] | 5626 | 0.143 | 0.4777 | No |
| 66 | XPOT | exportin for tRNA [Source:HGNC Symbol;Acc:HGNC:12826] | 5692 | 0.138 | 0.4775 | No |
| 67 | EIF4A2 | eukaryotic translation initiation factor 4A2 [Source:HGNC Symbol;Acc:HGNC:3284] | 5822 | 0.120 | 0.4754 | No |
| 68 | HSPA9 | heat shock protein family A (Hsp70) member 9 [Source:HGNC Symbol;Acc:HGNC:5244] | 5841 | 0.116 | 0.4762 | No |
| 69 | CNOT2 | CCR4-NOT transcription complex subunit 2 [Source:HGNC Symbol;Acc:HGNC:7878] | 5865 | 0.111 | 0.4768 | No |
| 70 | EDC4 | enhancer of mRNA decapping 4 [Source:HGNC Symbol;Acc:HGNC:17157] | 5914 | 0.105 | 0.4766 | No |
| 71 | EIF4A3 | eukaryotic translation initiation factor 4A3 [Source:HGNC Symbol;Acc:HGNC:18683] | 5944 | 0.099 | 0.4770 | No |
| 72 | POP4 | POP4 homolog, ribonuclease P/MRP subunit [Source:HGNC Symbol;Acc:HGNC:30081] | 6175 | 0.066 | 0.4715 | No |
| 73 | XBP1 | X-box binding protein 1 [Source:HGNC Symbol;Acc:HGNC:12801] | 6338 | 0.034 | 0.4675 | No |
| 74 | DDIT4 | DNA damage inducible transcript 4 [Source:HGNC Symbol;Acc:HGNC:24944] | 6446 | 0.023 | 0.4648 | No |
| 75 | MTREX | Mtr4 exosome RNA helicase [Source:HGNC Symbol;Acc:HGNC:18734] | 6499 | 0.011 | 0.4635 | No |
| 76 | IGFBP1 | insulin like growth factor binding protein 1 [Source:HGNC Symbol;Acc:HGNC:5469] | 11921 | 0.000 | 0.3169 | No |
| 77 | WFS1 | wolframin ER transmembrane glycoprotein [Source:HGNC Symbol;Acc:HGNC:12762] | 28064 | -0.041 | -0.1191 | No |
| 78 | ZBTB17 | zinc finger and BTB domain containing 17 [Source:HGNC Symbol;Acc:HGNC:12936] | 28073 | -0.043 | -0.1189 | No |
| 79 | GOSR2 | golgi SNAP receptor complex member 2 [Source:HGNC Symbol;Acc:HGNC:4431] | 28282 | -0.075 | -0.1237 | No |
| 80 | SEC31A | SEC31 homolog A, COPII coat complex component [Source:HGNC Symbol;Acc:HGNC:17052] | 28550 | -0.110 | -0.1297 | No |
| 81 | PDIA5 | protein disulfide isomerase family A member 5 [Source:HGNC Symbol;Acc:HGNC:24811] | 28660 | -0.126 | -0.1312 | No |
| 82 | PDIA6 | protein disulfide isomerase family A member 6 [Source:HGNC Symbol;Acc:HGNC:30168] | 28803 | -0.144 | -0.1334 | No |
| 83 | SHC1 | SHC adaptor protein 1 [Source:HGNC Symbol;Acc:HGNC:10840] | 28843 | -0.148 | -0.1328 | No |
| 84 | NHP2 | NHP2 ribonucleoprotein [Source:HGNC Symbol;Acc:HGNC:14377] | 28864 | -0.152 | -0.1317 | No |
| 85 | EXOC2 | exocyst complex component 2 [Source:HGNC Symbol;Acc:HGNC:24968] | 29032 | -0.177 | -0.1342 | No |
| 86 | HSP90B1 | heat shock protein 90 beta family member 1 [Source:HGNC Symbol;Acc:HGNC:12028] | 29143 | -0.190 | -0.1351 | No |
| 87 | RPS14 | ribosomal protein S14 [Source:HGNC Symbol;Acc:HGNC:10387] | 30400 | -0.369 | -0.1650 | No |
| 88 | VEGFA | vascular endothelial growth factor A [Source:HGNC Symbol;Acc:HGNC:12680] | 30658 | -0.411 | -0.1673 | No |
| 89 | ATF6 | activating transcription factor 6 [Source:HGNC Symbol;Acc:HGNC:791] | 30854 | -0.441 | -0.1677 | No |
| 90 | NFYB | nuclear transcription factor Y subunit beta [Source:HGNC Symbol;Acc:HGNC:7805] | 30915 | -0.451 | -0.1643 | No |
| 91 | STC2 | stanniocalcin 2 [Source:HGNC Symbol;Acc:HGNC:11374] | 31438 | -0.533 | -0.1725 | No |
| 92 | CEBPG | CCAAT enhancer binding protein gamma [Source:HGNC Symbol;Acc:HGNC:1837] | 31632 | -0.566 | -0.1714 | No |
| 93 | DCTN1 | dynactin subunit 1 [Source:HGNC Symbol;Acc:HGNC:2711] | 31724 | -0.583 | -0.1674 | No |
| 94 | EXOSC9 | exosome component 9 [Source:HGNC Symbol;Acc:HGNC:9137] | 31747 | -0.587 | -0.1615 | No |
| 95 | PSAT1 | phosphoserine aminotransferase 1 [Source:HGNC Symbol;Acc:HGNC:19129] | 32025 | -0.646 | -0.1618 | No |
| 96 | EEF2 | eukaryotic translation elongation factor 2 [Source:HGNC Symbol;Acc:HGNC:3214] | 32066 | -0.655 | -0.1556 | No |
| 97 | ALDH18A1 | aldehyde dehydrogenase 18 family member A1 [Source:HGNC Symbol;Acc:HGNC:9722] | 32069 | -0.655 | -0.1483 | No |
| 98 | ATP6V0D1 | ATPase H+ transporting V0 subunit d1 [Source:HGNC Symbol;Acc:HGNC:13724] | 32288 | -0.702 | -0.1464 | No |
| 99 | IMP3 | IMP U3 small nucleolar ribonucleoprotein 3 [Source:HGNC Symbol;Acc:HGNC:14497] | 32645 | -0.783 | -0.1473 | No |
| 100 | KDELR3 | KDEL endoplasmic reticulum protein retention receptor 3 [Source:HGNC Symbol;Acc:HGNC:6306] | 32679 | -0.790 | -0.1394 | No |
| 101 | SLC30A5 | solute carrier family 30 member 5 [Source:HGNC Symbol;Acc:HGNC:19089] | 32694 | -0.794 | -0.1310 | No |
| 102 | CKS1B | CDC28 protein kinase regulatory subunit 1B [Source:HGNC Symbol;Acc:HGNC:19083] | 32783 | -0.819 | -0.1242 | No |
| 103 | TUBB2A | tubulin beta 2A class IIa [Source:HGNC Symbol;Acc:HGNC:12412] | 32801 | -0.823 | -0.1155 | No |
| 104 | KHSRP | KH-type splicing regulatory protein [Source:HGNC Symbol;Acc:HGNC:6316] | 33348 | -0.971 | -0.1195 | No |
| 105 | PARN | poly(A)-specific ribonuclease [Source:HGNC Symbol;Acc:HGNC:8609] | 34173 | -1.235 | -0.1280 | No |
| 106 | EIF2AK3 | eukaryotic translation initiation factor 2 alpha kinase 3 [Source:HGNC Symbol;Acc:HGNC:3255] | 34887 | -1.505 | -0.1306 | No |
| 107 | ERN1 | endoplasmic reticulum to nucleus signaling 1 [Source:HGNC Symbol;Acc:HGNC:3449] | 35317 | -1.738 | -0.1228 | No |
| 108 | EXOSC5 | exosome component 5 [Source:HGNC Symbol;Acc:HGNC:24662] | 35582 | -1.889 | -0.1089 | No |
| 109 | EDEM1 | ER degradation enhancing alpha-mannosidase like protein 1 [Source:HGNC Symbol;Acc:HGNC:18967] | 35729 | -2.002 | -0.0906 | No |
| 110 | ERO1A | endoplasmic reticulum oxidoreductase 1 alpha [Source:HGNC Symbol;Acc:HGNC:13280] | 35737 | -2.007 | -0.0685 | No |
| 111 | FKBP14 | FKBP prolyl isomerase 14 [Source:HGNC Symbol;Acc:HGNC:18625] | 36414 | -2.600 | -0.0578 | No |
| 112 | H2AX | H2A.X variant histone [Source:HGNC Symbol;Acc:HGNC:4739] | 36470 | -2.674 | -0.0296 | No |
| 113 | WIPI1 | WD repeat domain, phosphoinositide interacting 1 [Source:HGNC Symbol;Acc:HGNC:25471] | 37031 | -4.162 | 0.0016 | No |
