Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #KO_LPS_versus_KO_NA.Nof1.cls #KO_LPS_versus_KO_NA_repos |
| Phenotype | Nof1.cls#KO_LPS_versus_KO_NA_repos |
| Upregulated in class | KO_NA |
| GeneSet | CROONQUIST_NRAS_SIGNALING_DN |
| Enrichment Score (ES) | -0.8539843 |
| Normalized Enrichment Score (NES) | -1.703177 |
| Nominal p-value | 0.0 |
| FDR q-value | 2.3931416E-4 |
| FWER p-Value | 0.003 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | GNAI1 | G protein subunit alpha i1 [Source:HGNC Symbol;Acc:HGNC:4384] | 1531 | 1.178 | -0.0337 | No |
| 2 | SBNO2 | strawberry notch homolog 2 [Source:HGNC Symbol;Acc:HGNC:29158] | 1675 | 1.104 | -0.0304 | No |
| 3 | HMGA1 | high mobility group AT-hook 1 [Source:HGNC Symbol;Acc:HGNC:5010] | 1779 | 1.048 | -0.0264 | No |
| 4 | EIF5 | eukaryotic translation initiation factor 5 [Source:HGNC Symbol;Acc:HGNC:3299] | 2460 | 0.759 | -0.0398 | No |
| 5 | SNRPA1 | small nuclear ribonucleoprotein polypeptide A' [Source:HGNC Symbol;Acc:HGNC:11152] | 5221 | 0.147 | -0.1134 | No |
| 6 | MYRF | myelin regulatory factor [Source:HGNC Symbol;Acc:HGNC:1181] | 5375 | 0.114 | -0.1168 | No |
| 7 | APOBEC3B | apolipoprotein B mRNA editing enzyme catalytic subunit 3B [Source:HGNC Symbol;Acc:HGNC:17352] | 12314 | 0.000 | -0.3042 | No |
| 8 | CENPA | centromere protein A [Source:HGNC Symbol;Acc:HGNC:1851] | 23956 | 0.000 | -0.6187 | No |
| 9 | ZWINT | ZW10 interacting kinetochore protein [Source:HGNC Symbol;Acc:HGNC:13195] | 26019 | 0.000 | -0.6744 | No |
| 10 | PTTG1 | PTTG1 regulator of sister chromatid separation, securin [Source:HGNC Symbol;Acc:HGNC:9690] | 30719 | -0.514 | -0.7980 | No |
| 11 | PLOD2 | procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 [Source:HGNC Symbol;Acc:HGNC:9082] | 30997 | -0.558 | -0.8018 | No |
| 12 | CSE1L | chromosome segregation 1 like [Source:HGNC Symbol;Acc:HGNC:2431] | 31993 | -0.752 | -0.8238 | No |
| 13 | CHEK1 | checkpoint kinase 1 [Source:HGNC Symbol;Acc:HGNC:1925] | 32734 | -0.955 | -0.8376 | No |
| 14 | PCNA | proliferating cell nuclear antigen [Source:HGNC Symbol;Acc:HGNC:8729] | 32753 | -0.958 | -0.8319 | No |
| 15 | CHAF1A | chromatin assembly factor 1 subunit A [Source:HGNC Symbol;Acc:HGNC:1910] | 33107 | -1.065 | -0.8345 | No |
| 16 | RFC3 | replication factor C subunit 3 [Source:HGNC Symbol;Acc:HGNC:9971] | 33208 | -1.098 | -0.8301 | No |
| 17 | DUT | deoxyuridine triphosphatase [Source:HGNC Symbol;Acc:HGNC:3078] | 34095 | -1.401 | -0.8449 | Yes |
| 18 | CDC25C | cell division cycle 25C [Source:HGNC Symbol;Acc:HGNC:1727] | 34146 | -1.427 | -0.8370 | Yes |
| 19 | HMGB2 | high mobility group box 2 [Source:HGNC Symbol;Acc:HGNC:5000] | 34312 | -1.491 | -0.8318 | Yes |
| 20 | CDK1 | cyclin dependent kinase 1 [Source:HGNC Symbol;Acc:HGNC:1722] | 34381 | -1.518 | -0.8237 | Yes |
| 21 | BRD8 | bromodomain containing 8 [Source:HGNC Symbol;Acc:HGNC:19874] | 34385 | -1.519 | -0.8139 | Yes |
| 22 | POLD3 | DNA polymerase delta 3, accessory subunit [Source:HGNC Symbol;Acc:HGNC:20932] | 34420 | -1.534 | -0.8049 | Yes |
| 23 | MCM4 | minichromosome maintenance complex component 4 [Source:HGNC Symbol;Acc:HGNC:6947] | 34684 | -1.643 | -0.8013 | Yes |
| 24 | PCLAF | PCNA clamp associated factor [Source:HGNC Symbol;Acc:HGNC:28961] | 34837 | -1.712 | -0.7943 | Yes |
| 25 | MCM3 | minichromosome maintenance complex component 3 [Source:HGNC Symbol;Acc:HGNC:6945] | 35062 | -1.840 | -0.7884 | Yes |
| 26 | TRIP13 | thyroid hormone receptor interactor 13 [Source:HGNC Symbol;Acc:HGNC:12307] | 35064 | -1.841 | -0.7765 | Yes |
| 27 | PLK4 | polo like kinase 4 [Source:HGNC Symbol;Acc:HGNC:11397] | 35101 | -1.865 | -0.7654 | Yes |
| 28 | CDC6 | cell division cycle 6 [Source:HGNC Symbol;Acc:HGNC:1744] | 35199 | -1.931 | -0.7555 | Yes |
| 29 | OIP5 | Opa interacting protein 5 [Source:HGNC Symbol;Acc:HGNC:20300] | 35217 | -1.946 | -0.7433 | Yes |
| 30 | NASP | nuclear autoantigenic sperm protein [Source:HGNC Symbol;Acc:HGNC:7644] | 35290 | -1.989 | -0.7323 | Yes |
| 31 | AURKA | aurora kinase A [Source:HGNC Symbol;Acc:HGNC:11393] | 35380 | -2.050 | -0.7214 | Yes |
| 32 | CKS1B | CDC28 protein kinase regulatory subunit 1B [Source:HGNC Symbol;Acc:HGNC:19083] | 35407 | -2.067 | -0.7087 | Yes |
| 33 | STIL | STIL centriolar assembly protein [Source:HGNC Symbol;Acc:HGNC:10879] | 35542 | -2.150 | -0.6984 | Yes |
| 34 | CCNB1 | cyclin B1 [Source:HGNC Symbol;Acc:HGNC:1579] | 35605 | -2.200 | -0.6857 | Yes |
| 35 | SMC2 | structural maintenance of chromosomes 2 [Source:HGNC Symbol;Acc:HGNC:14011] | 35759 | -2.331 | -0.6747 | Yes |
| 36 | GINS1 | GINS complex subunit 1 [Source:HGNC Symbol;Acc:HGNC:28980] | 35776 | -2.350 | -0.6599 | Yes |
| 37 | CDKN3 | cyclin dependent kinase inhibitor 3 [Source:HGNC Symbol;Acc:HGNC:1791] | 35813 | -2.385 | -0.6454 | Yes |
| 38 | SPC25 | SPC25 component of NDC80 kinetochore complex [Source:HGNC Symbol;Acc:HGNC:24031] | 35933 | -2.484 | -0.6325 | Yes |
| 39 | TPX2 | TPX2 microtubule nucleation factor [Source:HGNC Symbol;Acc:HGNC:1249] | 35941 | -2.490 | -0.6165 | Yes |
| 40 | RAD51C | RAD51 paralog C [Source:HGNC Symbol;Acc:HGNC:9820] | 35952 | -2.508 | -0.6005 | Yes |
| 41 | CDC20 | cell division cycle 20 [Source:HGNC Symbol;Acc:HGNC:1723] | 35993 | -2.546 | -0.5851 | Yes |
| 42 | MKI67 | marker of proliferation Ki-67 [Source:HGNC Symbol;Acc:HGNC:7107] | 36125 | -2.680 | -0.5712 | Yes |
| 43 | TRAIP | TRAF interacting protein [Source:HGNC Symbol;Acc:HGNC:30764] | 36174 | -2.734 | -0.5547 | Yes |
| 44 | SMC4 | structural maintenance of chromosomes 4 [Source:HGNC Symbol;Acc:HGNC:14013] | 36199 | -2.753 | -0.5375 | Yes |
| 45 | BUB1B | BUB1 mitotic checkpoint serine/threonine kinase B [Source:HGNC Symbol;Acc:HGNC:1149] | 36239 | -2.787 | -0.5205 | Yes |
| 46 | STMN1 | stathmin 1 [Source:HGNC Symbol;Acc:HGNC:6510] | 36260 | -2.803 | -0.5028 | Yes |
| 47 | MCM2 | minichromosome maintenance complex component 2 [Source:HGNC Symbol;Acc:HGNC:6944] | 36350 | -2.926 | -0.4862 | Yes |
| 48 | CCNB2 | cyclin B2 [Source:HGNC Symbol;Acc:HGNC:1580] | 36367 | -2.940 | -0.4676 | Yes |
| 49 | SPAG5 | sperm associated antigen 5 [Source:HGNC Symbol;Acc:HGNC:13452] | 36391 | -2.970 | -0.4489 | Yes |
| 50 | H2AX | H2A.X variant histone [Source:HGNC Symbol;Acc:HGNC:4739] | 36457 | -3.057 | -0.4308 | Yes |
| 51 | TOP2A | DNA topoisomerase II alpha [Source:HGNC Symbol;Acc:HGNC:11989] | 36461 | -3.062 | -0.4110 | Yes |
| 52 | POLD1 | DNA polymerase delta 1, catalytic subunit [Source:HGNC Symbol;Acc:HGNC:9175] | 36466 | -3.065 | -0.3912 | Yes |
| 53 | UBE2C | ubiquitin conjugating enzyme E2 C [Source:HGNC Symbol;Acc:HGNC:15937] | 36476 | -3.083 | -0.3715 | Yes |
| 54 | PLK1 | polo like kinase 1 [Source:HGNC Symbol;Acc:HGNC:9077] | 36502 | -3.111 | -0.3519 | Yes |
| 55 | MYBL2 | MYB proto-oncogene like 2 [Source:HGNC Symbol;Acc:HGNC:7548] | 36508 | -3.121 | -0.3318 | Yes |
| 56 | NCAPH | non-SMC condensin I complex subunit H [Source:HGNC Symbol;Acc:HGNC:1112] | 36546 | -3.187 | -0.3121 | Yes |
| 57 | MCM7 | minichromosome maintenance complex component 7 [Source:HGNC Symbol;Acc:HGNC:6950] | 36575 | -3.228 | -0.2919 | Yes |
| 58 | GPX4 | glutathione peroxidase 4 [Source:HGNC Symbol;Acc:HGNC:4556] | 36617 | -3.295 | -0.2716 | Yes |
| 59 | CCNA2 | cyclin A2 [Source:HGNC Symbol;Acc:HGNC:1578] | 36660 | -3.369 | -0.2509 | Yes |
| 60 | CHEK2 | checkpoint kinase 2 [Source:HGNC Symbol;Acc:HGNC:16627] | 36690 | -3.417 | -0.2295 | Yes |
| 61 | AURKB | aurora kinase B [Source:HGNC Symbol;Acc:HGNC:11390] | 36698 | -3.424 | -0.2074 | Yes |
| 62 | KIF22 | kinesin family member 22 [Source:HGNC Symbol;Acc:HGNC:6391] | 36700 | -3.426 | -0.1852 | Yes |
| 63 | KIF11 | kinesin family member 11 [Source:HGNC Symbol;Acc:HGNC:6388] | 36709 | -3.440 | -0.1631 | Yes |
| 64 | KIF2C | kinesin family member 2C [Source:HGNC Symbol;Acc:HGNC:6393] | 36710 | -3.442 | -0.1408 | Yes |
| 65 | GALE | UDP-galactose-4-epimerase [Source:HGNC Symbol;Acc:HGNC:4116] | 36720 | -3.454 | -0.1186 | Yes |
| 66 | PTP4A3 | protein tyrosine phosphatase 4A3 [Source:HGNC Symbol;Acc:HGNC:9636] | 36735 | -3.479 | -0.0964 | Yes |
| 67 | FOXM1 | forkhead box M1 [Source:HGNC Symbol;Acc:HGNC:3818] | 36828 | -3.703 | -0.0748 | Yes |
| 68 | WEE1 | WEE1 G2 checkpoint kinase [Source:HGNC Symbol;Acc:HGNC:12761] | 36844 | -3.755 | -0.0508 | Yes |
| 69 | NDC80 | NDC80 kinetochore complex component [Source:HGNC Symbol;Acc:HGNC:16909] | 36994 | -4.180 | -0.0277 | Yes |
| 70 | TK1 | thymidine kinase 1 [Source:HGNC Symbol;Acc:HGNC:11830] | 37070 | -4.666 | 0.0005 | Yes |
