Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #KO_LPS_versus_KO_NA.Nof1.cls #KO_LPS_versus_KO_NA_repos |
| Phenotype | Nof1.cls#KO_LPS_versus_KO_NA_repos |
| Upregulated in class | KO_LPS |
| GeneSet | IRF2_01 |
| Enrichment Score (ES) | 0.52072024 |
| Normalized Enrichment Score (NES) | 1.3457867 |
| Nominal p-value | 0.03846154 |
| FDR q-value | 1.0 |
| FWER p-Value | 1.0 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | LIF | LIF interleukin 6 family cytokine [Source:HGNC Symbol;Acc:HGNC:6596] | 0 | 4.995 | 0.0379 | Yes |
| 2 | IL27 | interleukin 27 [Source:HGNC Symbol;Acc:HGNC:19157] | 11 | 4.927 | 0.0751 | Yes |
| 3 | USP18 | ubiquitin specific peptidase 18 [Source:HGNC Symbol;Acc:HGNC:12616] | 35 | 4.665 | 0.1099 | Yes |
| 4 | OSM | oncostatin M [Source:HGNC Symbol;Acc:HGNC:8506] | 42 | 4.572 | 0.1445 | Yes |
| 5 | DDX58 | DExD/H-box helicase 58 [Source:HGNC Symbol;Acc:HGNC:19102] | 85 | 4.180 | 0.1751 | Yes |
| 6 | REL | REL proto-oncogene, NF-kB subunit [Source:HGNC Symbol;Acc:HGNC:9954] | 160 | 3.661 | 0.2009 | Yes |
| 7 | NT5C3A | 5'-nucleotidase, cytosolic IIIA [Source:HGNC Symbol;Acc:HGNC:17820] | 192 | 3.498 | 0.2266 | Yes |
| 8 | DTX3L | deltex E3 ubiquitin ligase 3L [Source:HGNC Symbol;Acc:HGNC:30323] | 193 | 3.490 | 0.2532 | Yes |
| 9 | TAPBP | TAP binding protein [Source:HGNC Symbol;Acc:HGNC:11566] | 215 | 3.342 | 0.2780 | Yes |
| 10 | TAP1 | transporter 1, ATP binding cassette subfamily B member [Source:HGNC Symbol;Acc:HGNC:43] | 220 | 3.316 | 0.3031 | Yes |
| 11 | PRDX5 | peroxiredoxin 5 [Source:HGNC Symbol;Acc:HGNC:9355] | 420 | 2.552 | 0.3171 | Yes |
| 12 | PSME1 | proteasome activator subunit 1 [Source:HGNC Symbol;Acc:HGNC:9568] | 468 | 2.436 | 0.3343 | Yes |
| 13 | PIGV | phosphatidylinositol glycan anchor biosynthesis class V [Source:HGNC Symbol;Acc:HGNC:26031] | 548 | 2.224 | 0.3490 | Yes |
| 14 | ATF3 | activating transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:785] | 642 | 2.069 | 0.3622 | Yes |
| 15 | PSMB8 | proteasome 20S subunit beta 8 [Source:HGNC Symbol;Acc:HGNC:9545] | 697 | 1.961 | 0.3757 | Yes |
| 16 | LSM6 | LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated [Source:HGNC Symbol;Acc:HGNC:17017] | 701 | 1.956 | 0.3905 | Yes |
| 17 | PSMB9 | proteasome 20S subunit beta 9 [Source:HGNC Symbol;Acc:HGNC:9546] | 764 | 1.869 | 0.4030 | Yes |
| 18 | CXCL10 | C-X-C motif chemokine ligand 10 [Source:HGNC Symbol;Acc:HGNC:10637] | 802 | 1.811 | 0.4157 | Yes |
| 19 | LRATD2 | LRAT domain containing 2 [Source:HGNC Symbol;Acc:HGNC:24166] | 854 | 1.752 | 0.4277 | Yes |
| 20 | CASZ1 | castor zinc finger 1 [Source:HGNC Symbol;Acc:HGNC:26002] | 949 | 1.633 | 0.4375 | Yes |
| 21 | FXYD5 | FXYD domain containing ion transport regulator 5 [Source:HGNC Symbol;Acc:HGNC:4029] | 953 | 1.625 | 0.4498 | Yes |
| 22 | PGM5 | phosphoglucomutase 5 [Source:HGNC Symbol;Acc:HGNC:8908] | 1003 | 1.574 | 0.4604 | Yes |
| 23 | SYNE2 | spectrin repeat containing nuclear envelope protein 2 [Source:HGNC Symbol;Acc:HGNC:17084] | 1015 | 1.562 | 0.4720 | Yes |
| 24 | TCIRG1 | T cell immune regulator 1, ATPase H+ transporting V0 subunit a3 [Source:HGNC Symbol;Acc:HGNC:11647] | 1050 | 1.519 | 0.4826 | Yes |
| 25 | PARP9 | poly(ADP-ribose) polymerase family member 9 [Source:HGNC Symbol;Acc:HGNC:24118] | 1117 | 1.452 | 0.4918 | Yes |
| 26 | PSMA3 | proteasome 20S subunit alpha 3 [Source:HGNC Symbol;Acc:HGNC:9532] | 1570 | 1.166 | 0.4885 | Yes |
| 27 | SLC38A2 | solute carrier family 38 member 2 [Source:HGNC Symbol;Acc:HGNC:13448] | 1596 | 1.146 | 0.4965 | Yes |
| 28 | MAP3K11 | mitogen-activated protein kinase kinase kinase 11 [Source:HGNC Symbol;Acc:HGNC:6850] | 1670 | 1.106 | 0.5029 | Yes |
| 29 | E2F3 | E2F transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:3115] | 1753 | 1.057 | 0.5087 | Yes |
| 30 | CDK6 | cyclin dependent kinase 6 [Source:HGNC Symbol;Acc:HGNC:1777] | 2170 | 0.867 | 0.5041 | Yes |
| 31 | ROCK1 | Rho associated coiled-coil containing protein kinase 1 [Source:HGNC Symbol;Acc:HGNC:10251] | 2236 | 0.842 | 0.5087 | Yes |
| 32 | PCGF5 | polycomb group ring finger 5 [Source:HGNC Symbol;Acc:HGNC:28264] | 2246 | 0.838 | 0.5148 | Yes |
| 33 | PRKD3 | protein kinase D3 [Source:HGNC Symbol;Acc:HGNC:9408] | 2263 | 0.831 | 0.5207 | Yes |
| 34 | RAPGEF6 | Rap guanine nucleotide exchange factor 6 [Source:HGNC Symbol;Acc:HGNC:20655] | 2790 | 0.651 | 0.5114 | No |
| 35 | MED13 | mediator complex subunit 13 [Source:HGNC Symbol;Acc:HGNC:22474] | 2940 | 0.616 | 0.5121 | No |
| 36 | ASH1L | ASH1 like histone lysine methyltransferase [Source:HGNC Symbol;Acc:HGNC:19088] | 3226 | 0.546 | 0.5085 | No |
| 37 | DNASE1L3 | deoxyribonuclease 1 like 3 [Source:HGNC Symbol;Acc:HGNC:2959] | 3403 | 0.504 | 0.5076 | No |
| 38 | UPF2 | UPF2 regulator of nonsense mediated mRNA decay [Source:HGNC Symbol;Acc:HGNC:17854] | 3450 | 0.494 | 0.5101 | No |
| 39 | IL11 | interleukin 11 [Source:HGNC Symbol;Acc:HGNC:5966] | 3711 | 0.436 | 0.5064 | No |
| 40 | B2M | beta-2-microglobulin [Source:HGNC Symbol;Acc:HGNC:914] | 4631 | 0.246 | 0.4834 | No |
| 41 | DLG1 | discs large MAGUK scaffold protein 1 [Source:HGNC Symbol;Acc:HGNC:2900] | 4821 | 0.215 | 0.4799 | No |
| 42 | TMEM229B | transmembrane protein 229B [Source:HGNC Symbol;Acc:HGNC:20130] | 5571 | 0.077 | 0.4602 | No |
| 43 | TMBIM4 | transmembrane BAX inhibitor motif containing 4 [Source:HGNC Symbol;Acc:HGNC:24257] | 5956 | 0.003 | 0.4499 | No |
| 44 | PRDM16 | PR/SET domain 16 [Source:HGNC Symbol;Acc:HGNC:14000] | 6597 | 0.000 | 0.4326 | No |
| 45 | ASPA | aspartoacylase [Source:HGNC Symbol;Acc:HGNC:756] | 7427 | 0.000 | 0.4101 | No |
| 46 | BHLHE22 | basic helix-loop-helix family member e22 [Source:HGNC Symbol;Acc:HGNC:11963] | 7849 | 0.000 | 0.3987 | No |
| 47 | PROX1 | prospero homeobox 1 [Source:HGNC Symbol;Acc:HGNC:9459] | 8036 | 0.000 | 0.3937 | No |
| 48 | HOXA6 | homeobox A6 [Source:HGNC Symbol;Acc:HGNC:5107] | 8438 | 0.000 | 0.3829 | No |
| 49 | KCNE4 | potassium voltage-gated channel subfamily E regulatory subunit 4 [Source:HGNC Symbol;Acc:HGNC:6244] | 9498 | 0.000 | 0.3542 | No |
| 50 | H4C7 | H4 clustered histone 7 [Source:HGNC Symbol;Acc:HGNC:4792] | 9901 | 0.000 | 0.3433 | No |
| 51 | LDB2 | LIM domain binding 2 [Source:HGNC Symbol;Acc:HGNC:6533] | 10772 | 0.000 | 0.3198 | No |
| 52 | TMPRSS5 | transmembrane serine protease 5 [Source:HGNC Symbol;Acc:HGNC:14908] | 11249 | 0.000 | 0.3069 | No |
| 53 | BST2 | bone marrow stromal cell antigen 2 [Source:HGNC Symbol;Acc:HGNC:1119] | 12304 | 0.000 | 0.2784 | No |
| 54 | MSX1 | msh homeobox 1 [Source:HGNC Symbol;Acc:HGNC:7391] | 12342 | 0.000 | 0.2774 | No |
| 55 | UBD | ubiquitin D [Source:HGNC Symbol;Acc:HGNC:18795] | 12636 | 0.000 | 0.2695 | No |
| 56 | GLRA1 | glycine receptor alpha 1 [Source:HGNC Symbol;Acc:HGNC:4326] | 12772 | 0.000 | 0.2658 | No |
| 57 | TMEM108 | transmembrane protein 108 [Source:HGNC Symbol;Acc:HGNC:28451] | 13340 | 0.000 | 0.2505 | No |
| 58 | PDGFC | platelet derived growth factor C [Source:HGNC Symbol;Acc:HGNC:8801] | 13380 | 0.000 | 0.2494 | No |
| 59 | IL15RA | interleukin 15 receptor subunit alpha [Source:HGNC Symbol;Acc:HGNC:5978] | 13996 | 0.000 | 0.2328 | No |
| 60 | FLT3LG | fms related receptor tyrosine kinase 3 ligand [Source:HGNC Symbol;Acc:HGNC:3766] | 14010 | 0.000 | 0.2324 | No |
| 61 | BLK | BLK proto-oncogene, Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:1057] | 15503 | 0.000 | 0.1921 | No |
| 62 | DLX4 | distal-less homeobox 4 [Source:HGNC Symbol;Acc:HGNC:2917] | 16712 | 0.000 | 0.1594 | No |
| 63 | NDN | necdin, MAGE family member [Source:HGNC Symbol;Acc:HGNC:7675] | 19187 | 0.000 | 0.0925 | No |
| 64 | BNC2 | basonuclin 2 [Source:HGNC Symbol;Acc:HGNC:30988] | 19193 | 0.000 | 0.0923 | No |
| 65 | TBX1 | T-box transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:11592] | 19643 | 0.000 | 0.0802 | No |
| 66 | AGBL2 | ATP/GTP binding protein like 2 [Source:HGNC Symbol;Acc:HGNC:26296] | 20503 | 0.000 | 0.0570 | No |
| 67 | BCL11A | BAF chromatin remodeling complex subunit BCL11A [Source:HGNC Symbol;Acc:HGNC:13221] | 20612 | 0.000 | 0.0540 | No |
| 68 | PIGR | polymeric immunoglobulin receptor [Source:HGNC Symbol;Acc:HGNC:8968] | 22682 | 0.000 | -0.0019 | No |
| 69 | NPR3 | natriuretic peptide receptor 3 [Source:HGNC Symbol;Acc:HGNC:7945] | 23542 | 0.000 | -0.0252 | No |
| 70 | EGFL6 | EGF like domain multiple 6 [Source:HGNC Symbol;Acc:HGNC:3235] | 23823 | 0.000 | -0.0328 | No |
| 71 | CCDC68 | coiled-coil domain containing 68 [Source:HGNC Symbol;Acc:HGNC:24350] | 24494 | 0.000 | -0.0509 | No |
| 72 | IFNB1 | interferon beta 1 [Source:HGNC Symbol;Acc:HGNC:5434] | 24599 | 0.000 | -0.0537 | No |
| 73 | IFNL2 | interferon lambda 2 [Source:HGNC Symbol;Acc:HGNC:18364] | 24702 | 0.000 | -0.0565 | No |
| 74 | IFNL3 | interferon lambda 3 [Source:HGNC Symbol;Acc:HGNC:18365] | 24713 | 0.000 | -0.0567 | No |
| 75 | KCNMB3 | potassium calcium-activated channel subfamily M regulatory beta subunit 3 [Source:HGNC Symbol;Acc:HGNC:6287] | 24758 | 0.000 | -0.0579 | No |
| 76 | XAF1 | XIAP associated factor 1 [Source:HGNC Symbol;Acc:HGNC:30932] | 27136 | 0.000 | -0.1222 | No |
| 77 | CUL2 | cullin 2 [Source:HGNC Symbol;Acc:HGNC:2552] | 27498 | -0.024 | -0.1318 | No |
| 78 | CAPRIN1 | cell cycle associated protein 1 [Source:HGNC Symbol;Acc:HGNC:6743] | 27965 | -0.097 | -0.1437 | No |
| 79 | KARS1 | lysyl-tRNA synthetase 1 [Source:HGNC Symbol;Acc:HGNC:6215] | 27974 | -0.099 | -0.1431 | No |
| 80 | RFX4 | regulatory factor X4 [Source:HGNC Symbol;Acc:HGNC:9985] | 28064 | -0.113 | -0.1447 | No |
| 81 | RTL9 | retrotransposon Gag like 9 [Source:HGNC Symbol;Acc:HGNC:29245] | 28191 | -0.133 | -0.1471 | No |
| 82 | IKZF2 | IKAROS family zinc finger 2 [Source:HGNC Symbol;Acc:HGNC:13177] | 28366 | -0.160 | -0.1506 | No |
| 83 | TERF2IP | TERF2 interacting protein [Source:HGNC Symbol;Acc:HGNC:19246] | 28429 | -0.167 | -0.1510 | No |
| 84 | EIF4A2 | eukaryotic translation initiation factor 4A2 [Source:HGNC Symbol;Acc:HGNC:3284] | 28606 | -0.189 | -0.1543 | No |
| 85 | GPR52 | G protein-coupled receptor 52 [Source:HGNC Symbol;Acc:HGNC:4508] | 28775 | -0.213 | -0.1572 | No |
| 86 | RIMS2 | regulating synaptic membrane exocytosis 2 [Source:HGNC Symbol;Acc:HGNC:17283] | 28966 | -0.243 | -0.1605 | No |
| 87 | DUSP10 | dual specificity phosphatase 10 [Source:HGNC Symbol;Acc:HGNC:3065] | 29105 | -0.265 | -0.1622 | No |
| 88 | GSDMD | gasdermin D [Source:HGNC Symbol;Acc:HGNC:25697] | 29212 | -0.283 | -0.1630 | No |
| 89 | MAPK6 | mitogen-activated protein kinase 6 [Source:HGNC Symbol;Acc:HGNC:6879] | 29824 | -0.372 | -0.1767 | No |
| 90 | TRMT112 | tRNA methyltransferase subunit 11-2 [Source:HGNC Symbol;Acc:HGNC:26940] | 29985 | -0.396 | -0.1780 | No |
| 91 | YY1AP1 | YY1 associated protein 1 [Source:HGNC Symbol;Acc:HGNC:30935] | 29990 | -0.396 | -0.1751 | No |
| 92 | NABP2 | nucleic acid binding protein 2 [Source:HGNC Symbol;Acc:HGNC:28412] | 30477 | -0.473 | -0.1846 | No |
| 93 | CSAD | cysteine sulfinic acid decarboxylase [Source:HGNC Symbol;Acc:HGNC:18966] | 30642 | -0.502 | -0.1853 | No |
| 94 | OTX1 | orthodenticle homeobox 1 [Source:HGNC Symbol;Acc:HGNC:8521] | 30886 | -0.540 | -0.1877 | No |
| 95 | PRKD2 | protein kinase D2 [Source:HGNC Symbol;Acc:HGNC:17293] | 30913 | -0.545 | -0.1843 | No |
| 96 | TRPM3 | transient receptor potential cation channel subfamily M member 3 [Source:HGNC Symbol;Acc:HGNC:17992] | 31277 | -0.606 | -0.1895 | No |
| 97 | SREK1 | splicing regulatory glutamic acid and lysine rich protein 1 [Source:HGNC Symbol;Acc:HGNC:17882] | 31282 | -0.607 | -0.1850 | No |
| 98 | HPCAL1 | hippocalcin like 1 [Source:HGNC Symbol;Acc:HGNC:5145] | 31300 | -0.610 | -0.1808 | No |
| 99 | RELCH | RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing [Source:HGNC Symbol;Acc:HGNC:29289] | 31372 | -0.628 | -0.1780 | No |
| 100 | MITF | melanocyte inducing transcription factor [Source:HGNC Symbol;Acc:HGNC:7105] | 31523 | -0.656 | -0.1771 | No |
| 101 | ABHD16A | abhydrolase domain containing 16A, phospholipase [Source:HGNC Symbol;Acc:HGNC:13921] | 31789 | -0.705 | -0.1789 | No |
| 102 | ESR1 | estrogen receptor 1 [Source:HGNC Symbol;Acc:HGNC:3467] | 31881 | -0.725 | -0.1758 | No |
| 103 | TRMT6 | tRNA methyltransferase 6 [Source:HGNC Symbol;Acc:HGNC:20900] | 31923 | -0.736 | -0.1714 | No |
| 104 | BBX | BBX high mobility group box domain containing [Source:HGNC Symbol;Acc:HGNC:14422] | 31948 | -0.742 | -0.1664 | No |
| 105 | ME3 | malic enzyme 3 [Source:HGNC Symbol;Acc:HGNC:6985] | 32254 | -0.825 | -0.1684 | No |
| 106 | USP5 | ubiquitin specific peptidase 5 [Source:HGNC Symbol;Acc:HGNC:12628] | 32500 | -0.885 | -0.1683 | No |
| 107 | DLX1 | distal-less homeobox 1 [Source:HGNC Symbol;Acc:HGNC:2914] | 32617 | -0.921 | -0.1644 | No |
| 108 | CCDC6 | coiled-coil domain containing 6 [Source:HGNC Symbol;Acc:HGNC:18782] | 32930 | -1.015 | -0.1651 | No |
| 109 | TGFB3 | transforming growth factor beta 3 [Source:HGNC Symbol;Acc:HGNC:11769] | 33002 | -1.038 | -0.1592 | No |
| 110 | TNFSF13B | TNF superfamily member 13b [Source:HGNC Symbol;Acc:HGNC:11929] | 33289 | -1.126 | -0.1584 | No |
| 111 | HDAC4 | histone deacetylase 4 [Source:HGNC Symbol;Acc:HGNC:14063] | 33587 | -1.225 | -0.1571 | No |
| 112 | PLXNC1 | plexin C1 [Source:HGNC Symbol;Acc:HGNC:9106] | 33631 | -1.241 | -0.1488 | No |
| 113 | VGLL4 | vestigial like family member 4 [Source:HGNC Symbol;Acc:HGNC:28966] | 33684 | -1.261 | -0.1406 | No |
| 114 | USF1 | upstream transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:12593] | 34390 | -1.522 | -0.1482 | No |
| 115 | SIPA1 | signal-induced proliferation-associated 1 [Source:HGNC Symbol;Acc:HGNC:10885] | 34573 | -1.591 | -0.1410 | No |
| 116 | DAP3 | death associated protein 3 [Source:HGNC Symbol;Acc:HGNC:2673] | 34658 | -1.630 | -0.1309 | No |
| 117 | AMER1 | APC membrane recruitment protein 1 [Source:HGNC Symbol;Acc:HGNC:26837] | 34669 | -1.636 | -0.1187 | No |
| 118 | RNF220 | ring finger protein 220 [Source:HGNC Symbol;Acc:HGNC:25552] | 34859 | -1.724 | -0.1108 | No |
| 119 | DDX17 | DEAD-box helicase 17 [Source:HGNC Symbol;Acc:HGNC:2740] | 35295 | -1.993 | -0.1074 | No |
| 120 | ARHGAP5 | Rho GTPase activating protein 5 [Source:HGNC Symbol;Acc:HGNC:675] | 35421 | -2.076 | -0.0950 | No |
| 121 | SORBS1 | sorbin and SH3 domain containing 1 [Source:HGNC Symbol;Acc:HGNC:14565] | 35521 | -2.137 | -0.0814 | No |
| 122 | KDM3A | lysine demethylase 3A [Source:HGNC Symbol;Acc:HGNC:20815] | 35647 | -2.235 | -0.0678 | No |
| 123 | ARHGEF6 | Rac/Cdc42 guanine nucleotide exchange factor 6 [Source:HGNC Symbol;Acc:HGNC:685] | 36038 | -2.590 | -0.0587 | No |
| 124 | NR3C2 | nuclear receptor subfamily 3 group C member 2 [Source:HGNC Symbol;Acc:HGNC:7979] | 36096 | -2.647 | -0.0402 | No |
| 125 | DEPDC7 | DEP domain containing 7 [Source:HGNC Symbol;Acc:HGNC:29899] | 36115 | -2.667 | -0.0204 | No |
| 126 | MCM8 | minichromosome maintenance 8 homologous recombination repair factor [Source:HGNC Symbol;Acc:HGNC:16147] | 36126 | -2.681 | -0.0003 | No |
| 127 | FAM13C | family with sequence similarity 13 member C [Source:HGNC Symbol;Acc:HGNC:19371] | 36728 | -3.468 | 0.0098 | No |
