Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #KO_LPS_versus_KO_NA.Nof1.cls #KO_LPS_versus_KO_NA_repos |
| Phenotype | Nof1.cls#KO_LPS_versus_KO_NA_repos |
| Upregulated in class | KO_LPS |
| GeneSet | NEMETH_INFLAMMATORY_RESPONSE_LPS_UP |
| Enrichment Score (ES) | 0.93054473 |
| Normalized Enrichment Score (NES) | 2.3331318 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0 |
| FWER p-Value | 0.0 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | PTGS2 | prostaglandin-endoperoxide synthase 2 [Source:HGNC Symbol;Acc:HGNC:9605] | 4 | 4.965 | 0.0254 | Yes |
| 2 | IL1RN | interleukin 1 receptor antagonist [Source:HGNC Symbol;Acc:HGNC:6000] | 12 | 4.907 | 0.0504 | Yes |
| 3 | ODC1 | ornithine decarboxylase 1 [Source:HGNC Symbol;Acc:HGNC:8109] | 34 | 4.688 | 0.0740 | Yes |
| 4 | TNFRSF1B | TNF receptor superfamily member 1B [Source:HGNC Symbol;Acc:HGNC:11917] | 39 | 4.636 | 0.0977 | Yes |
| 5 | TNF | tumor necrosis factor [Source:HGNC Symbol;Acc:HGNC:11892] | 43 | 4.568 | 0.1211 | Yes |
| 6 | MARCKSL1 | MARCKS like 1 [Source:HGNC Symbol;Acc:HGNC:7142] | 74 | 4.266 | 0.1422 | Yes |
| 7 | SLFN12 | schlafen family member 12 [Source:HGNC Symbol;Acc:HGNC:25500] | 83 | 4.184 | 0.1635 | Yes |
| 8 | FURIN | furin, paired basic amino acid cleaving enzyme [Source:HGNC Symbol;Acc:HGNC:8568] | 86 | 4.162 | 0.1848 | Yes |
| 9 | IER3 | immediate early response 3 [Source:HGNC Symbol;Acc:HGNC:5392] | 87 | 4.161 | 0.2062 | Yes |
| 10 | PNP | purine nucleoside phosphorylase [Source:HGNC Symbol;Acc:HGNC:7892] | 90 | 4.107 | 0.2272 | Yes |
| 11 | BCL2L1 | BCL2 like 1 [Source:HGNC Symbol;Acc:HGNC:992] | 95 | 4.075 | 0.2481 | Yes |
| 12 | BCL6B | BCL6B transcription repressor [Source:HGNC Symbol;Acc:HGNC:1002] | 108 | 3.989 | 0.2682 | Yes |
| 13 | NFKB1 | nuclear factor kappa B subunit 1 [Source:HGNC Symbol;Acc:HGNC:7794] | 130 | 3.895 | 0.2877 | Yes |
| 14 | STAT1 | signal transducer and activator of transcription 1 [Source:HGNC Symbol;Acc:HGNC:11362] | 145 | 3.779 | 0.3067 | Yes |
| 15 | NFKBIA | NFKB inhibitor alpha [Source:HGNC Symbol;Acc:HGNC:7797] | 159 | 3.663 | 0.3252 | Yes |
| 16 | GCH1 | GTP cyclohydrolase 1 [Source:HGNC Symbol;Acc:HGNC:4193] | 176 | 3.589 | 0.3432 | Yes |
| 17 | MT1X | metallothionein 1X [Source:HGNC Symbol;Acc:HGNC:7405] | 179 | 3.568 | 0.3615 | Yes |
| 18 | CEBPD | CCAAT enhancer binding protein delta [Source:HGNC Symbol;Acc:HGNC:1835] | 210 | 3.374 | 0.3780 | Yes |
| 19 | GLRX | glutaredoxin [Source:HGNC Symbol;Acc:HGNC:4330] | 218 | 3.326 | 0.3949 | Yes |
| 20 | TAP1 | transporter 1, ATP binding cassette subfamily B member [Source:HGNC Symbol;Acc:HGNC:43] | 220 | 3.316 | 0.4119 | Yes |
| 21 | ETS2 | ETS proto-oncogene 2, transcription factor [Source:HGNC Symbol;Acc:HGNC:3489] | 226 | 3.286 | 0.4287 | Yes |
| 22 | TNIP1 | TNFAIP3 interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:16903] | 228 | 3.279 | 0.4455 | Yes |
| 23 | HCK | HCK proto-oncogene, Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:4840] | 236 | 3.241 | 0.4620 | Yes |
| 24 | TRIM25 | tripartite motif containing 25 [Source:HGNC Symbol;Acc:HGNC:12932] | 237 | 3.234 | 0.4786 | Yes |
| 25 | CD44 | CD44 molecule (Indian blood group) [Source:HGNC Symbol;Acc:HGNC:1681] | 241 | 3.211 | 0.4950 | Yes |
| 26 | SQSTM1 | sequestosome 1 [Source:HGNC Symbol;Acc:HGNC:11280] | 244 | 3.199 | 0.5114 | Yes |
| 27 | C3AR1 | complement C3a receptor 1 [Source:HGNC Symbol;Acc:HGNC:1319] | 248 | 3.174 | 0.5276 | Yes |
| 28 | RHOC | ras homolog family member C [Source:HGNC Symbol;Acc:HGNC:669] | 250 | 3.172 | 0.5439 | Yes |
| 29 | SRGN | serglycin [Source:HGNC Symbol;Acc:HGNC:9361] | 264 | 3.120 | 0.5596 | Yes |
| 30 | GK | glycerol kinase [Source:HGNC Symbol;Acc:HGNC:4289] | 271 | 3.075 | 0.5752 | Yes |
| 31 | SLFN12L | schlafen family member 12 like [Source:HGNC Symbol;Acc:HGNC:33920] | 272 | 3.068 | 0.5910 | Yes |
| 32 | SLC11A1 | solute carrier family 11 member 1 [Source:HGNC Symbol;Acc:HGNC:10907] | 313 | 2.870 | 0.6046 | Yes |
| 33 | ADAR | adenosine deaminase RNA specific [Source:HGNC Symbol;Acc:HGNC:225] | 335 | 2.806 | 0.6185 | Yes |
| 34 | STK10 | serine/threonine kinase 10 [Source:HGNC Symbol;Acc:HGNC:11388] | 339 | 2.798 | 0.6328 | Yes |
| 35 | TXNRD1 | thioredoxin reductase 1 [Source:HGNC Symbol;Acc:HGNC:12437] | 340 | 2.796 | 0.6472 | Yes |
| 36 | CFLAR | CASP8 and FADD like apoptosis regulator [Source:HGNC Symbol;Acc:HGNC:1876] | 343 | 2.781 | 0.6614 | Yes |
| 37 | MSR1 | macrophage scavenger receptor 1 [Source:HGNC Symbol;Acc:HGNC:7376] | 355 | 2.739 | 0.6752 | Yes |
| 38 | HCLS1 | hematopoietic cell-specific Lyn substrate 1 [Source:HGNC Symbol;Acc:HGNC:4844] | 360 | 2.730 | 0.6891 | Yes |
| 39 | LCP2 | lymphocyte cytosolic protein 2 [Source:HGNC Symbol;Acc:HGNC:6529] | 401 | 2.606 | 0.7014 | Yes |
| 40 | IFRD1 | interferon related developmental regulator 1 [Source:HGNC Symbol;Acc:HGNC:5456] | 424 | 2.544 | 0.7139 | Yes |
| 41 | TGFB1 | transforming growth factor beta 1 [Source:HGNC Symbol;Acc:HGNC:11766] | 454 | 2.468 | 0.7258 | Yes |
| 42 | TPST1 | tyrosylprotein sulfotransferase 1 [Source:HGNC Symbol;Acc:HGNC:12020] | 523 | 2.298 | 0.7358 | Yes |
| 43 | ACSL4 | acyl-CoA synthetase long chain family member 4 [Source:HGNC Symbol;Acc:HGNC:3571] | 525 | 2.291 | 0.7475 | Yes |
| 44 | MYO10 | myosin X [Source:HGNC Symbol;Acc:HGNC:7593] | 526 | 2.289 | 0.7593 | Yes |
| 45 | RGS16 | regulator of G protein signaling 16 [Source:HGNC Symbol;Acc:HGNC:9997] | 571 | 2.182 | 0.7693 | Yes |
| 46 | ATF3 | activating transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:785] | 642 | 2.069 | 0.7780 | Yes |
| 47 | CLN3 | CLN3 lysosomal/endosomal transmembrane protein, battenin [Source:HGNC Symbol;Acc:HGNC:2074] | 650 | 2.041 | 0.7883 | Yes |
| 48 | IRGM | immunity related GTPase M [Source:HGNC Symbol;Acc:HGNC:29597] | 663 | 2.024 | 0.7984 | Yes |
| 49 | SAT1 | spermidine/spermine N1-acetyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:10540] | 731 | 1.925 | 0.8065 | Yes |
| 50 | ETF1 | eukaryotic translation termination factor 1 [Source:HGNC Symbol;Acc:HGNC:3477] | 741 | 1.913 | 0.8161 | Yes |
| 51 | SLC20A1 | solute carrier family 20 member 1 [Source:HGNC Symbol;Acc:HGNC:10946] | 747 | 1.893 | 0.8257 | Yes |
| 52 | RNF11 | ring finger protein 11 [Source:HGNC Symbol;Acc:HGNC:10056] | 748 | 1.892 | 0.8354 | Yes |
| 53 | IER2 | immediate early response 2 [Source:HGNC Symbol;Acc:HGNC:28871] | 829 | 1.780 | 0.8424 | Yes |
| 54 | CCL3 | C-C motif chemokine ligand 3 [Source:HGNC Symbol;Acc:HGNC:10627] | 850 | 1.758 | 0.8509 | Yes |
| 55 | DEGS1 | delta 4-desaturase, sphingolipid 1 [Source:HGNC Symbol;Acc:HGNC:13709] | 889 | 1.704 | 0.8586 | Yes |
| 56 | APBB1IP | amyloid beta precursor protein binding family B member 1 interacting protein [Source:HGNC Symbol;Acc:HGNC:17379] | 913 | 1.679 | 0.8666 | Yes |
| 57 | IL1RL1 | interleukin 1 receptor like 1 [Source:HGNC Symbol;Acc:HGNC:5998] | 915 | 1.676 | 0.8752 | Yes |
| 58 | JUND | JunD proto-oncogene, AP-1 transcription factor subunit [Source:HGNC Symbol;Acc:HGNC:6206] | 966 | 1.616 | 0.8821 | Yes |
| 59 | PML | promyelocytic leukemia [Source:HGNC Symbol;Acc:HGNC:9113] | 986 | 1.591 | 0.8898 | Yes |
| 60 | HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase [Source:HGNC Symbol;Acc:HGNC:5006] | 1144 | 1.431 | 0.8929 | Yes |
| 61 | MAP2K1 | mitogen-activated protein kinase kinase 1 [Source:HGNC Symbol;Acc:HGNC:6840] | 1167 | 1.417 | 0.8996 | Yes |
| 62 | EIF1 | eukaryotic translation initiation factor 1 [Source:HGNC Symbol;Acc:HGNC:3249] | 1200 | 1.393 | 0.9059 | Yes |
| 63 | CLEC4D | C-type lectin domain family 4 member D [Source:HGNC Symbol;Acc:HGNC:14554] | 1305 | 1.312 | 0.9098 | Yes |
| 64 | KPNA3 | karyopherin subunit alpha 3 [Source:HGNC Symbol;Acc:HGNC:6396] | 1438 | 1.225 | 0.9126 | Yes |
| 65 | SLC2A1 | solute carrier family 2 member 1 [Source:HGNC Symbol;Acc:HGNC:11005] | 1472 | 1.204 | 0.9179 | Yes |
| 66 | MLLT11 | MLLT11 transcription factor 7 cofactor [Source:HGNC Symbol;Acc:HGNC:16997] | 1544 | 1.174 | 0.9220 | Yes |
| 67 | PIP5K1B | phosphatidylinositol-4-phosphate 5-kinase type 1 beta [Source:HGNC Symbol;Acc:HGNC:8995] | 1774 | 1.050 | 0.9212 | Yes |
| 68 | CITED2 | Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2 [Source:HGNC Symbol;Acc:HGNC:1987] | 1858 | 1.013 | 0.9241 | Yes |
| 69 | WSB1 | WD repeat and SOCS box containing 1 [Source:HGNC Symbol;Acc:HGNC:19221] | 1908 | 0.992 | 0.9279 | Yes |
| 70 | TOP1 | DNA topoisomerase I [Source:HGNC Symbol;Acc:HGNC:11986] | 1992 | 0.948 | 0.9305 | Yes |
| 71 | RCN1 | reticulocalbin 1 [Source:HGNC Symbol;Acc:HGNC:9934] | 2514 | 0.736 | 0.9203 | No |
| 72 | MYADM | myeloid associated differentiation marker [Source:HGNC Symbol;Acc:HGNC:7544] | 3202 | 0.552 | 0.9045 | No |
| 73 | DAB2 | DAB adaptor protein 2 [Source:HGNC Symbol;Acc:HGNC:2662] | 3259 | 0.537 | 0.9058 | No |
| 74 | SAP30 | Sin3A associated protein 30 [Source:HGNC Symbol;Acc:HGNC:10532] | 3318 | 0.524 | 0.9069 | No |
| 75 | PRKCD | protein kinase C delta [Source:HGNC Symbol;Acc:HGNC:9399] | 3674 | 0.444 | 0.8996 | No |
| 76 | CCL23 | C-C motif chemokine ligand 23 [Source:HGNC Symbol;Acc:HGNC:10622] | 6042 | 0.000 | 0.8356 | No |
| 77 | TNFSF9 | TNF superfamily member 9 [Source:HGNC Symbol;Acc:HGNC:11939] | 8492 | 0.000 | 0.7694 | No |
| 78 | SLPI | secretory leukocyte peptidase inhibitor [Source:HGNC Symbol;Acc:HGNC:11092] | 8943 | 0.000 | 0.7573 | No |
| 79 | IFI16 | interferon gamma inducible protein 16 [Source:HGNC Symbol;Acc:HGNC:5395] | 11185 | 0.000 | 0.6967 | No |
| 80 | FCGR2B | Fc fragment of IgG receptor IIb [Source:HGNC Symbol;Acc:HGNC:3618] | 11197 | 0.000 | 0.6964 | No |
| 81 | CDKN1A | cyclin dependent kinase inhibitor 1A [Source:HGNC Symbol;Acc:HGNC:1784] | 12457 | 0.000 | 0.6624 | No |
| 82 | LILRB4 | leukocyte immunoglobulin like receptor B4 [Source:HGNC Symbol;Acc:HGNC:6608] | 13283 | 0.000 | 0.6401 | No |
| 83 | CASP4 | caspase 4 [Source:HGNC Symbol;Acc:HGNC:1505] | 26653 | 0.000 | 0.2788 | No |
| 84 | MAPKAPK2 | MAPK activated protein kinase 2 [Source:HGNC Symbol;Acc:HGNC:6887] | 28243 | -0.142 | 0.2366 | No |
| 85 | LTB | lymphotoxin beta [Source:HGNC Symbol;Acc:HGNC:6711] | 30460 | -0.469 | 0.1792 | No |
