Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #KO_LPS_versus_KO_NA.Nof1.cls #KO_LPS_versus_KO_NA_repos |
| Phenotype | Nof1.cls#KO_LPS_versus_KO_NA_repos |
| Upregulated in class | KO_LPS |
| GeneSet | GOBP_INTERFERON_GAMMA_MEDIATED_SIGNALING_PATHWAY |
| Enrichment Score (ES) | 0.80974734 |
| Normalized Enrichment Score (NES) | 2.0459814 |
| Nominal p-value | 0.0 |
| FDR q-value | 2.8867798E-4 |
| FWER p-Value | 0.001 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | GBP1 | guanylate binding protein 1 [Source:HGNC Symbol;Acc:HGNC:4182] | 19 | 4.836 | 0.0438 | Yes |
| 2 | OASL | 2'-5'-oligoadenylate synthetase like [Source:HGNC Symbol;Acc:HGNC:8090] | 37 | 4.663 | 0.0860 | Yes |
| 3 | SOCS3 | suppressor of cytokine signaling 3 [Source:HGNC Symbol;Acc:HGNC:19391] | 45 | 4.558 | 0.1275 | Yes |
| 4 | GBP2 | guanylate binding protein 2 [Source:HGNC Symbol;Acc:HGNC:4183] | 51 | 4.480 | 0.1684 | Yes |
| 5 | IRF7 | interferon regulatory factor 7 [Source:HGNC Symbol;Acc:HGNC:6122] | 54 | 4.451 | 0.2091 | Yes |
| 6 | TRIM34 | tripartite motif containing 34 [Source:HGNC Symbol;Acc:HGNC:10063] | 107 | 4.004 | 0.2444 | Yes |
| 7 | STAT1 | signal transducer and activator of transcription 1 [Source:HGNC Symbol;Acc:HGNC:11362] | 145 | 3.779 | 0.2780 | Yes |
| 8 | OAS1 | 2'-5'-oligoadenylate synthetase 1 [Source:HGNC Symbol;Acc:HGNC:8086] | 154 | 3.699 | 0.3116 | Yes |
| 9 | OAS3 | 2'-5'-oligoadenylate synthetase 3 [Source:HGNC Symbol;Acc:HGNC:8088] | 168 | 3.624 | 0.3445 | Yes |
| 10 | TRIM21 | tripartite motif containing 21 [Source:HGNC Symbol;Acc:HGNC:11312] | 195 | 3.470 | 0.3755 | Yes |
| 11 | PTAFR | platelet activating factor receptor [Source:HGNC Symbol;Acc:HGNC:9582] | 234 | 3.248 | 0.4042 | Yes |
| 12 | HCK | HCK proto-oncogene, Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:4840] | 236 | 3.241 | 0.4339 | Yes |
| 13 | TRIM25 | tripartite motif containing 25 [Source:HGNC Symbol;Acc:HGNC:12932] | 237 | 3.234 | 0.4635 | Yes |
| 14 | CD44 | CD44 molecule (Indian blood group) [Source:HGNC Symbol;Acc:HGNC:1681] | 241 | 3.211 | 0.4928 | Yes |
| 15 | OAS2 | 2'-5'-oligoadenylate synthetase 2 [Source:HGNC Symbol;Acc:HGNC:8087] | 276 | 3.036 | 0.5197 | Yes |
| 16 | NLRC5 | NLR family CARD domain containing 5 [Source:HGNC Symbol;Acc:HGNC:29933] | 290 | 2.979 | 0.5466 | Yes |
| 17 | SOCS1 | suppressor of cytokine signaling 1 [Source:HGNC Symbol;Acc:HGNC:19383] | 371 | 2.705 | 0.5692 | Yes |
| 18 | JAK2 | Janus kinase 2 [Source:HGNC Symbol;Acc:HGNC:6192] | 399 | 2.620 | 0.5925 | Yes |
| 19 | IRF1 | interferon regulatory factor 1 [Source:HGNC Symbol;Acc:HGNC:6116] | 496 | 2.371 | 0.6116 | Yes |
| 20 | IRF9 | interferon regulatory factor 9 [Source:HGNC Symbol;Acc:HGNC:6131] | 510 | 2.341 | 0.6327 | Yes |
| 21 | PARP14 | poly(ADP-ribose) polymerase family member 14 [Source:HGNC Symbol;Acc:HGNC:29232] | 580 | 2.164 | 0.6506 | Yes |
| 22 | IRGM | immunity related GTPase M [Source:HGNC Symbol;Acc:HGNC:29597] | 663 | 2.024 | 0.6669 | Yes |
| 23 | HLA-E | major histocompatibility complex, class I, E [Source:HGNC Symbol;Acc:HGNC:4962] | 783 | 1.845 | 0.6806 | Yes |
| 24 | PML | promyelocytic leukemia [Source:HGNC Symbol;Acc:HGNC:9113] | 986 | 1.591 | 0.6897 | Yes |
| 25 | HLA-B | major histocompatibility complex, class I, B [Source:HGNC Symbol;Acc:HGNC:4932] | 1095 | 1.472 | 0.7003 | Yes |
| 26 | PARP9 | poly(ADP-ribose) polymerase family member 9 [Source:HGNC Symbol;Acc:HGNC:24118] | 1117 | 1.452 | 0.7130 | Yes |
| 27 | MID1 | midline 1 [Source:HGNC Symbol;Acc:HGNC:7095] | 1251 | 1.347 | 0.7218 | Yes |
| 28 | FCGR1A | Fc fragment of IgG receptor Ia [Source:HGNC Symbol;Acc:HGNC:3613] | 1259 | 1.344 | 0.7339 | Yes |
| 29 | NR1H3 | nuclear receptor subfamily 1 group H member 3 [Source:HGNC Symbol;Acc:HGNC:7966] | 1413 | 1.240 | 0.7411 | Yes |
| 30 | IRF5 | interferon regulatory factor 5 [Source:HGNC Symbol;Acc:HGNC:6120] | 1426 | 1.232 | 0.7520 | Yes |
| 31 | HLA-A | major histocompatibility complex, class I, A [Source:HGNC Symbol;Acc:HGNC:4931] | 1464 | 1.209 | 0.7621 | Yes |
| 32 | IRF8 | interferon regulatory factor 8 [Source:HGNC Symbol;Acc:HGNC:5358] | 1473 | 1.204 | 0.7729 | Yes |
| 33 | TRIM26 | tripartite motif containing 26 [Source:HGNC Symbol;Acc:HGNC:12962] | 1580 | 1.155 | 0.7806 | Yes |
| 34 | SUMO1 | small ubiquitin like modifier 1 [Source:HGNC Symbol;Acc:HGNC:12502] | 1594 | 1.146 | 0.7908 | Yes |
| 35 | MT2A | metallothionein 2A [Source:HGNC Symbol;Acc:HGNC:7406] | 1701 | 1.091 | 0.7979 | Yes |
| 36 | HLA-C | major histocompatibility complex, class I, C [Source:HGNC Symbol;Acc:HGNC:4933] | 1772 | 1.050 | 0.8056 | Yes |
| 37 | HLA-G | major histocompatibility complex, class I, G [Source:HGNC Symbol;Acc:HGNC:4964] | 2297 | 0.816 | 0.7989 | Yes |
| 38 | HLA-F | major histocompatibility complex, class I, F [Source:HGNC Symbol;Acc:HGNC:4963] | 2333 | 0.802 | 0.8053 | Yes |
| 39 | MED1 | mediator complex subunit 1 [Source:HGNC Symbol;Acc:HGNC:9234] | 2431 | 0.768 | 0.8097 | Yes |
| 40 | IRF4 | interferon regulatory factor 4 [Source:HGNC Symbol;Acc:HGNC:6119] | 2971 | 0.608 | 0.8007 | No |
| 41 | HSP90AB1 | heat shock protein 90 alpha family class B member 1 [Source:HGNC Symbol;Acc:HGNC:5258] | 3572 | 0.463 | 0.7888 | No |
| 42 | PRKCD | protein kinase C delta [Source:HGNC Symbol;Acc:HGNC:9399] | 3674 | 0.444 | 0.7901 | No |
| 43 | B2M | beta-2-microglobulin [Source:HGNC Symbol;Acc:HGNC:914] | 4631 | 0.246 | 0.7665 | No |
| 44 | TXK | TXK tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:12434] | 4890 | 0.202 | 0.7614 | No |
| 45 | JAK1 | Janus kinase 1 [Source:HGNC Symbol;Acc:HGNC:6190] | 5390 | 0.110 | 0.7489 | No |
| 46 | CDC37 | cell division cycle 37, HSP90 cochaperone [Source:HGNC Symbol;Acc:HGNC:1735] | 5660 | 0.059 | 0.7422 | No |
| 47 | HLA-H | major histocompatibility complex, class I, H (pseudogene) [Source:HGNC Symbol;Acc:HGNC:4965] | 5909 | 0.009 | 0.7356 | No |
| 48 | ARG1 | arginase 1 [Source:HGNC Symbol;Acc:HGNC:663] | 6950 | 0.000 | 0.7075 | No |
| 49 | FCGR1B | Fc fragment of IgG receptor Ib [Source:HGNC Symbol;Acc:HGNC:3614] | 11188 | 0.000 | 0.5930 | No |
| 50 | IFI30 | IFI30 lysosomal thiol reductase [Source:HGNC Symbol;Acc:HGNC:5398] | 11204 | 0.000 | 0.5926 | No |
| 51 | NCAM1 | neural cell adhesion molecule 1 [Source:HGNC Symbol;Acc:HGNC:7656] | 11723 | 0.000 | 0.5786 | No |
| 52 | VCAM1 | vascular cell adhesion molecule 1 [Source:HGNC Symbol;Acc:HGNC:12663] | 13720 | 0.000 | 0.5246 | No |
| 53 | TRIM38 | tripartite motif containing 38 [Source:HGNC Symbol;Acc:HGNC:10059] | 15171 | 0.000 | 0.4854 | No |
| 54 | TRIM31 | tripartite motif containing 31 [Source:HGNC Symbol;Acc:HGNC:16289] | 15172 | 0.000 | 0.4854 | No |
| 55 | TRIM22 | tripartite motif containing 22 [Source:HGNC Symbol;Acc:HGNC:16379] | 15183 | 0.000 | 0.4852 | No |
| 56 | HLA-DRA | major histocompatibility complex, class II, DR alpha [Source:HGNC Symbol;Acc:HGNC:4947] | 16139 | 0.000 | 0.4593 | No |
| 57 | HPX | hemopexin [Source:HGNC Symbol;Acc:HGNC:5171] | 17405 | 0.000 | 0.4252 | No |
| 58 | TRIM5 | tripartite motif containing 5 [Source:HGNC Symbol;Acc:HGNC:16276] | 17739 | 0.000 | 0.4162 | No |
| 59 | HLA-DRB5 | major histocompatibility complex, class II, DR beta 5 [Source:HGNC Symbol;Acc:HGNC:4953] | 17991 | 0.000 | 0.4094 | No |
| 60 | ICAM1 | intercellular adhesion molecule 1 [Source:HGNC Symbol;Acc:HGNC:5344] | 18189 | 0.000 | 0.4041 | No |
| 61 | HLA-DQA2 | major histocompatibility complex, class II, DQ alpha 2 [Source:HGNC Symbol;Acc:HGNC:4943] | 18323 | 0.000 | 0.4005 | No |
| 62 | HLA-DQA1 | major histocompatibility complex, class II, DQ alpha 1 [Source:HGNC Symbol;Acc:HGNC:4942] | 18324 | 0.000 | 0.4005 | No |
| 63 | HLA-DQB2 | major histocompatibility complex, class II, DQ beta 2 [Source:HGNC Symbol;Acc:HGNC:4945] | 18351 | 0.000 | 0.3998 | No |
| 64 | HLA-DPA1 | major histocompatibility complex, class II, DP alpha 1 [Source:HGNC Symbol;Acc:HGNC:4938] | 18780 | 0.000 | 0.3882 | No |
| 65 | HLA-DPB1 | major histocompatibility complex, class II, DP beta 1 [Source:HGNC Symbol;Acc:HGNC:4940] | 18800 | 0.000 | 0.3877 | No |
| 66 | NMI | N-myc and STAT interactor [Source:HGNC Symbol;Acc:HGNC:7854] | 19249 | 0.000 | 0.3756 | No |
| 67 | IFNGR1 | interferon gamma receptor 1 [Source:HGNC Symbol;Acc:HGNC:5439] | 20441 | 0.000 | 0.3434 | No |
| 68 | IFNGR2 | interferon gamma receptor 2 [Source:HGNC Symbol;Acc:HGNC:5440] | 20443 | 0.000 | 0.3434 | No |
| 69 | IFNG | interferon gamma [Source:HGNC Symbol;Acc:HGNC:5438] | 20742 | 0.000 | 0.3353 | No |
| 70 | CIITA | class II major histocompatibility complex transactivator [Source:HGNC Symbol;Acc:HGNC:7067] | 22086 | 0.000 | 0.2990 | No |
| 71 | OTOP1 | otopetrin 1 [Source:HGNC Symbol;Acc:HGNC:19656] | 23157 | 0.000 | 0.2701 | No |
| 72 | IRF2 | interferon regulatory factor 2 [Source:HGNC Symbol;Acc:HGNC:6117] | 27482 | -0.022 | 0.1534 | No |
| 73 | NR1H2 | nuclear receptor subfamily 1 group H member 2 [Source:HGNC Symbol;Acc:HGNC:7965] | 27667 | -0.056 | 0.1490 | No |
| 74 | IRF6 | interferon regulatory factor 6 [Source:HGNC Symbol;Acc:HGNC:6121] | 27763 | -0.071 | 0.1471 | No |
| 75 | IRF3 | interferon regulatory factor 3 [Source:HGNC Symbol;Acc:HGNC:6118] | 27869 | -0.085 | 0.1450 | No |
| 76 | SP100 | SP100 nuclear antigen [Source:HGNC Symbol;Acc:HGNC:11206] | 27873 | -0.086 | 0.1457 | No |
| 77 | PTPN2 | protein tyrosine phosphatase non-receptor type 2 [Source:HGNC Symbol;Acc:HGNC:9650] | 28239 | -0.141 | 0.1371 | No |
| 78 | CAMK2D | calcium/calmodulin dependent protein kinase II delta [Source:HGNC Symbol;Acc:HGNC:1462] | 28743 | -0.211 | 0.1255 | No |
| 79 | TRIM8 | tripartite motif containing 8 [Source:HGNC Symbol;Acc:HGNC:15579] | 29361 | -0.305 | 0.1116 | No |
| 80 | HLA-DQB1 | major histocompatibility complex, class II, DQ beta 1 [Source:HGNC Symbol;Acc:HGNC:4944] | 29389 | -0.310 | 0.1137 | No |
| 81 | TRIM68 | tripartite motif containing 68 [Source:HGNC Symbol;Acc:HGNC:21161] | 29966 | -0.393 | 0.1017 | No |
| 82 | PIAS1 | protein inhibitor of activated STAT 1 [Source:HGNC Symbol;Acc:HGNC:2752] | 30778 | -0.522 | 0.0846 | No |
| 83 | HLA-DRB1 | major histocompatibility complex, class II, DR beta 1 [Source:HGNC Symbol;Acc:HGNC:4948] | 31188 | -0.593 | 0.0790 | No |
| 84 | CAMK2A | calcium/calmodulin dependent protein kinase II alpha [Source:HGNC Symbol;Acc:HGNC:1460] | 32910 | -1.009 | 0.0417 | No |
| 85 | PPARG | peroxisome proliferator activated receptor gamma [Source:HGNC Symbol;Acc:HGNC:9236] | 33389 | -1.156 | 0.0394 | No |
| 86 | TP53 | tumor protein p53 [Source:HGNC Symbol;Acc:HGNC:11998] | 33554 | -1.213 | 0.0460 | No |
| 87 | TRIM62 | tripartite motif containing 62 [Source:HGNC Symbol;Acc:HGNC:25574] | 33818 | -1.309 | 0.0509 | No |
| 88 | CAMK2B | calcium/calmodulin dependent protein kinase II beta [Source:HGNC Symbol;Acc:HGNC:1461] | 33957 | -1.357 | 0.0596 | No |
| 89 | CAMK2G | calcium/calmodulin dependent protein kinase II gamma [Source:HGNC Symbol;Acc:HGNC:1463] | 36175 | -2.735 | 0.0247 | No |
