Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #KO_LPS_versus_KO_NA.Nof1.cls #KO_LPS_versus_KO_NA_repos |
| Phenotype | Nof1.cls#KO_LPS_versus_KO_NA_repos |
| Upregulated in class | KO_NA |
| GeneSet | REN_BOUND_BY_E2F |
| Enrichment Score (ES) | -0.8496097 |
| Normalized Enrichment Score (NES) | -1.6590879 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.001327118 |
| FWER p-Value | 0.03 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | E2F3 | E2F transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:3115] | 1753 | 1.057 | -0.0383 | No |
| 2 | BRD2 | bromodomain containing 2 [Source:HGNC Symbol;Acc:HGNC:1103] | 3406 | 0.503 | -0.0787 | No |
| 3 | POLA2 | DNA polymerase alpha 2, accessory subunit [Source:HGNC Symbol;Acc:HGNC:30073] | 5712 | 0.053 | -0.1405 | No |
| 4 | H2AC18 | H2A clustered histone 18 [Source:HGNC Symbol;Acc:HGNC:4736] | 21603 | 0.000 | -0.5696 | No |
| 5 | CENPA | centromere protein A [Source:HGNC Symbol;Acc:HGNC:1851] | 23956 | 0.000 | -0.6331 | No |
| 6 | NAP1L4 | nucleosome assembly protein 1 like 4 [Source:HGNC Symbol;Acc:HGNC:7640] | 27863 | -0.084 | -0.7379 | No |
| 7 | SUPT4H1 | SPT4 homolog, DSIF elongation factor subunit [Source:HGNC Symbol;Acc:HGNC:11467] | 28472 | -0.175 | -0.7528 | No |
| 8 | CDC25A | cell division cycle 25A [Source:HGNC Symbol;Acc:HGNC:1725] | 29004 | -0.250 | -0.7650 | No |
| 9 | H3C4 | H3 clustered histone 4 [Source:HGNC Symbol;Acc:HGNC:4767] | 29816 | -0.371 | -0.7837 | No |
| 10 | H2BC21 | H2B clustered histone 21 [Source:HGNC Symbol;Acc:HGNC:4760] | 30068 | -0.409 | -0.7870 | No |
| 11 | PTTG1 | PTTG1 regulator of sister chromatid separation, securin [Source:HGNC Symbol;Acc:HGNC:9690] | 30719 | -0.514 | -0.8002 | No |
| 12 | CSTF1 | cleavage stimulation factor subunit 1 [Source:HGNC Symbol;Acc:HGNC:2483] | 31125 | -0.582 | -0.8062 | No |
| 13 | CHEK1 | checkpoint kinase 1 [Source:HGNC Symbol;Acc:HGNC:1925] | 32734 | -0.955 | -0.8415 | Yes |
| 14 | PCNA | proliferating cell nuclear antigen [Source:HGNC Symbol;Acc:HGNC:8729] | 32753 | -0.958 | -0.8338 | Yes |
| 15 | MLH1 | mutL homolog 1 [Source:HGNC Symbol;Acc:HGNC:7127] | 32781 | -0.966 | -0.8263 | Yes |
| 16 | BUB3 | BUB3 mitotic checkpoint protein [Source:HGNC Symbol;Acc:HGNC:1151] | 32897 | -1.007 | -0.8208 | Yes |
| 17 | H2AC6 | H2A clustered histone 6 [Source:HGNC Symbol;Acc:HGNC:4733] | 33081 | -1.056 | -0.8167 | Yes |
| 18 | RFC3 | replication factor C subunit 3 [Source:HGNC Symbol;Acc:HGNC:9971] | 33208 | -1.098 | -0.8108 | Yes |
| 19 | FEN1 | flap structure-specific endonuclease 1 [Source:HGNC Symbol;Acc:HGNC:3650] | 33397 | -1.158 | -0.8060 | Yes |
| 20 | CKS1BP7 | CDC28 protein kinase regulatory subunit 1B pseudogene 7 [Source:HGNC Symbol;Acc:HGNC:1999] | 33400 | -1.158 | -0.7962 | Yes |
| 21 | UMPS | uridine monophosphate synthetase [Source:HGNC Symbol;Acc:HGNC:12563] | 33456 | -1.174 | -0.7876 | Yes |
| 22 | TP53 | tumor protein p53 [Source:HGNC Symbol;Acc:HGNC:11998] | 33554 | -1.213 | -0.7799 | Yes |
| 23 | ORC1 | origin recognition complex subunit 1 [Source:HGNC Symbol;Acc:HGNC:8487] | 33656 | -1.251 | -0.7720 | Yes |
| 24 | PRIM2 | DNA primase subunit 2 [Source:HGNC Symbol;Acc:HGNC:9370] | 33817 | -1.309 | -0.7651 | Yes |
| 25 | DUT | deoxyuridine triphosphatase [Source:HGNC Symbol;Acc:HGNC:3078] | 34095 | -1.401 | -0.7607 | Yes |
| 26 | HMGB1 | high mobility group box 1 [Source:HGNC Symbol;Acc:HGNC:4983] | 34140 | -1.424 | -0.7497 | Yes |
| 27 | UNG | uracil DNA glycosylase [Source:HGNC Symbol;Acc:HGNC:12572] | 34368 | -1.513 | -0.7430 | Yes |
| 28 | CDK1 | cyclin dependent kinase 1 [Source:HGNC Symbol;Acc:HGNC:1722] | 34381 | -1.518 | -0.7303 | Yes |
| 29 | RBL1 | RB transcriptional corepressor like 1 [Source:HGNC Symbol;Acc:HGNC:9893] | 34459 | -1.548 | -0.7192 | Yes |
| 30 | H2AZ1 | H2A.Z variant histone 1 [Source:HGNC Symbol;Acc:HGNC:4741] | 34958 | -1.777 | -0.7175 | Yes |
| 31 | MCM3 | minichromosome maintenance complex component 3 [Source:HGNC Symbol;Acc:HGNC:6945] | 35062 | -1.840 | -0.7046 | Yes |
| 32 | POLA1 | DNA polymerase alpha 1, catalytic subunit [Source:HGNC Symbol;Acc:HGNC:9173] | 35129 | -1.886 | -0.6903 | Yes |
| 33 | MAD2L1 | mitotic arrest deficient 2 like 1 [Source:HGNC Symbol;Acc:HGNC:6763] | 35138 | -1.892 | -0.6744 | Yes |
| 34 | RAD51 | RAD51 recombinase [Source:HGNC Symbol;Acc:HGNC:9817] | 35198 | -1.930 | -0.6596 | Yes |
| 35 | CDC6 | cell division cycle 6 [Source:HGNC Symbol;Acc:HGNC:1744] | 35199 | -1.931 | -0.6431 | Yes |
| 36 | RPA3 | replication protein A3 [Source:HGNC Symbol;Acc:HGNC:10291] | 35348 | -2.023 | -0.6298 | Yes |
| 37 | CBX5 | chromobox 5 [Source:HGNC Symbol;Acc:HGNC:1555] | 35401 | -2.065 | -0.6136 | Yes |
| 38 | RAD54L | RAD54 like [Source:HGNC Symbol;Acc:HGNC:9826] | 35638 | -2.227 | -0.6010 | Yes |
| 39 | HLTF | helicase like transcription factor [Source:HGNC Symbol;Acc:HGNC:11099] | 35733 | -2.309 | -0.5839 | Yes |
| 40 | CDK2 | cyclin dependent kinase 2 [Source:HGNC Symbol;Acc:HGNC:1771] | 35755 | -2.327 | -0.5646 | Yes |
| 41 | SMC2 | structural maintenance of chromosomes 2 [Source:HGNC Symbol;Acc:HGNC:14011] | 35759 | -2.331 | -0.5448 | Yes |
| 42 | MCM5 | minichromosome maintenance complex component 5 [Source:HGNC Symbol;Acc:HGNC:6948] | 35807 | -2.374 | -0.5259 | Yes |
| 43 | PRKDC | protein kinase, DNA-activated, catalytic subunit [Source:HGNC Symbol;Acc:HGNC:9413] | 35825 | -2.397 | -0.5059 | Yes |
| 44 | RFC4 | replication factor C subunit 4 [Source:HGNC Symbol;Acc:HGNC:9972] | 35830 | -2.402 | -0.4855 | Yes |
| 45 | MCM6 | minichromosome maintenance complex component 6 [Source:HGNC Symbol;Acc:HGNC:6949] | 36129 | -2.683 | -0.4707 | Yes |
| 46 | CENPE | centromere protein E [Source:HGNC Symbol;Acc:HGNC:1856] | 36138 | -2.694 | -0.4479 | Yes |
| 47 | SMC4 | structural maintenance of chromosomes 4 [Source:HGNC Symbol;Acc:HGNC:14013] | 36199 | -2.753 | -0.4261 | Yes |
| 48 | DBF4 | DBF4 zinc finger [Source:HGNC Symbol;Acc:HGNC:17364] | 36273 | -2.821 | -0.4040 | Yes |
| 49 | RRM1 | ribonucleotide reductase catalytic subunit M1 [Source:HGNC Symbol;Acc:HGNC:10451] | 36359 | -2.931 | -0.3813 | Yes |
| 50 | RFC2 | replication factor C subunit 2 [Source:HGNC Symbol;Acc:HGNC:9970] | 36428 | -3.019 | -0.3574 | Yes |
| 51 | H2AX | H2A.X variant histone [Source:HGNC Symbol;Acc:HGNC:4739] | 36457 | -3.057 | -0.3321 | Yes |
| 52 | BARD1 | BRCA1 associated RING domain 1 [Source:HGNC Symbol;Acc:HGNC:952] | 36458 | -3.059 | -0.3060 | Yes |
| 53 | TOP2A | DNA topoisomerase II alpha [Source:HGNC Symbol;Acc:HGNC:11989] | 36461 | -3.062 | -0.2800 | Yes |
| 54 | POLD1 | DNA polymerase delta 1, catalytic subunit [Source:HGNC Symbol;Acc:HGNC:9175] | 36466 | -3.065 | -0.2540 | Yes |
| 55 | CCNA2 | cyclin A2 [Source:HGNC Symbol;Acc:HGNC:1578] | 36660 | -3.369 | -0.2305 | Yes |
| 56 | HMGB3 | high mobility group box 3 [Source:HGNC Symbol;Acc:HGNC:5004] | 36784 | -3.594 | -0.2031 | Yes |
| 57 | E2F2 | E2F transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:3114] | 36835 | -3.729 | -0.1727 | Yes |
| 58 | MSH2 | mutS homolog 2 [Source:HGNC Symbol;Acc:HGNC:7325] | 36935 | -3.972 | -0.1415 | Yes |
| 59 | RB1 | RB transcriptional corepressor 1 [Source:HGNC Symbol;Acc:HGNC:9884] | 36947 | -3.999 | -0.1077 | Yes |
| 60 | NDC80 | NDC80 kinetochore complex component [Source:HGNC Symbol;Acc:HGNC:16909] | 36994 | -4.180 | -0.0733 | Yes |
| 61 | TTK | TTK protein kinase [Source:HGNC Symbol;Acc:HGNC:12401] | 37006 | -4.236 | -0.0375 | Yes |
| 62 | TK1 | thymidine kinase 1 [Source:HGNC Symbol;Acc:HGNC:11830] | 37070 | -4.666 | 0.0005 | Yes |
