Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #KO_LPS_versus_KO_NA.Nof1.cls #KO_LPS_versus_KO_NA_repos |
| Phenotype | Nof1.cls#KO_LPS_versus_KO_NA_repos |
| Upregulated in class | KO_LPS |
| GeneSet | GOBP_INTERLEUKIN_1_MEDIATED_SIGNALING_PATHWAY |
| Enrichment Score (ES) | 0.7114555 |
| Normalized Enrichment Score (NES) | 1.8389387 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.034763057 |
| FWER p-Value | 0.266 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | IL1B | interleukin 1 beta [Source:HGNC Symbol;Acc:HGNC:5992] | 1 | 4.994 | 0.0470 | Yes |
| 2 | IL1A | interleukin 1 alpha [Source:HGNC Symbol;Acc:HGNC:5991] | 10 | 4.932 | 0.0932 | Yes |
| 3 | IL1RN | interleukin 1 receptor antagonist [Source:HGNC Symbol;Acc:HGNC:6000] | 12 | 4.907 | 0.1393 | Yes |
| 4 | PELI1 | pellino E3 ubiquitin protein ligase 1 [Source:HGNC Symbol;Acc:HGNC:8827] | 119 | 3.934 | 0.1735 | Yes |
| 5 | NFKB1 | nuclear factor kappa B subunit 1 [Source:HGNC Symbol;Acc:HGNC:7794] | 130 | 3.895 | 0.2099 | Yes |
| 6 | NFKBIA | NFKB inhibitor alpha [Source:HGNC Symbol;Acc:HGNC:7797] | 159 | 3.663 | 0.2436 | Yes |
| 7 | PSMB10 | proteasome 20S subunit beta 10 [Source:HGNC Symbol;Acc:HGNC:9538] | 206 | 3.402 | 0.2744 | Yes |
| 8 | SQSTM1 | sequestosome 1 [Source:HGNC Symbol;Acc:HGNC:11280] | 244 | 3.199 | 0.3035 | Yes |
| 9 | PSMA6 | proteasome 20S subunit alpha 6 [Source:HGNC Symbol;Acc:HGNC:9535] | 278 | 3.029 | 0.3311 | Yes |
| 10 | MYD88 | MYD88 innate immune signal transduction adaptor [Source:HGNC Symbol;Acc:HGNC:7562] | 311 | 2.881 | 0.3573 | Yes |
| 11 | PSME2 | proteasome activator subunit 2 [Source:HGNC Symbol;Acc:HGNC:9569] | 397 | 2.625 | 0.3797 | Yes |
| 12 | RIPK2 | receptor interacting serine/threonine kinase 2 [Source:HGNC Symbol;Acc:HGNC:10020] | 404 | 2.597 | 0.4040 | Yes |
| 13 | PSME1 | proteasome activator subunit 1 [Source:HGNC Symbol;Acc:HGNC:9568] | 468 | 2.436 | 0.4252 | Yes |
| 14 | PSMB8 | proteasome 20S subunit beta 8 [Source:HGNC Symbol;Acc:HGNC:9545] | 697 | 1.961 | 0.4375 | Yes |
| 15 | PSMF1 | proteasome inhibitor subunit 1 [Source:HGNC Symbol;Acc:HGNC:9571] | 703 | 1.954 | 0.4558 | Yes |
| 16 | PSMB9 | proteasome 20S subunit beta 9 [Source:HGNC Symbol;Acc:HGNC:9546] | 764 | 1.869 | 0.4718 | Yes |
| 17 | PSMA4 | proteasome 20S subunit alpha 4 [Source:HGNC Symbol;Acc:HGNC:9533] | 876 | 1.725 | 0.4850 | Yes |
| 18 | PSMD12 | proteasome 26S subunit, non-ATPase 12 [Source:HGNC Symbol;Acc:HGNC:9557] | 900 | 1.688 | 0.5003 | Yes |
| 19 | NOD2 | nucleotide binding oligomerization domain containing 2 [Source:HGNC Symbol;Acc:HGNC:5331] | 1147 | 1.428 | 0.5071 | Yes |
| 20 | NOD1 | nucleotide binding oligomerization domain containing 1 [Source:HGNC Symbol;Acc:HGNC:16390] | 1239 | 1.359 | 0.5174 | Yes |
| 21 | PSMD11 | proteasome 26S subunit, non-ATPase 11 [Source:HGNC Symbol;Acc:HGNC:9556] | 1283 | 1.323 | 0.5287 | Yes |
| 22 | PSMD7 | proteasome 26S subunit, non-ATPase 7 [Source:HGNC Symbol;Acc:HGNC:9565] | 1285 | 1.320 | 0.5411 | Yes |
| 23 | PSMC5 | proteasome 26S subunit, ATPase 5 [Source:HGNC Symbol;Acc:HGNC:9552] | 1321 | 1.302 | 0.5524 | Yes |
| 24 | IRAK2 | interleukin 1 receptor associated kinase 2 [Source:HGNC Symbol;Acc:HGNC:6113] | 1416 | 1.238 | 0.5615 | Yes |
| 25 | PSMA5 | proteasome 20S subunit alpha 5 [Source:HGNC Symbol;Acc:HGNC:9534] | 1503 | 1.187 | 0.5703 | Yes |
| 26 | PSMA3 | proteasome 20S subunit alpha 3 [Source:HGNC Symbol;Acc:HGNC:9532] | 1570 | 1.166 | 0.5795 | Yes |
| 27 | PSMB5 | proteasome 20S subunit beta 5 [Source:HGNC Symbol;Acc:HGNC:9542] | 1595 | 1.146 | 0.5897 | Yes |
| 28 | PSMB4 | proteasome 20S subunit beta 4 [Source:HGNC Symbol;Acc:HGNC:9541] | 1656 | 1.114 | 0.5985 | Yes |
| 29 | PSMC2 | proteasome 26S subunit, ATPase 2 [Source:HGNC Symbol;Acc:HGNC:9548] | 1705 | 1.088 | 0.6075 | Yes |
| 30 | PSMB6 | proteasome 20S subunit beta 6 [Source:HGNC Symbol;Acc:HGNC:9543] | 1710 | 1.081 | 0.6175 | Yes |
| 31 | PSMD6 | proteasome 26S subunit, non-ATPase 6 [Source:HGNC Symbol;Acc:HGNC:9564] | 1872 | 1.008 | 0.6227 | Yes |
| 32 | PSMD14 | proteasome 26S subunit, non-ATPase 14 [Source:HGNC Symbol;Acc:HGNC:16889] | 1927 | 0.982 | 0.6304 | Yes |
| 33 | PSMD3 | proteasome 26S subunit, non-ATPase 3 [Source:HGNC Symbol;Acc:HGNC:9560] | 1962 | 0.963 | 0.6386 | Yes |
| 34 | PSMC1 | proteasome 26S subunit, ATPase 1 [Source:HGNC Symbol;Acc:HGNC:9547] | 2210 | 0.852 | 0.6399 | Yes |
| 35 | UBE2N | ubiquitin conjugating enzyme E2 N [Source:HGNC Symbol;Acc:HGNC:12492] | 2293 | 0.819 | 0.6454 | Yes |
| 36 | PSMB7 | proteasome 20S subunit beta 7 [Source:HGNC Symbol;Acc:HGNC:9544] | 2336 | 0.800 | 0.6518 | Yes |
| 37 | PSMD1 | proteasome 26S subunit, non-ATPase 1 [Source:HGNC Symbol;Acc:HGNC:9554] | 2416 | 0.773 | 0.6569 | Yes |
| 38 | PSMD13 | proteasome 26S subunit, non-ATPase 13 [Source:HGNC Symbol;Acc:HGNC:9558] | 2640 | 0.696 | 0.6575 | Yes |
| 39 | PSMC6 | proteasome 26S subunit, ATPase 6 [Source:HGNC Symbol;Acc:HGNC:9553] | 2716 | 0.672 | 0.6618 | Yes |
| 40 | PSMD8 | proteasome 26S subunit, non-ATPase 8 [Source:HGNC Symbol;Acc:HGNC:9566] | 2720 | 0.670 | 0.6680 | Yes |
| 41 | TAB2 | TGF-beta activated kinase 1 (MAP3K7) binding protein 2 [Source:HGNC Symbol;Acc:HGNC:17075] | 2789 | 0.652 | 0.6723 | Yes |
| 42 | MAP3K8 | mitogen-activated protein kinase kinase kinase 8 [Source:HGNC Symbol;Acc:HGNC:6860] | 2835 | 0.640 | 0.6771 | Yes |
| 43 | PSMC4 | proteasome 26S subunit, ATPase 4 [Source:HGNC Symbol;Acc:HGNC:9551] | 2885 | 0.627 | 0.6817 | Yes |
| 44 | IL6 | interleukin 6 [Source:HGNC Symbol;Acc:HGNC:6018] | 2890 | 0.626 | 0.6874 | Yes |
| 45 | IKBKG | inhibitor of nuclear factor kappa B kinase regulatory subunit gamma [Source:HGNC Symbol;Acc:HGNC:5961] | 3070 | 0.587 | 0.6881 | Yes |
| 46 | IL1RAP | interleukin 1 receptor accessory protein [Source:HGNC Symbol;Acc:HGNC:5995] | 3112 | 0.574 | 0.6924 | Yes |
| 47 | PSMA2 | proteasome 20S subunit alpha 2 [Source:HGNC Symbol;Acc:HGNC:9531] | 3150 | 0.564 | 0.6967 | Yes |
| 48 | OTUD4 | OTU deubiquitinase 4 [Source:HGNC Symbol;Acc:HGNC:24949] | 3348 | 0.517 | 0.6963 | Yes |
| 49 | PSMA7 | proteasome 20S subunit alpha 7 [Source:HGNC Symbol;Acc:HGNC:9536] | 3377 | 0.512 | 0.7003 | Yes |
| 50 | PSMB3 | proteasome 20S subunit beta 3 [Source:HGNC Symbol;Acc:HGNC:9540] | 3517 | 0.476 | 0.7011 | Yes |
| 51 | PSME3 | proteasome activator subunit 3 [Source:HGNC Symbol;Acc:HGNC:9570] | 3552 | 0.469 | 0.7045 | Yes |
| 52 | IKBKB | inhibitor of nuclear factor kappa B kinase subunit beta [Source:HGNC Symbol;Acc:HGNC:5960] | 3648 | 0.449 | 0.7062 | Yes |
| 53 | UBB | ubiquitin B [Source:HGNC Symbol;Acc:HGNC:12463] | 3790 | 0.423 | 0.7064 | Yes |
| 54 | TOLLIP | toll interacting protein [Source:HGNC Symbol;Acc:HGNC:16476] | 3848 | 0.411 | 0.7087 | Yes |
| 55 | PSMD2 | proteasome 26S subunit, non-ATPase 2 [Source:HGNC Symbol;Acc:HGNC:9559] | 3917 | 0.396 | 0.7106 | Yes |
| 56 | PSMD5 | proteasome 26S subunit, non-ATPase 5 [Source:HGNC Symbol;Acc:HGNC:9563] | 4015 | 0.371 | 0.7115 | Yes |
| 57 | CHUK | component of inhibitor of nuclear factor kappa B kinase complex [Source:HGNC Symbol;Acc:HGNC:1974] | 4425 | 0.289 | 0.7031 | No |
| 58 | PSMC3 | proteasome 26S subunit, ATPase 3 [Source:HGNC Symbol;Acc:HGNC:9549] | 4564 | 0.264 | 0.7019 | No |
| 59 | PSMA1 | proteasome 20S subunit alpha 1 [Source:HGNC Symbol;Acc:HGNC:9530] | 4587 | 0.258 | 0.7037 | No |
| 60 | SKP1 | S-phase kinase associated protein 1 [Source:HGNC Symbol;Acc:HGNC:10899] | 4790 | 0.221 | 0.7003 | No |
| 61 | UBC | ubiquitin C [Source:HGNC Symbol;Acc:HGNC:12468] | 4861 | 0.207 | 0.7004 | No |
| 62 | RELA | RELA proto-oncogene, NF-kB subunit [Source:HGNC Symbol;Acc:HGNC:9955] | 4865 | 0.207 | 0.7022 | No |
| 63 | PSMD10 | proteasome 26S subunit, non-ATPase 10 [Source:HGNC Symbol;Acc:HGNC:9555] | 5549 | 0.081 | 0.6845 | No |
| 64 | FBXW11 | F-box and WD repeat domain containing 11 [Source:HGNC Symbol;Acc:HGNC:13607] | 5564 | 0.078 | 0.6849 | No |
| 65 | PSMD4 | proteasome 26S subunit, non-ATPase 4 [Source:HGNC Symbol;Acc:HGNC:9561] | 5744 | 0.045 | 0.6805 | No |
| 66 | BTRC | beta-transducin repeat containing E3 ubiquitin protein ligase [Source:HGNC Symbol;Acc:HGNC:1144] | 5945 | 0.004 | 0.6751 | No |
| 67 | PSMB11 | proteasome subunit beta 11 [Source:HGNC Symbol;Acc:HGNC:31963] | 6565 | 0.000 | 0.6584 | No |
| 68 | IL1RL2 | interleukin 1 receptor like 2 [Source:HGNC Symbol;Acc:HGNC:5999] | 6567 | 0.000 | 0.6584 | No |
| 69 | PELI2 | pellino E3 ubiquitin protein ligase family member 2 [Source:HGNC Symbol;Acc:HGNC:8828] | 8153 | 0.000 | 0.6155 | No |
| 70 | MIR21 | microRNA 21 [Source:HGNC Symbol;Acc:HGNC:31586] | 9255 | 0.000 | 0.5857 | No |
| 71 | MIR27A | microRNA 27a [Source:HGNC Symbol;Acc:HGNC:31613] | 15266 | 0.000 | 0.4233 | No |
| 72 | IL1R1 | interleukin 1 receptor type 1 [Source:HGNC Symbol;Acc:HGNC:5993] | 15821 | 0.000 | 0.4083 | No |
| 73 | IL1R2 | interleukin 1 receptor type 2 [Source:HGNC Symbol;Acc:HGNC:5994] | 15822 | 0.000 | 0.4083 | No |
| 74 | ZBP1 | Z-DNA binding protein 1 [Source:HGNC Symbol;Acc:HGNC:16176] | 25780 | 0.000 | 0.1391 | No |
| 75 | EGR1 | early growth response 1 [Source:HGNC Symbol;Acc:HGNC:3238] | 27646 | -0.053 | 0.0892 | No |
| 76 | TNIP2 | TNFAIP3 interacting protein 2 [Source:HGNC Symbol;Acc:HGNC:19118] | 27665 | -0.056 | 0.0892 | No |
| 77 | MAP3K3 | mitogen-activated protein kinase kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6855] | 27698 | -0.061 | 0.0889 | No |
| 78 | PSMB1 | proteasome 20S subunit beta 1 [Source:HGNC Symbol;Acc:HGNC:9537] | 27748 | -0.069 | 0.0882 | No |
| 79 | RPS27A | ribosomal protein S27a [Source:HGNC Symbol;Acc:HGNC:10417] | 27858 | -0.083 | 0.0861 | No |
| 80 | PLCB1 | phospholipase C beta 1 [Source:HGNC Symbol;Acc:HGNC:15917] | 27995 | -0.102 | 0.0834 | No |
| 81 | ZNF675 | zinc finger protein 675 [Source:HGNC Symbol;Acc:HGNC:30768] | 28139 | -0.125 | 0.0807 | No |
| 82 | RBX1 | ring-box 1 [Source:HGNC Symbol;Acc:HGNC:9928] | 28231 | -0.139 | 0.0795 | No |
| 83 | PSMB2 | proteasome 20S subunit beta 2 [Source:HGNC Symbol;Acc:HGNC:9539] | 28379 | -0.162 | 0.0771 | No |
| 84 | PSME4 | proteasome activator subunit 4 [Source:HGNC Symbol;Acc:HGNC:20635] | 28394 | -0.163 | 0.0782 | No |
| 85 | MAP3K7 | mitogen-activated protein kinase kinase kinase 7 [Source:HGNC Symbol;Acc:HGNC:6859] | 28603 | -0.188 | 0.0744 | No |
| 86 | VRK2 | VRK serine/threonine kinase 2 [Source:HGNC Symbol;Acc:HGNC:12719] | 28790 | -0.216 | 0.0714 | No |
| 87 | IRAK3 | interleukin 1 receptor associated kinase 3 [Source:HGNC Symbol;Acc:HGNC:17020] | 29344 | -0.303 | 0.0593 | No |
| 88 | PSMA8 | proteasome 20S subunit alpha 8 [Source:HGNC Symbol;Acc:HGNC:22985] | 29450 | -0.319 | 0.0594 | No |
| 89 | ST18 | ST18 C2H2C-type zinc finger transcription factor [Source:HGNC Symbol;Acc:HGNC:18695] | 29668 | -0.350 | 0.0569 | No |
| 90 | TRAF6 | TNF receptor associated factor 6 [Source:HGNC Symbol;Acc:HGNC:12036] | 29957 | -0.392 | 0.0528 | No |
| 91 | TAB3 | TGF-beta activated kinase 1 (MAP3K7) binding protein 3 [Source:HGNC Symbol;Acc:HGNC:30681] | 30123 | -0.417 | 0.0522 | No |
| 92 | PELI3 | pellino E3 ubiquitin protein ligase family member 3 [Source:HGNC Symbol;Acc:HGNC:30010] | 30264 | -0.440 | 0.0526 | No |
| 93 | UBE2V1 | ubiquitin conjugating enzyme E2 V1 [Source:HGNC Symbol;Acc:HGNC:12494] | 30364 | -0.456 | 0.0542 | No |
| 94 | UBA52 | ubiquitin A-52 residue ribosomal protein fusion product 1 [Source:HGNC Symbol;Acc:HGNC:12458] | 30391 | -0.458 | 0.0578 | No |
| 95 | IRAK4 | interleukin 1 receptor associated kinase 4 [Source:HGNC Symbol;Acc:HGNC:17967] | 30506 | -0.478 | 0.0592 | No |
| 96 | PSMD9 | proteasome 26S subunit, non-ATPase 9 [Source:HGNC Symbol;Acc:HGNC:9567] | 31838 | -0.712 | 0.0299 | No |
| 97 | CUL1 | cullin 1 [Source:HGNC Symbol;Acc:HGNC:2551] | 31886 | -0.728 | 0.0355 | No |
| 98 | IRAK1 | interleukin 1 receptor associated kinase 1 [Source:HGNC Symbol;Acc:HGNC:6112] | 33209 | -1.098 | 0.0101 | No |
| 99 | RPS6KA4 | ribosomal protein S6 kinase A4 [Source:HGNC Symbol;Acc:HGNC:10433] | 34261 | -1.472 | -0.0044 | No |
| 100 | MAPK3 | mitogen-activated protein kinase 3 [Source:HGNC Symbol;Acc:HGNC:6877] | 35871 | -2.437 | -0.0250 | No |
| 101 | TAB1 | TGF-beta activated kinase 1 (MAP3K7) binding protein 1 [Source:HGNC Symbol;Acc:HGNC:18157] | 36337 | -2.913 | -0.0102 | No |
| 102 | RPS6KA5 | ribosomal protein S6 kinase A5 [Source:HGNC Symbol;Acc:HGNC:10434] | 36581 | -3.240 | 0.0138 | No |
